MA47130A - Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations - Google Patents

Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations

Info

Publication number
MA47130A
MA47130A MA047130A MA47130A MA47130A MA 47130 A MA47130 A MA 47130A MA 047130 A MA047130 A MA 047130A MA 47130 A MA47130 A MA 47130A MA 47130 A MA47130 A MA 47130A
Authority
MA
Morocco
Prior art keywords
human
specifically binding
antibodies specifically
antibodies
binding
Prior art date
Application number
MA047130A
Other languages
English (en)
Other versions
MA47130B1 (fr
Inventor
Adam William Clarke
Anthony Gerard Doyle
David Jose Simon Laine
Matthew Pollard
Lynn Dorothy Poulton
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of MA47130A publication Critical patent/MA47130A/fr
Publication of MA47130B1 publication Critical patent/MA47130B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5443—IL-15

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
MA47130A 2016-12-21 2017-12-21 Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations MA47130B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437143P 2016-12-21 2016-12-21
EP17883800.9A EP3558369B1 (fr) 2016-12-21 2017-12-21 Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations
PCT/US2017/067917 WO2018119246A1 (fr) 2016-12-21 2017-12-21 Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations

Publications (2)

Publication Number Publication Date
MA47130A true MA47130A (fr) 2019-10-30
MA47130B1 MA47130B1 (fr) 2025-05-30

Family

ID=62627610

Family Applications (1)

Application Number Title Priority Date Filing Date
MA47130A MA47130B1 (fr) 2016-12-21 2017-12-21 Anticorps se liant spécifiquement à l'il-15 humaine et leurs utilisations

Country Status (29)

Country Link
US (3) US11267883B2 (fr)
EP (2) EP4585261B1 (fr)
JP (2) JP7155126B2 (fr)
KR (2) KR102706743B1 (fr)
CN (1) CN110234349B (fr)
AR (1) AR110414A1 (fr)
AU (2) AU2017382850B2 (fr)
CA (1) CA3046387A1 (fr)
CL (1) CL2019001729A1 (fr)
DK (1) DK3558369T3 (fr)
EA (1) EA201991514A1 (fr)
ES (1) ES3026508T3 (fr)
FI (1) FI3558369T3 (fr)
HR (1) HRP20250482T1 (fr)
HU (1) HUE071878T2 (fr)
IL (1) IL267113B2 (fr)
LT (1) LT3558369T (fr)
MA (1) MA47130B1 (fr)
MD (1) MD3558369T2 (fr)
MX (2) MX2019007357A (fr)
PE (1) PE20191497A1 (fr)
PH (1) PH12019501453A1 (fr)
PL (1) PL3558369T3 (fr)
PT (1) PT3558369T (fr)
RS (1) RS66900B1 (fr)
SI (1) SI3558369T1 (fr)
UA (1) UA126284C2 (fr)
WO (1) WO2018119246A1 (fr)
ZA (1) ZA201903848B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102160389B1 (ko) 2013-08-05 2020-09-28 트위스트 바이오사이언스 코포레이션 드 노보 합성된 유전자 라이브러리
CA2975852A1 (fr) 2015-02-04 2016-08-11 Twist Bioscience Corporation Procedes et dispositifs pour assemblage de novo d'acide oligonucleique
WO2016172377A1 (fr) 2015-04-21 2016-10-27 Twist Bioscience Corporation Dispositifs et procédés pour la synthèse de banques d'acides oligonucléiques
KR20180050411A (ko) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 올리고핵산 변이체 라이브러리 및 그의 합성
WO2017053450A1 (fr) 2015-09-22 2017-03-30 Twist Bioscience Corporation Substrats flexibles pour synthèse d'acide nucléique
EP4664304A3 (fr) 2016-09-21 2026-01-21 Atlas Data Storage, Inc. Stockage de données à base d'acide nucléique
HRP20250482T1 (hr) 2016-12-21 2025-06-20 Cephalon Llc Protutijela koja se specifično vežu na ljudski il-15 i njihove uporabe
WO2018156792A1 (fr) 2017-02-22 2018-08-30 Twist Bioscience Corporation Stockage de données reposant sur un acide nucléique
IL271205B2 (en) 2017-06-12 2025-02-01 Twist Bioscience Corp Methods for assembling continuous nucleic acids
WO2018231864A1 (fr) 2017-06-12 2018-12-20 Twist Bioscience Corporation Méthodes d'assemblage d'acides nucléiques continus
CN111566125A (zh) 2017-09-11 2020-08-21 特韦斯特生物科学公司 Gpcr结合蛋白及其合成
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
IL312616B2 (en) 2018-01-04 2025-08-01 Twist Bioscience Corp Dna-based digital information storage
EP3814497A4 (fr) 2018-05-18 2022-03-02 Twist Bioscience Corporation Polynucléotides, réactifs, et procédés d'hybridation d'acides nucléiques
WO2020023702A1 (fr) 2018-07-25 2020-01-30 AskGene Pharma, Inc. Nouveaux promédicaments d'il-21 et leurs procédés d'utilisation
US11828385B2 (en) 2018-12-25 2023-11-28 Ntn Corporation Flow control valve seal and flow control valve device
EP3902816A4 (fr) 2018-12-26 2022-09-14 Twist Bioscience Corporation Synthèse de novo polynucléotidique hautement précise
KR20210144698A (ko) 2019-02-26 2021-11-30 트위스트 바이오사이언스 코포레이션 항체 최적화를 위한 변이 핵산 라이브러리
CA3131689A1 (fr) 2019-02-26 2020-09-03 Twist Bioscience Corporation Banques de variants d'acides nucleiques pour le recepteur glp1
CN114341189A (zh) 2019-06-12 2022-04-12 奥美药业有限公司 全新il-15前药及其应用
EP3987019A4 (fr) 2019-06-21 2023-04-19 Twist Bioscience Corporation Assemblage de séquences d'acide nucléique basé sur des code-barres
US12091777B2 (en) 2019-09-23 2024-09-17 Twist Bioscience Corporation Variant nucleic acid libraries for CRTH2
CN115023440B (zh) 2019-09-23 2025-09-12 特韦斯特生物科学公司 结合CD3ε的抗体
AU2020400030B2 (en) 2019-12-09 2026-05-21 Twist Bioscience Corporation Variant nucleic acid libraries for adenosine receptors
AU2021205981A1 (en) 2020-01-11 2022-07-14 AskGene Pharma, Inc. Novel masked cytokines and methods of use thereof
CA3195512A1 (fr) * 2020-10-14 2022-04-21 Vahe Bedian Compositions et procedes pour le traitement d'une maladie oculaire thyroidienne
WO2022082201A1 (fr) * 2020-10-16 2022-04-21 Genentech, Inc. Anticorps dirigés contre le substrat de icaspase clivée et méthodes d'utilisation
WO2022159620A1 (fr) 2021-01-21 2022-07-28 Twist Bioscience Corporation Méthodes et compositions se rapportant à des récepteurs d'adénosine
CN116655771A (zh) * 2021-05-28 2023-08-29 苏州复融生物技术有限公司 一种新型白介素15突变体多肽的开发及其应用
US20250002599A1 (en) * 2021-09-03 2025-01-02 Novarock Biotherapeutics, Ltd. Bispecific and trispecific binding proteins to pd-l1, cd137, and/or tgf-beta and uses thereof
KR20250044344A (ko) 2022-08-04 2025-03-31 노파르티스 파르마 아게 아토피 피부염의 치료에 유용한 il-15 저해제
CN118894934A (zh) * 2023-05-05 2024-11-05 北京智仁美博生物科技有限公司 抗人il-15的抗体及其用途
CN117209605B (zh) * 2023-11-09 2024-01-30 北京百普赛斯生物科技股份有限公司 特异性结合il-15的抗体及其应用
WO2025227052A1 (fr) 2024-04-26 2025-10-30 Cephalon Llc Doses et formulations d'anticorps anti-il-15 pour le traitement de maladies immunitaires

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
HUP0104865A3 (en) 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
EP1355919B1 (fr) 2000-12-12 2010-11-24 MedImmune, LLC Molecules a demi-vies longues, compositions et utilisations de celles-ci
US7132510B2 (en) * 2000-12-29 2006-11-07 Bio-Technology General (Israel) Ltd. Specific human antibodies for selective cancer therapy
US7329405B2 (en) * 2001-08-23 2008-02-12 Genmab A/S Human antibodies specific for interleukin 15 (IL-15)
KR100911951B1 (ko) * 2001-08-23 2009-08-13 젠맵 에이/에스 인터루킨 15 (il-15)에 대하여 특이적인 인간 항체
US7247304B2 (en) * 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
JP4754219B2 (ja) * 2002-12-02 2011-08-24 アムジエン・フレモント・インコーポレイテツド 腫瘍壊死因子を対象とする抗体、およびそれらの使用
EA015897B1 (ru) * 2003-02-26 2011-12-30 Генмаб А/С Применение человеческого моноклонального антитела к ил-15 в составе композиции и лекарственного препарата (варианты), композиция и лекарственный препарат, его включающие
US20060057680A1 (en) * 2004-08-11 2006-03-16 Zheng Xin X Mutant interleukin-15 polypeptides
AU2006216291B2 (en) 2005-02-27 2011-01-27 Institute For Antibodies Co., Ltd. Anti-IgSF4 antibody and utilization of the same
EP3530736A3 (fr) * 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmée 1 (pd-1) et procédés de traitement du cancer à l'aide d'anticorps anti-pd-1 seuls ou combinés à d'autres formulations immunothérapeutiques
KR101703299B1 (ko) 2007-06-01 2017-02-06 오픈 모노클로날 테크놀로지, 인코포레이티드 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물
AR068767A1 (es) * 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
DK3241435T3 (da) 2009-07-08 2021-08-23 Kymab Ltd Dyremodeller og terapeutiske molekyler
AU2010306681A1 (en) * 2009-10-15 2012-04-19 Abbvie Inc. IL-1 binding proteins
WO2011119484A1 (fr) 2010-03-23 2011-09-29 Iogenetics, Llc Procédés bioinformatiques pour déterminer la liaison de peptides
JP5972871B2 (ja) * 2010-07-20 2016-08-17 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド 抗il−23ヘテロ二量体特異的抗体
JP5820688B2 (ja) 2011-03-23 2015-11-24 株式会社Kri 多糖類の溶解に用いられる溶媒ならびに該溶媒を用いた成形体および多糖類誘導体の製造方法
JP2014534806A (ja) * 2011-08-23 2014-12-25 ロシュ グリクアート アーゲー 抗mcsp抗体
CN104203982B (zh) * 2011-10-28 2018-08-31 特瓦制药澳大利亚私人有限公司 多肽构建体及其用途
WO2014131694A1 (fr) 2013-02-26 2014-09-04 Roche Glycart Ag Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t
UA118028C2 (uk) * 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
EP2963057A1 (fr) 2014-07-02 2016-01-06 Calypso Biotech SA Anticorps pour IL-15
MX387295B (es) 2015-03-31 2025-03-18 Medimmune Ltd Nueva forma de interleucina-33 (il33), formas mutadas de interleucina-33 (il33), anticuerpos, ensayos y métodos para usar los mismos.
EP3472202A1 (fr) * 2016-06-15 2019-04-24 Amgen Inc. Procédés et compositions pour le traitement de la maladie c liaque, sensibilité au gluten non c liaque et maladie c liaque réfractaire
MX2019004327A (es) 2016-10-14 2019-10-14 Xencor Inc Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1.
HRP20250482T1 (hr) 2016-12-21 2025-06-20 Cephalon Llc Protutijela koja se specifično vežu na ljudski il-15 i njihove uporabe

Also Published As

Publication number Publication date
EP4585261A3 (fr) 2025-08-13
UA126284C2 (uk) 2022-09-14
EP3558369A4 (fr) 2020-09-09
CN110234349B (zh) 2024-03-22
EP3558369B1 (fr) 2025-03-26
BR112019012570A8 (pt) 2023-01-24
DK3558369T3 (da) 2025-05-19
KR20190097094A (ko) 2019-08-20
BR112019012570A2 (pt) 2019-11-26
HUE071878T2 (hu) 2025-09-28
EP4585261B1 (fr) 2026-08-05
PL3558369T3 (pl) 2025-06-23
CN110234349A (zh) 2019-09-13
CA3046387A1 (fr) 2018-06-28
PE20191497A1 (es) 2019-10-21
IL267113B2 (en) 2024-09-01
LT3558369T (lt) 2025-07-25
EP3558369A1 (fr) 2019-10-30
EA201991514A1 (ru) 2019-12-30
WO2018119246A1 (fr) 2018-06-28
US20260152548A1 (en) 2026-06-04
KR20230135691A (ko) 2023-09-25
ES3026508T3 (en) 2025-06-11
AR110414A1 (es) 2019-03-27
RS66900B1 (sr) 2025-07-31
MD3558369T2 (ro) 2025-08-31
KR102706743B1 (ko) 2024-09-19
MX2019007357A (es) 2019-09-05
MA47130B1 (fr) 2025-05-30
US20200270339A1 (en) 2020-08-27
JP2022176324A (ja) 2022-11-25
MX2023014081A (es) 2023-12-06
IL267113A (en) 2019-08-29
JP7155126B2 (ja) 2022-10-18
AU2017382850A1 (en) 2019-07-04
CL2019001729A1 (es) 2019-09-13
US20220127352A1 (en) 2022-04-28
US12410247B2 (en) 2025-09-09
AU2017382850B2 (en) 2024-11-21
PT3558369T (pt) 2025-05-06
EP4585261A2 (fr) 2025-07-16
US11267883B2 (en) 2022-03-08
AU2025201185A1 (en) 2025-03-13
JP2020501583A (ja) 2020-01-23
ZA201903848B (en) 2023-02-22
HRP20250482T1 (hr) 2025-06-20
PH12019501453A1 (en) 2020-06-15
IL267113B1 (en) 2024-05-01
SI3558369T1 (sl) 2025-06-30
FI3558369T3 (fi) 2025-05-02

Similar Documents

Publication Publication Date Title
EP3891183A4 (fr) Anticorps anti-claudine et leurs utilisations
MA49457A (fr) Molécules d'anticorps se liant à cd73 et leurs utilisations
MA52459A (fr) Anticorps se liant spécifiquement à pd-1 et leurs méthodes d'utilisation
EP3759143A4 (fr) Anticorps anti-tigit et leurs utilisations
EP3625263A4 (fr) Anticorps anti-galectine-9 et leurs utilisations
EP3383916A4 (fr) Anticorps anti-cd73 et leurs utilisations
EP3362479A4 (fr) Agents de type anticorps spécifiques de l'antigène cd19 humain et leurs utilisations
EP3370769A4 (fr) Anticorps se liant spécifiquement à tim-3 et leurs utilisations
MA43308A (fr) Molécules d'anticorps se liant à april et leurs utilisations
EP3389702A4 (fr) Anticorps anti-lag-3 et leurs utilisations
MA44723A (fr) Anticorps agonistes se liant au cd40 humain et leurs utilisations
MA47789A (fr) Anticorps anti-phf-tau et leurs utilisations
MA44072A (fr) Anticorps se liant spécifiquement à hla-dr et leurs utilisations
EP3504243A4 (fr) Anticorps anti-tim-3 et leurs utilisations
EP3426288A4 (fr) Anticorps anti-pacap et leurs utilisations
EP3518971A4 (fr) Formulations thérapeutiques d'anticorps et de protéines et leurs utilisations
EP3681912A4 (fr) Anticorps spécifiques d'axl et leurs utilisations
MA49886A (fr) Anticorps anti-par2 et leurs utilisations
MA45233A (fr) Anticorps anti-gitr et leurs utilisations
MA45125A (fr) Anticorps anti-alpha-synucléine et leurs utilisations
EP3790586A4 (fr) Anticorps anti-dll3 et leurs utilisations
EP3645563A4 (fr) Anticorps anti-fam19a5 et leurs utilisations
EP3894440A4 (fr) Anticorps anti-il-27 et leurs utilisations
MA44665A (fr) Des anti-sirpa anticorps nouvelles et leurs utilisations therapeutiques
MA46036A (fr) Anticorps anti-vegf-a et anti-ang2 et leurs utilisations