MA46018A - Activateurs d'édition du génome - Google Patents
Activateurs d'édition du génomeInfo
- Publication number
- MA46018A MA46018A MA046018A MA46018A MA46018A MA 46018 A MA46018 A MA 46018A MA 046018 A MA046018 A MA 046018A MA 46018 A MA46018 A MA 46018A MA 46018 A MA46018 A MA 46018A
- Authority
- MA
- Morocco
- Prior art keywords
- activators
- genome editing
- compositions
- amelioration
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des compositions améliorées pour des compositions de thérapie génique destinées au traitement, à la prévention ou à l'amélioration de nombreuses maladies, troubles et affections.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662377357P | 2016-08-19 | 2016-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46018A true MA46018A (fr) | 2019-06-26 |
Family
ID=61197452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046018A MA46018A (fr) | 2016-08-19 | 2017-08-18 | Activateurs d'édition du génome |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190169597A1 (fr) |
| EP (1) | EP3500271A4 (fr) |
| JP (1) | JP2019528691A (fr) |
| CN (1) | CN109715171A (fr) |
| AU (1) | AU2017312132A1 (fr) |
| CA (1) | CA3034101A1 (fr) |
| MA (1) | MA46018A (fr) |
| WO (1) | WO2018035423A1 (fr) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (fr) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Évaluation et amélioration de la spécificité de clivage des nucléases |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| CN105939767B (zh) | 2014-01-08 | 2018-04-06 | 弗洛设计声能学公司 | 具有双声电泳腔的声电泳装置 |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3204496A1 (fr) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions et procédés pour activer une réparation dirigée par homologie |
| WO2016073990A2 (fr) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Procédés pour améliorer l'édition génomique médiée par crispr/cas |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| CA2999500A1 (fr) | 2015-09-24 | 2017-03-30 | Editas Medicine, Inc. | Utilisation d'exonucleases pour ameliorer l'edition de genome a mediation par crispr/cas |
| WO2017070632A2 (fr) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Éditeurs de nucléobases et leurs utilisations |
| WO2017165826A1 (fr) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Systèmes d'édition de génome comprenant des molécules d'enzyme modulant la réparation et leurs procédés d'utilisation |
| US11236313B2 (en) | 2016-04-13 | 2022-02-01 | Editas Medicine, Inc. | Cas9 fusion molecules, gene editing systems, and methods of use thereof |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| WO2018027078A1 (fr) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Éditeurs de nucléobases d'adénosine et utilisations associées |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (fr) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation d'acides aminés non naturels dans des protéines au moyen de l'édition de bases |
| SG11201901757YA (en) | 2016-09-08 | 2019-03-28 | Bluebird Bio Inc | Pd-1 homing endonuclease variants, compositions, and methods of use |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| EP3529347A1 (fr) | 2016-10-19 | 2019-08-28 | Flodesign Sonics, Inc. | Extraction par affinité de cellules par un procédé acoustique |
| WO2018119359A1 (fr) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Édition du gène récepteur ccr5 pour protéger contre l'infection par le vih |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
| AU2018221730B2 (en) | 2017-02-15 | 2024-06-20 | Novo Nordisk A/S | Donor repair templates multiplex genome editing |
| US20180258485A1 (en) * | 2017-03-07 | 2018-09-13 | The Regents Of The University Of Colorado, A Body Corporate | Boranephosphonate Detection Probes and Methods For Producing and Using the Same |
| WO2018165504A1 (fr) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression de la douleur par édition de gène |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| EP3652312A1 (fr) | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systèmes et procédés d'intégration ciblée et d'édition du génome et détection de celle-ci à l'aide de sites d'amorçage intégrés |
| EP3658573A1 (fr) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Procédés et compositions pour l'évolution d'éditeurs de bases à l'aide d'une évolution continue assistée par phage (pace) |
| EP3676376B1 (fr) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | Éditeurs de bases à haut rendement comprenant une gam |
| CA3082251A1 (fr) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Utilisations d'editeurs de bases adenosine |
| EP3716767A4 (fr) * | 2017-10-24 | 2021-11-24 | Sangamo Therapeutics, Inc. | Méthodes et compositions pour le traitement de maladies rares |
| CN114900773A (zh) | 2017-12-14 | 2022-08-12 | 弗洛设计声能学公司 | 声泳系统及其操作方法、控制声换能器及声学系统的方法 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3765094A4 (fr) | 2018-03-15 | 2021-12-22 | KSQ Therapeutics, Inc. | Compositions de régulation génique et procédés pour améliorer l'immunothérapie |
| WO2019226953A1 (fr) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Éditeurs de bases et leurs utilisations |
| EP3820495A4 (fr) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | Modificateurs d'arn épigénétiques programmables par arn et leurs utilisations |
| JP7470119B2 (ja) | 2018-08-24 | 2024-04-17 | シーエスエル ベーリング ジーン セラピー インコーポレイテッド | 無血清培地におけるベクター産生 |
| WO2020092453A1 (fr) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Éditeurs de nucléobases comprenant geocas9 et utilisations associées |
| CA3122094A1 (fr) | 2018-12-10 | 2020-06-18 | Bluebird Bio, Inc. | Variants de l'endonuclease homing pdcd-1 |
| JP2022513750A (ja) | 2018-12-10 | 2022-02-09 | 2セブンティ バイオ インコーポレイテッド | ホーミングエンドヌクレアーゼバリアント |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| KR20210121092A (ko) * | 2019-01-29 | 2021-10-07 | 유니버시티 오브 워싱턴 | 유전자 편집 방법 |
| WO2020191241A1 (fr) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Procédés et compositions pour l'édition de séquences nucléotidiques |
| WO2020214842A1 (fr) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Éditeurs de base d'adénine présentant des effets hors cible réduits |
| JP7618581B2 (ja) | 2019-04-23 | 2025-01-21 | サンガモ セラピューティクス, インコーポレイテッド | 9番染色体オープンリーディングフレーム72遺伝子発現のモジュレーターおよびその使用 |
| EP4034659A4 (fr) * | 2019-09-27 | 2024-10-16 | The Broad Institute, Inc. | Éditeurs de polynucléotides programmables de recombinaison homologue amplifiée |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021137241A1 (fr) * | 2020-01-02 | 2021-07-08 | Edity Therapeutics Ltd. | Compositions et méthodes d'administration |
| CA3177481A1 (fr) | 2020-05-08 | 2021-11-11 | David R. Liu | Methodes et compositions d'edition simultanee des deux brins d'une sequence nucleotidique double brin cible |
| CN114149990A (zh) * | 2020-09-08 | 2022-03-08 | 甘李药业股份有限公司 | 编辑造血干/祖细胞中bcl11a基因的方法 |
| WO2022112596A1 (fr) * | 2020-11-30 | 2022-06-02 | Cellectis Sa | Utilisation de composés d'aminoquinoline pour une intégration de gènes plus élevée |
| CN112716954B (zh) * | 2021-02-02 | 2022-03-15 | 广东省第二人民医院(广东省卫生应急医院) | 氯化两面针碱的药物新用途 |
| CN115161335B (zh) * | 2021-04-02 | 2023-08-25 | 南京启真基因工程有限公司 | 用于构建tardbp基因突变的als模型猪核移植供体细胞的基因编辑系统及其应用 |
| GB202114972D0 (en) * | 2021-10-19 | 2021-12-01 | Ospedale San Raffaele Srl | Gene therapy |
| KR102942263B1 (ko) * | 2021-11-05 | 2026-03-23 | 건국대학교 글로컬산학협력단 | 하이칸톤을 포함하는 우울장애 또는 신경염증질환의 예방 또는 치료용 조성물 |
| CN115197231B (zh) * | 2022-08-15 | 2023-01-17 | 北京中医药大学 | 广谱抗病毒中药单体小檗胺及其应用 |
| WO2024125313A1 (fr) * | 2022-12-15 | 2024-06-20 | 中国科学院遗传与发育生物学研究所 | Éditeur de bases et utilisation associée |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4547569A (en) * | 1982-11-24 | 1985-10-15 | The United States Of America As Represented By The Department Of Health And Human Services | Intercalating agents specifying nucleotides |
| WO1991019789A1 (fr) * | 1990-06-19 | 1991-12-26 | Commonwealth Scientific And Industrial Research Organisation | Endonucleases |
| EP2625278A1 (fr) * | 2010-10-08 | 2013-08-14 | Regents of the University of Minnesota | Procédé d'augmentation de fréquences de ciblage de gène |
| SG189482A1 (en) * | 2010-10-27 | 2013-05-31 | Cellectis | Method for increasing the efficiency of double-strand break-induced mutagenesis |
| EP2729567B1 (fr) * | 2011-07-08 | 2016-10-05 | Cellectis | Procédé d'amélioration de l'efficacité de mutagenèse induite par une cassure double brin |
| ES2728782T3 (es) * | 2012-05-25 | 2019-10-28 | Univ California | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN |
| US10227610B2 (en) * | 2013-02-25 | 2019-03-12 | Sangamo Therapeutics, Inc. | Methods and compositions for enhancing nuclease-mediated gene disruption |
| EP4286517A3 (fr) * | 2013-04-04 | 2024-03-13 | President and Fellows of Harvard College | Utilisations thérapeutiques de l'édition de génome au moyen de systèmes crispr/cas |
| BR112016025849A2 (pt) * | 2014-05-08 | 2017-10-17 | Chdi Foundation Inc | métodos e composições para o tratamento da doença de huntington |
| WO2016036754A1 (fr) * | 2014-09-02 | 2016-03-10 | The Regents Of The University Of California | Procédés et compositions pour assurer la modification de l'adn cible arn dépendante |
| US10577417B2 (en) * | 2014-09-17 | 2020-03-03 | Novartis Ag | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| WO2016073990A2 (fr) * | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Procédés pour améliorer l'édition génomique médiée par crispr/cas |
| WO2016115326A1 (fr) * | 2015-01-15 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Méthodes pour moduler l'édition génomique |
| WO2016126608A1 (fr) * | 2015-02-02 | 2016-08-11 | Novartis Ag | Cellules exprimant car dirigées contre de multiples antigènes tumoraux et leurs utilisations |
-
2017
- 2017-08-18 MA MA046018A patent/MA46018A/fr unknown
- 2017-08-18 US US16/325,013 patent/US20190169597A1/en not_active Abandoned
- 2017-08-18 WO PCT/US2017/047535 patent/WO2018035423A1/fr not_active Ceased
- 2017-08-18 EP EP17842186.3A patent/EP3500271A4/fr not_active Withdrawn
- 2017-08-18 AU AU2017312132A patent/AU2017312132A1/en not_active Abandoned
- 2017-08-18 JP JP2019509523A patent/JP2019528691A/ja active Pending
- 2017-08-18 CA CA3034101A patent/CA3034101A1/fr not_active Abandoned
- 2017-08-18 CN CN201780057367.9A patent/CN109715171A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018035423A1 (fr) | 2018-02-22 |
| CA3034101A1 (fr) | 2018-02-22 |
| AU2017312132A1 (en) | 2019-03-21 |
| EP3500271A4 (fr) | 2020-05-13 |
| EP3500271A1 (fr) | 2019-06-26 |
| JP2019528691A (ja) | 2019-10-17 |
| US20190169597A1 (en) | 2019-06-06 |
| CN109715171A (zh) | 2019-05-03 |
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| MA53937B1 (fr) | Compositions comprenant des souches bactériennes | |
| EP3902524A4 (fr) | Traitement de troubles cutanés avec des compositions comprenant un inhibiteur d'egfr | |
| MA42376A (fr) | Dérivés d'oxopyridine substitués | |
| MA39219B1 (fr) | Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique | |
| MA43335B1 (fr) | Compositions d'arni de transthyrétine (ttr) et procédés pour les utiliser pour le traitement ou la prévention de maladies associées à ttr | |
| MA40240A (fr) | Composés hétéroaryle d'inhibition de la kinase | |
| EP3606520A4 (fr) | Inhibiteurs de l'activité de la déshydrogénase à chaîne courte pour le traitement des troubles coronaires | |
| WO2018112446A3 (fr) | Utilisation de gènes à médiation par motif apoe4 pour le diagnostic et le traitement de la maladie d'alzheimer | |
| EP3458585A4 (fr) | Procédés de thérapie génique pour des maladies et des affections liées à l'âge | |
| PH12017500629A1 (en) | Immuniregulatory agents | |
| EP3368560A4 (fr) | Variants du facteur viii à cpg réduit, compositions, procédés et utilisations pour le traitement d'affections hémostatiques | |
| MA43169B1 (fr) | Composés héterocycliques en tant qu' inhibiteurs pi3k-gamma | |
| PH12016501600A1 (en) | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease | |
| MA34969B1 (fr) | Composes et compositions en tant qu inibiteurs de trk | |
| MX2017003624A (es) | Compuestos de piridona sustituida con pirazolilo como inhibidores de serina proteasas. | |
| MA38837B1 (fr) | Inhibiteurs de l'autotaxine contenant un noyau à cycle benzyle-amide cyclique hétéroaromatique | |
| JOP20200041A1 (ar) | تركيبات صيدلية تحتوي على أجسام مضادة لبيتا نشوي | |
| EP3934646A4 (fr) | Compositions pharmaceutiques pour le traitement de maladies ou de troubles oculaires | |
| MA38349A1 (fr) | Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3) | |
| EP3681477A4 (fr) | Méthode et composition améliorée pour le traitement d'états pathologiques, de maladies ou de troubles sensibles aux triterpènes | |
| EP2563794A4 (fr) | Inhibiteurs de l'activité protéine tyrosine kinase et leurs applications au traitement de troubles ophtalmiques | |
| MA51672A (fr) | Composés destinés au traitement des troubles kinases-dépendants | |
| EP4364805A3 (fr) | Nouvelles pyridazines | |
| EA201890460A1 (ru) | Композиции и способы лечения и предотвращения нейродегенеративных расстройств |