MA50786A - Produit d'association pour le traitement de troubles neurologiques et/ou psychiatriques - Google Patents
Produit d'association pour le traitement de troubles neurologiques et/ou psychiatriquesInfo
- Publication number
- MA50786A MA50786A MA050786A MA50786A MA50786A MA 50786 A MA50786 A MA 50786A MA 050786 A MA050786 A MA 050786A MA 50786 A MA50786 A MA 50786A MA 50786 A MA50786 A MA 50786A
- Authority
- MA
- Morocco
- Prior art keywords
- neurological
- treatment
- combination product
- psychiatric disorders
- psychiatric
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 239000013066 combination product Substances 0.000 title 1
- 229940127555 combination product Drugs 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- 208000020016 psychiatric disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382718 | 2017-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50786A true MA50786A (fr) | 2022-04-27 |
Family
ID=60382132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050786A MA50786A (fr) | 2017-10-26 | 2018-10-26 | Produit d'association pour le traitement de troubles neurologiques et/ou psychiatriques |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US11723894B2 (fr) |
| EP (1) | EP3713568A1 (fr) |
| MA (1) | MA50786A (fr) |
| WO (1) | WO2019081764A1 (fr) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| MA50786A (fr) | 2017-10-26 | 2022-04-27 | Blumentech S L | Produit d'association pour le traitement de troubles neurologiques et/ou psychiatriques |
| FI4349407T3 (fi) * | 2019-02-22 | 2025-06-02 | Gh Res Ireland Limited | 5-metoksi-n,n-dimetyylitryptamiini (5-meo-dmt) vaikean masennuksen hoitoon |
| HUE069534T2 (hu) * | 2019-02-22 | 2025-03-28 | Gh Res Ireland Limited | 5-Metoxi-N,N-dimetiltriptamint (5-MeO-DMT) tartalmazó készítmény mentális rendellenességek kezelésében történõ alkalmazásra |
| US12377112B2 (en) | 2019-04-17 | 2025-08-05 | Compass Pathfinder Limited | Methods of treating neurocognitive disorders, chronic pain and reducing inflammation |
| GB201907871D0 (en) * | 2019-06-03 | 2019-07-17 | Small Pharma Ltd | Therapeutic compositions |
| EP3753923A1 (fr) | 2019-06-19 | 2020-12-23 | GH Research Limited | Récrystallisation de 5-méthoxy-n,n-diméthyltryptamine (5-meo-dmt) dans de méthyl tert.-butyl éther (mtbe) sans ajouter un antisolvant |
| EP4003395A4 (fr) * | 2019-07-23 | 2023-07-19 | Caamtech, Inc. | Compositions contenant des composés à base de sécrétions de crapaud |
| BR112022002723A2 (pt) * | 2019-08-13 | 2022-07-19 | Univ Maryland | Métodos de tratamento de transtornos psicológicos e do cérebro |
| KR20220082092A (ko) * | 2019-11-07 | 2022-06-16 | 스몰 파마 엘티디 | 화합물 |
| CN119241381A (zh) | 2019-12-26 | 2025-01-03 | 吉尔伽美什制药公司 | 芳基环己基胺衍生物及其在精神障碍的治疗中的用途 |
| KR20220137081A (ko) * | 2020-02-04 | 2022-10-11 | 마인드셋 파마 인크. | Cns 장애의 치료를 위한 세로토닌성 사이키델릭 작용제로서의 실로신 유도체 |
| KR20260008838A (ko) * | 2020-02-18 | 2026-01-16 | 길가메쉬 파마슈티컬스, 인코포레이티드 | 기분 장애 치료에 사용되기 위한 특이적 트립타민 |
| EP3868364A1 (fr) * | 2020-02-24 | 2021-08-25 | GH Research Limited | Aérosol comrpenant 5-methoxy-n,n-dimethyltryptamine |
| JP2023515616A (ja) * | 2020-02-28 | 2023-04-13 | ユニヴェルシテートスピタル バーゼル | 5ht2aアゴニストの投与後の抑制効果 |
| WO2021226416A1 (fr) | 2020-05-08 | 2021-11-11 | Psilera Inc. | Nouvelles compositions de matière et compositions pharmaceutiques |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| MX2022014900A (es) * | 2020-06-02 | 2023-03-27 | Small Pharma Ltd | Composiciones terapeuticas que comprenden compuestos n,n-dimetiltriptamina deuterada o parcialmente deuterada. |
| US12042564B2 (en) * | 2020-06-02 | 2024-07-23 | Cybin Uk Ltd | Therapeutic solid dosage forms |
| EP3902541B1 (fr) * | 2020-06-02 | 2022-09-14 | Small Pharma Ltd | Compositions thérapeutiques comprenant des composés de n,n-dimethyltryptamine deutérés ou partiellement deutérés |
| US11773062B2 (en) | 2021-03-22 | 2023-10-03 | Small Pharma Ltd | Deuterated compounds |
| BR112022025306A2 (pt) | 2020-06-12 | 2023-02-28 | Beckley Psytech Ltd | Composição compreendendo um sal benzoato de 5-metóxin, n-dimetiltriptamina |
| US11406619B2 (en) | 2020-08-28 | 2022-08-09 | Small Pharma Ltd | Injectable formulations |
| JP7422474B2 (ja) * | 2020-08-28 | 2024-01-26 | サイビン ユーケー リミテッド | 注射用製剤 |
| AU2021337466A1 (en) | 2020-09-01 | 2023-03-30 | Enveric Biosciences Canada Inc. | Halogenated psilocybin derivatives and methods of using |
| WO2022047580A1 (fr) * | 2020-09-01 | 2022-03-10 | Magicmed Industries Inc. | Dérivés de psilocybine hydroxylés et leurs procédés d'utilisation |
| EP4221682A2 (fr) * | 2020-10-02 | 2023-08-09 | Cybin IRL Limited | Méthodes d'administration de médicaments psychédéliques par inhalation et systèmes de mise en oeuvre des méthodes |
| EP4031529B1 (fr) * | 2020-12-01 | 2023-09-27 | Small Pharma Ltd | Composés de n,n-diméthyltryptamine deutérés ou partiellement deutérés |
| US12521370B2 (en) | 2020-12-01 | 2026-01-13 | Cybin Uk Ltd | Inhalable formulations |
| WO2022117640A1 (fr) * | 2020-12-01 | 2022-06-09 | Small Pharma Ltd | Formulations inhalables |
| US11660289B2 (en) | 2020-12-01 | 2023-05-30 | Small Pharma Ltd. | Deuterated or partially deuterated N,N-dimethyltryptamine compounds |
| KR20230109765A (ko) * | 2020-12-09 | 2023-07-20 | 캄테크, 인크. | 다이알킬 트립타민 및 이의 치료적 용도 |
| EP4155306A1 (fr) | 2021-01-15 | 2023-03-29 | Beckley Psytech Limited | Analogue neuroactif d'ergoline |
| US12534441B2 (en) | 2021-01-15 | 2026-01-27 | Beckley Psytech Limited | Tryptamine analogues |
| WO2022160056A1 (fr) * | 2021-01-29 | 2022-08-04 | Algernon Pharmaceuticals Inc. | Sels de dmt et leur utilisation pour traiter une lésion cérébrale |
| US11312684B1 (en) | 2021-02-10 | 2022-04-26 | Eleusis Therapeutics Us, Inc. | Pharmaceutically acceptable salts of psilocin and uses thereof |
| US20220273628A1 (en) * | 2021-02-19 | 2022-09-01 | Universitätsspital Basel | Effects of lysergic acid diethylamide (lsd) and of lsd analogs to assist psychotherapy for generalized anxiety disorder or other anxiety not related to life-threatening illness |
| US20250281513A1 (en) * | 2021-03-30 | 2025-09-11 | Mynd Life Sciences Inc. | Use of psychedelics to treat dementia |
| JP2024512796A (ja) * | 2021-04-01 | 2024-03-19 | テラン バイオサイエンシーズ インク. | サイケデリック薬およびセロトニン受容体調節因子に関する方法と組成物 |
| JP2024517738A (ja) * | 2021-04-26 | 2024-04-23 | アタイ セラピューティクス, インコーポレイテッド | 新規のn,n-ジメチルトリプタミン組成物および方法 |
| US20230136824A1 (en) | 2021-04-26 | 2023-05-04 | ATAI Life Sciences AG | N-n-dimethyltryptamine (dmt) and dmt analog compositions, methods of making, and methods of use thereof |
| EP4329759A4 (fr) | 2021-04-30 | 2025-07-16 | Mind Medicine Inc | Formes cristallines de sels de lsd |
| JP2024517194A (ja) * | 2021-05-03 | 2024-04-19 | マインド メディシン, インコーポレイテッド | サイケデリック薬の用量を漸増する方法 |
| US12611399B2 (en) * | 2021-05-04 | 2026-04-28 | Definium Therapeutics US, Inc. | Movement disorders |
| CN117642383A (zh) * | 2021-05-24 | 2024-03-01 | 卡纳-化学有限责任公司 | 二甲-4-羟色胺的结晶盐 |
| CA3219041A1 (fr) | 2021-05-24 | 2022-12-01 | Canna-Chemistries Llc | Sels cristallins de psilocine |
| CA3218110A1 (fr) | 2021-05-25 | 2022-12-01 | Majed Fawaz | Nouveaux sels de n,n-dimethyltryptamine et nouvelles formes de sel cristallin |
| AU2022287974A1 (en) | 2021-06-09 | 2024-01-04 | Atai Therapeutics, Inc. | Novel prodrugs and conjugates of dimethyltryptamine |
| AU2022309017A1 (en) | 2021-07-07 | 2024-01-25 | Terran Biosciences Inc. | N,n-dimethyltryptamine and related psychedlics and uses thereof |
| JP7846211B2 (ja) | 2021-08-19 | 2026-04-14 | デフィニウム セラピューティクス ユーエス, インコーポレイテッド | 治療適用のためのd-リゼルグ酸ジエチルアミドの即時放出製剤 |
| EP4396162A4 (fr) * | 2021-09-03 | 2025-11-12 | Alexander Shulgin Res Institute Inc | Allyl tryptamines asymétriques |
| US11697638B2 (en) | 2021-09-08 | 2023-07-11 | Small Pharma Ltd | 5-methoxy-N,N-dimethyltryptamine crystalline forms |
| EP4159192A1 (fr) | 2021-09-30 | 2023-04-05 | Biomind Labs Inc | Spray nasal à base de diméthyltriptamine pour le traitement personnalisé des troubles neurologiques et psychiatriques |
| US20250011351A1 (en) | 2021-11-12 | 2025-01-09 | Terran Biosciences Inc. | Psilocybin and o-acetylpsilocin, salts and solid state forms thereof |
| WO2023092044A2 (fr) | 2021-11-17 | 2023-05-25 | Terran Biosciences, Inc. | Sels de composés de phénéthylamine, formes polymorphes et leurs méthodes d'utilisation |
| US12318477B2 (en) | 2021-11-18 | 2025-06-03 | Cybin Uk Ltd | Injectable and inhalable formulations |
| EP4448488A2 (fr) * | 2021-12-13 | 2024-10-23 | Beckley Psytech Limited | Sel de benzoate de 5-méthoxy-n,n-diméthyltryptamine |
| WO2023129956A2 (fr) * | 2021-12-30 | 2023-07-06 | ATAI Life Sciences AG | Analogues de diméthyltryptamine utilisés en tant que médicaments d'administration d'oxyde nitrique |
| SE2250051A1 (en) | 2022-01-20 | 2023-07-21 | Amidea Sweden Ab | New pharmaceutical composition and uses thereof |
| WO2023168023A1 (fr) | 2022-03-04 | 2023-09-07 | Reset Pharmaceuticals, Inc. | Co-cristaux ou sels comprenant de la psilocine |
| WO2023186837A1 (fr) * | 2022-03-27 | 2023-10-05 | GH Research Ireland Limited | Traitement de la depression post-partum |
| IL315899A (en) * | 2022-03-27 | 2024-11-01 | Gh Res Ireland Limited | 5-METHOXY-N,N-DIMETHYLTRYPTamine for the treatment of social/emotional withdrawal or withdrawal |
| US20240000795A1 (en) * | 2022-06-30 | 2024-01-04 | Terran Biosciences Inc. | Methods and compositions relating to controlling psychedelic effects with serotonin receptor modulators |
| US12264131B2 (en) | 2022-08-19 | 2025-04-01 | Beckley Psytech Limited | Pharmaceutically acceptable salts and compositions thereof |
| GB202212116D0 (en) | 2022-08-19 | 2022-10-05 | Beckley Psytech Ltd | Pharmaceutically acceptable salts and Compositions thereof |
| EP4584247A2 (fr) * | 2022-09-06 | 2025-07-16 | ATAI Therapeutics, Inc. | Amines cycliques et alkyliques substituées par un hétéroatome en tant qu'activateurs de récepteurs de la sérotonine |
| CN115813917A (zh) * | 2022-11-02 | 2023-03-21 | 张樟进 | 一种具有快速改善认知功能的化合物及应用 |
| WO2024097868A1 (fr) * | 2022-11-02 | 2024-05-10 | Caamtech, Inc. | Relations structure-activité pour psilocybine, baéocystine, aerugincine et analogues associés pour produire des effets pharmacologiques |
| US12246005B2 (en) | 2023-06-13 | 2025-03-11 | Beckley Psytech Limited | 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations |
| US12180158B1 (en) | 2023-08-03 | 2024-12-31 | Gilgamesh Pharmaceuticals, Inc. | Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine |
| US12129234B1 (en) | 2023-08-03 | 2024-10-29 | Gilgamesh Pharmaceuticals, Inc. | Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
| WO2025052388A1 (fr) * | 2023-09-07 | 2025-03-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Composés psychédéliques, leurs procédés de préparation et leurs utilisations |
| WO2025111597A1 (fr) * | 2023-11-22 | 2025-05-30 | Gilgamesh Pharmaceuticals, Inc. | Traitement de patients atteints de troubles de l'humeur à l'aide de n-éthyl-2-(5-fluoro-1h-indol-3-yl)-n-méthyléthan-1-amine ou d'un sel pharmaceutiquement acceptable de celle-ci |
| WO2025137730A1 (fr) * | 2023-12-22 | 2025-06-26 | Alexander Shulgin Research Institute, Inc. | Tryptamines n-substituées et lysergamides n-substitués et leur utilisation comme agents thérapeutiques |
| WO2026024588A1 (fr) * | 2024-07-22 | 2026-01-29 | Reunion Neuroscience, Inc. | Compositions et traitements liés à la tryptamine à libération prolongée |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075992A (en) | 1958-09-12 | 1963-01-29 | Sandoz Ltd | Esters of indoles |
| US6579899B1 (en) * | 1998-07-16 | 2003-06-17 | Massachusetts Institute Of Technology | Composition for treatment of stress |
| CA2529857A1 (fr) | 2002-07-30 | 2004-02-05 | Peter Migaly | Combinaison de therapie pour la depression, la prevention du suicide et divers troubles medicaux et psychiatriques |
| HRP20130713T1 (en) | 2007-03-19 | 2013-09-30 | Acadia Pharmaceuticals Inc. | Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics |
| US8986677B2 (en) | 2012-07-30 | 2015-03-24 | Pop Test Cortisol Llc | Therapeutic compositions and methods |
| WO2014144130A2 (fr) * | 2013-03-15 | 2014-09-18 | Als Mountain Llc | Composition pharmaceutique comprenant un activateur d'ampk et un agent sérotoninergique et procédés d'utilisation correspondants |
| NL2018190B1 (en) | 2017-01-18 | 2018-07-26 | Procare Beheer B V | Psilocybin or psilocin in combination with cannabinoid |
| MA50786A (fr) | 2017-10-26 | 2022-04-27 | Blumentech S L | Produit d'association pour le traitement de troubles neurologiques et/ou psychiatriques |
| US11045454B2 (en) | 2018-12-06 | 2021-06-29 | Palo Alto Investors LP | Methods of treating food allergy conditions |
| BR112022002723A2 (pt) | 2019-08-13 | 2022-07-19 | Univ Maryland | Métodos de tratamento de transtornos psicológicos e do cérebro |
-
2018
- 2018-10-26 MA MA050786A patent/MA50786A/fr unknown
- 2018-10-26 US US16/958,226 patent/US11723894B2/en active Active
- 2018-10-26 WO PCT/EP2018/079503 patent/WO2019081764A1/fr not_active Ceased
- 2018-10-26 EP EP18796407.7A patent/EP3713568A1/fr active Pending
-
2023
- 2023-06-21 US US18/339,174 patent/US20240165079A1/en not_active Abandoned
- 2023-06-21 US US18/339,172 patent/US20230330063A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3713568A1 (fr) | 2020-09-30 |
| US20230330063A1 (en) | 2023-10-19 |
| US20240165079A1 (en) | 2024-05-23 |
| WO2019081764A1 (fr) | 2019-05-02 |
| US11723894B2 (en) | 2023-08-15 |
| US20200397752A1 (en) | 2020-12-24 |
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