MA47458A - Pyridines à substitution hydrocarbylsulfonyle et leur utilisation dans le traitement du cancer - Google Patents
Pyridines à substitution hydrocarbylsulfonyle et leur utilisation dans le traitement du cancerInfo
- Publication number
- MA47458A MA47458A MA047458A MA47458A MA47458A MA 47458 A MA47458 A MA 47458A MA 047458 A MA047458 A MA 047458A MA 47458 A MA47458 A MA 47458A MA 47458 A MA47458 A MA 47458A
- Authority
- MA
- Morocco
- Prior art keywords
- hydrocarbylsulfonyl
- pyridines
- substitution
- cancer treatment
- cancer
- Prior art date
Links
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000006467 substitution reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762455641P | 2017-02-07 | 2017-02-07 | |
| US201762594794P | 2017-12-05 | 2017-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA47458A true MA47458A (fr) | 2019-12-18 |
Family
ID=61274298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA047458A MA47458A (fr) | 2017-02-07 | 2018-02-07 | Pyridines à substitution hydrocarbylsulfonyle et leur utilisation dans le traitement du cancer |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11161815B2 (fr) |
| EP (1) | EP3580203A1 (fr) |
| JP (1) | JP7229176B2 (fr) |
| KR (1) | KR20190115014A (fr) |
| CN (1) | CN110382464A (fr) |
| AU (1) | AU2018218522B2 (fr) |
| BR (1) | BR112019016248A2 (fr) |
| CA (1) | CA3051539A1 (fr) |
| MA (1) | MA47458A (fr) |
| MX (1) | MX392900B (fr) |
| RU (1) | RU2019128063A (fr) |
| WO (1) | WO2018146472A1 (fr) |
| ZA (1) | ZA201904966B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201514021D0 (en) | 2015-08-07 | 2015-09-23 | Arner Elias Set Jeno | Novel Pyridines and their use in the treatment of cancer |
| AU2018218518B2 (en) | 2017-02-07 | 2022-03-17 | Oblique Therapeutics Ab | Sulfinylpyridines and their use in the treatment of cancer |
| BR112019016223A2 (pt) | 2017-02-07 | 2020-04-07 | Oblique Therapeutics Ab | piridinas substituídas por heteroarilsulfonila e uso das mesmas no tratamento de câncer |
| RU2019128063A (ru) * | 2017-02-07 | 2021-03-09 | Облик Терапьютикс Аб | Углеводородсульфонилзамещенные пиридины и их применение при лечении рака |
| MX389800B (es) | 2017-02-07 | 2025-03-20 | Oblique Therapeutics Ab | Piridinas sustituidas con heterociclilsulfonilo y su uso en el tratamiento del cancer |
| SG11202007535VA (en) * | 2018-02-12 | 2020-09-29 | Cinda Pharma Ab | Thioredoxin reductase inhibitors for use in the treatment of cancer |
| EP4201929B1 (fr) * | 2021-12-24 | 2024-08-14 | geneXplain GmbH | Inhibiteurs quinoxaline de thiorédoxine réductase |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3064846D1 (en) | 1979-12-19 | 1983-10-20 | Duphar Int Res | New nitrothiophenes, method of preparing the new compounds, as well as fungicidal and/or bactericidal compositions on the basis of the new compounds |
| US4456469A (en) | 1980-03-07 | 1984-06-26 | E. I. Du Pont De Nemours And Company | Pyridyl sulfone herbicides |
| AU543161B2 (en) | 1980-03-07 | 1985-04-04 | E.I. Du Pont De Nemours And Company | Pyrimidine or s.triazine derivatives |
| US4791127A (en) | 1985-10-07 | 1988-12-13 | Nippon Kayaku Kabushiki Kaisha | Alkanesulfonate derivatives and their use as insecticides, acaricides or nematicides |
| JPS63166865A (ja) * | 1986-12-22 | 1988-07-11 | バイエル・アクチエンゲゼルシヤフト | 置換されたフエノキシピリジン類 |
| DE3729071A1 (de) * | 1986-12-22 | 1988-06-30 | Bayer Ag | Substituierte phenoxypyridine |
| DE3812177A1 (de) | 1988-04-13 | 1989-10-26 | Bayer Ag | 2-phenylsulfinyl-nitro-pyridine, verfahren zu ihrer herstellung und ihre verwendung |
| AU2395095A (en) | 1994-04-29 | 1995-11-29 | G.D. Searle & Co. | Method of using (h+/k+) atpase inhibitors as antiviral agents |
| DE19531148A1 (de) * | 1995-08-24 | 1997-02-27 | Basf Ag | Fungizide Pyridin-2-yl-Derivate |
| US6069144A (en) * | 1995-08-24 | 2000-05-30 | Basf Aktiengesellschaft | N-heterocyclic compounds, intermediate products used to prepare them, agents containing them and their use in antifungal applications |
| DE19531348A1 (de) | 1995-08-25 | 1997-02-27 | Gsf Forschungszentrum Umwelt | Antikörper mit zwei oder mehr Spezifitäten zur selektiven Eliminierung von Zellen in vivo |
| WO1998054139A1 (fr) | 1997-05-30 | 1998-12-03 | Basf Aktiengesellschaft | Procede de fabrication de thiopyridines substituees |
| US6284923B1 (en) | 1997-08-22 | 2001-09-04 | Tularik Inc | Substituted benzene compounds as antiproliferative and cholesterol lowering action |
| JP2001519345A (ja) | 1997-10-02 | 2001-10-23 | メルク エンド カムパニー インコーポレーテッド | プレニルタンパク質トランスフェラーゼの阻害剤 |
| US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6191170B1 (en) | 1998-01-13 | 2001-02-20 | Tularik Inc. | Benzenesulfonamides and benzamides as therapeutic agents |
| EP0930302B1 (fr) | 1998-01-16 | 2003-04-02 | F.Hoffmann-La Roche Ag | Dérivés de benzosulfone |
| AU2001250783A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| WO2003068744A1 (fr) | 2002-02-18 | 2003-08-21 | Ishihara Sangyo Kaisha, Ltd. | Derives de la pyridine ou leurs sels, et inhibiteurs de production de citokine renfermant ces derives |
| US20030236287A1 (en) * | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
| US7037902B2 (en) | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
| EP1651595A2 (fr) | 2003-05-30 | 2006-05-03 | Rigel Pharmaceuticals, Inc. | Inhibiteurs de ligase d'ubiquitine |
| HRP20090093T3 (en) | 2004-06-04 | 2009-03-31 | Arena Pharmaceuticals Inc. | Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| US20060019967A1 (en) * | 2004-07-21 | 2006-01-26 | Su-Ying Wu | SARS CoV main protease inhibitors |
| GB0426313D0 (en) | 2004-12-01 | 2005-01-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO2006083692A2 (fr) | 2005-01-28 | 2006-08-10 | Mount Sinai Schoool Of Medicine | Procédés d'identification de modulateurs de bromodomaines |
| GB0504828D0 (en) | 2005-03-09 | 2005-04-13 | Merck Sharp & Dohme | Therapeutic agents |
| US20100048713A1 (en) | 2006-01-06 | 2010-02-25 | Aarhus Universitet | Compounds acting on the serotonin transporter |
| AU2007246172A1 (en) | 2006-04-28 | 2007-11-08 | Avexa Limited | Integrase inhibitors 3 |
| US20090005422A1 (en) * | 2006-05-22 | 2009-01-01 | Thioredoxin Systems Ab | Bacterial thioredoxin reductase inhibitors and methods for use thereof |
| MX2010000617A (es) | 2007-07-17 | 2010-05-17 | Plexxikon Inc | Compuestos y metodos para modulacion de cinasa, e indicaciones de estos. |
| TW201028381A (en) * | 2008-07-14 | 2010-08-01 | Shionogi & Co | Pyridine derivative having ttk inhibition activity |
| CN101723932B (zh) | 2008-10-31 | 2013-11-20 | 北京以岭生物工程技术有限公司 | 硝基吡啶乙烯亚胺化合物、其药物组合物及其制备方法和用途 |
| AU2010253820A1 (en) | 2009-05-28 | 2011-12-22 | President And Fellows Of Harvard College | N,N-diarylurea compounds and N,N'-diarylthiourea compounds as inhibitors of translation initiation |
| CA2771190C (fr) | 2009-08-17 | 2020-01-21 | Memorial Sloan-Kettering Cancer Center | Composes de liaison a une proteine de choc thermique, compositions et procedes pour les fabriquer et les utiliser |
| EP2535059A4 (fr) | 2010-02-10 | 2014-03-12 | Public Univ Corp Yokohama City | Utilisation d'un composé se liant à msin3b qui se lie, de façon spécifique, au facteur silenceur de la spécification neuronale nrsf |
| CN102206172B (zh) | 2010-03-30 | 2015-02-25 | 中国医学科学院医药生物技术研究所 | 一组取代双芳基化合物及其制备方法和抗病毒应用 |
| WO2012025638A1 (fr) | 2010-08-27 | 2012-03-01 | Universität des Saarlandes | Inhibiteurs sélectifs de la 17-bêta-hydroxystéroïde déshydrogénase de type 1 |
| WO2013119931A1 (fr) | 2012-02-10 | 2013-08-15 | The Board Of Regents Of The University Of Texas System | Modulateurs de protéines d'échange directement activées par l'ampc (epac) |
| US8946418B1 (en) | 2013-07-10 | 2015-02-03 | Boehringer Ingelheim International Gmbh | Chiral nitrogen-phosphorus ligands and their use for asymmetric hydrogenation of alkenes |
| CN104672214B (zh) | 2013-12-03 | 2019-04-12 | 上海翰森生物医药科技有限公司 | 具有alk抑制活性的化合物及其制备与用途 |
| CN105503827B (zh) | 2014-10-11 | 2019-09-24 | 上海翰森生物医药科技有限公司 | Egfr抑制剂及其制备方法和用途 |
| CN104672241B (zh) | 2015-01-29 | 2018-04-24 | 王磊 | 吡咯并[2,3-d]嘧啶类化合物及其用途 |
| CN104987324B (zh) | 2015-06-04 | 2018-05-04 | 湖北生物医药产业技术研究院有限公司 | 作为alk抑制剂的嘧啶衍生物 |
| CN105085483B (zh) | 2015-06-04 | 2019-01-01 | 湖北生物医药产业技术研究院有限公司 | 激酶抑制剂及其应用 |
| GB201514021D0 (en) * | 2015-08-07 | 2015-09-23 | Arner Elias Set Jeno | Novel Pyridines and their use in the treatment of cancer |
| MX389800B (es) | 2017-02-07 | 2025-03-20 | Oblique Therapeutics Ab | Piridinas sustituidas con heterociclilsulfonilo y su uso en el tratamiento del cancer |
| RU2019128063A (ru) * | 2017-02-07 | 2021-03-09 | Облик Терапьютикс Аб | Углеводородсульфонилзамещенные пиридины и их применение при лечении рака |
| AU2018218518B2 (en) | 2017-02-07 | 2022-03-17 | Oblique Therapeutics Ab | Sulfinylpyridines and their use in the treatment of cancer |
| BR112019016223A2 (pt) | 2017-02-07 | 2020-04-07 | Oblique Therapeutics Ab | piridinas substituídas por heteroarilsulfonila e uso das mesmas no tratamento de câncer |
-
2018
- 2018-02-07 RU RU2019128063A patent/RU2019128063A/ru unknown
- 2018-02-07 MA MA047458A patent/MA47458A/fr unknown
- 2018-02-07 EP EP18707131.1A patent/EP3580203A1/fr not_active Withdrawn
- 2018-02-07 KR KR1020197024697A patent/KR20190115014A/ko not_active Ceased
- 2018-02-07 MX MX2019009266A patent/MX392900B/es unknown
- 2018-02-07 JP JP2019563699A patent/JP7229176B2/ja active Active
- 2018-02-07 CA CA3051539A patent/CA3051539A1/fr active Pending
- 2018-02-07 AU AU2018218522A patent/AU2018218522B2/en not_active Ceased
- 2018-02-07 US US16/484,057 patent/US11161815B2/en not_active Expired - Fee Related
- 2018-02-07 BR BR112019016248A patent/BR112019016248A2/pt not_active IP Right Cessation
- 2018-02-07 WO PCT/GB2018/050346 patent/WO2018146472A1/fr not_active Ceased
- 2018-02-07 CN CN201880010169.1A patent/CN110382464A/zh active Pending
-
2019
- 2019-07-29 ZA ZA2019/04966A patent/ZA201904966B/en unknown
-
2021
- 2021-10-29 US US17/514,288 patent/US20220119348A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3580203A1 (fr) | 2019-12-18 |
| AU2018218522A1 (en) | 2019-08-15 |
| US11161815B2 (en) | 2021-11-02 |
| ZA201904966B (en) | 2023-12-20 |
| RU2019128063A3 (fr) | 2021-05-21 |
| RU2019128063A (ru) | 2021-03-09 |
| AU2018218522B2 (en) | 2021-08-05 |
| US20200239417A1 (en) | 2020-07-30 |
| CN110382464A (zh) | 2019-10-25 |
| US20220119348A1 (en) | 2022-04-21 |
| CA3051539A1 (fr) | 2018-08-16 |
| KR20190115014A (ko) | 2019-10-10 |
| JP7229176B2 (ja) | 2023-02-27 |
| MX392900B (es) | 2025-03-24 |
| MX2019009266A (es) | 2019-11-05 |
| BR112019016248A2 (pt) | 2020-04-14 |
| WO2018146472A1 (fr) | 2018-08-16 |
| JP2020506970A (ja) | 2020-03-05 |
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