MA49368A - Imidazopyrimidines à substitution diazabicyclique et leur utilisation pour traiter des maladies des voies respiratoires - Google Patents

Imidazopyrimidines à substitution diazabicyclique et leur utilisation pour traiter des maladies des voies respiratoires

Info

Publication number
MA49368A
MA49368A MA049368A MA49368A MA49368A MA 49368 A MA49368 A MA 49368A MA 049368 A MA049368 A MA 049368A MA 49368 A MA49368 A MA 49368A MA 49368 A MA49368 A MA 49368A
Authority
MA
Morocco
Prior art keywords
imidazopyrimidines
diazabicyclic
substitute
respiratory tract
tract diseases
Prior art date
Application number
MA049368A
Other languages
English (en)
Other versions
MA49368B1 (fr
Inventor
Udo Albus
Moritz Beck-Broichsitter
Karl Collins
Martina Delbeck
Doris Gehring
Michael Hahn
Niels Lindner
Klemens Lustig
Thomas Müller
Janine Nicolai
Björn Rosenstein
Original Assignee
Bayer Ag
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG filed Critical Bayer Ag
Publication of MA49368A publication Critical patent/MA49368A/fr
Publication of MA49368B1 publication Critical patent/MA49368B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA49368A 2017-06-14 2018-06-07 Imidazopyrimidines à substitution diazabicyclique et leur utilisation pour traiter des maladies des voies respiratoires MA49368B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17176046 2017-06-14
EP17193252 2017-09-26
EP18728646.3A EP3638675B1 (fr) 2017-06-14 2018-06-07 Imidazopyrimidines à substitution diazabicyclique et leur utilisation pour traiter des maladies des voies respiratoires
PCT/EP2018/064977 WO2018228907A1 (fr) 2017-06-14 2018-06-07 Imidazopyrimidines à substitution diazabicyclique et leur utilisation pour traiter des maladies des voies respiratoires

Publications (2)

Publication Number Publication Date
MA49368A true MA49368A (fr) 2021-04-14
MA49368B1 MA49368B1 (fr) 2024-06-28

Family

ID=62492660

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49368A MA49368B1 (fr) 2017-06-14 2018-06-07 Imidazopyrimidines à substitution diazabicyclique et leur utilisation pour traiter des maladies des voies respiratoires

Country Status (36)

Country Link
US (3) US11098063B2 (fr)
EP (1) EP3638675B1 (fr)
JP (2) JP6896113B2 (fr)
KR (1) KR102364134B1 (fr)
CN (4) CN115554299A (fr)
AR (1) AR112099A1 (fr)
AU (1) AU2018283331B2 (fr)
BR (1) BR112019026450A2 (fr)
CA (1) CA3066942A1 (fr)
CL (1) CL2019003650A1 (fr)
CO (1) CO2019014047A2 (fr)
CR (1) CR20190563A (fr)
CU (1) CU24603B1 (fr)
DO (1) DOP2019000308A (fr)
EA (1) EA202090043A1 (fr)
EC (1) ECSP19088492A (fr)
ES (1) ES2985167T3 (fr)
GE (2) GEP20227366B (fr)
HR (1) HRP20240678T1 (fr)
HU (1) HUE066512T2 (fr)
IL (1) IL271117B (fr)
JO (1) JOP20190284A1 (fr)
MA (1) MA49368B1 (fr)
MX (2) MX2019014983A (fr)
MY (1) MY204293A (fr)
NI (1) NI201900126A (fr)
NZ (1) NZ758821A (fr)
PE (1) PE20200016A1 (fr)
PH (1) PH12019502828A1 (fr)
PL (1) PL3638675T3 (fr)
RS (1) RS65543B1 (fr)
SG (1) SG11201911508XA (fr)
TW (1) TWI801388B (fr)
UA (1) UA125186C2 (fr)
UY (1) UY37773A (fr)
WO (1) WO2018228907A1 (fr)

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WO2018227427A1 (fr) 2017-06-14 2018-12-20 Bayer Aktiengesellschaft Dérivés de diazépane pontés substitués et leur utilisation
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EP3965762A1 (fr) 2019-05-09 2022-03-16 Bayer Aktiengesellschaft Combinaison d'un antagoniste de récepteur ?2-adrénergiques de sous-type c (alpha-2c) avec un bloqueur de canal task-1/3 pour le traitement de l'apnée du sommeil
CN114929694B (zh) 2019-11-06 2025-02-07 拜耳公司 肾上腺素能受体adrac2拮抗剂
MX2023000369A (es) * 2020-07-06 2023-02-13 Bayer Ag Combinación de antagonistas del receptor adrenérgico a2 subtipo c (alfa 2c) con un bloqueador de canales task1/3 para el tratamiento de la apnea del sueño.
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AU2022422284A1 (en) 2021-12-22 2024-07-04 Bayer Aktiengesellschaft Combination of a task1/3 channel blocker with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
MX2024007765A (es) 2021-12-22 2024-07-04 Bayer Ag Combinacion de un bloqueante de canal task1/3 con un antagonista del receptor muscarinico para el tratamiento de apnea del sue?o.
KR20240132345A (ko) 2022-01-07 2024-09-03 바이엘 악티엔게젤샤프트 수면 무호흡의 치료를 위한 2,3-디히드로벤조[b][1,4]디옥신-2-일메틸)피페라진-1-일 유도체
MX2024008523A (es) 2022-01-07 2024-07-19 Bayer Ag Antagonistas del adrenoceptor a2 subtipo c para el tratamiento de la apnea del sue?o.
WO2025068514A1 (fr) 2023-09-28 2025-04-03 Bayer Aktiengesellschaft Carboxamides hétérocycliques substitués et leur utilisation
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MX2018007040A (es) 2015-12-10 2018-08-15 Bayer Pharma AG Derivados de 2-fenil-3-(piperazinometil) imidazo[1,2-a] piridina como bloqueadores de los canales task-1 y task-2 para el tratamiento de trastornos respiratorios relacionados con el sueño.
CN108699084A (zh) 2015-12-10 2018-10-23 拜耳制药股份公司 取代全氢吡咯并[3,4-c]吡咯衍生物及其用途
JOP20190005A1 (ar) 2016-07-20 2019-01-20 Bayer Ag مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها
JOP20190148A1 (ar) 2016-12-21 2019-06-18 Bayer Pharma AG أشكال جرعات صيدلية تحتوي على مثبطات قنوات task-1 و task-3 واستخدامها لمعالجة الاضطرابات التنفسية
JOP20190141A1 (ar) 2016-12-21 2019-06-12 Bayer Pharma AG أشكال جرعات صيدلية تحتوي على مثبطات لقناة task-1 و task-3 واستخدامها في معالجة اضطراب تنفسي
JOP20190284A1 (ar) * 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
WO2018227427A1 (fr) 2017-06-14 2018-12-20 Bayer Aktiengesellschaft Dérivés de diazépane pontés substitués et leur utilisation
EP3886806A1 (fr) 2018-11-27 2021-10-06 Bayer Aktiengesellschaft Procédé de fabrication de formes pharmaceutiques contenant des inhibiteurs des canaux task-1 et task-3 et leur utilisation pour le traitement de troubles respiratoires
US20220218700A1 (en) 2019-05-09 2022-07-14 Bayer Aktiengesellschaft Combination of an ?2-adrenoceptor subtype c (alpha-2c) antagonists with a task1/3 channel blocker for the treatment of sleep apnea
EP3965762A1 (fr) 2019-05-09 2022-03-16 Bayer Aktiengesellschaft Combinaison d'un antagoniste de récepteur ?2-adrénergiques de sous-type c (alpha-2c) avec un bloqueur de canal task-1/3 pour le traitement de l'apnée du sommeil

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Publication number Publication date
JP2020523388A (ja) 2020-08-06
IL271117B (en) 2022-03-01
RS65543B1 (sr) 2024-06-28
CN115554300A (zh) 2023-01-03
UY37773A (es) 2019-01-02
US20250154175A1 (en) 2025-05-15
HUE066512T2 (hu) 2024-08-28
CN115583959A (zh) 2023-01-10
TW201919638A (zh) 2019-06-01
HRP20240678T1 (hr) 2024-08-16
BR112019026450A2 (pt) 2020-07-14
SG11201911508XA (en) 2020-01-30
ECSP19088492A (es) 2019-12-27
EA202090043A1 (ru) 2020-04-02
GEP20227366B (en) 2022-03-25
UA125186C2 (uk) 2022-01-26
JOP20190284A1 (ar) 2019-12-11
CU20190101A7 (es) 2020-10-20
KR20200014915A (ko) 2020-02-11
JP2021127346A (ja) 2021-09-02
PH12019502828A1 (en) 2020-10-26
CN115554299A (zh) 2023-01-03
ES2985167T3 (es) 2024-11-04
US12180227B2 (en) 2024-12-31
US11098063B2 (en) 2021-08-24
NI201900126A (es) 2020-04-02
PL3638675T3 (pl) 2024-07-01
KR102364134B1 (ko) 2022-02-18
MA49368B1 (fr) 2024-06-28
AR112099A1 (es) 2019-09-18
US20200109155A1 (en) 2020-04-09
IL271117A (en) 2020-01-30
CL2019003650A1 (es) 2020-07-10
JP6896113B2 (ja) 2021-06-30
CO2019014047A2 (es) 2020-01-17
CA3066942A1 (fr) 2018-12-20
CN110719911B (zh) 2022-10-21
CN110719911A (zh) 2020-01-21
AU2018283331B2 (en) 2022-08-04
US20220017540A1 (en) 2022-01-20
AU2018283331A1 (en) 2019-12-19
MX2022012716A (es) 2022-11-07
CN115554300B (zh) 2024-10-29
NZ758821A (en) 2025-05-02
CU24603B1 (es) 2022-06-06
TWI801388B (zh) 2023-05-11
CN115583959B (zh) 2024-04-26
CR20190563A (es) 2020-04-22
EP3638675A1 (fr) 2020-04-22
DOP2019000308A (es) 2020-01-31
MX2019014983A (es) 2020-02-24
GEAP202115256A (en) 2021-10-11
MY204293A (en) 2024-08-21
EP3638675C0 (fr) 2024-04-17
PE20200016A1 (es) 2020-01-06
EP3638675B1 (fr) 2024-04-17
WO2018228907A1 (fr) 2018-12-20

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