MA46471A - Protéines actriib à variant et leurs utilisations - Google Patents
Protéines actriib à variant et leurs utilisationsInfo
- Publication number
- MA46471A MA46471A MA046471A MA46471A MA46471A MA 46471 A MA46471 A MA 46471A MA 046471 A MA046471 A MA 046471A MA 46471 A MA46471 A MA 46471A MA 46471 A MA46471 A MA 46471A
- Authority
- MA
- Morocco
- Prior art keywords
- variant proteins
- actriib variant
- actriib
- proteins
- variant
- Prior art date
Links
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404718P | 2016-10-05 | 2016-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46471A true MA46471A (fr) | 2021-05-19 |
Family
ID=61831930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046471A MA46471A (fr) | 2016-10-05 | 2017-10-05 | Protéines actriib à variant et leurs utilisations |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11267865B2 (fr) |
| EP (1) | EP3523328A4 (fr) |
| JP (2) | JP7280182B2 (fr) |
| KR (2) | KR102595559B1 (fr) |
| CN (1) | CN110036025B (fr) |
| AU (3) | AU2017338916B2 (fr) |
| BR (1) | BR112019006918A2 (fr) |
| CA (1) | CA3039525A1 (fr) |
| MA (1) | MA46471A (fr) |
| WO (1) | WO2018067874A1 (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| DK3227675T3 (da) | 2014-12-03 | 2023-05-30 | Celgene Corp | Activin-actrii-antagonister og anvendelser til behandling af myelodysplastisk syndrom |
| DK3286206T3 (da) | 2015-04-22 | 2021-05-03 | Biogen Ma Inc | Hidtil ukendte hybride actriib-ligand-trap-proteiner til behandling af muskelsvindsygdomme |
| US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントActRIIBタンパク質およびその使用 |
| JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| WO2018089715A1 (fr) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Variants de type iia du récepteur de l'activine et leurs méthodes d'utilisation |
| KR20250059538A (ko) | 2017-11-09 | 2025-05-02 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンiib型受容体変異体および同変異体を含む医薬組成物 |
| AU2019262139A1 (en) * | 2018-05-03 | 2020-11-26 | Acceleron Pharma Inc. | Multispecific binders of TGFβ-superfamily ligands and uses thereof |
| CA3099325A1 (fr) * | 2018-05-03 | 2019-11-07 | Acceleron Pharma Inc. | Nouveaux liants de ligands de la superfamille des tgfs et leurs utilisations |
| KR20250133994A (ko) * | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP2021526835A (ja) * | 2018-06-15 | 2021-10-11 | アクセルロン ファーマ インコーポレイテッド | 二機能性および三機能性融合タンパク質およびその使用 |
| CN109293763B (zh) * | 2018-10-26 | 2021-10-26 | 中国农业科学院特产研究所 | 水貂激活素b蛋白及其制备与应用 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| KR20220148189A (ko) * | 2020-02-03 | 2022-11-04 | 악셀레론 파마 인코포레이티드 | 변이체 actriib 단백질 및 이의 용도 |
| KR20230004515A (ko) | 2020-03-20 | 2023-01-06 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 ii 키메라 및 이의 사용 방법 |
| EP4121090A4 (fr) * | 2020-03-20 | 2024-09-04 | Keros Therapeutics, Inc. | Procédés d'utilisation de variants du récepteur de l'activine de type iia |
| EP4121088A4 (fr) | 2020-03-20 | 2024-07-03 | Keros Therapeutics, Inc. | Procédés d'utilisation de variants de récepteur de l'activine de type iib |
| CA3177830A1 (fr) | 2020-05-13 | 2021-11-18 | Maria BECONI | Anticorps anti-hemojuveline (hjv) pour le traitement de la myelofibrose |
| AU2021297998A1 (en) * | 2020-06-25 | 2022-12-15 | Gliknik Inc. | ACE2-Fc fusion proteins and methods of use |
| US12186370B1 (en) | 2020-11-05 | 2025-01-07 | Celgene Corporation | ACTRIIB ligand trap compositions and uses thereof |
| US20240181007A1 (en) * | 2021-01-08 | 2024-06-06 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| AU2023210700A1 (en) | 2022-01-28 | 2024-08-15 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3382562D1 (de) | 1982-09-24 | 1992-06-25 | Us Health | Wiederherstellung von gewebe bei tieren. |
| NZ210699A (en) | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| DE3588058T3 (de) | 1984-07-16 | 2005-04-07 | Celtrix Pharmaceuticals, Inc., Palo Alto | Knorpel-induzierende Polypeptid-Faktoren aus Knochen |
| EP0272253A4 (fr) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | Procede pour ameliorer la stabilite des glycoproteines. |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US20050186593A1 (en) * | 1991-05-10 | 2005-08-25 | The Salk Institute For Biological Studies | Cloning and recombinant production of CRF receptor(s) |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ATE352638T1 (de) | 1995-04-11 | 2007-02-15 | Gen Hospital Corp | REVERSE ßTWO-HYBRIDß-SYSTEME |
| US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP1007673B1 (fr) | 1997-07-30 | 2008-12-17 | Emory University | Nouvelle proteine de mineralisation osseuse, adn, vecteurs et systemes d'expressions |
| EP1147413B1 (fr) | 1999-01-21 | 2006-04-05 | Metamorphix, Inc. | Inhibiteurs de facteurs de differenciation de la croissance et leurs utilisations |
| EP1729793B1 (fr) | 2004-03-02 | 2015-07-22 | Acceleron Pharma Inc. | Inhibiteurs d'alk7 et de la myostatine pour le traitement de l'amyotrophie |
| ES2561048T3 (es) | 2004-07-23 | 2016-02-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| EP2035456A1 (fr) | 2006-06-22 | 2009-03-18 | Novo Nordisk A/S | Production d'anticorps bispécifiques |
| CN104524548A (zh) | 2006-12-18 | 2015-04-22 | 阿塞勒隆制药公司 | 活化素-actrii拮抗剂及在提高红细胞水平中的用途 |
| US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| TW201940502A (zh) * | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| SI2235064T1 (sl) | 2008-01-07 | 2016-04-29 | Amgen Inc. | Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov |
| JP5719766B2 (ja) | 2008-05-02 | 2015-05-20 | アクセルロン ファーマ, インコーポレイテッド | 血管新生および周皮細胞組成物を調節するための方法および組成物 |
| CN107252486B (zh) * | 2008-06-26 | 2021-10-22 | 阿塞勒隆制药公司 | 激活素-actrii的拮抗剂及在提高红细胞水平中的用途 |
| LT3750552T (lt) * | 2008-08-14 | 2023-06-26 | Acceleron Pharma Inc. | Gdf gaudyklės |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| CA2749544A1 (fr) * | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Procedes permettant d'augmenter l'adiponectine |
| JP5755635B2 (ja) | 2009-03-30 | 2015-07-29 | アクセルロン ファーマ, インコーポレイテッド | Bmp−alk3アンタゴニストおよび骨成長促進のためのその使用 |
| JP2012529294A (ja) * | 2009-06-12 | 2012-11-22 | アクセルロン ファーマ, インコーポレイテッド | 切断型ActRIIB−Fc融合タンパク質 |
| CA2770822C (fr) * | 2009-08-13 | 2020-03-24 | Acceleron Pharma Inc. | Utilisation combinee de pieges gdf et d'activateurs du recepteur de l'erythropoietine pour augmenter les taux de globules rouges |
| ES2613523T3 (es) | 2009-09-09 | 2017-05-24 | Acceleron Pharma, Inc. | Antagonistas de ActRIIb y dosificación y usos de los mismos |
| WO2011034605A2 (fr) | 2009-09-16 | 2011-03-24 | Genentech, Inc. | Complexes protéiques contenant une super-hélice et/ou une attache et leurs utilisations |
| WO2012027065A2 (fr) | 2010-08-27 | 2012-03-01 | Celgene Corporation | Polythérapie pour traiter des maladies |
| CN102850458B (zh) | 2011-06-28 | 2014-10-01 | 华博生物医药技术(上海)有限公司 | 新型重组双功能融合蛋白及其制法和用途 |
| EP3520805B1 (fr) * | 2011-10-17 | 2021-03-10 | Acceleron Pharma Inc. | Procédés et compositions pour traiter de la myélofibrose |
| WO2013063536A1 (fr) | 2011-10-27 | 2013-05-02 | Acceleron Pharma, Inc. | AGENTS DE LIAISON À ActRIIB ET UTILISATIONS DE CEUX-CI |
| CN105658672A (zh) | 2013-08-22 | 2016-06-08 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
| KR102520970B1 (ko) * | 2014-03-21 | 2023-04-12 | 악셀레론 파마 인코포레이티드 | 액티빈 b 및/또는 gdf11을 억제함으로써 적혈 혈액 세포 수준을 증가시키고 비효율적인 적혈구 생성을 치료하는 방법 |
| MX388380B (es) * | 2014-04-18 | 2025-03-19 | Acceleron Pharma Inc | Composiciones para usarse en el incremento de los niveles de glóbulos rojos y el tratamiento de enfermedad de células falciformes. |
| TN2016000553A1 (en) | 2014-06-13 | 2018-04-04 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| DK3227675T3 (da) | 2014-12-03 | 2023-05-30 | Celgene Corp | Activin-actrii-antagonister og anvendelser til behandling af myelodysplastisk syndrom |
| HK1250373A1 (zh) | 2015-04-06 | 2018-12-14 | Acceleron Pharma Inc. | Alk7:actriib异多聚体和其用途 |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| MD3280727T2 (ro) | 2015-04-06 | 2021-06-30 | Acceleron Pharma Inc | Proteine de fuziune ale receptorului de tip I și de tip II cu un singur braț și utilizările acestora |
| DK3286206T3 (da) | 2015-04-22 | 2021-05-03 | Biogen Ma Inc | Hidtil ukendte hybride actriib-ligand-trap-proteiner til behandling af muskelsvindsygdomme |
| WO2016205370A1 (fr) | 2015-06-15 | 2016-12-22 | Santa Maria Biotherapeutics, Inc. | Méthodes d'utilisation de protéines à base du récepteur iib de l'activine |
| US20200231652A1 (en) | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
| US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| US20200071382A1 (en) | 2016-07-07 | 2020-03-05 | Acceleron Pharma Inc. | Tgf-beta superfamily heteromultimers and uses thereof |
| CA3039545A1 (fr) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Heteromultimeres de recepteurs de type i et de type ii de la superfamille des tgf-beta et leurs utilisations |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントActRIIBタンパク質およびその使用 |
| US10934532B2 (en) | 2016-10-05 | 2021-03-02 | Acceleron Pharma Inc. | ALK4.ActRIIB heteromultimers |
| JOP20190085A1 (ar) | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| WO2018089715A1 (fr) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Variants de type iia du récepteur de l'activine et leurs méthodes d'utilisation |
-
2017
- 2017-10-05 JP JP2019518302A patent/JP7280182B2/ja active Active
- 2017-10-05 BR BR112019006918A patent/BR112019006918A2/pt unknown
- 2017-10-05 WO PCT/US2017/055421 patent/WO2018067874A1/fr not_active Ceased
- 2017-10-05 EP EP17859219.2A patent/EP3523328A4/fr active Pending
- 2017-10-05 US US16/340,048 patent/US11267865B2/en active Active
- 2017-10-05 AU AU2017338916A patent/AU2017338916B2/en active Active
- 2017-10-05 KR KR1020197012902A patent/KR102595559B1/ko active Active
- 2017-10-05 KR KR1020237036672A patent/KR102761094B1/ko active Active
- 2017-10-05 CN CN201780074935.6A patent/CN110036025B/zh active Active
- 2017-10-05 CA CA3039525A patent/CA3039525A1/fr active Pending
- 2017-10-05 MA MA046471A patent/MA46471A/fr unknown
-
2022
- 2022-03-07 US US17/687,934 patent/US12240887B2/en active Active
- 2022-03-11 AU AU2022201698A patent/AU2022201698A1/en not_active Abandoned
-
2023
- 2023-01-19 JP JP2023006458A patent/JP7617962B2/ja active Active
-
2024
- 2024-02-05 AU AU2024200684A patent/AU2024200684A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7617962B2 (ja) | 2025-01-20 |
| WO2018067874A1 (fr) | 2018-04-12 |
| JP2019536440A (ja) | 2019-12-19 |
| US20200055919A1 (en) | 2020-02-20 |
| EP3523328A4 (fr) | 2020-04-01 |
| CN110036025A (zh) | 2019-07-19 |
| US12240887B2 (en) | 2025-03-04 |
| CN110036025B (zh) | 2024-03-22 |
| US11267865B2 (en) | 2022-03-08 |
| AU2024200684A1 (en) | 2024-02-22 |
| BR112019006918A2 (pt) | 2019-06-25 |
| EP3523328A1 (fr) | 2019-08-14 |
| KR102595559B1 (ko) | 2023-10-30 |
| JP7280182B2 (ja) | 2023-05-23 |
| CA3039525A1 (fr) | 2018-04-12 |
| JP2023033573A (ja) | 2023-03-10 |
| KR20230152811A (ko) | 2023-11-03 |
| AU2017338916A1 (en) | 2019-04-18 |
| KR20190073414A (ko) | 2019-06-26 |
| KR102761094B1 (ko) | 2025-02-03 |
| US20220306724A1 (en) | 2022-09-29 |
| AU2017338916B2 (en) | 2022-03-24 |
| AU2022201698A1 (en) | 2022-04-07 |
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