MA46997B1 - Préparation de complexes solides de cyclodextrine permettant une administration de substance pharmaceutique active ophtalmique - Google Patents

Préparation de complexes solides de cyclodextrine permettant une administration de substance pharmaceutique active ophtalmique

Info

Publication number
MA46997B1
MA46997B1 MA46997A MA46997A MA46997B1 MA 46997 B1 MA46997 B1 MA 46997B1 MA 46997 A MA46997 A MA 46997A MA 46997 A MA46997 A MA 46997A MA 46997 B1 MA46997 B1 MA 46997B1
Authority
MA
Morocco
Prior art keywords
preparation
active pharmaceutical
pharmaceutical substance
administration
cyclodextrin complexes
Prior art date
Application number
MA46997A
Other languages
English (en)
Other versions
MA46997A (fr
Inventor
Thorsteinn Loftsson
Zoltan Fulop
Original Assignee
Oculis SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61656066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA46997(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Oculis SA filed Critical Oculis SA
Publication of MA46997A publication Critical patent/MA46997A/fr
Publication of MA46997B1 publication Critical patent/MA46997B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions ophtalmiques contenant des complexes solides de substance pharmaceutique active et de cyclodextrine, leur méthode de préparation et leurs utilisations. Les compositions peuvent comprendre un complexe médicament à principe actif/cyclodextrine sensiblement dissout dans un vecteur aqueux de gouttes ophtalmiques. La composition ophtalmique se présente globalement sous la forme d'une microsuspension comprenant un complexe de principes actifs ayant un diamètre inférieur à environ 100 µm.
MA46997A 2016-11-29 2017-11-29 Préparation de complexes solides de cyclodextrine permettant une administration de substance pharmaceutique active ophtalmique MA46997B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662427737P 2016-11-29 2016-11-29
PCT/IB2017/001659 WO2018100434A1 (fr) 2016-11-29 2017-11-29 Préparation de complexes solides de cyclodextrine permettant une administration de substance pharmaceutique active ophtalmique

Publications (2)

Publication Number Publication Date
MA46997A MA46997A (fr) 2019-10-09
MA46997B1 true MA46997B1 (fr) 2022-01-31

Family

ID=61656066

Family Applications (1)

Application Number Title Priority Date Filing Date
MA46997A MA46997B1 (fr) 2016-11-29 2017-11-29 Préparation de complexes solides de cyclodextrine permettant une administration de substance pharmaceutique active ophtalmique

Country Status (30)

Country Link
US (7) US11135311B2 (fr)
EP (2) EP3548091B1 (fr)
JP (2) JP7138103B2 (fr)
KR (3) KR20230025939A (fr)
CN (2) CN117018220A (fr)
AR (2) AR110270A1 (fr)
AU (1) AU2017369971B2 (fr)
CL (1) CL2019001447A1 (fr)
CO (1) CO2019005729A2 (fr)
CY (1) CY1124917T1 (fr)
DK (1) DK3548091T3 (fr)
EA (1) EA201991299A1 (fr)
ES (1) ES2903383T3 (fr)
HR (1) HRP20220046T1 (fr)
HU (1) HUE057221T2 (fr)
IL (2) IL266964B2 (fr)
LT (1) LT3548091T (fr)
MA (1) MA46997B1 (fr)
MD (1) MD3548091T2 (fr)
MX (1) MX389363B (fr)
PH (1) PH12019550088A1 (fr)
PL (1) PL3548091T3 (fr)
PT (1) PT3548091T (fr)
RS (1) RS62845B1 (fr)
SI (1) SI3548091T1 (fr)
SM (1) SMT202200025T1 (fr)
TW (2) TWI773706B (fr)
UA (1) UA124774C2 (fr)
WO (1) WO2018100434A1 (fr)
ZA (1) ZA201903307B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE057221T2 (hu) 2016-11-29 2022-04-28 Oculis SA Szilárd ciklodextrin komplexek készítményei szemészetileg aktív gyógyászati hatóanyag adagolásához
IT201900000561A1 (it) * 2019-01-14 2020-07-14 Medivis S R L Formulazioni topiche oftalmiche chimicamente e fisicamente stabili a base di Nepafenac
CN110051859B (zh) * 2019-06-06 2020-06-12 鲁南制药集团股份有限公司 一种阿昔替尼环糊精包合物
SI3993807T1 (sl) * 2019-07-01 2026-04-30 Oculis Operations Sarl Postopek za stabiliziranje ph vodnega sestavka, ki obsega zdravilo
TWI756547B (zh) * 2019-07-15 2022-03-01 高雄榮民總醫院 奈米眼藥水及其製造方法
CA3173676A1 (fr) * 2020-04-24 2021-10-28 Guangzhou Kangrui Biological Pharmaceutical Technology Co., Ltd. Formulation pour le traitement d'affections ophtalmiques
EP4171507A1 (fr) * 2020-06-30 2023-05-03 Oculis SA Préparation de complexes de cyclodextrine solides pour l'administration de substance pharmaceutique active ophtalmique
CN111728953B (zh) * 2020-07-29 2023-08-08 中国科学院上海药物研究所 一种托法替布或其盐的缓释制剂及其制备方法
JP2024504980A (ja) * 2021-01-21 2024-02-02 テジュン ファーマシューティカル カンパニー リミテッド 点眼組成物
WO2022156371A1 (fr) * 2021-01-22 2022-07-28 成都瑞沐生物医药科技有限公司 Support ou substance auxiliaire de préparation ophtalmique, son procédé de préparation et son application
US11998562B2 (en) * 2021-01-25 2024-06-04 University Of South Florida Ophthalmological formulations for the prevention of a coronavirus infection
CN117881411A (zh) * 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法
US20240350402A1 (en) * 2021-08-31 2024-10-24 The Cleveland Clinic Foundation Topical drug treatment to prevent or reduce corneal scarring
WO2023039213A1 (fr) * 2021-09-09 2023-03-16 Biora Therapeutics, Inc. Formulations aqueuses de tofacitinib et de sels de tofacitinib
WO2023132947A1 (fr) * 2022-01-05 2023-07-13 The Regents Of The University Of California Complexes de closo-dodécaiododécaborate et leurs procédés d'utilisation
CN118647364A (zh) 2022-02-02 2024-09-13 奥库里斯经营管理有限责任公司 多剂量眼用组合物
US20250367170A1 (en) * 2022-05-24 2025-12-04 The Cleveland Clinic Foundation Topical angiotensin ii receptor blockers (arbs) for treating eye conditions
CN118892544A (zh) * 2023-04-28 2024-11-05 维眸生物科技(浙江)有限公司 一种用于治疗非感染性炎症疾病的眼科组合物
WO2025044131A1 (fr) * 2023-08-28 2025-03-06 Theratocular Biotek Co., Ltd. Méthodes de production d'une composition ophtalmique de médicaments faiblement solubles dans l'eau
WO2025082585A1 (fr) 2023-10-16 2025-04-24 Oculis Operations Sàrl Procédé de traitement d'œdème maculaire diabétique
TW202519198A (zh) 2023-10-16 2025-05-16 瑞士商歐可麗營運有限公司 治療糖尿病黃斑水腫的方法
WO2025169089A1 (fr) 2024-02-05 2025-08-14 Sun Pharmaceutical Industries Limited Compositions ophtalmiques d'inhibiteurs de tyrosine kinase et leurs utilisations
KR102838026B1 (ko) * 2024-04-30 2025-07-28 주식회사 스카이테라퓨틱스 액시티닙 신규 분자 회합체를 포함하는 점안 조성물 및 이의 제조방법
WO2026094048A1 (fr) 2024-10-30 2026-05-07 Able Tx Ltd. Administration de médicaments dans le segment postérieur de l'œil

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
JPS60149530A (ja) 1984-01-13 1985-08-07 Takeda Chem Ind Ltd 水性製剤
JP2577049B2 (ja) 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
SG45449A1 (en) 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
US5472954A (en) * 1992-07-14 1995-12-05 Cyclops H.F. Cyclodextrin complexation
US5324718A (en) 1992-07-14 1994-06-28 Thorsteinn Loftsson Cyclodextrin/drug complexation
EP0709099A3 (fr) 1994-09-28 1996-07-24 Senju Pharma Co Suspension aqueuse nasale comprenant cyclodextrine
TW434023B (en) 1995-09-18 2001-05-16 Novartis Ag Preserved ophthalmic composition
EP0877600B1 (fr) 1996-08-09 2003-10-22 Alcon Manufacturing Ltd. Systemes conservateurs pour compositions pharmaceutiques contenant des cyclodextrines
EP0938896A1 (fr) 1998-01-15 1999-09-01 Novartis AG Compositions pharmaceutiques autoclavables contenant des agents de chelation
US20020198174A1 (en) * 2001-05-07 2002-12-26 Allergan Sales, Inc. Disinfecting and solubilizing steroid compositions
CN1320880C (zh) 1998-12-23 2007-06-13 伊迪亚股份公司 改进的体内局部无创伤用制剂
DE19957788A1 (de) 1999-12-01 2001-07-05 Schott Glas Tropfflasche
DE10036871A1 (de) 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
ATE424808T1 (de) * 2000-11-15 2009-03-15 Chandavarkar Mohan A Pharmazeutische zusammensetzungen mit corticosteroiden und antiinfektiva
WO2004069280A1 (fr) 2003-02-06 2004-08-19 Cipla Ltd Complexes d'inclusion pharmaceutiques contenant un steroide et un agent antibacterien facultatif
MXPA05008913A (es) * 2003-02-21 2005-10-05 Sun Pharmaceutical Ind Ltd Formulacion oftalmica estable que contiene antibiotico y corticoesteroide.
ES2584183T3 (es) 2003-03-28 2016-09-26 Ares Trading S.A. Formulaciones de cladribina para suministro mejorado oral y transmucosa
DE602004023516D1 (de) 2003-08-07 2009-11-19 Allergan Inc Zusammensetzungen zur abgabe von therapeutika in die augen und verfahren zu ihrer herstellung und verwendung
CN1559413A (zh) 2004-02-26 2005-01-05 胡秀爱 地塞米松磷酸钠冻干粉针及制备方法
US20050234018A1 (en) 2004-04-15 2005-10-20 Allergan, Inc. Drug delivery to the back of the eye
US6969706B1 (en) 2004-05-12 2005-11-29 Allergan, Inc. Preserved pharmaceutical compositions comprising cyclodextrins
WO2006062875A1 (fr) 2004-12-08 2006-06-15 Merck & Co., Inc. Formulation nanoparticulaire ophtalmique d’un inhibiteur selectif de la cyclooxygenase-2
CN100584332C (zh) 2004-12-08 2010-01-27 胡世兴 含有粉防己碱的眼用制剂及其在制备治疗眼科疾病的含有粉防己碱的眼用制剂中的应用
US20060292099A1 (en) 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US7893040B2 (en) 2005-07-22 2011-02-22 Oculis Ehf Cyclodextrin nanotechnology for ophthalmic drug delivery
US20080119448A1 (en) 2006-11-02 2008-05-22 Friedlaender Mitchell H Methods of treating an ocular allergy with low dose dexamethasone
ES2493641T3 (es) 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
US8524267B2 (en) 2008-04-18 2013-09-03 Warsaw Orthopedic, Inc. Dexamethasone formulations in a biodegradable material
US10463677B2 (en) 2008-11-07 2019-11-05 Cydex Pharmaceuticals, Inc. Composition containing sulfoalkyl ether cyclodextrin and latanoprost
CN101926760A (zh) 2009-06-24 2010-12-29 天津金耀集团有限公司 2-羟丙基-β-环糊精包合地塞米松注射液
JP5810098B2 (ja) 2010-12-28 2015-11-11 ロート製薬株式会社 水性眼科組成物
US20140163080A1 (en) * 2011-02-03 2014-06-12 Gnt, Llc Compositions and Methods for Treatment of Glaucoma
CN104411334A (zh) * 2012-05-08 2015-03-11 欧尼斯治疗公司 用于配制肽蛋白酶体抑制剂的环糊精络合法
KR101475776B1 (ko) 2012-08-24 2014-12-24 영진약품공업 주식회사 이중 포화 인지질을 포함하는 안정한 피부 외용 조성물
WO2014032026A1 (fr) * 2012-08-24 2014-02-27 Mitra Ashim K Formulation ophtalmique d'acide gras ou lipidique de polyoxyle, et traitement de pathologies oculaires
EP3043777B1 (fr) 2013-09-10 2020-04-22 Fresh Cut Development, LLC Spray sublingual contenant de la buprénorphine
KR20180028992A (ko) 2015-05-29 2018-03-19 오쿨리스 이에이치에프. 시클로스포린 a/시클로덱스트린 나노입자의 형성
EP3302426A4 (fr) 2015-05-29 2018-12-05 Sydnexis, Inc. Formulations pharmaceutiques stabilisées de d2o
WO2017083799A1 (fr) 2015-11-13 2017-05-18 Ohr Pharmaceutical, Inc. Formulations ophtalmiques de squalamine
US11129823B2 (en) 2016-05-09 2021-09-28 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
HUE057221T2 (hu) * 2016-11-29 2022-04-28 Oculis SA Szilárd ciklodextrin komplexek készítményei szemészetileg aktív gyógyászati hatóanyag adagolásához
JP2020535217A (ja) 2017-09-01 2020-12-03 マリー アンド プール エンタープライゼズ，リミテッド 眼病態を治療するための方法および組成物
US20190105264A1 (en) 2017-10-06 2019-04-11 Aciont Inc. Non-invasive ocular drug delivery devices
SG11202006782YA (en) 2018-01-31 2020-08-28 Twi Pharmaceuticals Inc Topical formulations comprising tofacitinib
CN113473970A (zh) 2018-12-27 2021-10-01 瑟菲斯眼科股份有限公司 用以治疗眼表疾病的眼科药物组合物和方法
SI3993807T1 (sl) * 2019-07-01 2026-04-30 Oculis Operations Sarl Postopek za stabiliziranje ph vodnega sestavka, ki obsega zdravilo
PT3993807T (pt) * 2020-05-12 2026-02-02 Oculis Operations Sarl Método para estabilizar o ph de uma composição aquosa compreendendo um fármaco
CN118647364A (zh) * 2022-02-02 2024-09-13 奥库里斯经营管理有限责任公司 多剂量眼用组合物
CN115837027A (zh) 2022-11-15 2023-03-24 中国药科大学 一种眼用地塞米松药物组合物

Also Published As

Publication number Publication date
DK3548091T3 (da) 2022-01-17
IL310360A (en) 2024-03-01
CN110177576B (zh) 2023-08-11
UA124774C2 (uk) 2021-11-17
AR110270A1 (es) 2019-03-13
TW201818943A (zh) 2018-06-01
US12233133B2 (en) 2025-02-25
IL266964A (en) 2019-07-31
CN110177576A (zh) 2019-08-27
KR102525438B1 (ko) 2023-04-26
US20190343846A1 (en) 2019-11-14
MX2019006221A (es) 2019-10-07
CY1124917T1 (el) 2023-01-05
KR20230025939A (ko) 2023-02-23
CO2019005729A2 (es) 2019-08-30
AU2017369971A1 (en) 2019-06-13
AU2017369971B2 (en) 2023-06-01
EP3548091B1 (fr) 2021-12-01
BR112019011067A2 (pt) 2019-12-17
MA46997A (fr) 2019-10-09
US20240091377A1 (en) 2024-03-21
US20180147297A1 (en) 2018-05-31
TWI810167B (zh) 2023-08-01
CA3045226A1 (fr) 2018-06-07
MX389363B (es) 2025-03-20
SMT202200025T1 (it) 2022-05-12
MD3548091T2 (ro) 2022-03-31
PL3548091T3 (pl) 2022-03-28
HUE057221T2 (hu) 2022-04-28
AR110269A1 (es) 2019-03-13
US11491240B2 (en) 2022-11-08
US11135311B2 (en) 2021-10-05
CL2019001447A1 (es) 2019-08-09
TW201825100A (zh) 2018-07-16
KR20240036731A (ko) 2024-03-20
TWI773706B (zh) 2022-08-11
US12521448B2 (en) 2026-01-13
LT3548091T (lt) 2022-02-10
SI3548091T1 (sl) 2022-04-29
CN117018220A (zh) 2023-11-10
US20220008555A1 (en) 2022-01-13
IL266964B1 (en) 2024-02-01
EA201991299A1 (ru) 2019-11-29
US20250177561A1 (en) 2025-06-05
HRP20220046T1 (hr) 2022-04-15
ES2903383T3 (es) 2022-04-01
ZA201903307B (en) 2020-09-30
PH12019550088A1 (en) 2020-06-15
IL310360B1 (en) 2026-02-01
JP7138103B2 (ja) 2022-09-15
KR102774277B1 (ko) 2025-03-04
WO2018100434A1 (fr) 2018-06-07
RS62845B1 (sr) 2022-02-28
KR20190091308A (ko) 2019-08-05
PT3548091T (pt) 2022-01-21
EP3548091A1 (fr) 2019-10-09
JP2019535798A (ja) 2019-12-12
IL266964B2 (en) 2024-06-01
JP2022172291A (ja) 2022-11-15
JP7455917B2 (ja) 2024-03-26
EP4194011A1 (fr) 2023-06-14
US20230037486A1 (en) 2023-02-09
US20230042785A1 (en) 2023-02-09

Similar Documents

Publication Publication Date Title
EA201991299A1 (ru) Приготовление твердых циклодекстриновых комплексов для доставки офтальмологических активных фармацевтических ингредиентов
Tripathi et al. Recent advances and mechanistic insights into antibacterial activity, antibiofilm activity, and cytotoxicity of silver nanoparticles
Chiodo et al. Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs
de Faria et al. An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages
Kumar et al. Triple Drug Combination of Zidovudine, Efavirenz and Lamivudine Loaded Lactoferrin Nanoparticles: an Effective Nano First-Line Regimen for HIV Therapy: Kumar, Lakshmi and Kondapi
AU2019219767A1 (en) Treatments for resistant acne
MA39726A (fr) Compositions pharmaceutiques de composés thérapeutiquement actifs
MY166045A (en) Abeta antibody formulation
WO2007027941A3 (fr) Compositions et methode de preparation de medicaments a faible solubilite dans l'eau presentant une stabilite accrue
Hartjen et al. Assessment of the range of the HIV-1 infectivity enhancing effect of individual human semen specimen and the range of inhibition by EGCG
MA42231B1 (fr) Nouveaux dérivés d'hydroxyacide, leur procédé de préparation, et compositions pharmaceutiques les contenant
MA55402B1 (fr) Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie
MA40111B1 (fr) Dérivés du tétrahydronaphtalène inhibant la protéine mcl-1
EA201890367A1 (ru) Композиции и способы для лиофильных форм наночастиц
MA55046B1 (fr) Utilisation de dérivés d'indole n-substitués comme modulateurs des récepteurs des pge2
MA45222A (fr) Nouveaux dérivés de pipéridinyle, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant
FR3029790B1 (fr) Microbille d'hydrogel de chitosane
EA201891977A1 (ru) Стабильная парентеральная лекарственная форма нимодипина
MA35411B1 (fr) Nouvelle composition thérapeutique contenant de l'apomorphine comme principe actif
RU2017146716A (ru) Способ образования наночастиц циклоспорина а/ циклодекстрина
JP2015504078A (ja) 医薬品のための経粘膜投与システム
MA33676B1 (fr) Compositions pharmaceutiques comprenant des dérivés de bisphosphonate et du cholécalciférol à dose élevée
AU2016338637A1 (en) Combination antibacterial composition and short-course antibacterial regimen
EP4233850A3 (fr) Formulations de capsules
MA46342B1 (fr) Dérivés de chromane, d'isochromane et de dihydroisobenzofurane en tant que modulateurs allostériques négatifs de mglur2, compositions et leur utilisation