MA45035A - Combinaisons d'arnm codant pour des polypeptides de modulation immunitaire et leurs utilisations - Google Patents

Combinaisons d'arnm codant pour des polypeptides de modulation immunitaire et leurs utilisations

Info

Publication number
MA45035A
MA45035A MA045035A MA45035A MA45035A MA 45035 A MA45035 A MA 45035A MA 045035 A MA045035 A MA 045035A MA 45035 A MA45035 A MA 45035A MA 45035 A MA45035 A MA 45035A
Authority
MA
Morocco
Prior art keywords
rnam
polypeptides
coding
combinations
immune modulation
Prior art date
Application number
MA045035A
Other languages
English (en)
Other versions
MA45035B1 (fr
Inventor
Ailin Bai
Kerry Benenato
Joshua Frederick
Susannah Hewitt
Stephen Hoge
Ellalahewage Sathyajith Kumarasinghe
Lain Mcfadyen
Vladimir Presnyak
Original Assignee
Modernatx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Modernatx Inc filed Critical Modernatx Inc
Publication of MA45035A publication Critical patent/MA45035A/fr
Publication of MA45035B1 publication Critical patent/MA45035B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
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    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
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MA45035A 2016-05-18 2017-05-18 Combinaisons d'arnm codant pour des polypeptides de modulation immunitaire et leurs utilisations MA45035B1 (fr)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201662338483P 2016-05-18 2016-05-18
US201662338496P 2016-05-18 2016-05-18
US201662338467P 2016-05-18 2016-05-18
US201662338506P 2016-05-18 2016-05-18
US201662404175P 2016-10-04 2016-10-04
US201662404173P 2016-10-04 2016-10-04
US201662415424P 2016-10-31 2016-10-31
US201662438945P 2016-12-23 2016-12-23
US201662438942P 2016-12-23 2016-12-23
US201762443693P 2017-01-07 2017-01-07
US201762472513P 2017-03-16 2017-03-16
US201762480400P 2017-04-01 2017-04-01
EP17727999.9A EP3458474B1 (fr) 2016-05-18 2017-05-18 Combinaisons d'arnm codant pour des polypeptides de modulation immunitaire et leurs utilisations
PCT/US2017/033395 WO2017201325A1 (fr) 2016-05-18 2017-05-18 Combinaisons d'arnm codant pour des polypeptides de modulation immunitaire et leurs utilisations

Publications (2)

Publication Number Publication Date
MA45035A true MA45035A (fr) 2019-03-27
MA45035B1 MA45035B1 (fr) 2024-11-29

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MA45035A MA45035B1 (fr) 2016-05-18 2017-05-18 Combinaisons d'arnm codant pour des polypeptides de modulation immunitaire et leurs utilisations

Country Status (19)

Country Link
US (10) US10172808B2 (fr)
EP (2) EP3458474B1 (fr)
JP (2) JP7194594B2 (fr)
KR (2) KR102482867B1 (fr)
CN (2) CN116726203A (fr)
AU (2) AU2017266929B2 (fr)
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US20230026381A1 (en) 2023-01-26
WO2017201325A1 (fr) 2017-11-23
HRP20221135T1 (hr) 2022-11-25
JP7194594B2 (ja) 2022-12-22
US11071716B2 (en) 2021-07-27
US10406113B2 (en) 2019-09-10
KR20190020299A (ko) 2019-02-28
EP3458474B1 (fr) 2022-07-06
US20200113844A1 (en) 2020-04-16
HRP20221135T8 (hr) 2023-02-03
PL3458474T3 (pl) 2022-11-14
US20230041964A1 (en) 2023-02-09
KR102482867B1 (ko) 2023-01-02
AU2017266929B2 (en) 2023-05-11
ES2932516T3 (es) 2023-01-20
US10322090B2 (en) 2019-06-18
US20210038529A1 (en) 2021-02-11
CN109476718A (zh) 2019-03-15
JP2019519517A (ja) 2019-07-11
US10285950B2 (en) 2019-05-14
US20190060246A1 (en) 2019-02-28
US20190111003A1 (en) 2019-04-18
KR20230008243A (ko) 2023-01-13
US10322091B2 (en) 2019-06-18
US20180318229A1 (en) 2018-11-08
SI3458474T1 (sl) 2022-10-28
CN109476718B (zh) 2023-07-04
US11185510B2 (en) 2021-11-30
LT3458474T (lt) 2022-10-10
RS63625B1 (sr) 2022-10-31
JP7586883B2 (ja) 2024-11-19
CA3024917A1 (fr) 2017-11-23
WO2017201325A8 (fr) 2018-08-30
AU2023210606A1 (en) 2023-08-24
CN116726203A (zh) 2023-09-12
AU2017266929A1 (en) 2019-01-17
US10172808B2 (en) 2019-01-08
EP4137509A1 (fr) 2023-02-22
JP2023022326A (ja) 2023-02-14
US11596609B2 (en) 2023-03-07
EP3458474A1 (fr) 2019-03-27
US11344504B1 (en) 2022-05-31
US20190105281A1 (en) 2019-04-11
SMT202300003T1 (it) 2023-03-17
AU2017266929A8 (en) 2019-03-14
MA45035B1 (fr) 2024-11-29

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