MA49398A - Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci - Google Patents

Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci

Info

Publication number
MA49398A
MA49398A MA049398A MA49398A MA49398A MA 49398 A MA49398 A MA 49398A MA 049398 A MA049398 A MA 049398A MA 49398 A MA49398 A MA 49398A MA 49398 A MA49398 A MA 49398A
Authority
MA
Morocco
Prior art keywords
igf
monoclonal antibodies
monoclonal
antibodies
Prior art date
Application number
MA049398A
Other languages
English (en)
Inventor
Eric Steven Burak
John Richard Forbes
Matthew David Burr Moran
Ryan Wayne Simms
John Fitzmaurice Valliant
Original Assignee
Eric Steven Burak
Fusion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eric Steven Burak, Fusion Pharmaceuticals Inc filed Critical Eric Steven Burak
Publication of MA49398A publication Critical patent/MA49398A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/1036—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
MA049398A 2017-05-05 2018-05-04 Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci MA49398A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762502288P 2017-05-05 2017-05-05
US201762545945P 2017-08-15 2017-08-15

Publications (1)

Publication Number Publication Date
MA49398A true MA49398A (fr) 2020-04-22

Family

ID=64016737

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049398A MA49398A (fr) 2017-05-05 2018-05-04 Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci

Country Status (15)

Country Link
US (2) US11433148B2 (fr)
EP (1) EP3638320A4 (fr)
JP (2) JP7191938B2 (fr)
KR (2) KR20200004861A (fr)
CN (1) CN110891614A (fr)
AU (2) AU2018261890B2 (fr)
BR (1) BR112019023249A8 (fr)
CA (1) CA3062538A1 (fr)
CL (1) CL2019003169A1 (fr)
IL (2) IL313115A (fr)
MA (1) MA49398A (fr)
MX (1) MX2024006675A (fr)
RU (1) RU2019139434A (fr)
WO (1) WO2018204872A2 (fr)
ZA (1) ZA201908072B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018204869A1 (fr) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Améliorations pharmacocinétiques de chélates bifonctionnels et leurs utilisations
EP3638320A4 (fr) * 2017-05-05 2021-01-20 Centre for Probe Development and Commercialization Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
CN118638787A (zh) 2017-12-06 2024-09-13 艾维迪提生物科学公司 治疗肌萎缩和强直性肌营养不良的组合物和方法
BR112021010799A2 (pt) * 2018-12-03 2021-08-24 Fusion Pharmaceuticals Inc. Terapia combinada com radioimunoconjugados e inibidor do ponto de verificação
AU2020367415A1 (en) 2019-10-18 2022-05-19 Nihon Medi-Physics Co., Ltd. RI-labeled humanized antibody
BR112022013678A2 (pt) * 2020-01-10 2022-11-16 Fusion Pharmaceuticals Inc Quelatos macrocíclicos e seus usos
TW202131946A (zh) * 2020-01-10 2021-09-01 加拿大商融合製藥公司 持續性免疫療法
CA3176617A1 (fr) * 2020-03-23 2021-09-30 Fusion Pharmaceuticals Inc. Radioimmunoconjugues cibles par fgfr3 et leurs utilisations
IL296393B1 (en) * 2020-03-27 2025-12-01 Avidity Biosciences Inc Compositions and methods of treating muscle dystrophy
CR20230204A (es) * 2020-10-14 2023-10-11 Viridian Therapeutics Inc Composiciones y métodos para el tratamiento de la enfermedad ocular tiroidea
TW202320850A (zh) 2021-08-10 2023-06-01 美商維里迪恩醫療股份有限公司 用於治療甲狀腺眼病之組合物、劑量及方法
AU2021466827A1 (en) * 2021-09-29 2024-04-11 Fusion Pharmaceuticals Inc. Egfrviii-targeted compounds and uses thereof
WO2023070202A1 (fr) * 2021-10-25 2023-05-04 Fusion Pharmaceuticals Inc. Composés ciblant la claudine 18,2 et leurs utilisations
AR127556A1 (es) * 2021-11-02 2024-02-07 Fusion Pharmaceuticals Inc Métodos para tratar el cáncer utilizando un radioinmunoconjugado
TW202423906A (zh) * 2022-08-22 2024-06-16 美商雅博得樂醫療公司 Vhh抗體dota結合物
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024216389A1 (fr) * 2023-04-20 2024-10-24 Fusion Pharmaceuticals Inc. Composés ciblant la claudine 18,2 et leurs utilisations
WO2024229406A1 (fr) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Polythérapie pour une maladie ou un trouble lié à ras
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (fr) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Procédés de traitement d'une maladie ou d'un trouble lié à la protéine ras
WO2025265060A1 (fr) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026015801A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026015790A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015796A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015825A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026050446A1 (fr) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Inhibiteurs de ras

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175343A (en) 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4889931A (en) 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1990009379A1 (fr) 1989-02-10 1990-08-23 Celltech Limited Aza-macrocycles et procedes pour leur preparation
US5053503A (en) 1989-02-17 1991-10-01 Centocor Chelating agents
US6274713B1 (en) 1989-04-07 2001-08-14 Salutar, Inc. Polychelants
US5364613A (en) 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US7385041B2 (en) 1990-04-25 2008-06-10 Bracco International B.V. Dual functioning excipient for metal chelate contrast agents
ZA914616B (en) 1990-06-18 1993-02-24 Dow Chemical Co The use of macrocyclic aminophosphonic acid complexes as imaging agents
US5386011A (en) 1990-12-27 1995-01-31 Abbott Laboratories Hexapeptide anaphylatoxin-receptor ligands
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
CA2110799A1 (fr) 1991-06-14 1992-12-23 Arnold H. Horwitz Fragments d'anticorps d'origine microbienne, et conjugues
EP0646019B9 (fr) 1992-06-09 2002-12-18 Neorx Corporation Biotine-DOTA conjugués et leur utilisation dans des procédés de préciblage
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
GB9504922D0 (en) 1995-03-10 1995-04-26 Nycomed As Process
US20010023288A1 (en) * 1999-07-07 2001-09-20 Wilbur D. Scott Trifunctional reagent for conjugation to a biomolecule
SI0970126T1 (en) 1997-04-14 2001-08-31 Micromet Ag Novel method for the production of antihuman antigen receptors and uses thereof
IT1291624B1 (it) 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1304501B1 (it) 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
EP1191948A2 (fr) 1999-06-11 2002-04-03 Neorx Corporation Complexe a forte dose de radionucleides destine a la suppression de la moelle osseuse
DE10002939C1 (de) 2000-01-13 2001-09-20 Schering Ag Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln
US20020052354A1 (en) 2000-01-27 2002-05-02 Schering Ag Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
US6264966B1 (en) 2000-02-22 2001-07-24 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
ES2221903T3 (es) 2000-05-12 2005-01-16 University Hospital Agentes pro-quelantes para la preparacion de moleculas marcadas con metales radiactivos que tienen propiedades biologicas mejoradas.
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
EP1385556A4 (fr) * 2001-05-02 2005-10-19 Univ Missouri System At Columb Conjugues peptidiques avid du recepteur liberant la gastrine
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
DE10135355C1 (de) 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
TWI284539B (en) 2001-07-30 2007-08-01 Epix Pharm Inc A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
AU2003261398A1 (en) 2002-08-06 2004-02-23 Epix Pharmaceuticals, Inc. Peptide aggregates
DE10250870A1 (de) 2002-10-31 2004-05-13 Switch Biotech Ag Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung
EP1592456A1 (fr) 2003-02-13 2005-11-09 BRACCO IMAGING S.p.A. Imagerie de phase par rayons x a contraste ameliore
DK1603598T3 (da) 2003-03-19 2009-01-26 Univ Bern Radiomærkede konjugater baseret på substans P og anvendelser heraf
US20060155120A1 (en) 2003-05-23 2006-07-13 Amedio John C Optically pure and enriched isomers of chelating ligands and contrast agents
JP4262545B2 (ja) 2003-07-09 2009-05-13 三菱電機株式会社 カスコード接続回路及びその集積回路
JP5139678B2 (ja) * 2003-07-24 2013-02-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法
DE602004025592D1 (de) 2003-09-12 2010-04-01 Life Technologies Corp Anwendungen des Resonanzenergietransfers zwischen Terbium und GFP
JP2007514758A (ja) 2003-12-19 2007-06-07 シェーリング　コーポレイション 医薬組成物
WO2005079803A1 (fr) 2004-02-13 2005-09-01 Pfizer Products, Inc. Composes pour traitement des maladies cardio-vasculaires
WO2006015318A2 (fr) 2004-07-30 2006-02-09 Biogen Idec Inc. Molecules de liaison et leurs procedes d'utilisation
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
US20060222595A1 (en) 2005-03-31 2006-10-05 Priyabrata Mukherjee Nanoparticles for therapeutic and diagnostic applications
US7618957B2 (en) 2005-07-15 2009-11-17 Bayer Schering Pharma Aktiengesellschaft Perfluoroalkyl-containing complexes, process for their production as well as their use
WO2007009637A2 (fr) 2005-07-15 2007-01-25 Bayer Schering Pharma Aktiengesellschaft Complexes perfluoro-alkyles, leur procede de production et leur utilisation
US20100226884A1 (en) 2009-01-20 2010-09-09 Immunomedics, Inc. Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
US20070293656A1 (en) 2005-12-29 2007-12-20 Epix Pharmaceuticals, Inc. Collagen binding peptides
JP2009530294A (ja) 2006-03-15 2009-08-27 マリンクロット インコーポレイテッド 置換芳香族部分を有するキレート化接合体およびその誘導体
EA200802061A1 (ru) * 2006-03-28 2009-04-28 Байоджен Айдек Эмэй Инк. Антитело или его фрагмент, специфично связывающееся с рецептором 1 инсулиноподобного фактора роста (igf-r1) (варианты), композиция на его основе, полинуклеотид, кодирующий вариабельную область антитела (варианты), содержащие полинуклеотид композиция (варианты) и вектор, содержащая вектор клетка-хозяин (варианты), способ продуцирования антитела или его фрагмента (варианты) и способ лечения гиперпролиферативного заболевания у животного организма
US7777029B2 (en) 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
US20080213811A1 (en) 2006-08-11 2008-09-04 Invitrogen Corporation Sensor proteins and assay methods
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
GB0624587D0 (en) 2006-12-08 2007-01-17 Univ Muenchen Tech Chelating agent
EP2114461A2 (fr) 2007-01-19 2009-11-11 Mallinckrodt Inc. Ligands de liaison à la cycloxygénase-2 diagnostiques et thérapeutiques
WO2008134289A2 (fr) 2007-04-26 2008-11-06 Mallinckrodt Inc. Complexes de lanthanide insaturés de manière coordonnée à relaxivité élevée
EP2185272B1 (fr) 2007-08-27 2018-05-02 Liebel-Flarsheim Company LLC Elimination de silice a partir de composes hydrosolubles par nanofiltration et chromatographie en phase inverse
WO2009032145A1 (fr) 2007-08-28 2009-03-12 Biogen Idec Ma Inc. Anticorps anti-igf-1r et leurs utilisations
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
EP2100900A1 (fr) * 2008-03-07 2009-09-16 Universitätsspital Basel Conjugués d'antagoniste de peptide analogue de bombésine
DE102008045937B4 (de) 2008-04-11 2017-01-26 Johannes-Gutenberg-Universität Mainz Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons
CN102065895A (zh) * 2008-04-11 2011-05-18 比奥根艾迪克Ma公司 抗-igf-1r抗体和其它化合物的治疗联合
WO2010009246A2 (fr) 2008-07-16 2010-01-21 The General Hospital Corporation Procédés et réactifs pour préparer des sondes multifonctionnelles
EP2147684A1 (fr) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Agents de diagnostics sélectifs contre les métalloprotéases
CN102271713B (zh) 2008-11-06 2013-07-31 路易莎·布拉奇 神经降压肽衍生的分枝肽及其用途
WO2010088527A2 (fr) 2009-01-30 2010-08-05 Mayo Foundation For Medical Education And Research Peptides et nanoparticules pour des applications thérapeutiques et diagnostiques
WO2010108063A1 (fr) 2009-03-19 2010-09-23 Wyeth Llc Procédés de préparation de l'acide [2-(8,9-dioxo-2,6-diaza-bicyclo[5.2.0]non-1(7)-èn-2-yl)éthyl]phosphonique et de ses précurseurs
SG176947A1 (en) * 2009-07-03 2012-01-30 Avipep Pty Ltd Immuno-conjugates and methods for producing them
WO2011005609A2 (fr) 2009-07-08 2011-01-13 Mayo Foundation For Medical Education And Research Imagerie des volumes et de la motilité gastro-intestinaux
EP2515914A4 (fr) 2009-12-23 2013-09-11 Scripps Research Inst Bioconjugaison de la tyrosine par des réactions de type ène en milieu aqueux
EP2525820B1 (fr) 2010-01-19 2016-05-11 Immunomedics, Inc. Nouvelle classe d'anticorps humanisés monospécifiques et bispécifiques qui ciblent le récepteur du facteur de croissance insulinique de type 1 (igf-1r)
EP2397466B1 (fr) 2010-06-15 2012-11-28 Centre National De La Recherche Scientifique CNRS Composés organiques activables par rayons X et photons gamma, leur préparation et leurs utilisations
WO2012021796A2 (fr) 2010-08-12 2012-02-16 S&T Global, Inc. Nouveaux dérivés de cyclosporine destinés à la prévention ou au traitement d'une infection virale
JP6063384B2 (ja) * 2010-10-14 2017-01-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． プレターゲットキット、プレターゲット方法及びその使用試薬
US12097269B2 (en) 2010-10-27 2024-09-24 Vikas Kundra Dual mode gadolinium nanoparticle contrast agents
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
US20120213781A1 (en) * 2011-02-11 2012-08-23 Zyngenia, Inc. Monovalent and Multivalent Multispecific Complexes and Uses Thereof
WO2012122420A2 (fr) 2011-03-09 2012-09-13 Pharmacofore, Inc. Promédicaments opioïdes présentant des groupes de liaison hétérocycliques
DK2721045T3 (en) 2011-06-20 2017-07-24 Radiomedix Inc COMPOSITIONS, METHODS OF SYNTHESIS AND USE OF CARBOHYDRATE TARGETED AGENTS
FR2976825B1 (fr) 2011-06-22 2014-02-21 Total Sa Nanotraceurs pour le marquage d'eaux d'injection de champs petroliers
EP2604281B1 (fr) 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Analogues conjugués de somatostatine coupés pour des applications biologiques
KR20130083592A (ko) 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
EP2852685A1 (fr) * 2012-03-30 2015-04-01 Merck Sharp & Dohme Corp. Biomarqueur igf1 pour une thérapie d'inhibition d'igf1r
KR20150030709A (ko) 2012-06-14 2015-03-20 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
CN102743770B (zh) 2012-06-18 2017-07-21 申宝忠 一种靶向性分子成像探针及活体分子成像方法
JP6251744B2 (ja) 2012-09-07 2017-12-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． ＭＲＩ用の両親媒性錯体を含む常磁性固体脂質ナノ粒子（ｐＳＬＮ）
US9931412B2 (en) 2013-02-08 2018-04-03 The Regents Of The University Of Michigan Targeted theranostics
CN105164136B (zh) 2013-05-06 2017-12-22 默克专利股份公司 作为激酶抑制剂的大环化合物
US10786497B2 (en) 2013-08-16 2020-09-29 Equip, Llc Discrete PEG constructs
WO2015038968A1 (fr) 2013-09-13 2015-03-19 The General Hospital Corporation Sondes de liaison à la fibrine activables
GEP20237479B (en) 2013-10-18 2023-03-27 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
US10758636B2 (en) 2013-11-12 2020-09-01 Centre For Probe Development And Commercialization Residualizing linkers and uses thereof
US20170050989A1 (en) 2013-12-03 2017-02-23 The General Hospital Corporation Molecular Imaging Probes
FR3015547B1 (fr) 2013-12-20 2016-01-01 Total Sa Methode pour ajuster le taux d'inhibiteurs dans un puits de petrole ou de gaz
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
WO2015157595A1 (fr) 2014-04-11 2015-10-15 Medimmune, Llc Composés conjugués comprenant des anticorps à cystéine manipulée
US11602525B2 (en) 2014-04-25 2023-03-14 Rinat Neuroscience Corp. Antibody-drug conjugates with high drug loading
WO2015176056A1 (fr) 2014-05-16 2015-11-19 Memorial Sloan Kettering Cancer Center Marquage en une étape par actinium-225 d'anticorps pour obtenir une haute activité spécifique
EP3180037A1 (fr) 2014-07-29 2017-06-21 Vrije Universiteit Brussel Fragments d'anticorps radio-marqués destinés à être utilisés pour le pronostic et le diagnostic du cancer, ainsi que dans la prédiction de la réponse à un traitement anticancéreux
BE1021191B1 (fr) 2014-08-29 2015-10-27 Anmi S.A. Kit pour radiomarquage.
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
DE102014115154A1 (de) 2014-10-17 2016-04-21 SCV-SpezialChemikalien-Vertrieb GmbH Konjugierte Bisphosphonate für die Diagnostik und Therapie von Knochenerkrankungen
ES2822990T3 (es) 2014-11-25 2021-05-05 Bristol Myers Squibb Co Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes
US20190015518A1 (en) 2016-01-04 2019-01-17 University Of Kansas Drug delivery compositions and methods
US10758634B2 (en) 2016-03-18 2020-09-01 Wake Forest University Compounds, compositions and associated methods using zirconium-89 in immuno-positron emission tomography
EP3638320A4 (fr) * 2017-05-05 2021-01-20 Centre for Probe Development and Commercialization Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
US10093741B1 (en) * 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
WO2018204869A1 (fr) * 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Améliorations pharmacocinétiques de chélates bifonctionnels et leurs utilisations
TW202227143A (zh) * 2020-08-27 2022-07-16 加拿大商探針開發暨商業化中心 放射性藥物及方法
AU2022397307A1 (en) * 2021-11-26 2024-06-06 Full-Life Technologies Uk Limited Cleavable radioligands for targeting cell surface receptors and uses thereof

Also Published As

Publication number Publication date
JP2020518674A (ja) 2020-06-25
JP7191938B2 (ja) 2022-12-19
JP2023025209A (ja) 2023-02-21
BR112019023249A8 (pt) 2021-02-23
MX2024006675A (es) 2024-06-24
AU2018261890B2 (en) 2025-03-20
CA3062538A1 (fr) 2018-11-08
US20190083662A1 (en) 2019-03-21
IL270457A (fr) 2020-01-30
IL270457B2 (en) 2024-11-01
KR20200004861A (ko) 2020-01-14
IL270457B1 (en) 2024-07-01
US11433148B2 (en) 2022-09-06
KR20240160664A (ko) 2024-11-11
BR112019023249A2 (pt) 2020-06-02
AU2025204253A1 (en) 2025-06-26
ZA201908072B (en) 2023-04-26
EP3638320A2 (fr) 2020-04-22
WO2018204872A3 (fr) 2018-12-13
RU2019139434A3 (fr) 2021-06-17
WO2018204872A2 (fr) 2018-11-08
CN110891614A (zh) 2020-03-17
US20230052140A1 (en) 2023-02-16
NZ759831A (en) 2025-05-30
EP3638320A4 (fr) 2021-01-20
RU2019139434A (ru) 2021-06-07
IL313115A (en) 2024-07-01
AU2018261890A1 (en) 2019-11-28
CL2019003169A1 (es) 2020-08-14

Similar Documents

Publication Publication Date Title
EP3638320A4 (fr) Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
EP3762030A4 (fr) Anticorps anti-cd73 et utilisations associées
EP3838289A4 (fr) Anticorps anti-tigit et ses utilisations
EP3400243A4 (fr) Anticorps anti-pd-l1 et utilisations associées
EP3589660A4 (fr) Anticorps anti-pd-l1 et utilisations associées
MA49687A (fr) Anticorps anti-ctla-4 et leurs utilisations
EP3891183A4 (fr) Anticorps anti-claudine et leurs utilisations
EP3625263A4 (fr) Anticorps anti-galectine-9 et leurs utilisations
EP3759143A4 (fr) Anticorps anti-tigit et leurs utilisations
EP3383916A4 (fr) Anticorps anti-cd73 et leurs utilisations
EP3684812A4 (fr) Anticorps anti-ctla4 et utilisations associées
EP3389702A4 (fr) Anticorps anti-lag-3 et leurs utilisations
EP3356416A4 (fr) Anticorps anti-pd-1 et ses utilisations
EP3621642A4 (fr) Anticorps monoclonaux humains contre lag3 et leurs utilisations
MA47789A (fr) Anticorps anti-phf-tau et leurs utilisations
EP3735427A4 (fr) Anticorps anti-mct1 et utilisations associées
EP3587453A4 (fr) Anticorps anti-pd-l1 et son application
EP3897719A4 (fr) Anticorps bispécifiques clivables par la protéase et utilisations associées
EP3426686A4 (fr) Anticorps anti-pacap humanisés et leurs utilisations
EP3328895A4 (fr) Anticorps anti-pd-l1 et leurs utilisations
EP3733702A4 (fr) Anticorps anti-lag-3 et utilisations associées
MA49886A (fr) Anticorps anti-par2 et leurs utilisations
MA45233A (fr) Anticorps anti-gitr et leurs utilisations
EP3645563A4 (fr) Anticorps anti-fam19a5 et leurs utilisations
EP3661555A4 (fr) Anticorps bispécifiques et leurs utilisations