MA45939A - Dérivé de pyridone polycyclique substitué et composition pharmaceutique contenant un promédicament de celui-ci - Google Patents

Dérivé de pyridone polycyclique substitué et composition pharmaceutique contenant un promédicament de celui-ci

Info

Publication number
MA45939A
MA45939A MA045939A MA45939A MA45939A MA 45939 A MA45939 A MA 45939A MA 045939 A MA045939 A MA 045939A MA 45939 A MA45939 A MA 45939A MA 45939 A MA45939 A MA 45939A
Authority
MA
Morocco
Prior art keywords
substitute
proof
pharmaceutical composition
same
composition containing
Prior art date
Application number
MA045939A
Other languages
English (en)
Inventor
Toshiyuki Akiyama
Makoto Kawai
Masayoshi Miyagawa
Azusa Okano
Kenji Tomita
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61020748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA45939(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MA45939A publication Critical patent/MA45939A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA045939A 2016-08-10 2017-08-09 Dérivé de pyridone polycyclique substitué et composition pharmaceutique contenant un promédicament de celui-ci MA45939A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2016157732 2016-08-10

Publications (1)

Publication Number Publication Date
MA45939A true MA45939A (fr) 2019-06-19

Family

ID=61020748

Family Applications (1)

Application Number Title Priority Date Filing Date
MA045939A MA45939A (fr) 2016-08-10 2017-08-09 Dérivé de pyridone polycyclique substitué et composition pharmaceutique contenant un promédicament de celui-ci

Country Status (22)

Country Link
US (4) US10759814B2 (fr)
EP (2) EP4458348A3 (fr)
JP (2) JP6249434B1 (fr)
KR (3) KR20190014086A (fr)
CN (1) CN110494141A (fr)
AR (1) AR109315A1 (fr)
AU (2) AU2017310774B2 (fr)
CA (1) CA3033180C (fr)
CL (2) CL2019000325A1 (fr)
CR (1) CR20190123A (fr)
ES (1) ES2989872T3 (fr)
IL (1) IL264709B2 (fr)
MA (1) MA45939A (fr)
MX (2) MX390287B (fr)
PE (1) PE20190662A1 (fr)
PL (1) PL3498281T3 (fr)
RU (1) RU2727962C1 (fr)
SG (2) SG10201912212XA (fr)
TW (2) TWI663172B (fr)
UA (1) UA125218C2 (fr)
WO (1) WO2018030463A1 (fr)
ZA (2) ZA201900935B (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20230215T1 (hr) * 2015-04-28 2023-04-14 Shionogi & Co., Ltd. Supstituirani policiklički derivati piridona i njihov predlijek
SG10201911957QA (en) * 2015-12-15 2020-02-27 Shionogi & Co Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug
US10858366B2 (en) 2016-03-08 2020-12-08 Novartis Ag Tricyclic compounds useful to treat orthomyxovirus infections
AU2017282305B2 (en) 2016-06-20 2021-06-10 Shionogi & Co., Ltd. Method for producing substituted polycyclic pyridone derivative and crystal of same
UA125218C2 (uk) * 2016-08-10 2022-02-02 Сіоногі Енд Ко., Лтд. Фармацевтичні композиції, що містять заміщені поліциклічні піридонові похідні та їх проліки
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
AU2018331172B2 (en) * 2017-09-18 2022-12-01 Sunshine Lake Pharma Co., Ltd. Influenza virus replication inhibitor and use thereof
WO2019070059A1 (fr) 2017-10-06 2019-04-11 塩野義製薬株式会社 Procédé pour la production stéréosélective d'un dérivé de pyridone polycyclique substitué
CN110041327B (zh) * 2018-01-17 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CA3088926A1 (fr) * 2018-01-17 2019-07-25 Jiangxi Caishi Pharmaceutical Technology Co., Ltd. Derive de pyridone, composition de celui-ci et son utilisation en tant que medicament contre la grippe
CN111303147B (zh) * 2018-12-12 2024-07-02 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
MX2020008959A (es) * 2018-02-28 2020-10-05 Novartis Ag Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza.
CN108440564B (zh) * 2018-04-11 2019-08-06 安帝康（无锡）生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药
WO2019208540A1 (fr) 2018-04-24 2019-10-31 塩野義製薬株式会社 Formulation solide présentant une excellente stabilité
EP3785716A4 (fr) * 2018-04-24 2022-03-02 Shionogi & Co., Ltd Formulation solide présentant une excellente stabilité
CN109956956B (zh) * 2018-05-15 2020-07-07 广东东阳光药业有限公司 一种并环吡啶酮化合物的制备方法
CN108558907B (zh) * 2018-06-01 2019-08-09 海化生命(厦门)科技有限公司 一种关键中间体2的制备方法
CN110317211B (zh) * 2018-07-27 2022-05-13 深圳市塔吉瑞生物医药有限公司 一种取代的多环性吡啶酮化合物及其前药
CN110872247A (zh) * 2018-08-29 2020-03-10 上海复星星泰医药科技有限公司 Xofluza含硫杂环化合物、其中间体及制备方法
WO2020058745A1 (fr) * 2018-09-18 2020-03-26 Shionogi & Co., Ltd. Traitement de la grippe à l'aide de dérivés de pyridone polycycliques substitués et leurs promédicaments
CN111377944A (zh) * 2018-12-25 2020-07-07 广东东阳光药业有限公司 Baloxavir marboxil晶型及其制备方法
EP3934758A1 (fr) 2019-03-05 2022-01-12 Assia Chemical Industries Ltd Formes à l'état solide de baloxavir marboxil
MX2021010884A (es) * 2019-03-12 2022-01-19 Shionogi & Co Tratamiento de la influenza con derivados de piridona policiclica sustituida y profarmacos de los mismos en un sujeto que tiene influenza y factor de riesgo de complicacion.
EP3714889A1 (fr) 2019-03-29 2020-09-30 F. Hoffmann-La Roche AG Composé et procédé pour la prévention de la transmission du virus de la grippe
WO2020205835A1 (fr) * 2019-04-01 2020-10-08 Nikang Therapeutics, Inc. Composés de pyridone polycycliques fusionnés utilisés en tant qu'inhibiteurs de réplication du virus de la grippe
CN111825699B (zh) * 2019-04-15 2023-02-21 上海复星星泰医药科技有限公司 含硫杂环化合物及其制备方法
RU2720305C1 (ru) * 2019-05-07 2020-04-28 Андрей Александрович Иващенко Замещенный 3,4,12,12а-тетрагидро-1Н-[1,4]оксазино[3,4-c]пиридо[2,1-f] [1,2,4]триазин-6,8-дион, фармацевтическая композиция, способы их получения и применения
CN111909174B (zh) * 2019-05-08 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物的晶型及制备方法和应用
CN110105372B (zh) * 2019-06-05 2022-05-10 南京焕然生物科技有限公司 一种r-7-(苄氧基)-四氢-1h-恶嗪并吡啶并-三嗪-6,8-二酮的制备方法
CN114907378A (zh) * 2019-07-11 2022-08-16 南京征祥医药有限公司 可用于治疗流感病毒感染的化合物
WO2021028024A1 (fr) * 2019-08-13 2021-02-18 F. Hoffmann-La Roche Ag Posologie améliorée du baloxavir marboxil pour patients pédiatriques
WO2021037956A1 (fr) * 2019-08-27 2021-03-04 Atriva Therapeutics Gmbh Combinaisons d'inhibiteurs de mek à des inhibiteurs d'endonucléase cap-dépendants
CN112552315B (zh) * 2019-09-26 2023-05-23 北京澳合药物研究院有限公司 一种巴洛沙韦玛波酯及其衍生物的纯化方法
WO2021057834A1 (fr) * 2019-09-27 2021-04-01 广东东阳光药业有限公司 Forme cristalline de composé ester et son procédé de préparation
CN112707862B (zh) * 2019-10-24 2022-09-27 广东东阳光药业有限公司 一种并环吡啶酮化合物的制备方法
WO2021093860A1 (fr) * 2019-11-13 2021-05-20 南京知和医药科技有限公司 Composé bis-tricyclique substitué, composition pharmaceutique et utilisation de celui-ci
CN118480041A (zh) * 2019-12-23 2024-08-13 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
CN113045589B (zh) * 2019-12-27 2024-08-23 广东东阳光药业股份有限公司 流感病毒复制抑制剂及其用途
CN112898346B (zh) * 2020-01-23 2023-11-10 南京知和医药科技有限公司 水溶性多环化合物及其药物组合物和用途
CN112940009A (zh) * 2020-02-03 2021-06-11 南京知和医药科技有限公司 一种磺酸多环化合物及其药物组合物和用途
CN112876510A (zh) * 2020-02-10 2021-06-01 石家庄迪斯凯威医药科技有限公司 一种磷酸酯类多环化合物及其药物组合物和用途
CN111647005A (zh) * 2020-06-15 2020-09-11 安徽皓元药业有限公司 巴洛沙韦新晶型及其制备方法
CN111875619B (zh) * 2020-07-30 2021-06-25 深圳市新阳唯康科技有限公司 巴洛沙韦酯的晶型及其制备方法
CN111961064A (zh) * 2020-08-25 2020-11-20 石家庄龙泽制药股份有限公司 巴洛沙韦酯的新晶型及其制备方法和应用
CN112409379B (zh) * 2020-09-28 2023-07-28 长沙晶易医药科技股份有限公司 氘代的二氢二苯并硫杂卓化合物以及包含该化合物的药物组合物
CN112400801B (zh) * 2020-12-07 2022-07-22 天津医科大学第二医院 一种喉癌前病变动物模型及其构建方法和应用
AU2022205484B2 (en) * 2021-01-08 2024-12-05 Phaeno Therapeutics Co., Ltd. Pyridone multiple-membered ring derivatives and use thereof
TW202308646A (zh) * 2021-05-10 2023-03-01 大陸商南京征祥醫藥有限公司 治療流感化合物的晶型及應用
CN117343079B (zh) * 2022-07-05 2024-08-20 山东如至生物医药科技有限公司 一种新型抗流感病毒化合物及其药物组合物和用途
CN118496239A (zh) * 2023-04-14 2024-08-16 南京卡文迪许生物工程技术有限公司 一种酰乙酯多环化合物及其药物组合物和用途
CN116284048B (zh) * 2023-05-18 2023-08-15 长沙晶易医药科技股份有限公司 一种化合物及其制备方法、药物组合物和用途
CN116969970B (zh) * 2023-06-21 2026-02-03 山东大学 巴洛沙韦酯晶型b1及其制备方法
WO2025152855A1 (fr) * 2024-01-16 2025-07-24 上海翊石医药科技有限公司 Composé pour le traitement de la grippe et son procédé de préparation

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1830312A (en) * 1919-05-08 1931-11-03 Westinghouse Lamp Co Electric lamp
GB2280435A (en) 1993-07-29 1995-02-01 Merck & Co Inc Anti-viral agent
US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
CN100409844C (zh) * 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
WO2006066414A1 (fr) 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones et procedes d’inhibition de l’integrase du vih
JP5131689B2 (ja) 2005-10-27 2013-01-30 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体
WO2009042502A1 (fr) 2007-09-27 2009-04-02 Air Cruisers Company Glissière d'évacuation de vaisseau et équipement associé
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
PL2444400T3 (pl) * 2009-06-15 2018-08-31 Shionogi & Co., Ltd. Podstawiona policykliczna pochodna karbamoilopirydonowa
US9216995B2 (en) 2010-04-12 2015-12-22 Shionogi & Co., Ltd. Pyridone derivative having integrase inhibitory activity
US8987441B2 (en) * 2010-09-24 2015-03-24 Shionogi & Co., Ltd. Substituted polycyclic carbamoyl pyridone derivative prodrug
US8859290B2 (en) 2011-07-22 2014-10-14 Rutgers, The State University Of New Jersey Inhibitors of influenza endonuclease activity and tools for their discovery
US20130102601A1 (en) 2011-10-21 2013-04-25 F. Hoffmann-La Roche Ltd Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease
US20130102600A1 (en) 2011-10-21 2013-04-25 F. Hoffmann-La Roche Ltd Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease
HK1204987A1 (en) 2012-05-23 2015-12-11 Savira Pharmaceuticals Gmbh 7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease
CN104334563B (zh) 2012-05-23 2017-03-08 萨维拉制药有限公司 7‑氧代‑噻唑并吡啶碳酸衍生物和它们在治疗、改善或预防病毒疾病中的用途
CA2879245A1 (fr) 2012-08-06 2014-02-13 Savira Pharmaceuticals Gmbh Derives d'acide dihydroxypyrimidinecarbonique et leur utilisation dans le traitement, l'amelioration ou la prevention d'une maladie virale
US9573938B2 (en) 2012-09-11 2017-02-21 Rutgers, The State University Of New Jersey Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
WO2014074926A1 (fr) 2012-11-09 2014-05-15 Rutgers, The State University Of New Jersey Hydroxyquinolones thérapeutiques
HK1211288A1 (en) 2013-01-08 2016-05-20 Savira Pharmaceuticals Gmbh Naphthyridinone derivatives and their use in the treatment,amelioration or prevention of a viral disease
MX2015008288A (es) 2013-01-08 2016-06-02 Savira Pharmaceuticals Gmbh Derivados de piridona y su uso en el tratamiento, mejora o prevencion de una enfermedad viral.
AU2014204889A1 (en) 2013-01-08 2015-06-11 European Molecular Biology Laboratory Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
CN105722831B (zh) 2013-09-12 2019-08-06 艾丽奥斯生物制药有限公司 哒嗪酮化合物及其用途
AU2014318832B2 (en) 2013-09-12 2018-11-29 Janssen Biopharma, Inc. Aza-pyridone compounds and uses thereof
CN107074880A (zh) 2014-07-07 2017-08-18 萨维拉制药有限公司 二氢吡啶并吡嗪‑1,8‑二酮和它们在治疗、改善或预防病毒疾病中的用途
CN107001355A (zh) 2014-07-07 2017-08-01 萨维拉制药有限公司 吡啶并吡嗪化合物和它们在治疗、改善或预防流感中的用途
WO2016084922A1 (fr) * 2014-11-28 2016-06-02 塩野義製薬株式会社 Dérivé 1,2,4-triazine et composition pharmaceutique correspondante
HRP20241039T1 (hr) 2015-04-28 2024-11-08 Shionogi & Co., Ltd Supstituirani derivat policikličkog piridona i njegov predlijek
HRP20230215T1 (hr) * 2015-04-28 2023-04-14 Shionogi & Co., Ltd. Supstituirani policiklički derivati piridona i njihov predlijek
US20170081331A1 (en) 2015-09-18 2017-03-23 F. Hoffmann-La Roche Ag Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease
TW201726678A (zh) 2015-10-30 2017-08-01 赫孚孟拉羅股份公司 嘧啶酮衍生物及其於治療、改善或預防病毒性疾病之用途
SG10201911957QA (en) * 2015-12-15 2020-02-27 Shionogi & Co Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug
WO2017109088A1 (fr) 2015-12-23 2017-06-29 Savira Pharmaceuticals Gmbh Dérivés pyrimidone et leur utilisation dans le traitement, le soulagement ou la prévention d'une maladie virale
JP6806413B2 (ja) 2016-02-03 2021-01-06 塩野義製薬株式会社 多環性ピリドン誘導体およびそのプロドラッグ
WO2017156194A1 (fr) 2016-03-08 2017-09-14 The Regents Of The University Of California Compositions et procédés pour inhiber l'endonucléase de la pa de l'arn polymérase de la grippe
US10858366B2 (en) 2016-03-08 2020-12-08 Novartis Ag Tricyclic compounds useful to treat orthomyxovirus infections
PL416447A1 (pl) 2016-03-10 2017-09-11 Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy
WO2017158147A1 (fr) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Dérivés de pyrimidone et leur utilisation pour le traitement, la prévention ou l'atténuation des symptômes d'une maladie virale
WO2017158151A1 (fr) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Dérivés de pyrimidone et leur utilisation dans le traitement, le soulagement ou la prévention d'une maladie virale
AU2017282305B2 (en) 2016-06-20 2021-06-10 Shionogi & Co., Ltd. Method for producing substituted polycyclic pyridone derivative and crystal of same
WO2017223231A1 (fr) 2016-06-21 2017-12-28 Alios Biopharma, Inc. (s)-8-(benzhydryl)-6-isopropyl-3,5-dioxo-5,6,7,8,-tétrahydro-3 h-pyrazino-[1,2-b] pyridazin-yl-isobutyrate, agent antiviral destiné à être utilisé dans le traitement de la grippe
UA125218C2 (uk) * 2016-08-10 2022-02-02 Сіоногі Енд Ко., Лтд. Фармацевтичні композиції, що містять заміщені поліциклічні піридонові похідні та їх проліки
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
CN108440564B (zh) 2018-04-11 2019-08-06 安帝康（无锡）生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药

Also Published As

Publication number Publication date
NZ750052A (en) 2024-08-30
JP2018048172A (ja) 2018-03-29
US20250257072A1 (en) 2025-08-14
US10759814B2 (en) 2020-09-01
EP3498281A1 (fr) 2019-06-19
ZA201900935B (en) 2020-09-30
CA3033180C (fr) 2022-05-31
PL3498281T3 (pl) 2024-11-12
CA3033180A1 (fr) 2018-02-15
JPWO2018030463A1 (ja) 2018-08-16
NZ791086A (en) 2025-08-29
AU2023202350A1 (en) 2023-05-11
KR20190014086A (ko) 2019-02-11
ES2989872T3 (es) 2024-11-28
UA125218C2 (uk) 2022-02-02
CL2020002032A1 (es) 2020-11-06
AU2017310774A1 (en) 2019-02-07
MX390287B (es) 2025-03-20
WO2018030463A1 (fr) 2018-02-15
JP6249434B1 (ja) 2017-12-20
KR20190018469A (ko) 2019-02-22
EP3498281C0 (fr) 2024-08-28
EP3498281B1 (fr) 2024-08-28
JP6267397B1 (ja) 2018-01-24
AR109315A1 (es) 2018-11-21
MX2019001640A (es) 2019-08-05
TWI711621B (zh) 2020-12-01
TW201808963A (zh) 2018-03-16
PE20190662A1 (es) 2019-05-08
US20200361958A1 (en) 2020-11-19
BR112019001911A2 (pt) 2019-05-07
US20220281890A1 (en) 2022-09-08
AU2023202350B2 (en) 2024-08-29
MX2021010629A (es) 2021-09-28
SG10201912212XA (en) 2020-02-27
ZA201908427B (en) 2021-05-26
AU2017310774A2 (en) 2019-03-14
IL264709B (en) 2022-10-01
US11306106B2 (en) 2022-04-19
SG11201900869QA (en) 2019-02-27
CR20190123A (es) 2019-04-30
TW201932113A (zh) 2019-08-16
EP3498281A4 (fr) 2020-04-08
WO2018030463A9 (fr) 2019-01-24
AU2017310774B2 (en) 2023-01-19
CN110494141A (zh) 2019-11-22
EP4458348A2 (fr) 2024-11-06
CL2019000325A1 (es) 2019-07-19
IL264709B2 (en) 2023-02-01
KR20190007517A (ko) 2019-01-22
IL264709A (fr) 2019-03-31
TWI663172B (zh) 2019-06-21
RU2727962C1 (ru) 2020-07-28
EP4458348A3 (fr) 2025-01-29
US20190169206A1 (en) 2019-06-06

Similar Documents

Publication Publication Date Title
MA45939A (fr) Dérivé de pyridone polycyclique substitué et composition pharmaceutique contenant un promédicament de celui-ci
EP3412660A4 (fr) Dérivé de sulfonamide et composition pharmaceutique le contenant
EP3493799A4 (fr) Composition pharmaceutique decannabis
EP3548000A4 (fr) Compositions pharmaceutiques d'atropine
EP3483284C0 (fr) Nanovésicules dérivées de bactéries du genrepropionibacterium
EP3493798A4 (fr) Composition pharmaceutique decannabis
EP3603620A4 (fr) Composition de liposome et composition pharmaceutique
EP3426348A4 (fr) Dérivé de 3-désoxy et compositions pharmaceutiques associées
EP3454899C0 (fr) Composition pharmaceutique
EP3434285A4 (fr) Composition pharmaceutique et ses utilisations
EP3505161A4 (fr) Composition pharmaceutique sublinguale d'édaravone et de (+)-2-bornéol
EP3429589A4 (fr) Composition pharmaceutique du nilotinib
EP3556771A4 (fr) Anticorps de claudine 5 et médicament le contenant
MA50368A (fr) Nouveau dérivé de 1h-pyrazolopyridine et composition pharmaceutique le contenant
EP3402470A4 (fr) Composition pharmaceutique stable
MA47516A (fr) Composition pharmaceutique
EP3542821A4 (fr) MOLÉCULE INDUISANT LA DÉGRADATION DE p53 ET COMPOSITION PHARMACEUTIQUE
EP3434681A4 (fr) Complexe de curcumine-bore et agent pharmaceutique le contenant
MA43978A (fr) Dérivé de sulfonamide hétérocyclique et médicament le contenant
EP3582759A4 (fr) Composition pharmaceutique bioéquivalente de bromhydrate de vortioxétine
EP3478078A4 (fr) Mélanges d'alcaloïdes de sébadille et d'azadirachtine et utilisations de ces mélanges
MA45158A (fr) Composition pharmaceutique comprenant de l'éteplirsen
EP3646863A4 (fr) Composition pharmaceutique
EP3646867A4 (fr) Composition pharmaceutique
EP3694522A4 (fr) Formulation de comprimé pharmaceutique bicouche