MA49761A - Dérivés d'acide glycyrrhétinique de traitement de l'hyperkaliémie - Google Patents

Dérivés d'acide glycyrrhétinique de traitement de l'hyperkaliémie

Info

Publication number
MA49761A
MA49761A MA049761A MA49761A MA49761A MA 49761 A MA49761 A MA 49761A MA 049761 A MA049761 A MA 049761A MA 49761 A MA49761 A MA 49761A MA 49761 A MA49761 A MA 49761A
Authority
MA
Morocco
Prior art keywords
hyperkaliemia
treatment
acid derivatives
glycyrrhetinic acid
glycyrrhetinic
Prior art date
Application number
MA049761A
Other languages
English (en)
Inventor
Tao Chen
Dean Dragoli
Michael Leadbetter
Jason Lewis
Gary Luehr
Original Assignee
Ardelyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardelyx Inc filed Critical Ardelyx Inc
Publication of MA49761A publication Critical patent/MA49761A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00Simple or compound lenses
    • G02B3/0006Arrays
    • G02B3/0037Arrays characterized by the distribution or form of lenses
    • G02B3/0056Arrays characterized by the distribution or form of lenses arranged along two different directions in a plane, e.g. honeycomb arrangement of lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00Optical elements other than lenses
    • G02B5/02Diffusing elements; Afocal elements
    • G02B5/0205Diffusing elements; Afocal elements characterised by the diffusing properties
    • G02B5/021Diffusing elements; Afocal elements characterised by the diffusing properties the diffusion taking place at the element's surface, e.g. by means of surface roughening or microprismatic structures
    • GPHYSICS
    • G02OPTICS
    • G02FOPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/133Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
    • G02F1/1333Constructional arrangements; Manufacturing methods
    • G02F1/1335Structural association of cells with optical devices, e.g. polarisers or reflectors
    • G02F1/133524Light-guides, e.g. fibre-optic bundles, louvered or jalousie light-guides
    • GPHYSICS
    • G02OPTICS
    • G02FOPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
    • G02F1/00Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
    • G02F1/01Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour 
    • G02F1/13Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour  based on liquid crystals, e.g. single liquid crystal display cells
    • G02F1/133Constructional arrangements; Operation of liquid crystal cells; Circuit arrangements
    • G02F1/1333Constructional arrangements; Manufacturing methods
    • G02F1/1335Structural association of cells with optical devices, e.g. polarisers or reflectors
    • G02F1/133526Lenses, e.g. microlenses or Fresnel lenses
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B2207/00Coding scheme for general features or characteristics of optical elements and systems of subclass G02B, but not including elements and systems which would be classified in G02B6/00 and subgroups
    • G02B2207/123Optical louvre elements, e.g. for directional light blocking

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nonlinear Science (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Mathematical Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
MA049761A 2017-08-04 2018-08-06 Dérivés d'acide glycyrrhétinique de traitement de l'hyperkaliémie MA49761A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762541095P 2017-08-04 2017-08-04

Publications (1)

Publication Number Publication Date
MA49761A true MA49761A (fr) 2020-06-10

Family

ID=63364189

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049761A MA49761A (fr) 2017-08-04 2018-08-06 Dérivés d'acide glycyrrhétinique de traitement de l'hyperkaliémie

Country Status (17)

Country Link
US (3) US11768319B2 (fr)
EP (2) EP4397366A3 (fr)
JP (3) JP7281446B2 (fr)
KR (2) KR20240144491A (fr)
CN (2) CN111386279A (fr)
AU (3) AU2018335130B2 (fr)
BR (1) BR112020002322A2 (fr)
CA (1) CA3071992A1 (fr)
EA (1) EA202090438A1 (fr)
IL (3) IL318937A (fr)
MA (1) MA49761A (fr)
MX (2) MX2020001412A (fr)
PH (1) PH12020500432A1 (fr)
SG (1) SG11202000950TA (fr)
UA (1) UA126584C2 (fr)
WO (1) WO2019060051A1 (fr)
ZA (2) ZA202001352B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12021551892A1 (en) * 2019-02-07 2022-08-01 Ardelyx Inc Glycyrrhetinic acid derivatives for use in treating hyperkalemia
CN111018938B (zh) * 2019-12-10 2021-05-25 中国人民解放军第二军医大学 一种五环三萜类甘草次酸衍生物及制备方法与应用

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US5519008A (en) * 1992-09-10 1996-05-21 Glycomed Incorporated Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)
DK0612723T3 (da) 1993-02-20 1998-03-30 Hoechst Ag Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf
IL109570A0 (en) 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE19518796A1 (de) 1995-05-22 1996-11-28 Hoechst Ag Fluorphenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19548812A1 (de) 1995-12-27 1997-07-03 Hoechst Ag Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation
DE19633966A1 (de) 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO1999012540A1 (fr) * 1997-09-11 1999-03-18 Snow Brand Milk Products Co., Ltd. Remedes contre des maladies hormonales
DE19945302A1 (de) 1999-09-22 2001-03-29 Merck Patent Gmbh Biphenylderivate als NHE-3-Inhibitoren
US6887870B1 (en) 1999-10-12 2005-05-03 Bristol-Myers Squibb Company Heterocyclic sodium/proton exchange inhibitors and method
DE10015248A1 (de) 2000-03-28 2001-10-04 Merck Patent Gmbh Bisamidino-Verbindungen als NHE-3 Inhibitoren
DE10019062A1 (de) 2000-04-18 2001-10-25 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren
DE10043667A1 (de) 2000-09-05 2002-03-14 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline
DE10046993A1 (de) 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
DE10063294A1 (de) 2000-12-19 2002-07-04 Aventis Pharma Gmbh Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6736705B2 (en) 2001-04-27 2004-05-18 Hitachi Global Storage Technologies Polishing process for glass or ceramic disks used in disk drive data storage devices
US6911453B2 (en) 2001-12-05 2005-06-28 Aventis Pharma Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them
DE10161767A1 (de) 2001-12-15 2003-06-26 Merck Patent Gmbh 2-Guanidino-4-heterocyclyl-chinazoline
US6703405B2 (en) 2001-12-22 2004-03-09 Aventis Pharma Deutschland Gmbh Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them
DE10163992A1 (de) 2001-12-24 2003-07-03 Merck Patent Gmbh 4-Aryl-chinazoline
GB0224830D0 (en) 2002-10-24 2002-12-04 Sterix Ltd Compound
CN1254051C (zh) 2002-10-25 2006-04-26 华为技术有限公司 城域网传输设备中用户数据业务子速率传送方法
US6923466B2 (en) 2002-12-17 2005-08-02 James Tsai Collapsible handcart capable of extending the area of carrier by operating handle
US20050054705A1 (en) 2003-02-04 2005-03-10 Aventis Pharma Deutschland Gmbh N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE112004001165T5 (de) 2003-06-25 2006-05-04 Cmet Inc., Yokohama Durch aktinische Strahlung härtbare stereolithographische Harzzusammensetzung mit verbesserter Stabilität
WO2005020612A1 (fr) 2003-08-20 2005-03-03 Musky Communications (Proprietary) Limited Communication telephonique
WO2005027882A1 (fr) * 2003-09-22 2005-03-31 Bionetworks Gmbh Prevention et traitement de la perte osseuse induite par inflammation et/ou immuno-mediee
WO2005054705A2 (fr) 2003-11-26 2005-06-16 Brian Judd Appareil pour l'amortissement de vibration de choc dans des outils a main
US20050244367A1 (en) 2004-05-03 2005-11-03 Ilypsa, Inc. Phospholipase inhibitors localized in the gastrointestinal lumen
KR20070038042A (ko) 2004-05-14 2007-04-09 파세코 코퍼레이션 컨테이너 핸들러들을 위한 상황 보고 디바이스들을 만드는장치 및 방법
DE102004046492A1 (de) 2004-09-23 2006-03-30 Sanofi-Aventis Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
DE102004054847A1 (de) 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE102005044817A1 (de) 2005-09-20 2007-03-22 Sanofi-Aventis Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
CA2626961A1 (fr) 2005-11-03 2007-05-18 Ilypsa, Inc. Inhibiteurs de phospholipases, notamment inhibiteurs de phospholipases multivalents, leur utilisation, notamment en tant qu'inhibiteurs de phospholipases localises dans une lumiere
EP1960356A2 (fr) 2005-11-03 2008-08-27 Ilypsa, Inc. Composes d'indole multivalents et leur utilisation en tant qu'inhibiteurs de phospholipases a2
GB0604899D0 (en) 2006-03-10 2006-04-19 York Pharma Plc Derivatives of 18-glycyrrhetinic acid
GB0610009D0 (en) 2006-05-19 2006-06-28 Health Prot Agency Culture medium
GB2438389A (en) 2006-05-23 2007-11-28 Gkn Aerospace Transparency Sys Heating system for leading edge of aircraft
MX381407B (es) 2008-12-31 2025-03-12 Ardelyx Inc Compuestos y métodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrógeno (nhe) en el tratamiento de trastornos asociados con retención de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.
EP2228380A1 (fr) 2009-03-13 2010-09-15 onepharm Research & Development GmbH Nouveaux dérivés de triterpène
US8846647B2 (en) 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
WO2014027777A2 (fr) 2012-08-14 2014-02-20 한국콜마 주식회사 Nouveau dérivé d'acide ursolique et son procédé de préparation
MX366293B (es) 2012-08-21 2019-07-04 Ardelyx Inc Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal.
CA2880432C (fr) 2012-08-21 2023-03-14 Ardelyx, Inc. Composes et procedes destines a inhiber un antiport medie par nhe dans le traitement des troubles associes a une retention de fluide ou a une surcharge de sel et des troubles du t ractus gastro-intestinal
EP3236940B1 (fr) 2014-12-23 2020-02-05 Ardelyx, Inc. Compositions et méthodes de traitement de l'hyperkaliémie

Also Published As

Publication number Publication date
AU2018335130A1 (en) 2020-03-19
JP2025029026A (ja) 2025-03-05
SG11202000950TA (en) 2020-02-27
JP2020529449A (ja) 2020-10-08
EP3661945B1 (fr) 2024-04-03
US20210163524A1 (en) 2021-06-03
MX2023015126A (es) 2024-01-23
IL272443A (en) 2020-03-31
KR20240144491A (ko) 2024-10-02
EP3661945A1 (fr) 2020-06-10
ZA202001352B (en) 2024-10-30
EP4397366A2 (fr) 2024-07-10
IL318937A (en) 2025-04-01
US11768319B2 (en) 2023-09-26
US20250067907A1 (en) 2025-02-27
KR20200074085A (ko) 2020-06-24
CN118440135A (zh) 2024-08-06
IL272443B1 (en) 2023-10-01
IL272443B2 (en) 2024-02-01
JP2023054360A (ja) 2023-04-13
US20230273354A1 (en) 2023-08-31
CN111386279A (zh) 2020-07-07
AU2018335130B2 (en) 2023-02-16
AU2025201400A1 (en) 2025-03-20
EA202090438A1 (ru) 2020-06-15
EP4397366A3 (fr) 2024-11-20
IL306058A (en) 2023-11-01
ZA202102866B (en) 2022-10-26
MX2020001412A (es) 2020-08-03
PH12020500432A1 (en) 2021-01-25
JP7281446B2 (ja) 2023-05-25
BR112020002322A2 (pt) 2020-09-01
WO2019060051A1 (fr) 2019-03-28
UA126584C2 (uk) 2022-11-02
AU2023203009A1 (en) 2023-06-01
CA3071992A1 (fr) 2019-03-28

Similar Documents

Publication Publication Date Title
EP3491149A4 (fr) Traitement d'acide nucléique indépendant
IL271046A (en) Compounds for treating huntington's disease
EP3517528A4 (fr) Sel d'addition d'acide de dérivé de benzimidazole
EP3331896A4 (fr) Procédés de préparation d'acides biliaires et de leurs dérivés
EP3642217A4 (fr) Procédés et intermédiaires pour la préparation de dérivés de l'acide biliaire
EP3353189A4 (fr) Procédés et intermédiaires pour la préparation de dérivés de l'acide biliaire
MA43746A (fr) Dérivés de 2-cyanoisoindoline pour le traitement du cancer
EP3370721A4 (fr) Traitement de l'ostéoarthrite
MA45192A (fr) Traitement d'association
EP3402787A4 (fr) Procédés de préparation d'acide 2,5-furandicarboxylique et des intermédiaires et dérivés correspondants
MA44083A (fr) Composés de biarylmonobactame pour le traitement d'infections bactériennes
EP3277381C0 (fr) Dérivés de nitrobenzyle d'agents anticancéreux
MA49628A (fr) Processus pour la purification de l'acide hyaluronique
EP3612152A4 (fr) Administration topique de composés d'acide nucléique
EP3503904A4 (fr) Traitement par ascaroside de l'oesophagite à éosinophiles
MA44875A (fr) Compositions pour le traitement de troubles acido-basiques
EP3408254A4 (fr) Sels de l'acide 5-aminolévulinique et dérivés
EP3538219A4 (fr) Compositions topiques destinées au traitement de l'acné
EP3419981A4 (fr) Polythérapies utilisées dans le traitement de l'amyotrophie spinale
EP3848382C0 (fr) Intermédiaires pour la production des dérivés des acides biliaires, surtout de l'acide obéticholique
FR3049601B1 (fr) Procede ameliore de production d'acide (meth)acrylique
MA42985A (fr) Traitement de troubles liés à l'acide biliaire
MA55917A (fr) Procédé de cristallisation de dérivés d'aripiprazole dans des formulations à libération prolongée pour le traitement de la schizophrénie
MA42614A (fr) Dérivés d'acide 5-(n-benzyl tétrahydroisoquinolin-6-yl) pyridin-3-yl-acétique utilisés comme inhibiteurs de la réplication du virus de l'immunodéficience humaine
MA43583A (fr) Dérivés d'acide pentanoïque substitués par pyrrolo-[2,3-b]pyrimidne-pyridines pour traiter des infections par le virus de la grippe