MA43817B1 - Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 - Google Patents
Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2Info
- Publication number
- MA43817B1 MA43817B1 MA43817A MA43817A MA43817B1 MA 43817 B1 MA43817 B1 MA 43817B1 MA 43817 A MA43817 A MA 43817A MA 43817 A MA43817 A MA 43817A MA 43817 B1 MA43817 B1 MA 43817B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- orexin
- receptor antagonists
- treating depression
- compound
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne, entre autres, des méthodes de traitement d'un sujet souffrant d'une dépression ou chez qui une dépression a été diagnostiquée, comprenant l'administration à un sujet ayant besoin d'un tel traitement d'une quantité efficace d'un composé de formule (i), ou d'un sel pharmaceutiquement acceptable de celui-ci, dans laquelle les r1 à r4 sont décrits dans la description, et le composé étant administré avant le coucher.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662306487P | 2016-03-10 | 2016-03-10 | |
| PCT/US2017/021565 WO2017156266A1 (fr) | 2016-03-10 | 2017-03-09 | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA43817A MA43817A (fr) | 2018-11-28 |
| MA43817B1 true MA43817B1 (fr) | 2022-04-29 |
Family
ID=59776691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA43817A MA43817B1 (fr) | 2016-03-10 | 2017-03-09 | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 |
| MA43468A MA43468B1 (fr) | 2016-03-10 | 2017-03-09 | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA43468A MA43468B1 (fr) | 2016-03-10 | 2017-03-09 | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 |
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US10828302B2 (fr) |
| EP (2) | EP4091634A1 (fr) |
| JP (4) | JP7066622B2 (fr) |
| KR (4) | KR102559922B1 (fr) |
| CN (2) | CN108883110B (fr) |
| AU (3) | AU2017231828B2 (fr) |
| BR (1) | BR112018067906A2 (fr) |
| CA (2) | CA3016706A1 (fr) |
| CL (1) | CL2018002533A1 (fr) |
| CO (1) | CO2018009561A2 (fr) |
| CR (1) | CR20180433A (fr) |
| CY (1) | CY1125247T1 (fr) |
| DK (1) | DK3426251T3 (fr) |
| DO (1) | DOP2018000196A (fr) |
| EA (1) | EA201891930A1 (fr) |
| ES (1) | ES2913469T3 (fr) |
| HR (1) | HRP20220642T1 (fr) |
| HU (1) | HUE058759T2 (fr) |
| IL (3) | IL319248A (fr) |
| LT (1) | LT3426251T (fr) |
| MA (2) | MA43817B1 (fr) |
| MD (1) | MD3426251T2 (fr) |
| MX (1) | MX2018010852A (fr) |
| MY (1) | MY197558A (fr) |
| NI (1) | NI201800086A (fr) |
| PH (1) | PH12018501903B1 (fr) |
| PL (1) | PL3426251T3 (fr) |
| PT (1) | PT3426251T (fr) |
| RS (1) | RS63296B1 (fr) |
| SG (1) | SG11201807597UA (fr) |
| SI (1) | SI3426251T1 (fr) |
| SM (1) | SMT202200239T1 (fr) |
| SV (1) | SV2018005740A (fr) |
| UA (1) | UA125873C2 (fr) |
| WO (1) | WO2017156266A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2585806T3 (es) | 2009-10-23 | 2016-10-10 | Janssen Pharmaceutica N.V. | Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina |
| US10828302B2 (en) * | 2016-03-10 | 2020-11-10 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| WO2020023723A1 (fr) * | 2018-07-27 | 2020-01-30 | Icahn School Of Medicine At Mount Sinai | Procédé de traitement d'une agression avec des antagonistes de récepteur de l'orexine |
| MX2021005698A (es) | 2018-11-14 | 2021-07-07 | Janssen Pharmaceutica Nv | Metodos sinteticos mejorados para elaborar compuestos heterociclicos fusionados como moduladores del receptor de orexina. |
| WO2020168337A1 (fr) | 2019-02-17 | 2020-08-20 | Magid Abraham | Compositions et méthodes pour le traitement de la dépression et d'autres troubles |
| PE20220842A1 (es) | 2019-08-07 | 2022-05-24 | Janssen Pharmaceutica Nv | Metodos sinteticos mejorados para la elaboracion de compuestos de (2h-1,2,3-triazol-2-il)fenilo como moduladores del receptor de orexina |
| KR102119231B1 (ko) | 2019-09-05 | 2020-06-04 | 정소진 | 코르크칩을 이용한 신발용 밑창의 제조방법 및 그 제조방법에 의해 제조되는 신발용 밑창, 이를 포함하는 신발 |
| WO2022122009A1 (fr) * | 2020-12-11 | 2022-06-16 | 苏州晶云药物科技股份有限公司 | Formes cristallines d'un composé dérivé du pyrrole et leur procédé de préparation |
| WO2022194122A1 (fr) * | 2021-03-16 | 2022-09-22 | 上海翰森生物医药科技有限公司 | Composé hétérocyclique polycyclique contenant de l'azote, son procédé de préparation et son utilisation |
| CN113393944A (zh) * | 2021-06-17 | 2021-09-14 | 中国科学院长春应用化学研究所 | 基于代谢组学的芪参颗粒治疗慢性心力衰竭的药代动力学-药效动力学分析方法 |
| KR20230074653A (ko) | 2021-11-19 | 2023-05-31 | 고려대학교 세종산학협력단 | 신규 우레아계 또는 카바메이트계 p2x7 수용체 길항제 및 이를 유효성분으로 포함하는 주요 우울 장애의 예방 또는 치료용 약학 조성물 |
| WO2023180556A1 (fr) * | 2022-03-24 | 2023-09-28 | Janssen Pharmaceutica Nv | Méthodes de traitement de l'agitation chez des sujets souffrant d'un trouble cognitif léger ou d'un trouble neurocognitif majeur |
| KR20250065855A (ko) * | 2022-09-14 | 2025-05-13 | 장쑤 한서 파마슈티칼 그룹 캄파니 리미티드 | 질소 함유 헤테로고리의 다환식 화합물의 유리 염기 결정형 및 이의 제조 방법 |
| WO2024125395A1 (fr) * | 2022-12-12 | 2024-06-20 | 江苏恩华药业股份有限公司 | Dérivé de tétrahydrocyclopentyl[c]pyrrole substitué, procédé de préparation, intermédiaire et utilisation associés |
| JP7626487B2 (ja) * | 2022-12-16 | 2025-02-04 | 株式会社エフアンドエフ | 認知症及び/又はうつ病推定aiシステム並びに教師データ作成方法 |
| WO2025003991A1 (fr) * | 2023-06-29 | 2025-01-02 | Janssen Pharmaceutica Nv | Méthode de traitement de la dépression à l'aide de seltorexant |
| CN117338772B (zh) * | 2023-11-22 | 2024-04-09 | 徐州医科大学 | 一种药物组合物及其在制备用于预防和/或治疗重性抑郁障碍的药物中的应用 |
Family Cites Families (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7503310A (nl) * | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| CA2222322A1 (fr) | 1995-06-06 | 1996-12-12 | Abbott Laboratories | Composes de type quinolizinone |
| GB9519563D0 (en) | 1995-09-26 | 1995-11-29 | Merck Sharp & Dohme | Therapeutic agents |
| WO2000055143A1 (fr) | 1999-03-17 | 2000-09-21 | F. Hoffmann-La Roche Ag | Derives d'oxazolone et utilisations de ces derniers en tant que modulateurs du recepteur adrenergique alpha-1 |
| US6375897B1 (en) | 2000-02-14 | 2002-04-23 | Ansys Technologies, Inc. | Urine collection cup |
| US6809105B2 (en) | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
| MY137020A (en) | 2000-04-27 | 2008-12-31 | Abbott Lab | Diazabicyclic central nervous system active agents |
| EP1288202A4 (fr) | 2000-05-11 | 2003-07-02 | Banyu Pharma Co Ltd | Derives n-acyltetrahydroisoquinoline |
| SE0100326D0 (sv) | 2001-02-02 | 2001-02-02 | Astrazeneca Ab | New compounds |
| WO2002070527A1 (fr) | 2001-03-02 | 2002-09-12 | Akzo Nobel N.V. | Purification selective de masses d'organo-metalliques |
| CA2440803A1 (fr) | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulateurs de l'activite du recepteur de la chimiokine |
| BR0210609A (pt) | 2001-06-28 | 2004-07-20 | Smithkline Beecham Plc | Derivados de amina cìclica n-aroila como antagonistas do receptor da orexina |
| US6455722B1 (en) | 2001-06-29 | 2002-09-24 | Pabu Services, Inc. | Process for the production of pentaerythritol phosphate alcohol |
| GB2383315B (en) | 2001-12-18 | 2005-04-06 | Christopher Donald Clarke | Vehicle imaging system |
| GB0130341D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| DE10226943A1 (de) | 2002-06-17 | 2004-01-08 | Bayer Ag | Phenylaminopyrimidine und ihre Verwendung |
| ES2278197T3 (es) | 2002-07-09 | 2007-08-01 | Actelion Pharmaceuticals Ltd. | Derivados de 7,8,9,10-tetrahidro-6h-azepino, 6,7,8,9-tetrahidro-pirido y 2,3-dihidro-2h-pirrolo(1,2-b)-quinazolinona. |
| US7279578B2 (en) | 2002-10-11 | 2007-10-09 | Actelion Pharmaceuticals Ltd. | Sulfonylamino-acetic acid derivatives |
| GB0225944D0 (en) | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| MXPA05010137A (es) | 2003-03-26 | 2005-11-16 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroisoquinolil acetamida para usarse como antagonistas del receptor de orexina. |
| DE602004011204T2 (de) | 2003-04-28 | 2008-12-24 | Actelion Pharmaceuticals Ltd. | Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten. |
| US20040242641A1 (en) | 2003-05-27 | 2004-12-02 | Buckley Michael J. | (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent |
| WO2005005439A1 (fr) | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
| TW200507850A (en) | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
| WO2005023231A1 (fr) | 2003-09-10 | 2005-03-17 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Proteine de liaison du tractus polypyrimidique favorisant la biogenese d'un granule insulino-secretoire |
| US7399765B2 (en) | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| US20050065178A1 (en) | 2003-09-19 | 2005-03-24 | Anwer Basha | Substituted diazabicycloakane derivatives |
| US20050176680A1 (en) | 2003-12-11 | 2005-08-11 | Sepracor, Inc. | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| HUP0400405A3 (en) | 2004-02-10 | 2009-03-30 | Sanofi Synthelabo | Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates |
| PT1751111E (pt) | 2004-03-01 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina substituída |
| US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7435830B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US20070270417A1 (en) | 2004-07-22 | 2007-11-22 | Glaxo Group Limited | Antibacterial Agents |
| EP1781670A1 (fr) | 2004-07-22 | 2007-05-09 | Cumbre Pharmaceuticals Inc. | Derives de rifamycine pour traiter des infections microbiennes |
| FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| CA2579227A1 (fr) | 2004-11-04 | 2006-05-18 | Neurogen Corporation | Urees arylalkyle utilisees comme antagonistes cb1 |
| WO2006056848A1 (fr) | 2004-11-24 | 2006-06-01 | Pfizer Limited | Derives d'octahydropyrrolo[3,4-c]pyrrole |
| DE102004061344A1 (de) | 2004-12-20 | 2006-07-06 | Siemens Ag | Verfahren zur sicheren Auslegung eines Systems, zugehörige Systemkomponente und Software |
| US20060258672A1 (en) | 2005-05-13 | 2006-11-16 | Joseph Barbosa | Multicyclic compounds and methods of their use |
| WO2006124897A2 (fr) | 2005-05-13 | 2006-11-23 | Lexicon Genetics Incorporated | Procedes et compositions d'amelioration de la cognition |
| GB0510204D0 (en) | 2005-05-19 | 2005-06-22 | Chroma Therapeutics Ltd | Enzyme inhibitors |
| US20080175795A1 (en) | 2005-06-30 | 2008-07-24 | Bexel Pharmaceuticals, Inc. | Novel derivatives of amino acids for treatment of obesity and related disorders |
| GB0514018D0 (en) | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
| JP2009506061A (ja) | 2005-08-26 | 2009-02-12 | メルク エンド カムパニー インコーポレーテッド | ジアザスピロデカンオレキシン受容体拮抗薬 |
| FR2896798A1 (fr) | 2006-01-27 | 2007-08-03 | Sanofi Aventis Sa | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| FR2896799B1 (fr) | 2006-02-02 | 2008-03-28 | Sanofi Aventis Sa | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
| WO2007126934A2 (fr) | 2006-03-29 | 2007-11-08 | Merck & Co., Inc. | Antagonistes des récepteurs de l'orexine sous forme de composés amidoéthylthioéther |
| EP2001485B1 (fr) | 2006-03-29 | 2015-09-09 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs de l'orexine sous forme de composés diazépane |
| ATE496051T1 (de) | 2006-04-26 | 2011-02-15 | Actelion Pharmaceuticals Ltd | Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten |
| WO2007146761A2 (fr) | 2006-06-12 | 2007-12-21 | Neurogen Corporation | Diaryl pyrimidinones et composés associés |
| CA2657787A1 (fr) | 2006-07-14 | 2008-01-17 | Merck And Co., Inc. | Prolines bis-amides substituees en 2 antagonistes du recepteur de l'orexine |
| PL2049529T3 (pl) | 2006-07-14 | 2011-01-31 | Merck Sharp & Dohme | Podstawione związki diazepanowe - antagoniści receptora oreksyny |
| CA2657623A1 (fr) | 2006-07-14 | 2008-01-17 | Merck & Co., Inc. | Diazepans pontes antagonistes du recepteur de l'orexine |
| DE602007012910D1 (de) | 2006-08-15 | 2011-04-14 | Actelion Pharmaceuticals Ltd | Azetidinverbindungen als orexin-rezeptor-antagonisten |
| WO2008026149A1 (fr) | 2006-08-28 | 2008-03-06 | Actelion Pharmaceuticals Ltd | Dérivés de 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulène en tant qu'antagonistes de récepteur d'orexine |
| CA2662835A1 (fr) | 2006-09-18 | 2008-03-27 | Remy Lemoine | Derives d'octahydropyrrolo-[3,4-c]-pyrrole et leur utilisation en tant qu'agents antiviraux |
| TW200823227A (en) | 2006-09-29 | 2008-06-01 | Actelion Pharmaceuticals Ltd | 3-aza-bicyclo[3.1.0]hexane derivatives |
| WO2008052139A2 (fr) | 2006-10-25 | 2008-05-02 | Somaxon Pharmaceuticals, Inc. | Doxepine à dose ultrafaible, et ses procédés d'utilisation pour traiter des troubles du sommeil |
| CA2668811A1 (fr) | 2006-11-07 | 2008-06-05 | Lexicon Pharmaceuticals, Inc. | Methodes de traitement des troubles cognitifs et de la demence |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| US20110077200A1 (en) | 2006-12-06 | 2011-03-31 | Somaxon Pharmaceuticals, Inc. | Combination therapy using low-dose doxepin for the improvement of sleep |
| ATE545647T1 (de) | 2006-12-22 | 2012-03-15 | Actelion Pharmaceuticals Ltd | 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat |
| CL2008000836A1 (es) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| JP2010525077A (ja) | 2007-04-25 | 2010-07-22 | ブリストル−マイヤーズ スクイブ カンパニー | 非塩基性メラニン凝集ホルモン受容体−1アンタゴニスト |
| CA2688776A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
| FR2918061B1 (fr) | 2007-06-28 | 2010-10-22 | Sanofi Aventis | Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique. |
| GB0712888D0 (en) | 2007-07-03 | 2007-08-15 | Glaxo Group Ltd | Novel compounds |
| EP2176258A1 (fr) | 2007-07-03 | 2010-04-21 | Glaxo Group Limited | Dérivés de pipéridine utiles comme antagonistes vis-àvis des récepteurs de l'orexine |
| ATE524466T1 (de) | 2007-07-03 | 2011-09-15 | Actelion Pharmaceuticals Ltd | 3-azabicycloä3.3.0üoktanverbindungen |
| US20090011994A1 (en) | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
| WO2009011775A1 (fr) | 2007-07-13 | 2009-01-22 | Merck & Co., Inc. | Antagoniste de récepteurs d'amidoéthylalkylaminoorexine |
| FR2918986B1 (fr) | 2007-07-19 | 2009-09-04 | Sanofi Aventis Sa | Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique |
| KR20100046047A (ko) | 2007-07-27 | 2010-05-04 | 액테리온 파마슈티칼 리미티드 | 2-아자-비시클로[3.3.0]옥탄 유도체 |
| US20090036422A1 (en) | 2007-08-02 | 2009-02-05 | Henner Knust | Monoamide derivatives as orexin receptor antagonists |
| AU2008288151A1 (en) | 2007-08-15 | 2009-02-19 | Actelion Pharmaceuticals Ltd | 1,2-diamido-ethylene derivatives as orexin antagonists |
| WO2009040730A2 (fr) | 2007-09-24 | 2009-04-02 | Actelion Pharmaceuticals Ltd | Pyrrolidines et pipéridines en tant qu'antagonistes du récepteur de l'orexine |
| EP2214676B1 (fr) | 2007-10-29 | 2012-11-21 | Merck Sharp & Dohme Corp. | Antagonistes des récepteurs de l'orexine, de type diazépan substitué |
| EP2058001A1 (fr) | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Amélioration de l'immunogénicité des antigènes |
| CN101903372B (zh) | 2007-12-21 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | 作为食欲肽受体拮抗剂的杂芳基衍生物 |
| BRPI0821676A2 (pt) | 2007-12-21 | 2015-06-16 | Astrazeneca Ab | Composto, composição farmacêutica, e, processo para a preparação dos compostos. |
| GB0806536D0 (en) | 2008-04-10 | 2008-05-14 | Glaxo Group Ltd | Novel compounds |
| CN105168219B (zh) | 2008-05-27 | 2018-11-20 | 细胞内治疗公司 | 用于睡眠障碍和其他疾病的方法和组合物 |
| ES2386526T3 (es) | 2008-07-29 | 2012-08-22 | F. Hoffmann-La Roche Ag | Pirrolidin-3-ilmetilaminas, como antagonistas de orexina |
| AR072899A1 (es) | 2008-08-07 | 2010-09-29 | Merck Sharp & Dohme | Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad. |
| US20100267730A1 (en) | 2008-10-09 | 2010-10-21 | Giuseppe Alvaro | Novel compounds |
| US8093255B2 (en) | 2008-10-09 | 2012-01-10 | Glaxo Group Limited | Imidazo[1,2-A]pyrimidines as orexin receptor antagonists |
| US8129384B2 (en) | 2008-10-09 | 2012-03-06 | Glaxo Group Limited | Imidazo[1,2-a]pyrazines as orexin receptor antagonists |
| AU2009307918A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| EP2349269A4 (fr) | 2008-10-21 | 2012-04-25 | Merck Sharp & Dohme | Antagonistes de récepteur d orexine de pipéridine 2,5-disubstituée |
| JP2012506379A (ja) | 2008-10-21 | 2012-03-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 二置換アゼパンオレキシン受容体アンタゴニスト |
| AU2009307916A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted morpholine orexin receptor antagonists |
| EP2350061B1 (fr) | 2008-10-21 | 2013-08-14 | Merck Sharp & Dohme Corp. | Antagonistes de récepteur de l'orexine de type pipéridine 2,3-disubstituée |
| AU2009307913A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| US8703770B2 (en) | 2008-10-30 | 2014-04-22 | Merck Sharp & Dohme Corp. | Pyridazine carboxamide orexin receptor antagonists |
| US8399494B2 (en) | 2008-10-30 | 2013-03-19 | Merck Sharp & Dohme Corp. | 2,5-disubstituted phenyl carboxamide orexin receptor antagonists |
| JP5635991B2 (ja) | 2008-10-30 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | イソニコチンアミドオレキシン受容体アンタゴニスト |
| JP2012509911A (ja) | 2008-11-26 | 2012-04-26 | グラクソ グループ リミテッド | 新規の化合物 |
| WO2010060472A1 (fr) | 2008-11-26 | 2010-06-03 | Glaxo Group Limited | Dérivés de l’imidazopyridazine agissant en tant qu’antagonistes de l’orexine |
| JP2012509910A (ja) | 2008-11-26 | 2012-04-26 | グラクソ グループ リミテッド | 新規の化合物 |
| AR074426A1 (es) | 2008-12-02 | 2011-01-19 | Glaxo Group Ltd | Compuesto de n-(((1s,4s,6s)-3-(2-piridinilcarbonil)3-azabiciclo (4,1.0)hept-4-il) metil)-2-heteroarilamina, su uso para la prepracion de un medicamento para el tratamiento de una enfermedad que requiere un antagonista de un receptor de orexina humana y composicion farmaceutica que lo comprende |
| JP2012510494A (ja) | 2008-12-02 | 2012-05-10 | グラクソ グループ リミテッド | N−{[(ir、4s、6r)−3−(2−ピリジニルカルボニル)−3−アザビシクロ[4.1.0]ヘプタ−4−イル]メチル}−2−ヘテロアリールアミン誘導体およびその使用 |
| GB0823467D0 (en) | 2008-12-23 | 2009-01-28 | Glaxo Group Ltd | Novel Compounds |
| US20100214135A1 (en) | 2009-02-26 | 2010-08-26 | Microsoft Corporation | Dynamic rear-projected user interface |
| WO2010122151A1 (fr) | 2009-04-24 | 2010-10-28 | Glaxo Group Limited | 3 -azabicyclo [4.1.0] heptanes utilisés comme antagonistes de l'orexine |
| WO2011023585A1 (fr) | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | Dérivés de pipéridine utilisés comme antagonistes d'orexines |
| WO2011023578A1 (fr) | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | Dérivés de 5-méthylpipéridine comme antagonistes de récepteurs à orexines pour le traitement d'un trouble du sommeil |
| ES2585806T3 (es) | 2009-10-23 | 2016-10-10 | Janssen Pharmaceutica N.V. | Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina |
| WO2011050200A1 (fr) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Composés hétérocycliques condensés en tant que modulateurs de récepteur d'orexine |
| WO2011050202A1 (fr) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Composés hétérocycliques condensés en tant que modulateurs de récepteur d'orexine |
| US8877773B2 (en) | 2009-10-24 | 2014-11-04 | Indiana University Research And Technology Corporation | Methods for treating chronic obstructive pulmonary disease |
| TWI410630B (zh) | 2009-11-10 | 2013-10-01 | Ct Lab Inc | 一種用以治療與食慾素受體1、食慾素受體2、體抑素受體2或多巴胺d2l受體相關之疾病的方法和組合物 |
| PL2516425T3 (pl) * | 2009-12-23 | 2016-03-31 | Jasco Pharmaceuticals Llc | Inhibitory kinaz aminopirydynowych |
| PH12013501206A1 (en) | 2010-12-17 | 2018-04-11 | Taisho Pharmaceutical Co Ltd | Pyrazole derivative |
| WO2012089606A1 (fr) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Dérivés azabicyclo [4.1.0] hept-4-yle en tant qu'antagonistes du récepteur humain de l'orexine |
| WO2012089607A1 (fr) | 2010-12-28 | 2012-07-05 | Glaxo Group Limited | Nouveaux composés dotés d'un cœur 3a-azabicyclo[4.1.0]heptane agissant sur les récepteurs d'orexine |
| US9586962B2 (en) | 2011-04-20 | 2017-03-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators |
| EP2708537A4 (fr) | 2011-05-10 | 2014-10-01 | Taisho Pharmaceutical Co Ltd | Dérivé à cycle hétéroaromatique |
| EP2730573A4 (fr) | 2011-07-05 | 2014-12-03 | Taisho Pharmaceutical Co Ltd | Dérivé de méthylpipéridine |
| US9029364B2 (en) | 2011-10-21 | 2015-05-12 | Merck Sharp & Dohme Corp. | 2,5-disubstituted thiomorpholine orexin receptor antagonists |
| ES2672732T3 (es) | 2012-02-07 | 2018-06-15 | Eolas Therapeutics Inc. | Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| US9493481B2 (en) | 2012-02-23 | 2016-11-15 | Vanderbilt University | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 |
| US9266870B2 (en) | 2012-06-15 | 2016-02-23 | Taisho Pharmaceutical Co., Ltd | Heteroaromatic methyl cyclic amine derivative |
| WO2013187466A1 (fr) | 2012-06-15 | 2013-12-19 | 大正製薬株式会社 | Dérivé cyclique hétéroaromatique alkylé à chaîne ramifiée |
| JP2014015452A (ja) | 2012-06-15 | 2014-01-30 | Taisho Pharmaceutical Co Ltd | ピラゾール誘導体を含有する医薬 |
| JP2014111586A (ja) | 2012-11-09 | 2014-06-19 | Taisho Pharmaceutical Co Ltd | ヘテロ芳香環誘導体を含有する医薬 |
| WO2014085208A1 (fr) | 2012-11-27 | 2014-06-05 | Merck Sharp & Dohme Corp. | Composés de 2-pyridylamino-4-nitrile-pipéridinyl, antagonistes des récepteurs de l'orexine |
| JP2016028017A (ja) | 2012-12-13 | 2016-02-25 | 大正製薬株式会社 | フッ素置換ピペリジン化合物 |
| JP2014141480A (ja) | 2012-12-28 | 2014-08-07 | Taisho Pharmaceutical Co Ltd | メチルピペリジン誘導体を含有する医薬 |
| TWI621618B (zh) | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代2-氮雜雙環類及其作為食慾素受體調控劑之用途 |
| WO2015018027A1 (fr) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Antagonistes thiazoles des récepteurs de l'orexine |
| IL305990B2 (en) | 2013-12-03 | 2025-12-01 | Intra Cellular Therapies Inc | Long-acting injectable composition comprising polymeric microspheres of heterocycle fused gamma-carboline compounds or a pharmaceutical composition for sustained or delayed release comprising the compounds and their use in the treatment of bipolar disorder i and/or bipolar ii disorder |
| US9586934B2 (en) | 2013-12-09 | 2017-03-07 | Merck Sharp & Dohme Corp. | 2-pyridyloxy-4-methyl orexin receptor antagonists |
| JP5930010B2 (ja) | 2013-12-13 | 2016-06-08 | 大正製薬株式会社 | ヘテロ芳香環メチル環状アミン誘導体を含有する医薬 |
| JP2015131802A (ja) | 2013-12-13 | 2015-07-23 | 大正製薬株式会社 | 分岐鎖アルキルヘテロ芳香環誘導体を含有する医薬 |
| US9617246B2 (en) * | 2013-12-18 | 2017-04-11 | Merck Sharp & Dohme Corp. | Thioether-piperidinyl orexin receptor antagonists |
| WO2015123355A1 (fr) | 2014-02-12 | 2015-08-20 | Eolas Therapeutics, Inc. | Prolines/pipéridines substituées en tant qu'antagonistes du récepteur de l'orexine |
| TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| JP2017100951A (ja) | 2014-04-04 | 2017-06-08 | 大正製薬株式会社 | オキサゾリジノン及びオキサジナノン誘導体 |
| JP2017100950A (ja) | 2014-04-04 | 2017-06-08 | 大正製薬株式会社 | オキソ複素環誘導体 |
| CN105377840B (zh) | 2014-05-28 | 2017-12-22 | 杭州普晒医药科技有限公司 | 一种二氮杂环庚烷化合物的盐及其晶型与无定型物 |
| JP6663909B2 (ja) | 2014-08-13 | 2020-03-13 | エオラス セラピューティクス, インコーポレイテッド | オレキシンレセプターモジュレーターとしてのジフルオロピロリジン |
| US20160051533A1 (en) | 2014-08-20 | 2016-02-25 | Ladd Research LLC | Diagnosis and pharmacological treatment of seasonal affective disorder and symptoms of seasonality |
| GB201415569D0 (en) | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
| WO2017012502A1 (fr) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Composés de quinazoline substitués, ainsi que préparation et utilisations de ceux-ci |
| GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
| US10828302B2 (en) * | 2016-03-10 | 2020-11-10 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| GB201820458D0 (en) | 2018-12-14 | 2019-01-30 | Heptares Therapeutics Ltd | Ox1 antagonists |
-
2017
- 2017-03-09 US US15/454,628 patent/US10828302B2/en active Active
- 2017-03-09 HU HUE17764092A patent/HUE058759T2/hu unknown
- 2017-03-09 CN CN201780016369.3A patent/CN108883110B/zh active Active
- 2017-03-09 RS RS20220487A patent/RS63296B1/sr unknown
- 2017-03-09 MY MYPI2018703204A patent/MY197558A/en unknown
- 2017-03-09 BR BR112018067906A patent/BR112018067906A2/pt not_active Application Discontinuation
- 2017-03-09 IL IL319248A patent/IL319248A/en unknown
- 2017-03-09 AU AU2017231828A patent/AU2017231828B2/en active Active
- 2017-03-09 EP EP22168101.8A patent/EP4091634A1/fr active Pending
- 2017-03-09 SM SM20220239T patent/SMT202200239T1/it unknown
- 2017-03-09 SI SI201731154T patent/SI3426251T1/sl unknown
- 2017-03-09 HR HRP20220642TT patent/HRP20220642T1/hr unknown
- 2017-03-09 JP JP2018547296A patent/JP7066622B2/ja active Active
- 2017-03-09 PL PL17764092.7T patent/PL3426251T3/pl unknown
- 2017-03-09 PT PT177640927T patent/PT3426251T/pt unknown
- 2017-03-09 EA EA201891930A patent/EA201891930A1/ru unknown
- 2017-03-09 MX MX2018010852A patent/MX2018010852A/es unknown
- 2017-03-09 KR KR1020227033141A patent/KR102559922B1/ko active Active
- 2017-03-09 KR KR1020237025023A patent/KR20230116948A/ko not_active Ceased
- 2017-03-09 IL IL288321A patent/IL288321B2/en unknown
- 2017-03-09 CR CR20180433A patent/CR20180433A/es unknown
- 2017-03-09 KR KR1020257016875A patent/KR20250083571A/ko active Pending
- 2017-03-09 SG SG11201807597UA patent/SG11201807597UA/en unknown
- 2017-03-09 LT LTEPPCT/US2017/021565T patent/LT3426251T/lt unknown
- 2017-03-09 UA UAA201810094A patent/UA125873C2/uk unknown
- 2017-03-09 CA CA3016706A patent/CA3016706A1/fr active Pending
- 2017-03-09 DK DK17764092.7T patent/DK3426251T3/da active
- 2017-03-09 CN CN202210483090.9A patent/CN115154470B/zh active Active
- 2017-03-09 KR KR1020187026455A patent/KR102448342B1/ko active Active
- 2017-03-09 MA MA43817A patent/MA43817B1/fr unknown
- 2017-03-09 MA MA43468A patent/MA43468B1/fr unknown
- 2017-03-09 MD MDE20190089T patent/MD3426251T2/ro unknown
- 2017-03-09 PH PH1/2018/501903A patent/PH12018501903B1/en unknown
- 2017-03-09 ES ES17764092T patent/ES2913469T3/es active Active
- 2017-03-09 WO PCT/US2017/021565 patent/WO2017156266A1/fr not_active Ceased
- 2017-03-09 CA CA2960253A patent/CA2960253A1/fr active Pending
- 2017-03-09 EP EP17764092.7A patent/EP3426251B1/fr active Active
-
2018
- 2018-08-29 IL IL261461A patent/IL261461B/en unknown
- 2018-09-05 CL CL2018002533A patent/CL2018002533A1/es unknown
- 2018-09-06 NI NI201800086A patent/NI201800086A/es unknown
- 2018-09-10 SV SV2018005740A patent/SV2018005740A/es unknown
- 2018-09-12 CO CONC2018/0009561A patent/CO2018009561A2/es unknown
- 2018-09-18 DO DO2018000196A patent/DOP2018000196A/es unknown
-
2020
- 2020-11-09 US US17/092,725 patent/US11241432B2/en active Active
-
2021
- 2021-08-10 JP JP2021130744A patent/JP2021181474A/ja not_active Withdrawn
- 2021-12-15 US US17/551,955 patent/US12201634B2/en active Active
-
2022
- 2022-06-15 CY CY20221100412T patent/CY1125247T1/el unknown
- 2022-11-09 JP JP2022179528A patent/JP7534373B2/ja active Active
- 2022-11-29 AU AU2022279416A patent/AU2022279416C1/en active Active
-
2024
- 2024-02-13 JP JP2024019351A patent/JP2024056847A/ja not_active Withdrawn
-
2025
- 2025-01-10 US US19/016,620 patent/US20250221992A1/en active Pending
- 2025-05-20 AU AU2025203695A patent/AU2025203695A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA43817B1 (fr) | Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2 | |
| MA52219B1 (fr) | Traitement de l'hidradénite suppurée à l'aide d'inhibiteurs de jak | |
| MA50240B1 (fr) | Modulateurs de la protéine régulatrice de la conductance transmembranaire de la fibrose kystique et procédés d'utilisation | |
| MA54229B1 (fr) | Composés et compositions destinés au traitement d'états pathologiques associés à une activité de nlrp | |
| MA39070A1 (fr) | Anticorps anti-cd38 spécifiques pour le traitement de cancers humains | |
| MA33593B1 (fr) | Composés hétérocycliques et leurs utilisations | |
| MA46219A (fr) | Composés de co-agonistes du glucagon et du glp-1 | |
| MA40768B1 (fr) | Dérivés d'indole mono ou di-substitué en tant qu'inhibiteurs de réplication du virus de la dengue | |
| ZA202103820B (en) | Capsule formulations | |
| MA40769A (fr) | Indoles mono ou di-substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue | |
| MA44612B1 (fr) | Méthodes de traitement de cancers pédiatriques | |
| MA38315A1 (fr) | Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales | |
| MA58993A1 (fr) | Antagoniste du récepteur crf1 pour le traitement de l'hyperplasie surrénale congénitale | |
| MA33302B1 (fr) | 2, 4-diaminopyrimidines pour le traitement de maladies caracterisees par une proliferation cellulaire excessive ou anormale | |
| MA42811A (fr) | Dérivés d'indole monosubstitués ou disubstitués utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue | |
| MA39294B1 (fr) | Polythérapie contre le cancer | |
| MA38358A1 (fr) | Formulations de composés organiques | |
| MA42301B1 (fr) | Sel cristallin de fumarate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl)azétidin-1-yl]-méthanone | |
| MA43876B1 (fr) | Compositions pharmaceutiques et leur utilisations contre les maladies de surcharge lysosomale | |
| MA43913A (fr) | Modulateurs allostériques positifs du récepteur m1 muscarinique | |
| CL2019000753A1 (es) | Composición farmacéutica que comprende antagonista de receptor mineralocorticoide y su uso. | |
| MA45639B1 (fr) | Combinaison d'antagonistes purs du récepteur 5-ht6 avec des inhibiteurs d'acétylcholinestérase | |
| MA49396A (fr) | Traitement de la migraine avec acétyl-leucine | |
| FR3070261B1 (fr) | Produit de combinaison pour soulager les symptomes lies aux infections des voies respiratoires superieures | |
| MA54276B1 (fr) | Montélukast destinée au traitement de l'arthrose de la main |