MA43832B1 - Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine - Google Patents

Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine

Info

Publication number
MA43832B1
MA43832B1 MA43832A MA43832A MA43832B1 MA 43832 B1 MA43832 B1 MA 43832B1 MA 43832 A MA43832 A MA 43832A MA 43832 A MA43832 A MA 43832A MA 43832 B1 MA43832 B1 MA 43832B1
Authority
MA
Morocco
Prior art keywords
acid addition
addition salt
methylmethanamine
pyrrol
difluorophenyl
Prior art date
Application number
MA43832A
Other languages
English (en)
Inventor
Aeri Kim
Kwan Hyung Cho
Original Assignee
Dae Woong Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma filed Critical Dae Woong Pharma
Priority claimed from PCT/KR2017/002913 external-priority patent/WO2017164575A1/fr
Publication of MA43832B1 publication Critical patent/MA43832B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La présente invention décrit un nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine. Le sel d'addition d'acide ci-dessus décrit présente non seulement une excellente activité inhibitrice de la pompe à protons, une excellente activité inhibitrice des dégâts gastriques et un excellent effet de renforcement des facteurs de défense, mais également une excellente activité d'éradication de h. Pylori et il peut donc être efficacement utilisé pour la prévention et le traitement des lésions gastro-intestinales dues à l'ulcère du tractus gastro-intestinal, à la gastrite, au reflux œsophagien, ou à h. Pylori.
MA43832A 2016-03-25 2017-03-17 Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine MA43832B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20160036081 2016-03-25
PCT/KR2017/002913 WO2017164575A1 (fr) 2016-03-25 2017-03-17 Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine

Publications (1)

Publication Number Publication Date
MA43832B1 true MA43832B1 (fr) 2020-08-31

Family

ID=60141235

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43832A MA43832B1 (fr) 2016-03-25 2017-03-17 Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine

Country Status (28)

Country Link
US (1) US10487053B2 (fr)
EP (1) EP3433232B1 (fr)
JP (1) JP6609065B2 (fr)
KR (2) KR20170113040A (fr)
CN (1) CN108602771B (fr)
AR (1) AR107964A1 (fr)
AU (1) AU2017238917B2 (fr)
CA (1) CA3014753C (fr)
CL (1) CL2018002415A1 (fr)
CO (1) CO2018008834A2 (fr)
DO (2) DOP2018000191A (fr)
ES (1) ES2811478T3 (fr)
HR (1) HRP20201571T1 (fr)
HU (1) HUE053741T2 (fr)
JO (1) JOP20170071B1 (fr)
MA (1) MA43832B1 (fr)
MX (1) MX379775B (fr)
MY (1) MY196355A (fr)
NZ (1) NZ745267A (fr)
PE (1) PE20190169A1 (fr)
PH (1) PH12018501845B1 (fr)
PL (1) PL3433232T3 (fr)
PT (1) PT3433232T (fr)
RS (1) RS60857B1 (fr)
SG (1) SG11201806968RA (fr)
SI (1) SI3433232T1 (fr)
TN (1) TN2018000269A1 (fr)
TW (1) TWI607753B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102081920B1 (ko) * 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CA3157981C (fr) * 2019-12-18 2024-03-26 Daewoong Pharmaceutical Co., Ltd. Composition pharmaceutique liquide de 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethaneamine
KR20210156235A (ko) * 2020-06-17 2021-12-24 일동제약(주) 신규한 산 분비 억제제 및 이의 용도
DK4245298T3 (en) * 2020-12-18 2026-03-30 Daewoong Pharmaceutical Co Ltd Hidtil ukendt formulering til oral administration, som omfatter 1-(5-(2,4-difluorphenyl)-1-((3-fluorphenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamin
MX2023013985A (es) * 2021-05-26 2023-12-12 Daewoong Pharmaceutical Co Ltd Contenedor de medicina que comprende la composicion farmaceutica liquida de 1-(5-(2,4-difluorofenil)-1-((3-fluorofenil)sulfonil)-4- metoxi-1h-pirrol-3-il)-n-metilmetanamina.
US20240261261A1 (en) * 2021-05-26 2024-08-08 Daewoong Pharmaceutical Co., Ltd. New formulation for injection comprising 1-(5-(2,4-difluorophenyl)-1-((3-fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine
TW202304426A (zh) * 2021-05-26 2023-02-01 南韓商大熊製藥股份有限公司 用於注射之包含１－（５－（２，４－二氟苯基）－１－（（３－氟苯基）磺醯基）－４－甲氧基－１ｈ－吡咯－３－基）－ｎ－甲基甲胺的新調配物
WO2023113487A1 (fr) * 2021-12-15 2023-06-22 주식회사 대웅제약 Posologie pour composition d'injection de fexuprazan
US20250084026A1 (en) * 2021-12-15 2025-03-13 Ildong Pharmaceutical Co., Ltd. Novel salt of 1-sulfonyl pyrrole derivative, preparation method thereof and pharmaceutical composition comprising thereof
WO2023113474A1 (fr) * 2021-12-15 2023-06-22 일동제약(주) Nouveau sel de dérivé 1-sulfonylpyrrole, son procédé de préparation et composition pharmaceutique comprenant celui-ci
US20250268862A1 (en) * 2022-04-25 2025-08-28 Daewoong Pharmaceutical Co., Ltd. Potassium-competitive acid blockers for the treatment of pathological hypersecretory conditions
TW202411215A (zh) * 2022-05-23 2024-03-16 南韓商日東製藥股份有限公司 ６－甲氧基吡啶－３－基衍生物之製造方法
WO2023229323A1 (fr) * 2022-05-23 2023-11-30 일동제약(주) Procédé de préparation d'un dérivé de 6-méthoxypyridin-3-yle
CN117820193A (zh) * 2022-09-29 2024-04-05 安徽皓元药业有限公司 一种非苏拉赞盐酸盐晶型a及其制备方法
KR102938657B1 (ko) * 2023-02-15 2026-03-12 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336107B1 (fr) 2004-09-30 2015-09-23 Takeda Pharmaceutical Company Limited Inhibiteurs de pompe a protons
EP2327692B9 (fr) * 2005-08-30 2014-06-04 Takeda Pharmaceutical Company Limited Dérivés de1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl-1-H-pyrrole substitués et leur utilisation en tant qu'inhibiteurs de la sécrétion d'acide gastrique
EP2005957B1 (fr) * 2006-03-31 2012-05-30 Takeda Pharmaceutical Company Limited Inhibiteur de secretion d'acide
US20100113524A1 (en) 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
CN104718189B (zh) * 2012-11-19 2017-03-15 江苏豪森药业集团有限公司 吡咯磺酰类衍生物、其制备方法及其在医药上的应用
WO2014133059A1 (fr) * 2013-02-28 2014-09-04 武田薬品工業株式会社 Procédé de production d'un composé de chlorure de sulfonyle
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN104447490B (zh) * 2014-11-19 2017-06-06 连云港恒运医药有限公司 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途
CN104447491B (zh) * 2014-11-19 2017-06-23 连云港恒运医药有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其中间体和医药用途
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물

Also Published As

Publication number Publication date
EP3433232B1 (fr) 2020-07-15
AU2017238917B2 (en) 2019-07-11
PE20190169A1 (es) 2019-02-01
KR102417830B1 (ko) 2022-07-06
TWI607753B (zh) 2017-12-11
ES2811478T3 (es) 2021-03-12
TW201737908A (zh) 2017-11-01
KR20200105771A (ko) 2020-09-09
MY196355A (en) 2023-03-24
TN2018000269A1 (en) 2020-01-16
EP3433232A1 (fr) 2019-01-30
PH12018501845B1 (en) 2022-02-18
PH12018501845A1 (en) 2019-05-15
AR107964A1 (es) 2018-07-04
JP6609065B2 (ja) 2019-11-20
US20190031609A1 (en) 2019-01-31
BR112018069540A2 (pt) 2019-01-29
CN108602771B (zh) 2021-07-16
DOP2018000191A (es) 2018-09-30
CN108602771A (zh) 2018-09-28
AU2017238917A1 (en) 2018-08-16
KR20170113040A (ko) 2017-10-12
CO2018008834A2 (es) 2018-10-10
MX2018009220A (es) 2018-09-10
CL2018002415A1 (es) 2018-12-28
HRP20201571T1 (hr) 2020-12-11
PL3433232T3 (pl) 2020-12-14
NZ745267A (en) 2020-03-27
DOP2021000001A (es) 2021-03-15
HUE053741T2 (hu) 2021-07-28
PT3433232T (pt) 2020-07-21
MX379775B (es) 2025-03-11
CA3014753C (fr) 2023-08-29
CA3014753A1 (fr) 2017-09-28
SI3433232T1 (sl) 2020-10-30
US10487053B2 (en) 2019-11-26
JP2019509320A (ja) 2019-04-04
RS60857B1 (sr) 2020-10-30
EP3433232A4 (fr) 2019-07-31
HK1254394A1 (zh) 2019-07-19
JOP20170071B1 (ar) 2021-08-17
SG11201806968RA (en) 2018-09-27

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