MA50395A - Sels de (r)-9-(2,5-difluorophénéthyl)-4-éthyl-2-méthyl-1-oxa-4,9-diazaspiro [5.5]undécan-3-one - Google Patents
Sels de (r)-9-(2,5-difluorophénéthyl)-4-éthyl-2-méthyl-1-oxa-4,9-diazaspiro [5.5]undécan-3-oneInfo
- Publication number
- MA50395A MA50395A MA050395A MA50395A MA50395A MA 50395 A MA50395 A MA 50395A MA 050395 A MA050395 A MA 050395A MA 50395 A MA50395 A MA 50395A MA 50395 A MA50395 A MA 50395A
- Authority
- MA
- Morocco
- Prior art keywords
- difluorophenethyl
- undecan
- diazaspiro
- oxa
- salts
- Prior art date
Links
- KALIKXMQWFLZKB-CQSZACIVSA-N (2R)-9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one Chemical class FC1=C(CCN2CCC3(CN(C([C@H](O3)C)=O)CC)CC2)C=C(C=C1)F KALIKXMQWFLZKB-CQSZACIVSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382695 | 2017-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50395A true MA50395A (fr) | 2020-08-26 |
Family
ID=60201976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050395A MA50395A (fr) | 2017-10-17 | 2018-10-16 | Sels de (r)-9-(2,5-difluorophénéthyl)-4-éthyl-2-méthyl-1-oxa-4,9-diazaspiro [5.5]undécan-3-one |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11236110B2 (fr) |
| EP (1) | EP3697795B1 (fr) |
| JP (1) | JP2020537648A (fr) |
| KR (1) | KR20200071107A (fr) |
| CN (1) | CN111263764A (fr) |
| AR (1) | AR113770A1 (fr) |
| AU (1) | AU2018353107B2 (fr) |
| BR (1) | BR112020007359A2 (fr) |
| CA (1) | CA3076765A1 (fr) |
| CO (1) | CO2020005710A2 (fr) |
| DK (1) | DK3697795T3 (fr) |
| ES (1) | ES2974331T3 (fr) |
| FI (1) | FI3697795T3 (fr) |
| IL (1) | IL273751B2 (fr) |
| LT (1) | LT3697795T (fr) |
| MA (1) | MA50395A (fr) |
| MX (1) | MX2020004214A (fr) |
| MY (1) | MY200894A (fr) |
| PH (1) | PH12020550104A1 (fr) |
| PT (1) | PT3697795T (fr) |
| RU (1) | RU2020115274A (fr) |
| SG (1) | SG11202002731YA (fr) |
| SI (1) | SI3697795T1 (fr) |
| TW (1) | TWI835755B (fr) |
| WO (1) | WO2019076475A1 (fr) |
| ZA (1) | ZA202002202B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021018824A1 (fr) * | 2019-07-31 | 2021-02-04 | Esteve Pharmaceuticals, S.A. | Utilisation de (r)-9-(2,5-difluorophénéthyl)-4-éthyl-2-méthyl-1-oxa-4,9-diazaspiro[5,5]undécan-3-one pour le traitement de la douleur nociceptive, de la douleur neuropathique, de la douleur arthritique et de la douleur cancéreuse, tout en ayant des effets secondaires réduits par comparaison avec les opioïdes |
| WO2024105225A1 (fr) | 2022-11-18 | 2024-05-23 | Universitat De Barcelona | Combinaisons synergiques d'un antagoniste du récepteur sigma 1 (s1r) et d'un inhibiteur d'époxyde hydrolase soluble (sehi) et leur utilisation dans le traitement de la douleur |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4332804A (en) | 1981-03-23 | 1982-06-01 | Syntex (U.S.A.) Inc. | 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones |
| US4353900A (en) | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones |
| US6114541A (en) | 1997-03-10 | 2000-09-05 | Hoffmann-La Roche Inc. | Method for the preparation of α-Bromo-Lactam derivatives |
| DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| WO2007058322A1 (fr) | 2005-11-18 | 2007-05-24 | Ono Pharmaceutical Co., Ltd. | Composé contenant un groupe basique et son utilisation |
| MX2009009355A (es) | 2007-03-01 | 2009-09-11 | Mitsubishi Tanabe Pharma Corp | Compuesto de bencimidazol y uso farmaceutico del mismo. |
| EP1982714A1 (fr) | 2007-04-16 | 2008-10-22 | Laboratorios del Dr. Esteve S.A. | Pyrano-pyrazole-aminés |
| EP2020414A1 (fr) | 2007-06-20 | 2009-02-04 | Laboratorios del Dr. Esteve S.A. | Derivés spiro[piperidine-4,4'-thieno[3,2-c]pyran] et composés similaires en tant que inhibiteurs du recepteur sigma pour le traitement de pyschose |
| EP2197876A1 (fr) | 2007-08-29 | 2010-06-23 | Glaxosmithkline LLC | Inhibiteurs de kinase à base de thiazole et d'oxazole |
| PT2242759E (pt) | 2008-02-06 | 2012-12-17 | Astrazeneca Ab | Compostos |
| CN103517910B (zh) | 2011-03-14 | 2016-12-14 | 沃泰克斯药物股份有限公司 | 作为离子通道调节剂的吗啉-螺环哌啶酰胺 |
| GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
| PT2989104T (pt) * | 2013-04-23 | 2019-11-26 | Esteve Pharmaceuticals Sa | Compostos de pirazino[1,2-a]indole, sua preparação e utilização em medicamentos |
| US9751881B2 (en) | 2013-07-31 | 2017-09-05 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| JP2017100951A (ja) * | 2014-04-04 | 2017-06-08 | 大正製薬株式会社 | オキサゾリジノン及びオキサジナノン誘導体 |
| TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| TW201615643A (zh) * | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物 |
| TW201615642A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
-
2018
- 2018-10-16 FI FIEP18796360.8T patent/FI3697795T3/fi active
- 2018-10-16 TW TW107136281A patent/TWI835755B/zh not_active IP Right Cessation
- 2018-10-16 CA CA3076765A patent/CA3076765A1/fr active Pending
- 2018-10-16 LT LTEPPCT/EP2018/000470T patent/LT3697795T/lt unknown
- 2018-10-16 MX MX2020004214A patent/MX2020004214A/es unknown
- 2018-10-16 AR ARP180102999A patent/AR113770A1/es unknown
- 2018-10-16 MA MA050395A patent/MA50395A/fr unknown
- 2018-10-16 PT PT187963608T patent/PT3697795T/pt unknown
- 2018-10-16 AU AU2018353107A patent/AU2018353107B2/en active Active
- 2018-10-16 SG SG11202002731YA patent/SG11202002731YA/en unknown
- 2018-10-16 BR BR112020007359-8A patent/BR112020007359A2/pt unknown
- 2018-10-16 EP EP18796360.8A patent/EP3697795B1/fr active Active
- 2018-10-16 SI SI201831070T patent/SI3697795T1/sl unknown
- 2018-10-16 JP JP2020520801A patent/JP2020537648A/ja active Pending
- 2018-10-16 CN CN201880069276.1A patent/CN111263764A/zh active Pending
- 2018-10-16 KR KR1020207013907A patent/KR20200071107A/ko not_active Ceased
- 2018-10-16 ES ES18796360T patent/ES2974331T3/es active Active
- 2018-10-16 RU RU2020115274A patent/RU2020115274A/ru unknown
- 2018-10-16 WO PCT/EP2018/000470 patent/WO2019076475A1/fr not_active Ceased
- 2018-10-16 IL IL273751A patent/IL273751B2/en unknown
- 2018-10-16 US US16/649,824 patent/US11236110B2/en not_active Expired - Fee Related
- 2018-10-16 DK DK18796360.8T patent/DK3697795T3/da active
- 2018-10-16 MY MYPI2020001580A patent/MY200894A/en unknown
-
2020
- 2020-03-20 PH PH12020550104A patent/PH12020550104A1/en unknown
- 2020-05-04 ZA ZA2020/02202A patent/ZA202002202B/en unknown
- 2020-05-09 CO CONC2020/0005710A patent/CO2020005710A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020537648A (ja) | 2020-12-24 |
| ES2974331T3 (es) | 2024-06-26 |
| SG11202002731YA (en) | 2020-05-28 |
| TW201922752A (zh) | 2019-06-16 |
| AU2018353107A1 (en) | 2020-04-23 |
| TWI835755B (zh) | 2024-03-21 |
| US20200331929A1 (en) | 2020-10-22 |
| DK3697795T3 (da) | 2024-02-26 |
| CA3076765A1 (fr) | 2019-04-25 |
| IL273751B2 (en) | 2024-02-01 |
| MX2020004214A (es) | 2020-08-13 |
| KR20200071107A (ko) | 2020-06-18 |
| FI3697795T3 (fi) | 2024-02-23 |
| EP3697795B1 (fr) | 2023-11-22 |
| EP3697795A1 (fr) | 2020-08-26 |
| RU2020115274A (ru) | 2021-11-01 |
| LT3697795T (lt) | 2024-04-10 |
| AR113770A1 (es) | 2020-06-10 |
| BR112020007359A2 (pt) | 2020-09-29 |
| ZA202002202B (en) | 2025-04-30 |
| SI3697795T1 (sl) | 2024-05-31 |
| IL273751A (en) | 2020-05-31 |
| IL273751B1 (en) | 2023-10-01 |
| AU2018353107B2 (en) | 2023-07-06 |
| CN111263764A (zh) | 2020-06-09 |
| MY200894A (en) | 2024-01-22 |
| WO2019076475A1 (fr) | 2019-04-25 |
| PT3697795T (pt) | 2024-02-29 |
| PH12020550104A1 (en) | 2021-01-25 |
| RU2020115274A3 (fr) | 2022-04-29 |
| CO2020005710A2 (es) | 2020-05-29 |
| US11236110B2 (en) | 2022-02-01 |
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