MA46472A - Hétéromultimères alk4:actriib et leurs utilisations - Google Patents

Hétéromultimères alk4:actriib et leurs utilisations

Info

Publication number
MA46472A
MA46472A MA046472A MA46472A MA46472A MA 46472 A MA46472 A MA 46472A MA 046472 A MA046472 A MA 046472A MA 46472 A MA46472 A MA 46472A MA 46472 A MA46472 A MA 46472A
Authority
MA
Morocco
Prior art keywords
actriib
alk4 heteromultimers
alk4
heteromultimers
Prior art date
Application number
MA046472A
Other languages
English (en)
Inventor
Roselyne Castonguay
Asya Grinberg
Ravindra Kumar
Dianne S Sako
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of MA46472A publication Critical patent/MA46472A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA046472A 2016-10-05 2017-10-05 Hétéromultimères alk4:actriib et leurs utilisations MA46472A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662404727P 2016-10-05 2016-10-05
US201762510417P 2017-05-24 2017-05-24

Publications (1)

Publication Number Publication Date
MA46472A true MA46472A (fr) 2019-08-14

Family

ID=61831282

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046472A MA46472A (fr) 2016-10-05 2017-10-05 Hétéromultimères alk4:actriib et leurs utilisations

Country Status (11)

Country Link
US (3) US10934532B2 (fr)
EP (1) EP3522913A4 (fr)
JP (2) JP7219705B2 (fr)
KR (1) KR20190075078A (fr)
CN (1) CN110678195A (fr)
AU (1) AU2017338921A1 (fr)
BR (1) BR112019006993A2 (fr)
CA (1) CA3039573A1 (fr)
MA (1) MA46472A (fr)
TW (1) TW201813978A (fr)
WO (1) WO2018067879A1 (fr)

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CN113683708A (zh) 2015-04-06 2021-11-23 阿塞勒隆制药公司 单臂i型和ii型受体融合蛋白和其用途
MA41919A (fr) 2015-04-06 2018-02-13 Acceleron Pharma Inc Hétéromultimères alk4:actriib et leurs utilisations
EP3280435B1 (fr) 2015-04-06 2021-06-02 Acceleron Pharma Inc. Hétéromultimères de récepteur de type i et de type ii de la superfamille de tgf-bêta et leurs utilisations
US20170306027A1 (en) 2016-04-06 2017-10-26 Acceleron Pharma Inc. Alk7 antagonists and uses thereof
EP3522912A4 (fr) 2016-10-05 2020-10-14 Acceleron Pharma Inc. Hétéromultimères de récepteurs de type i et de type ii de la superfamille des tgf-bêta et leurs utilisations
AU2017338916B2 (en) 2016-10-05 2022-03-24 Acceleron Pharma Inc. Variant ActRIIB proteins and uses thereof
CN110678195A (zh) 2016-10-05 2020-01-10 阿塞勒隆制药公司 ALK4:ActRIIB异多聚体及其用途
EP3788067A4 (fr) 2018-05-03 2022-01-19 Acceleron Pharma Inc. Nouveaux liants de ligands de la superfamille des tgfbêta et leurs utilisations
CN111269943B (zh) * 2019-08-10 2023-01-06 湖南文理学院 一种通过基因敲除技术增加斑马鱼生长速度的方法
WO2021119136A1 (fr) * 2019-12-10 2021-06-17 Acceleron Pharma Inc. Hétéromultimères actriia et actriib à bras unique et méthodes de traitement de l'hypertension pulmonaire
US20230183319A1 (en) * 2020-02-03 2023-06-15 Acceleron Pharma Inc. Variant actriib proteins and uses thereof
CN115515618A (zh) * 2020-03-13 2022-12-23 阿塞勒隆制药公司 用于治疗肾脏疾病或病症的单臂ActRIIA和ActRIIB异多聚体和方法
EP4121088A4 (fr) 2020-03-20 2024-07-03 Keros Therapeutics, Inc. Procédés d'utilisation de variants de récepteur de l'activine de type iib
EP4121078A4 (fr) 2020-03-20 2024-08-14 Keros Therapeutics, Inc. Chimères de type ii du récepteur d'activine et leurs méthodes d'utilisation
WO2021257655A1 (fr) * 2020-06-17 2021-12-23 Acceleron Pharma Inc. Antagonistes de l'actrii-alk4 et méthodes de traitement de l'insuffisance cardiaque
US20220288226A1 (en) * 2020-08-27 2022-09-15 Enosi Life Sciences Corp. Methods and compositions to treat autoimmune diseases and cancer
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WO2024238950A1 (fr) * 2023-05-18 2024-11-21 Keros Therapeutics, Inc. Procédés d'utilisation de variants du récepteur de l'activine de type ii
WO2025183964A1 (fr) * 2024-02-27 2025-09-04 Alivegen Usa, Inc Méthodes de traitement de troubles liés à la myostatine ou à l'activine à l'aide de nouvelles protéines de piégeage de ligand actriib hybride

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Also Published As

Publication number Publication date
WO2018067879A1 (fr) 2018-04-12
CN110678195A (zh) 2020-01-10
JP2022177286A (ja) 2022-11-30
US20250084388A1 (en) 2025-03-13
JP7219705B2 (ja) 2023-02-08
US20210363502A1 (en) 2021-11-25
BR112019006993A2 (pt) 2019-09-03
JP2019536438A (ja) 2019-12-19
US20180163187A1 (en) 2018-06-14
EP3522913A4 (fr) 2020-10-28
US12054753B2 (en) 2024-08-06
AU2017338921A1 (en) 2019-04-18
CA3039573A1 (fr) 2018-04-12
TW201813978A (zh) 2018-04-16
US10934532B2 (en) 2021-03-02
KR20190075078A (ko) 2019-06-28
EP3522913A1 (fr) 2019-08-14

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