MA47691A - Anticorps anti-cd33 et leurs procédés d'utilisation - Google Patents

Anticorps anti-cd33 et leurs procédés d'utilisation

Info

Publication number
MA47691A
MA47691A MA047691A MA47691A MA47691A MA 47691 A MA47691 A MA 47691A MA 047691 A MA047691 A MA 047691A MA 47691 A MA47691 A MA 47691A MA 47691 A MA47691 A MA 47691A
Authority
MA
Morocco
Prior art keywords
antibodies
processes
Prior art date
Application number
MA047691A
Other languages
English (en)
Inventor
Patricia Culp
Helen Lam
Seung-Joo Lee
Nels P Nielson
Robert Pejchal
Arnon Rosenthal
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of MA47691A publication Critical patent/MA47691A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA047691A 2017-08-03 2018-08-02 Anticorps anti-cd33 et leurs procédés d'utilisation MA47691A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762541024P 2017-08-03 2017-08-03
US201862667388P 2018-05-04 2018-05-04

Publications (1)

Publication Number Publication Date
MA47691A true MA47691A (fr) 2020-01-08

Family

ID=63245104

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047691A MA47691A (fr) 2017-08-03 2018-08-02 Anticorps anti-cd33 et leurs procédés d'utilisation

Country Status (20)

Country Link
US (3) US10711062B2 (fr)
EP (1) EP3589658A1 (fr)
JP (3) JP7299160B2 (fr)
KR (1) KR102733407B1 (fr)
CN (2) CN117700548A (fr)
AU (1) AU2018310985A1 (fr)
BR (1) BR112019023789A2 (fr)
CA (1) CA3057447A1 (fr)
CL (3) CL2019003095A1 (fr)
CO (1) CO2019012200A2 (fr)
CR (1) CR20190486A (fr)
EC (1) ECSP19078414A (fr)
IL (3) IL270238B (fr)
MA (1) MA47691A (fr)
MY (1) MY205541A (fr)
PE (1) PE20200486A1 (fr)
PH (1) PH12019502463A1 (fr)
TW (1) TW201920268A (fr)
WO (1) WO2019028283A1 (fr)
ZA (1) ZA201906366B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11174313B2 (en) 2015-06-12 2021-11-16 Alector Llc Anti-CD33 antibodies and methods of use thereof
KR20180033502A (ko) 2015-06-12 2018-04-03 알렉터 엘엘씨 항-cd33 항체 및 그의 사용 방법
US11472877B2 (en) * 2016-03-04 2022-10-18 Alector Llc Anti-TREM1 antibodies and methods of use thereof
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
TWI868807B (zh) 2017-08-03 2025-01-01 美商阿列克特有限責任公司 抗trem2抗體及其使用方法
MA47691A (fr) 2017-08-03 2020-01-08 Alector Llc Anticorps anti-cd33 et leurs procédés d'utilisation
JP7353576B2 (ja) 2018-02-20 2023-10-02 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｃｄ３３、ｎｋｇ２ｄ、及びｃｄ１６に結合する多重特異性結合タンパク質、ならびにその使用方法
JOP20190116A1 (ar) 2018-05-24 2019-11-24 Janssen Biotech Inc الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها
BR112021003016A2 (pt) 2018-08-31 2021-05-18 Alector Llc anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, métodos para produzir um anticorpo e para prevenir, reduzir o risco ou tratar uma doença e composição farmacêutica
US12103969B2 (en) * 2018-09-25 2024-10-01 Academia Sinica Anti-Siglec antibody, pharmaceutical composition comprising the same, and uses thereof
US12441793B2 (en) * 2019-02-22 2025-10-14 Memorial Sloan Kettering Cancer Center CD33 antibodies and methods of using the same to treat cancer
WO2020239947A1 (fr) * 2019-05-29 2020-12-03 Centre National De La Recherche Scientifique Procédé de pronostic de la leucémie
WO2021022083A2 (fr) * 2019-07-31 2021-02-04 Alector Llc Anticorps anti-ms4a4a et leurs procédés d'utilisation
EP4073119A1 (fr) * 2019-12-12 2022-10-19 Alector LLC Procédés d'utilisation d'anticorps anti-cd33
WO2023081898A1 (fr) 2021-11-08 2023-05-11 Alector Llc Cd33 soluble en tant que biomarqueur pour une efficacité anti-cd33
TW202340235A (zh) 2021-12-17 2023-10-16 美商戴納立製藥公司 多肽工程、文庫及工程ｃｄ９８重鏈以及轉鐵蛋白受體結合多肽
US20240173425A1 (en) * 2022-06-22 2024-05-30 Eli Lilly And Company Human cd33 antibodies and glucocorticoid conjugates
CN117447595B (zh) * 2022-07-26 2024-06-28 北京东方百泰生物科技股份有限公司 一种抗Siglec-15单克隆抗体
EP4688852A2 (fr) 2023-04-03 2026-02-11 Alchemab Therapeutics Ltd. Anticorps anti-cd33
CN116375874B (zh) * 2023-04-14 2023-12-26 上海精翰生物科技有限公司 一种cd33抗体及其应用
WO2025174974A1 (fr) * 2024-02-14 2025-08-21 Bristol-Myers Squibb Company Anticorps anti-cd33 et leurs utilisations
WO2025202213A1 (fr) 2024-03-26 2025-10-02 Institut National de la Santé et de la Recherche Médicale Nanoparticule lipidique chargée d'agent antitumoral et fonctionnalisée pour cibler des cellules immosuppressives
CN121673409A (zh) * 2024-09-12 2026-03-17 安诺柏德生物医药科技(苏州)有限公司 靶向人cd33的人源化抗体及其应用
CN120965883B (zh) * 2025-10-21 2026-01-30 上海交通大学医学院附属仁济医院 一种cd33阻断性人源化抗体及用途

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