MA44969A - 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation - Google Patents

5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation

Info

Publication number
MA44969A
MA44969A MA044969A MA44969A MA44969A MA 44969 A MA44969 A MA 44969A MA 044969 A MA044969 A MA 044969A MA 44969 A MA44969 A MA 44969A MA 44969 A MA44969 A MA 44969A
Authority
MA
Morocco
Prior art keywords
tetrahydro
ones
triazolo
pyrrolo
pyridin
Prior art date
Application number
MA044969A
Other languages
English (en)
Other versions
MA44969B1 (fr
Inventor
Volker Badock
Nicole Biber
Damian Brockschnieder
Kersten Matthias Gericke
Florian Kölling
Niels Lindner
Klemens Lustig
Jörg Meding
Heinrich Meier
Ondozabal Hideki Miyatake
Stephen Moore
Dieter Moosmayer
Thomas Neubauer
Alexander Schulz
Martina Schäfer
Carsten Terjung
Andreas Timmermann
Dmitry Zubov
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Priority claimed from PCT/EP2017/060900 external-priority patent/WO2017194459A1/fr
Publication of MA44969A publication Critical patent/MA44969A/fr
Publication of MA44969B1 publication Critical patent/MA44969B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA44969A 2016-05-09 2017-05-08 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation MA44969B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2016168809 2016-05-09
PCT/EP2017/060900 WO2017194459A1 (fr) 2016-05-09 2017-05-08 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation
EP17723053.9A EP3455224B1 (fr) 2016-05-09 2017-05-08 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation

Publications (2)

Publication Number Publication Date
MA44969A true MA44969A (fr) 2019-03-20
MA44969B1 MA44969B1 (fr) 2024-06-28

Family

ID=65351627

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44969A MA44969B1 (fr) 2016-05-09 2017-05-08 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation

Country Status (7)

Country Link
EP (1) EP3455224B1 (fr)
ES (1) ES2987656T3 (fr)
HR (1) HRP20240589T1 (fr)
HU (1) HUE066246T2 (fr)
MA (1) MA44969B1 (fr)
PL (1) PL3455224T3 (fr)
RS (1) RS65596B1 (fr)

Also Published As

Publication number Publication date
MA44969B1 (fr) 2024-06-28
EP3455224C0 (fr) 2024-03-27
EP3455224B1 (fr) 2024-03-27
EP3455224A1 (fr) 2019-03-20
ES2987656T3 (es) 2024-11-15
PL3455224T3 (pl) 2024-07-01
HUE066246T2 (hu) 2024-07-28
HRP20240589T1 (hr) 2024-07-19
RS65596B1 (sr) 2024-06-28

Similar Documents

Publication Publication Date Title
DK3478682T3 (da) [1,2,4]triazolo[1,5-a]pyridinylsubstituerede indolforbindelser
IL262548A (en) 8,7,6,5-tetrahydro [4,2,1] triazolo [3,4-a] pyridine-3- (2 h) -union and 7,6,5,2-tetrahydro-3 h-pyrrolo [1, 2-c] [4,2,1] and converted thiazole-3-ones and their use
MA46470A (fr) 1h-imidazo[4,5-b]pyridin-2(3h)-ones substituées et leur utilisation en tant que modulateurs du récepteur glun2b
AU2017262960A1 (en) Substituted 5,6,7,8-tetrahydro(1,2,4)triazolo(4,3-a)pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo(2,1-c)(1,2,4)triazol-3-ones, and use thereof
IL260923B (en) History of pyrazolo[5,1-a]pyrazin-4-yl as jak inhibitors
EP3452481A4 (fr) Imidazo[1,2-b]pyridazines substituées, imidazo[1,5-b]pyridazines substituées, composés apparentés et leur utilisation dans le traitement de troubles médicaux
IL266305B (en) History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors
HUE046057T2 (hu) Új spiro[3H-indol-3,2'-pirrolidin]-2(1H)-on vegyületek és származékok, mint MDM2-P53-inhibitorok
EP3162090A4 (fr) Procédé de balayage de balise multi-couche, noeud d'accès, et équipement utilisateur
PL3310784T3 (pl) Związki tricykliczne i ich zastosowanie jako inhibitory fosfodiesterazy
HRP20182114T1 (hr) Spojevi 6,7-dihidropirazolo[1,5-a]pirazin-4(5h)-ona i njihova uporaba kao negativnih alosternih modulatora receptora mglu2
HUE043108T2 (hu) (5,6-dihidro)pirimido[4,5-e]indolizinek
MA43840A (fr) Utilisation de 2,3-dihydroimidazo[1,2-c]quinazolines substituées
IL247947B (en) 7,6,5,4-tetrahydro-pyrazolo[5,1-a]pyrazine compounds and 8,7,6,5-tetrahydro-h4-pyrazolo[5,1-a][4,1]diazepine compounds as ros1 inhibitors
SI3114126T1 (sl) Derivati 1,2-dihidro-3H-pirolo(1,2-C)imidazol-3-ona in njihova uporaba kot antibakterijska sredstva
DK3068401T3 (da) 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-on, salte deraf og fremgangsmåder til anvendelse
IL247948B (en) 7,6,5,4-tetrahydro-pyrazolo[5,1-a]pyrimidine derivatives and 3,2-dihydro-h1-imidazo[2,1-b]pyrazole derivatives as ros1 inhibitors
PT3545144T (pt) Elementos de nó, kits e métodos
EP3551630A4 (fr) Dérivés d'imidazo [1,5-a]pyrazine en tant qu'inhibiteurs de pi3kdelta
GB201802644D0 (en) Monocyclic,thieno, pyrido and pyrrolo pyrimidine compounds and methods of use and manufacture of the same
DK3459953T3 (da) Hidtil ukendt 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-on-derivat
HUE057202T2 (hu) Kombinációs kezelések 1H-pirazolo[4,3-b]piridinek alkalmazásával
EP3127360A4 (fr) Équipement utilisateur et noeud d'accès et procédés respectifs
IL257796B (en) Soluble and solid pyric pyrophosphate formulations, kits, and methods used therein
MA44969A (fr) 5,6,7,8-tétrahydro[1,2,4]triazolo[4,3- a]pyridin-3(2h)-ones et 2,5,6,7-tétrahydro-3h-pyrrolo[2,1 -c][1,2,4]triazol-3-ones substituées et leur utilisation