MA43832B1 - Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine - Google Patents

Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine

Info

Publication number
MA43832B1
MA43832B1 MA43832A MA43832A MA43832B1 MA 43832 B1 MA43832 B1 MA 43832B1 MA 43832 A MA43832 A MA 43832A MA 43832 A MA43832 A MA 43832A MA 43832 B1 MA43832 B1 MA 43832B1
Authority
MA
Morocco
Prior art keywords
acid addition
addition salt
methylmethanamine
pyrrol
difluorophenyl
Prior art date
Application number
MA43832A
Other languages
English (en)
Inventor
Aeri Kim
Kwan Hyung Cho
Original Assignee
Dae Woong Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma filed Critical Dae Woong Pharma
Priority claimed from PCT/KR2017/002913 external-priority patent/WO2017164575A1/fr
Publication of MA43832B1 publication Critical patent/MA43832B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La présente invention décrit un nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine. Le sel d'addition d'acide ci-dessus décrit présente non seulement une excellente activité inhibitrice de la pompe à protons, une excellente activité inhibitrice des dégâts gastriques et un excellent effet de renforcement des facteurs de défense, mais également une excellente activité d'éradication de h. Pylori et il peut donc être efficacement utilisé pour la prévention et le traitement des lésions gastro-intestinales dues à l'ulcère du tractus gastro-intestinal, à la gastrite, au reflux œsophagien, ou à h. Pylori.
MA43832A 2016-03-25 2017-03-17 Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine MA43832B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160036081 2016-03-25
PCT/KR2017/002913 WO2017164575A1 (fr) 2016-03-25 2017-03-17 Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine

Publications (1)

Publication Number Publication Date
MA43832B1 true MA43832B1 (fr) 2020-08-31

Family

ID=60141235

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43832A MA43832B1 (fr) 2016-03-25 2017-03-17 Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine

Country Status (28)

Country Link
US (1) US10487053B2 (fr)
EP (1) EP3433232B1 (fr)
JP (1) JP6609065B2 (fr)
KR (2) KR20170113040A (fr)
CN (1) CN108602771B (fr)
AR (1) AR107964A1 (fr)
AU (1) AU2017238917B2 (fr)
CA (1) CA3014753C (fr)
CL (1) CL2018002415A1 (fr)
CO (1) CO2018008834A2 (fr)
DO (2) DOP2018000191A (fr)
ES (1) ES2811478T3 (fr)
HR (1) HRP20201571T1 (fr)
HU (1) HUE053741T2 (fr)
JO (1) JOP20170071B1 (fr)
MA (1) MA43832B1 (fr)
MX (1) MX379775B (fr)
MY (1) MY196355A (fr)
NZ (1) NZ745267A (fr)
PE (1) PE20190169A1 (fr)
PH (1) PH12018501845B1 (fr)
PL (1) PL3433232T3 (fr)
PT (1) PT3433232T (fr)
RS (1) RS60857B1 (fr)
SG (1) SG11201806968RA (fr)
SI (1) SI3433232T1 (fr)
TN (1) TN2018000269A1 (fr)
TW (1) TWI607753B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102081920B1 (ko) 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
KR102570011B1 (ko) * 2019-12-18 2023-08-23 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루우로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 액상 약학적 조성물
CN115884968B (zh) * 2020-06-17 2024-06-21 日东制药株式会社 新型酸分泌抑制剂及其用途
DK4245298T3 (en) * 2020-12-18 2026-03-30 Daewoong Pharmaceutical Co Ltd Hidtil ukendt formulering til oral administration, som omfatter 1-(5-(2,4-difluorphenyl)-1-((3-fluorphenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamin
JP7802829B2 (ja) * 2021-05-26 2026-01-20 デウン ファーマシューティカル カンパニー リミテッド １－（５－（２，４－ジフルオロフェニル）－１－（（３－フルオロフェニル）スルホニル）－４－メトキシ－１ｈ－ピロール－３－イル）－ｎ－メチルメタンアミンを含む新規な注射用製剤
TN2023000270A1 (en) * 2021-05-26 2025-07-02 Daewoong Pharmaceutical Co Ltd Medicine container containing liquid pharmaceutical composition of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine
TW202304426A (zh) * 2021-05-26 2023-02-01 南韓商大熊製藥股份有限公司 用於注射之包含１－（５－（２，４－二氟苯基）－１－（（３－氟苯基）磺醯基）－４－甲氧基－１ｈ－吡咯－３－基）－ｎ－甲基甲胺的新調配物
US20240415808A1 (en) * 2021-12-15 2024-12-19 Daewoong Pharmaceutical Co., Ltd. Dosage Regimen for Fexuprazan Injection Composition
CN118401510A (zh) * 2021-12-15 2024-07-26 日东制药株式会社 1-磺酰基吡咯衍生物的新颖盐类、其制备方法及包含其的药物组合物
KR20240119083A (ko) * 2021-12-15 2024-08-06 일동제약(주) 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
WO2023211843A1 (fr) * 2022-04-25 2023-11-02 Daewoong Pharmaceutical Co., Ltd. Bloqueurs d'acide compétitif pour le potassium pour le traitement d'états hypersécrétoires pathologiques
WO2023229323A1 (fr) * 2022-05-23 2023-11-30 일동제약(주) Procédé de préparation d'un dérivé de 6-méthoxypyridin-3-yle
CN119365448A (zh) * 2022-05-23 2025-01-24 日东制药株式会社 一种6-甲氧基吡啶-3-基衍生物的制备方法
CN117820193A (zh) * 2022-09-29 2024-04-05 安徽皓元药业有限公司 一种非苏拉赞盐酸盐晶型a及其制备方法
KR102938657B1 (ko) * 2023-02-15 2026-03-12 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101178747B1 (ko) 2004-09-30 2012-09-03 다케다 야쿠힌 고교 가부시키가이샤 프로톤 펌프 저해제
PE20070540A1 (es) 2005-08-30 2007-06-26 Takeda Pharmaceutical Derivados de pirrol como inhibidores de la secrecion acida
WO2007114338A1 (fr) * 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited Inhibiteur de secretion d'acide
WO2008036211A1 (fr) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Promédicaments d'inhibiteurs de pompes à protons comprenant le groupe fonctionnel (1h-pyrrol-1-yl)-1h-benzimidazole
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
CA2891523A1 (fr) * 2012-11-19 2014-05-22 Jiangsu Hansoh Pharmaceutical Co., Ltd. Derive pyrrole sulfonamide, procede de preparation et application medicale associes
WO2014133059A1 (fr) * 2013-02-28 2014-09-04 武田薬品工業株式会社 Procédé de production d'un composé de chlorure de sulfonyle
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN104447490B (zh) * 2014-11-19 2017-06-06 连云港恒运医药有限公司 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途
CN104447491B (zh) * 2014-11-19 2017-06-23 连云港恒运医药有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其中间体和医药用途
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물

Also Published As

Publication number Publication date
TN2018000269A1 (en) 2020-01-16
PH12018501845B1 (en) 2022-02-18
EP3433232B1 (fr) 2020-07-15
MX2018009220A (es) 2018-09-10
SI3433232T1 (sl) 2020-10-30
JP6609065B2 (ja) 2019-11-20
HK1254394A1 (zh) 2019-07-19
HRP20201571T1 (hr) 2020-12-11
JOP20170071B1 (ar) 2021-08-17
NZ745267A (en) 2020-03-27
US10487053B2 (en) 2019-11-26
ES2811478T3 (es) 2021-03-12
KR20170113040A (ko) 2017-10-12
MY196355A (en) 2023-03-24
MX379775B (es) 2025-03-11
CN108602771B (zh) 2021-07-16
CA3014753A1 (fr) 2017-09-28
DOP2018000191A (es) 2018-09-30
KR102417830B1 (ko) 2022-07-06
AU2017238917A1 (en) 2018-08-16
TW201737908A (zh) 2017-11-01
BR112018069540A2 (pt) 2019-01-29
AU2017238917B2 (en) 2019-07-11
US20190031609A1 (en) 2019-01-31
JP2019509320A (ja) 2019-04-04
DOP2021000001A (es) 2021-03-15
CL2018002415A1 (es) 2018-12-28
PL3433232T3 (pl) 2020-12-14
KR20200105771A (ko) 2020-09-09
PH12018501845A1 (en) 2019-05-15
PT3433232T (pt) 2020-07-21
HUE053741T2 (hu) 2021-07-28
SG11201806968RA (en) 2018-09-27
RS60857B1 (sr) 2020-10-30
CA3014753C (fr) 2023-08-29
PE20190169A1 (es) 2019-02-01
TWI607753B (zh) 2017-12-11
CN108602771A (zh) 2018-09-28
EP3433232A1 (fr) 2019-01-30
EP3433232A4 (fr) 2019-07-31
AR107964A1 (es) 2018-07-04
CO2018008834A2 (es) 2018-10-10

Similar Documents

Publication Publication Date Title
MA43832B1 (fr) Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine
MA40887B1 (fr) Nouveaux dérivés de 4-méthoxy pyrrole ou leurs sels, et composition pharmaceutique les comprenant
FI3498693T3 (fi) Heterosyklinen yhdiste
SA521422270B1 (ar) Apol1 مثبطات لـ وطرق لاستخدامها
EA201790453A3 (ru) Новая соль присоединения кислоты 1-(5-(2,4-дифторфенил)-1-((3- фторфенил)сульфонил)-4-метокси-1h-пиррол-3-ил)-n-метилметанамина
EA201270824A1 (ru) Соединения для уменьшения продукции бета-амилоида
MA35639B1 (fr) Compose heterocyclique aromatique dihydroxy
EA201990159A1 (ru) Биарилметильные гетероциклы
CA3015494C (fr) Nouvelles compositions et methodes therapeutiques
EA202191476A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA202190588A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
EA202190621A1 (ru) Фармацевтическая композиция, содержащая антитромбоцитарное средство и ингибитор секреции желудочной кислоты
EA201892020A1 (ru) Индольные производные и их применение в качестве ингибиторов протеинкиназы
MA52297B1 (fr) Composé hétérocyclique
CA3156340A1 (fr) Compose de n-(1h-imidazol-2-yl)benzamide et composition pharmaceutique le comprenant en tant que principe actif
EA201691962A1 (ru) Амидозамещенные азольные соединения в качестве ингибиторов tnks1 и/или tnks2
EA201991490A1 (ru) Ароматические амиды карбоновых кислот в качестве антагонистов рецепторов брадикинина в1
PH12022551415A1 (en) Liquid pharmaceutical composition of 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine
FR3047665B1 (fr) Celastrol et ses derives dans le traitement des tumeurs et pathologies pre-cancereuses cutanees
EA202191477A1 (ru) Гетероароматические соединения в качестве ингибиторов ванина
NO20071231L (no) Nye anvendelser av 2-fenyl-substituerte imidazotriazinonderivater
EP3831397A4 (fr) Composition pharmaceutique comprenant comme principe actif de la proanthocyanidine pour la prévention ou le traitement du carcinome épidermoïde
EA202192313A1 (ru) Структурированные молекулярные векторы для противовоспалительных соединений и их применение
TH1801002749A (th) สารบรรพเภสัชของสารประกอบที่เป็นสารยับยั้ง jak สำหรับการรักษาโรคที่มีอาการอักเสบของระบบทางเดินอาหาร
EA202191724A1 (ru) Ингибиторы пути jak1 для лечения заболевания желудочно-кишечного тракта