MA46453A - Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alpha - Google Patents

Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alpha

Info

Publication number
MA46453A
MA46453A MA046453A MA46453A MA46453A MA 46453 A MA46453 A MA 46453A MA 046453 A MA046453 A MA 046453A MA 46453 A MA46453 A MA 46453A MA 46453 A MA46453 A MA 46453A
Authority
MA
Morocco
Prior art keywords
compounds useful
ifn alpha
response modulators
alpha response
imidazopyridazine compounds
Prior art date
Application number
MA046453A
Other languages
English (en)
Inventor
Michael E Mertzman
Steven H Spergel
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA46453A publication Critical patent/MA46453A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA046453A 2016-10-07 2017-10-02 Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alpha MA46453A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662405309P 2016-10-07 2016-10-07

Publications (1)

Publication Number Publication Date
MA46453A true MA46453A (fr) 2019-08-14

Family

ID=60117794

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046453A MA46453A (fr) 2016-10-07 2017-10-02 Composés imidazopyridazine utiles en tant que modulateurs de réponses il-12, il-23 et/ou ifn alpha

Country Status (8)

Country Link
US (1) US10836770B2 (fr)
EP (1) EP3523305B1 (fr)
JP (1) JP7097875B2 (fr)
KR (1) KR102531036B1 (fr)
CN (1) CN110036015B (fr)
ES (1) ES2902995T3 (fr)
MA (1) MA46453A (fr)
WO (1) WO2018067432A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR117398A1 (es) 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
JP7179161B2 (ja) 2018-09-10 2022-11-28 イーライ リリー アンド カンパニー 乾癬および全身性エリテマトーデスの処置に有用なピラゾロ［１，５－ａ］ピリミジン－３－カルボキサミド誘導体
AU2019339355A1 (en) * 2018-09-13 2021-05-13 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
DK3870579T3 (da) 2018-10-22 2025-01-02 Alumis Inc Tyk2-inhibitorer og anvendelser deraf
WO2020094363A1 (fr) 2018-11-05 2020-05-14 Syngenta Participations Ag Composés azole-amide à action pesticide
AR117177A1 (es) 2018-12-10 2021-07-14 Lilly Co Eli DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa
US11174264B2 (en) 2019-01-23 2021-11-16 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
JP2022523434A (ja) 2019-03-08 2022-04-22 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物的に活性なアゾール－アミド化合物
CN113597424B (zh) 2019-03-20 2025-04-18 先正达农作物保护股份公司 杀有害生物活性的唑酰胺化合物
BR112021018822A2 (pt) 2019-03-22 2021-11-23 Syngenta Crop Protection Ag Derivados de n-[1-(5-bromo-2-pirimidin-2-il-1,2,4-triazol-3-il)etil]-2-ciclopropil-6-(trifluorometil)piridina-4-carboxamida e compostos relacionados como inseticidas
CN114269336A (zh) 2019-04-30 2022-04-01 细胞基因公司 包含阿普斯特和tyk2抑制剂的联合疗法
WO2021162944A1 (fr) 2020-02-12 2021-08-19 Eli Lilly And Company Dérivés de 7-(méthylamino)pyrazolo [1,5-a]pyrimidine-3-carboxamide substitués
TWI810520B (zh) 2020-02-12 2023-08-01 美商美國禮來大藥廠 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺化合物
EP3944859A1 (fr) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Procédé de traitement des toxicités immunitaires induites par des inhibiteurs des points de contrôle immunitaire
CN115916207A (zh) * 2020-08-20 2023-04-04 轶诺(浙江)药业有限公司 一类五元并六元杂环化合物及其作为蛋白受体激酶抑制剂的用途
KR20230069984A (ko) * 2020-09-16 2023-05-19 알루미스, 인크. Tyk2 억제제 및 그의 용도
US20240246944A1 (en) 2021-03-16 2024-07-25 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Amino heteroaryl compounds and compositions
CA3236262A1 (fr) 2021-10-25 2023-05-04 Isaac Marx Agents de degradation de tyk2 et leurs utilisations
CN116655636A (zh) * 2022-02-17 2023-08-29 上海轶诺药业有限公司 一类五元并六元杂环化合物及其作为蛋白激酶抑制剂的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
WO2009100375A1 (fr) 2008-02-06 2009-08-13 Bristol-Myers Squibb Company Imidazopyridazines substituées utiles en tant qu’inhibiteurs de kinase
EP2768509B1 (fr) * 2011-10-20 2017-03-22 Glaxosmithkline LLC Azahétérocycles bicycliques substitués et analogues comme modulateurs de la sirtuine
CN105992768B (zh) * 2013-12-10 2018-04-20 百时美施贵宝公司 用作IL‑12、IL‑23和/或IFNα响应的调节剂的咪唑并哒嗪化合物
US10479793B2 (en) * 2015-11-18 2019-11-19 Bristol-Myers Squibb Company Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses

Also Published As

Publication number Publication date
CN110036015A (zh) 2019-07-19
ES2902995T3 (es) 2022-03-30
KR20190057132A (ko) 2019-05-27
KR102531036B1 (ko) 2023-05-09
CN110036015B (zh) 2022-07-19
US10836770B2 (en) 2020-11-17
EP3523305B1 (fr) 2021-12-08
JP7097875B2 (ja) 2022-07-08
JP2019530699A (ja) 2019-10-24
US20190225620A1 (en) 2019-07-25
EP3523305A1 (fr) 2019-08-14
WO2018067432A1 (fr) 2018-04-12

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