MA50524A - Nouveaux indole-2-carboxamides à substitution amino-thiazole hautement actifs agissant contre le virus de l'hépatite b (vhb) - Google Patents
Nouveaux indole-2-carboxamides à substitution amino-thiazole hautement actifs agissant contre le virus de l'hépatite b (vhb)Info
- Publication number
- MA50524A MA50524A MA050524A MA50524A MA50524A MA 50524 A MA50524 A MA 50524A MA 050524 A MA050524 A MA 050524A MA 50524 A MA50524 A MA 50524A MA 50524 A MA50524 A MA 50524A
- Authority
- MA
- Morocco
- Prior art keywords
- hbv
- thiazole
- hepatitis
- virus
- highly active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17199687 | 2017-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50524A true MA50524A (fr) | 2020-09-09 |
Family
ID=60201941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050524A MA50524A (fr) | 2017-11-02 | 2018-11-02 | Nouveaux indole-2-carboxamides à substitution amino-thiazole hautement actifs agissant contre le virus de l'hépatite b (vhb) |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US11267825B2 (fr) |
| EP (1) | EP3704127A1 (fr) |
| JP (1) | JP2021501764A (fr) |
| KR (1) | KR20200083551A (fr) |
| CN (1) | CN111448199A (fr) |
| AR (1) | AR113826A1 (fr) |
| AU (1) | AU2018361364B2 (fr) |
| BR (1) | BR112020008762A2 (fr) |
| CA (1) | CA3081386A1 (fr) |
| CL (1) | CL2020001145A1 (fr) |
| CU (1) | CU20200037A7 (fr) |
| EA (1) | EA202091113A1 (fr) |
| EC (1) | ECSP20029558A (fr) |
| GE (2) | GEP20227373B (fr) |
| IL (1) | IL274298A (fr) |
| MA (1) | MA50524A (fr) |
| MX (1) | MX2020004839A (fr) |
| PH (1) | PH12020550525A1 (fr) |
| SG (1) | SG11202003700TA (fr) |
| TW (1) | TW201930315A (fr) |
| UY (1) | UY37962A (fr) |
| WO (1) | WO2019086141A1 (fr) |
| ZA (1) | ZA202002249B (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PY1991603A (es) * | 2018-11-02 | 2020-09-17 | Aicuris Gmbh & Co Kg | Nueva 6,7-dihidro-4h-pirazolo [1,5-a] pirazina indole -2-carboxamidas activas contra el virus de la hepatitis b (vhb) |
| UY38434A (es) * | 2018-11-02 | 2020-05-29 | Aicuris Gmbh & Co Kg | Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv) |
| EP3962914A1 (fr) * | 2019-04-30 | 2022-03-09 | AiCuris GmbH & Co. KG | Nouveaux indole-2-carboxamides actifs contre le virus de l'hépatite b (vhb) |
| WO2021118727A2 (fr) * | 2019-11-08 | 2021-06-17 | President And Fellows Of Harvard College | Acides aminés fluorogéniques |
| CA3202764A1 (fr) | 2020-11-23 | 2022-05-27 | Enanta Pharmaceuticals, Inc. | Nouveaux agents antiviraux derives de spiropyrrolidine |
| US11970502B2 (en) | 2021-05-04 | 2024-04-30 | Enanta Pharmaceuticals, Inc. | Macrocyclic antiviral agents |
| US11912714B2 (en) | 2021-11-12 | 2024-02-27 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11858945B2 (en) | 2021-11-12 | 2024-01-02 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
| WO2023137007A1 (fr) * | 2022-01-11 | 2023-07-20 | Enanta Pharmaceuticals, Inc. | Procédés de préparation d'acide 4,6,7-trifluoro-1h-indole-2-carboxylique |
| US12145942B2 (en) | 2022-04-05 | 2024-11-19 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| CN116068100A (zh) * | 2022-11-24 | 2023-05-05 | 上海研诺医药科技有限公司 | 一种测定4-羟乙基哌嗪乙磺酸的检测方法 |
| CN116396204B (zh) * | 2023-03-29 | 2024-09-24 | 无锡科华生物科技有限公司 | 一种4,6,7-三氟-1h-吲哚-2-羧酸的制备方法 |
| CN117886810A (zh) * | 2023-12-18 | 2024-04-16 | 徐州医科大学 | 一种吲哚啉类化合物及其制备方法和应用 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6290998A (en) | 1997-03-07 | 1998-09-29 | Novo Nordisk A/S | 4,5,6,7-tetrahydro-thieno{3,2-c}pyridine derivatives, their preparation and use |
| DE19817264A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
| WO2000058302A1 (fr) | 1999-03-25 | 2000-10-05 | Bayer Aktiengesellschaft | Nouvelles dihydropyrimidines et leur utilisation pour traiter l'hepatite b |
| WO2001045712A1 (fr) | 1999-12-22 | 2001-06-28 | Bayer Aktiengesellschaft | Combinaison de medicaments pour lutter contre des maladies virales |
| DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| EP2266991B1 (fr) | 2003-11-12 | 2018-07-11 | Daiichi Sankyo Company, Limited | Processus de production de dérivé de thiazole |
| WO2006033995A2 (fr) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidine-4-ones possedant une activite antihepatite b |
| AU2007225273A1 (en) | 2006-03-10 | 2007-09-20 | Neurogen Corporation | Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues |
| WO2008085118A1 (fr) | 2007-01-12 | 2008-07-17 | Astrazeneca Ab | Composés pyridiniques: utilisation comme antagonistes de p2y12 |
| ES2445199T3 (es) | 2008-06-05 | 2014-02-28 | Glaxo Group Limited | Derivados de benzpirazol como inhibidores de PI3-quinasas |
| US8024013B2 (en) | 2008-07-09 | 2011-09-20 | Sony Ericsson Mobile Communications Ab | Regulating power duty cycle of an RF transmitter/receiver responsive to distance moved |
| JPWO2010024258A1 (ja) | 2008-08-29 | 2012-01-26 | 塩野義製薬株式会社 | Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体 |
| WO2010114971A1 (fr) | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Composés utilisables pour le traitement de troubles à médiation par le récepteur métabotropique 5 au glutamate et leurs procédés d'utilisation |
| EP2611298A4 (fr) | 2010-08-31 | 2014-07-30 | Univ Vanderbilt | Composés bicycliques d'oxazole et de thiazole et leur utilisation en tant que modulateurs allostériques des récepteurs mglur5 |
| HUE028435T2 (en) | 2010-09-02 | 2016-12-28 | Suven Life Sciences Ltd | Heterocyclic compounds as histamine H3 receptor ligands |
| EP2720695A4 (fr) | 2011-06-15 | 2014-11-12 | Nono Inc | Agents et méthodes de traitement de maladies ischémiques et d'autres maladies |
| JP5977347B2 (ja) | 2011-07-01 | 2016-08-24 | バルーク エス．ブルームバーグ インスティテュート | Ｈｂｖ感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体 |
| SG11201401531RA (en) | 2011-11-11 | 2014-07-30 | Pfizer | 2-thiopyrimidinones |
| EA037918B1 (ru) | 2011-12-21 | 2021-06-07 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
| AU2013207205B2 (en) | 2012-01-06 | 2017-02-02 | Janssen Sciences Ireland Uc | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of Hepatitis B |
| HK1208465A1 (en) | 2012-08-28 | 2016-03-04 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| SG11201501360TA (en) | 2012-08-28 | 2015-03-30 | Janssen Sciences Ireland Uc | Fused bicyclic sulfamoyl derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| US9695178B2 (en) | 2013-01-15 | 2017-07-04 | Suzhou Kintor Pharmaceuticals, Inc. | 6-(2-pyridyl)-7,8-dihydro-5H-pyrido[4,3-D]pyrimidine analogs as hedgehog pathway signaling inhibitors and therapeutic applications thereof |
| US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
| RS57999B1 (sr) | 2013-05-17 | 2019-01-31 | Janssen Sciences Ireland Uc | Derivati sulfamoiltiofenamida i njihova primena kao lekovi za tretman hepatitisa b |
| WO2014184328A1 (fr) | 2013-05-17 | 2014-11-20 | F. Hoffmann-La Roche Ag | Héteroaryldihydropyrimidines pontées en position 6 pour le traitement et la prophylaxie d'une infection par le virus de l'hépatite b |
| ES2774749T3 (es) | 2013-07-25 | 2020-07-22 | Janssen Sciences Ireland Unlimited Co | Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis B |
| US10220034B2 (en) | 2013-10-18 | 2019-03-05 | Indiana University Research And Technology Corporation | Hepatitis B viral assembly effectors |
| EA201690979A1 (ru) | 2013-11-14 | 2016-08-31 | Новира Терапьютикс, Инк. | Производные азепана и способы лечения инфекций гепатита в |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| AU2015226206B2 (en) | 2014-03-07 | 2017-03-16 | F. Hoffmann-La Roche Ag | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection |
| MX363600B (es) | 2014-03-13 | 2019-03-28 | Univ Indiana Res & Tech Corp | Moduladores alostericos de proteina nucleo de hepatitis b. |
| MY196243A (en) | 2014-03-28 | 2023-03-24 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine Compounds and Their Application In Pharmaceuticals |
| AU2015255656A1 (en) | 2014-05-09 | 2016-11-10 | Assembly Biosciences, Inc. | Methods and compositions for treating hepatitis B virus infections |
| RU2664329C1 (ru) | 2014-08-14 | 2018-08-16 | Ф. Хоффманн-Ля Рош Аг | Новые пиридазоны и триазиноны для лечения и профилактики заражения вирусом гепатита b |
| WO2016089990A1 (fr) | 2014-12-02 | 2016-06-09 | Novira Therapeutics, Inc. | Composés de sulfonamide inverse à base de sulfure, alkyle et pyridyle pour le traitement du vhb |
| WO2016109684A2 (fr) | 2014-12-30 | 2016-07-07 | Novira Therapeutics, Inc. | Dérivés et méthodes de traitement d'infections provoquées par le virus de l'hépatite b |
| MA41338B1 (fr) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Composés de pyrazine pour le traitement de maladies infectieuses |
| MA52701A (fr) | 2015-03-16 | 2021-03-31 | Hoffmann La Roche | Traitement combiné avec un agoniste tlr7 et un inhibiteur d'assemblage de capside du virus de l'hépatite b |
| CA2979537C (fr) * | 2015-03-18 | 2023-08-29 | Abide Therapeutics, Inc. | Carbamates de piperazine et procedes de preparation et d'utilisation de ceux-ci |
| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2016177655A1 (fr) | 2015-05-04 | 2016-11-10 | F. Hoffmann-La Roche Ag | Tétrahydropyridopyrimidines et tétrahydropyridopyridines comme inhibiteurs d'ag hbs (antigène de surface du virus de l'hépatite b) et production d'adn de vhb pour le traitement d'infections par le virus de l'hépatite b |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| WO2017011552A1 (fr) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Agents antiviraux de l'hépatite b |
| CN107849037B (zh) | 2015-07-21 | 2020-04-17 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的三环4-吡啶酮-3-甲酸衍生物 |
| WO2017015451A1 (fr) | 2015-07-22 | 2017-01-26 | Enanta Pharmaceuticals, Inc. | Agents antiviraux de l'hépatite b |
| TWI721016B (zh) | 2015-09-15 | 2021-03-11 | 美商艾森伯利生物科學公司 | B型肝炎核心蛋白質調節劑 |
| HK1259410A1 (zh) | 2015-09-29 | 2019-11-29 | 诺维拉治疗公司 | 乙型肝炎抗病毒剂的晶体形式 |
| WO2017076286A1 (fr) | 2015-11-04 | 2017-05-11 | 南京明德新药研发股份有限公司 | Forme cristalline, procédé de préparation et intermédiaire d'un composé à cycle dihydropyridine |
| US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| BR112018067964B1 (pt) | 2016-03-07 | 2024-01-16 | Enanta Pharmaceuticals, Inc | Composto, composição farmacêutica que o compreende e uso do referido composto |
| CN109153682B (zh) | 2016-05-20 | 2021-05-25 | 豪夫迈·罗氏有限公司 | 用于治疗感染性疾病的具有氧、硫和氮连接基的新的吡嗪化合物 |
| JP7051804B2 (ja) | 2016-07-14 | 2022-04-11 | エフ．ホフマン－ラ ロシュ アーゲー | 感染症の治療のための６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物と６，７－ジヒドロ－４Ｈ－トリアゾロ［１，５－ａ］ピラジン化合物 |
| JP7034133B2 (ja) | 2016-07-14 | 2022-03-11 | エフ．ホフマン－ラ ロシュ アーゲー | 感染性疾患の処置のためのカルボキシ ６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物 |
| WO2018011160A1 (fr) | 2016-07-14 | 2018-01-18 | F. Hoffmann-La Roche Ag | Composés de 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine pour le traitement de maladies infectieuses |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CA3036245C (fr) | 2016-09-13 | 2021-07-20 | Arbutus Biopharma Corporation | Composes de chromane-8-carboxamide substitues et analogues de ceux-ci, et procedes les utilisant |
| JOP20190105A1 (ar) * | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | مثبطات أحادي أسيل جليسرول ليباز (magl) |
| ES2898217T3 (es) | 2017-03-02 | 2022-03-04 | Assembly Biosciences Inc | Compuestos de sulfamida cíclica y métodos de uso de los mismos |
| MA49014A (fr) | 2017-03-21 | 2020-02-05 | Arbutus Biopharma Corp | Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant |
| CN111527087A (zh) * | 2017-11-02 | 2020-08-11 | 艾库里斯有限及两合公司 | 具有抗乙型肝炎病毒(hbv)活性的新的高活性的吡唑并-哌啶取代的吲哚-2-甲酰胺 |
-
2018
- 2018-11-02 GE GEAP201815351A patent/GEP20227373B/en unknown
- 2018-11-02 MA MA050524A patent/MA50524A/fr unknown
- 2018-11-02 SG SG11202003700TA patent/SG11202003700TA/en unknown
- 2018-11-02 CN CN201880079554.1A patent/CN111448199A/zh active Pending
- 2018-11-02 TW TW107139067A patent/TW201930315A/zh unknown
- 2018-11-02 WO PCT/EP2018/000502 patent/WO2019086141A1/fr not_active Ceased
- 2018-11-02 US US16/761,189 patent/US11267825B2/en active Active
- 2018-11-02 AU AU2018361364A patent/AU2018361364B2/en not_active Ceased
- 2018-11-02 KR KR1020207015662A patent/KR20200083551A/ko not_active Ceased
- 2018-11-02 AR ARP180103202A patent/AR113826A1/es unknown
- 2018-11-02 BR BR112020008762-9A patent/BR112020008762A2/pt not_active IP Right Cessation
- 2018-11-02 GE GEAP202115351A patent/GEAP202115351A/en unknown
- 2018-11-02 JP JP2020524457A patent/JP2021501764A/ja active Pending
- 2018-11-02 CA CA3081386A patent/CA3081386A1/fr not_active Abandoned
- 2018-11-02 EA EA202091113A patent/EA202091113A1/ru unknown
- 2018-11-02 MX MX2020004839A patent/MX2020004839A/es unknown
- 2018-11-02 CU CU2020000037A patent/CU20200037A7/es unknown
- 2018-11-02 EP EP18811439.1A patent/EP3704127A1/fr not_active Withdrawn
- 2018-11-05 UY UY0001037962A patent/UY37962A/es not_active Application Discontinuation
-
2020
- 2020-04-27 IL IL274298A patent/IL274298A/en unknown
- 2020-04-30 CL CL2020001145A patent/CL2020001145A1/es unknown
- 2020-04-30 PH PH12020550525A patent/PH12020550525A1/en unknown
- 2020-05-04 ZA ZA2020/02249A patent/ZA202002249B/en unknown
- 2020-06-01 EC ECSENADI202029558A patent/ECSP20029558A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA202002249B (en) | 2022-01-26 |
| CU20200037A7 (es) | 2021-03-11 |
| EA202091113A1 (ru) | 2020-08-28 |
| JP2021501764A (ja) | 2021-01-21 |
| BR112020008762A2 (pt) | 2020-10-20 |
| CA3081386A1 (fr) | 2019-05-09 |
| CN111448199A (zh) | 2020-07-24 |
| SG11202003700TA (en) | 2020-05-28 |
| AU2018361364A1 (en) | 2020-05-21 |
| WO2019086141A8 (fr) | 2019-08-29 |
| US11267825B2 (en) | 2022-03-08 |
| GEAP202115351A (en) | 2021-12-10 |
| KR20200083551A (ko) | 2020-07-08 |
| IL274298A (en) | 2020-06-30 |
| ECSP20029558A (es) | 2020-07-31 |
| MX2020004839A (es) | 2020-10-16 |
| PH12020550525A1 (en) | 2021-04-26 |
| AU2018361364B2 (en) | 2020-11-26 |
| AR113826A1 (es) | 2020-06-17 |
| US20200354379A1 (en) | 2020-11-12 |
| UY37962A (es) | 2019-05-31 |
| GEP20227373B (en) | 2022-04-25 |
| EP3704127A1 (fr) | 2020-09-09 |
| WO2019086141A1 (fr) | 2019-05-09 |
| CL2020001145A1 (es) | 2020-10-09 |
| TW201930315A (zh) | 2019-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA50524A (fr) | Nouveaux indole-2-carboxamides à substitution amino-thiazole hautement actifs agissant contre le virus de l'hépatite b (vhb) | |
| MA50520A (fr) | Nouveaux indole-2-carboxamides à substitution pyrazolo-pipéridine hautement actifs agissant contre le virus de l'hépatite b (vhb) | |
| MA45863A (fr) | Agent arni contre l'infection par le virus de l'hépatite b | |
| IL282598A (en) | 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| USD816303S1 (en) | Athletic garment | |
| EP3426245A4 (fr) | Agents antiviraux contre l'hépatite b | |
| MA46535A (fr) | Méganucléases modifiées spécifiques de séquences de reconnaissance dans le génome du virus de l'hépatite b | |
| EP3675637A4 (fr) | Agents antiviraux contre l'hépatite b | |
| MA51311A (fr) | Vaccins contre le virus de l'hépatite b (vhb) et utilisations associées | |
| EP3590942A4 (fr) | Inhibiteur d'antigène de surface du virus de l'hépatite b | |
| IL287278A (en) | Novel indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| IL279537A (en) | Aav compositions | |
| DK3577124T3 (da) | Nukleotid hemisulfatsalt til behandlingen af hepatitis C virus | |
| IL282480A (en) | Novel 6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine indole-2-carboxamides active against the hepatitis b virus (hbv) | |
| USD936110S1 (en) | Centralizer | |
| EP3804153A4 (fr) | Serdes avec mécanisme d'auto-contrainte d'injection de gigue | |
| USD853466S1 (en) | Camera extension pole | |
| EP3441389A4 (fr) | Composé pyrazole-oxazolidinone pour lutter contre le virus de l'hépatite b | |
| HUE071618T2 (hu) | Fúziós fehérjéket tartalmazó gyógyszerkészítmény hepatitisz, májfibrózis és májzsugor megelõzésére vagy kezelésére | |
| MA51312A (fr) | Méthodes et compositions permettant d'induire une réponse immunitaire contre le virus de l'hépatite b (vhb) | |
| EP3625349A4 (fr) | Virus modifiés | |
| EP3515929A4 (fr) | Vaccins thérapeutiques contre le virus de l'hépatite b | |
| SG11202000347UA (en) | A composition for treating and/or preventing hepatitis b virus infection and the use thereof | |
| EP3434280A4 (fr) | Vaccin contre l'hépatite b fortement dosé à base d'hansenula recombinée | |
| EP3476044A4 (fr) | Réseaux d'adaptation à étages multiples et techniques associées |