MA47521A - Agents thérapeutiques pour maladies neurodégénératives - Google Patents

Agents thérapeutiques pour maladies neurodégénératives

Info

Publication number
MA47521A
MA47521A MA047521A MA47521A MA47521A MA 47521 A MA47521 A MA 47521A MA 047521 A MA047521 A MA 047521A MA 47521 A MA47521 A MA 47521A MA 47521 A MA47521 A MA 47521A
Authority
MA
Morocco
Prior art keywords
therapeutic agents
neurodegenerative diseases
neurodegenerative
diseases
therapeutic
Prior art date
Application number
MA047521A
Other languages
English (en)
Inventor
Michael Strupp
Original Assignee
Intrabio Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59859424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA47521(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1613829.9A external-priority patent/GB201613829D0/en
Priority claimed from GBGB1702551.1A external-priority patent/GB201702551D0/en
Priority claimed from GBGB1705766.2A external-priority patent/GB201705766D0/en
Priority claimed from GBGB1706867.7A external-priority patent/GB201706867D0/en
Application filed by Intrabio Ltd filed Critical Intrabio Ltd
Publication of MA47521A publication Critical patent/MA47521A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA047521A 2016-08-11 2017-08-11 Agents thérapeutiques pour maladies neurodégénératives MA47521A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1613829.9A GB201613829D0 (en) 2016-08-11 2016-08-11 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GBGB1702551.1A GB201702551D0 (en) 2017-02-16 2017-02-16 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GBGB1705766.2A GB201705766D0 (en) 2017-04-10 2017-04-10 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage
GBGB1706867.7A GB201706867D0 (en) 2017-04-28 2017-04-28 Therapeutic agents for neurodegenerative diseases, lysosomal storage disorders and neurodegenerative diseases associated with defects in lysosomal storage

Publications (1)

Publication Number Publication Date
MA47521A true MA47521A (fr) 2021-04-21

Family

ID=59859424

Family Applications (2)

Application Number Title Priority Date Filing Date
MA047521A MA47521A (fr) 2016-08-11 2017-08-11 Agents thérapeutiques pour maladies neurodégénératives
MA43828A MA43828B1 (fr) 2016-08-11 2017-08-11 Agents thérapeutiques pour maladies neurodégénératives

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA43828A MA43828B1 (fr) 2016-08-11 2017-08-11 Agents thérapeutiques pour maladies neurodégénératives

Country Status (28)

Country Link
US (3) US12144792B2 (fr)
EP (3) EP3583940A1 (fr)
JP (3) JP6957602B2 (fr)
KR (4) KR20220093385A (fr)
CN (4) CN116492328A (fr)
AU (3) AU2017308865B2 (fr)
BR (1) BR112019002730A2 (fr)
CA (1) CA3033564A1 (fr)
CY (1) CY1121930T1 (fr)
DK (1) DK3416631T3 (fr)
ES (1) ES2733677T3 (fr)
HR (1) HRP20191055T1 (fr)
HU (1) HUE045043T2 (fr)
IL (3) IL310799A (fr)
LT (1) LT3416631T (fr)
MA (2) MA47521A (fr)
MD (1) MD3416631T2 (fr)
ME (1) ME03454B (fr)
MX (3) MX383499B (fr)
PL (1) PL3416631T3 (fr)
PT (1) PT3416631T (fr)
RS (1) RS59048B1 (fr)
RU (1) RU2756519C2 (fr)
SG (1) SG11201901063SA (fr)
SI (1) SI3416631T1 (fr)
SM (1) SMT201900370T1 (fr)
TN (1) TN2019000033A1 (fr)
WO (1) WO2018029658A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10219815B2 (en) 2005-09-22 2019-03-05 The Regents Of The University Of Michigan Histotripsy for thrombolysis
JP6979882B2 (ja) 2015-06-24 2021-12-15 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン 脳組織の治療のための組織破砕療法システムおよび方法
HUE052837T2 (hu) 2016-08-11 2021-05-28 Intrabio Ltd Lizoszóma-tárolási betegségre irányuló gyógyászati készítmények és alkalmazásaik
BR112019002730A2 (pt) 2016-08-11 2019-05-14 Intrabio Ltd acetil-leucina, ou um sal farmaceuticamente aceitável da mesma, para uso em um método de tratamento de uma doença neurodegenetativa
GB201709459D0 (en) 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
SMT202500483T1 (it) * 2017-10-18 2026-01-12 Intrabio Ltd Agenti terapeutici da utilizzare nel trattamento della sindrome delle gambe senza riposo
SI3752141T1 (sl) * 2018-02-15 2024-09-30 Intrabio Ltd. Acetil-levcin za uporabo pri zdravljenju sindroma nemirnih nog
CN113286552B (zh) 2018-11-28 2025-05-02 希斯托索尼克斯公司 组织摧毁术系统及方法
KR20250022899A (ko) * 2018-12-06 2025-02-17 인트라바이오 리미티드 아세틸-류신의 중수소화된 유사체
SG11202109512SA (en) * 2019-03-02 2021-09-29 Intrabio Ltd Leucine, acetyl leucine, and related analogs for treating disease
WO2021055443A1 (fr) * 2019-09-17 2021-03-25 Hoffmann-La Roche Inc. Améliorations apportées à des soins de santé personnalisés destinés à des patients atteints de troubles de la motricité
WO2021144720A1 (fr) * 2020-01-13 2021-07-22 Intrabio Ltd Traitement de maladies neurodégénératives tardives chez des porteurs de mutations hétérozygotes du gène npc1
CA3179105A1 (fr) * 2020-05-22 2021-11-25 Michael Strupp Association d'acetylleucine et de 4-aminopyridine ou d'acetazolamide pour traiter l'ataxie
WO2022264037A1 (fr) * 2021-06-14 2022-12-22 Intrabio Ltd. Dérivés d'acides aminés à chaîne ramifiée pour traiter une maladie
US20240149078A1 (en) 2022-10-28 2024-05-09 Histosonics, Inc. Histotripsy systems and methods
KR20260003742A (ko) 2023-04-20 2026-01-07 히스토소닉스, 인크. 치료 계획 및 요법을 위한 사용자 인터페이스들 및 작업 흐름들을 포함하는 히스토트립시 시스템들 및 연관된 방법들
WO2025151578A1 (fr) * 2024-01-12 2025-07-17 Intrabio Inc. N-acétyl-leucine destinée à être utilisée dans le traitement d'alpha-synucléinopathies prodromales
WO2025163129A1 (fr) * 2024-02-01 2025-08-07 Intrabio Ltd. Acétylleucine pour le traitement de la maladie de parkinson
US12403111B2 (en) 2024-02-02 2025-09-02 SynGAP Research Fund Compositions and methods for treating neurodevelopmental disorders
WO2025175092A1 (fr) * 2024-02-14 2025-08-21 Intrabio Inc. Acétylleucine pour le traitement de troubles liés à syngap1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060063827A1 (en) * 2004-09-23 2006-03-23 Yu Ruey J Systemic administration of therapeutic amino acids and N-acetylamino acids
US20050222209A1 (en) * 2004-04-01 2005-10-06 Zeldis Jerome B Methods and compositions for the treatment, prevention or management of dysfunctional sleep and dysfunctional sleep associated with disease
FR2905600B1 (fr) 2006-09-13 2010-01-15 Pf Medicament Traitement des vertiges par l'acetyl-l-leucine.
WO2008101693A2 (fr) 2007-02-22 2008-08-28 Beiersdorf Ag Applications cosmétiques et pharmaceutiques d'acides aminés n-acylés, et composés structurellement apparentés
TN2010000251A1 (fr) * 2010-06-03 2011-11-11 Rekik Raouf N-acetyl-dl-leucine medicament neuro et retino protecteur
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
EP3062810A4 (fr) * 2013-10-28 2017-05-03 Naurex Inc. Modulateurs du récepteur nmda et promédicaments, sels et utilisations de ces derniers
HUE069219T2 (hu) 2016-04-19 2025-02-28 Intrabio Ltd Acetil-leucin vagy gyógyszerészetileg elfogadható sója javított mozgásképességért
BR112019002730A2 (pt) 2016-08-11 2019-05-14 Intrabio Ltd acetil-leucina, ou um sal farmaceuticamente aceitável da mesma, para uso em um método de tratamento de uma doença neurodegenetativa

Also Published As

Publication number Publication date
RU2019106506A (ru) 2020-09-17
CA3033564A1 (fr) 2018-02-15
WO2018029658A1 (fr) 2018-02-15
IL310801A (en) 2024-04-01
TN2019000033A1 (fr) 2020-07-15
MA43828B1 (fr) 2019-09-30
DK3416631T3 (da) 2019-07-15
RU2021128045A (ru) 2021-11-16
ME03454B (fr) 2020-01-20
SMT201900370T1 (it) 2019-09-09
JP2022003085A (ja) 2022-01-11
AU2017308865B2 (en) 2023-04-13
EP4467195A2 (fr) 2024-11-27
AU2023202121B2 (en) 2025-01-23
US20240189267A1 (en) 2024-06-13
EP3416631A1 (fr) 2018-12-26
PL3416631T3 (pl) 2019-11-29
AU2017308865A1 (en) 2019-02-21
US20200179320A1 (en) 2020-06-11
AU2023202121A1 (en) 2023-05-04
JP2019524822A (ja) 2019-09-05
JP7833272B2 (ja) 2026-03-19
JP2023175762A (ja) 2023-12-12
EP4467195A3 (fr) 2025-03-19
US12144792B2 (en) 2024-11-19
US20230210799A1 (en) 2023-07-06
MA43828A (fr) 2018-12-26
IL310799A (en) 2024-04-01
CN116492328A (zh) 2023-07-28
RS59048B1 (sr) 2019-08-30
MX2024004439A (es) 2025-11-03
SI3416631T1 (sl) 2019-09-30
RU2756519C2 (ru) 2021-10-01
PT3416631T (pt) 2019-07-11
EP3583940A1 (fr) 2019-12-25
MX383499B (es) 2025-03-14
MD3416631T2 (ro) 2019-09-30
JP6957602B2 (ja) 2021-11-02
HRP20191055T1 (hr) 2019-09-06
IL264641A (en) 2019-04-30
CN109789114A (zh) 2019-05-21
KR20220093385A (ko) 2022-07-05
CN121081445A (zh) 2025-12-09
KR20240068761A (ko) 2024-05-17
AU2025202077A1 (en) 2025-04-10
CY1121930T1 (el) 2020-10-14
IL264641B1 (en) 2024-03-01
MX2019001575A (es) 2019-08-01
KR20190039227A (ko) 2019-04-10
MX2021006901A (es) 2021-07-07
HUE045043T2 (hu) 2019-12-30
BR112019002730A2 (pt) 2019-05-14
IL264641B2 (en) 2024-07-01
KR102413756B1 (ko) 2022-06-27
SG11201901063SA (en) 2019-03-28
CN116459244A (zh) 2023-07-21
RU2019106506A3 (fr) 2020-10-29
ES2733677T3 (es) 2019-12-02
EP3416631B1 (fr) 2019-05-15
KR20250042197A (ko) 2025-03-26
KR102785448B1 (ko) 2025-03-21
LT3416631T (lt) 2019-08-26

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