MA47608A - Anticorps humanisé pour le traitement ou la prévention de troubles cognitifs, son procédé de production et agent pour le traitement ou la prévention de troubles cognitifs l'utilisant - Google Patents

Anticorps humanisé pour le traitement ou la prévention de troubles cognitifs, son procédé de production et agent pour le traitement ou la prévention de troubles cognitifs l'utilisant

Info

Publication number: MA47608A
Authority: MA; Morocco
Prior art keywords: prevention; treatment; cognitive disorders; agent; production process
Prior art date: 2017-02-27

Application number

MA047608A

Other languages

English (en)

Inventor

Jeanne E Baker

Hiroshi Eguchi

Angela Marie Jablonski

Daniel Stephen Malashock

Carl Mieczkowski

Takashi Murakami

Naoko Namiki

Batteur Sophie Parmentier

Gopalan Raghunathan (Raghu)

Akira Tanokura

Original Assignee

Merck Sharp & Dohme

Teijin Pharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-02-27

Filing date

2018-02-27

Publication date

2020-01-01

2018-02-27 Application filed by Merck Sharp & Dohme, Teijin Pharma Ltd filed Critical Merck Sharp & Dohme

2020-01-01 Publication of MA47608A publication Critical patent/MA47608A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Psychology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

MA047608A 2017-02-27 2018-02-27 Anticorps humanisé pour le traitement ou la prévention de troubles cognitifs, son procédé de production et agent pour le traitement ou la prévention de troubles cognitifs l'utilisant MA47608A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2017035594A JP2018139530A (ja)	2017-02-27	2017-02-27	認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤

Publications (1)

Publication Number	Publication Date
MA47608A true MA47608A (fr)	2020-01-01

Family

ID=62025891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA047608A MA47608A (fr)	2017-02-27	2018-02-27	Anticorps humanisé pour le traitement ou la prévention de troubles cognitifs, son procédé de production et agent pour le traitement ou la prévention de troubles cognitifs l'utilisant

Country Status (27)

Country	Link
US (3)	US10556950B2 (fr)
EP (1)	EP3585810B1 (fr)
JP (4)	JP2018139530A (fr)
KR (1)	KR102701634B1 (fr)
CN (2)	CN111320695B (fr)
AR (2)	AR110875A1 (fr)
AU (1)	AU2018224390C1 (fr)
BR (1)	BR112019016490A2 (fr)
CA (1)	CA3052538A1 (fr)
CL (3)	CL2019002296A1 (fr)
CO (1)	CO2019008786A2 (fr)
CR (1)	CR20190363A (fr)
DO (1)	DOP2019000215A (fr)
EA (1)	EA201991726A1 (fr)
ES (1)	ES3063126T3 (fr)
GE (2)	GEP20227392B (fr)
IL (1)	IL267945B2 (fr)
JO (1)	JOP20180014A1 (fr)
MA (1)	MA47608A (fr)
MX (2)	MX2019009945A (fr)
MY (1)	MY193821A (fr)
NI (1)	NI201900086A (fr)
PE (2)	PE20191614A1 (fr)
PH (1)	PH12019501929A1 (fr)
SG (2)	SG10201913419TA (fr)
TW (2)	TWI848904B (fr)
WO (2)	WO2018154392A1 (fr)

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PL2857039T3 (pl) *	2012-05-31	2020-05-18	Osaka City University	Środek terapeutyczny lub środek profilaktyczny na otępienie
SG11201907422RA (en)	2017-02-17	2019-09-27	Denali Therapeutics Inc	Anti-tau antibodies and methods of use thereof
JP2018139530A (ja)	2017-02-27	2018-09-13	帝人ファーマ株式会社	認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤
AU2018352308B2 (en)	2017-10-16	2025-06-05	Eisai R&D Management Co., Ltd.	Anti-tau antibodies and uses thereof
US20210355199A1 (en)	2018-06-28	2021-11-18	University Of Virginia Patent Foundation	Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
US12365724B2 (en) *	2018-12-10	2025-07-22	New York University	Antibodies binding to phospho-tau comprising phosphorylated Ser396 and Ser404 and methods of detecting thereof
US20220381790A1 (en)	2019-02-11	2022-12-01	University Of Virginia Patent Foundation	Selection and blockade of fertilization competent male and female gametes
EP3934677A4 (fr)	2019-03-13	2022-11-16	University of Virginia Patent Foundation	Compositions et méthodes pour favoriser la viabilité des îlots et améliorer la sécrétion d'insuline
JP7181438B2 (ja) *	2019-08-06	2022-11-30	アプリノイアセラピューティクスリミテッド	病理学的タウ種に結合する抗体及びその使用
CN115605594A (zh) *	2020-06-02	2023-01-13	帝人制药株式会社（Jp）	抗igf-1受体人源化抗体
CA3183835A1 (fr) *	2020-06-25	2021-12-30	Jeanne E. Baker	Anticorps a haute affinite ciblant la proteine tau phosphorylee a la position 413 de serine
US20250034559A1 (en)	2021-11-17	2025-01-30	Voyager Therapeutics, Inc.	Compositions and methods for the treatment of tau-related disorders
CN115322255B (zh) *	2022-04-25	2025-03-07	上海药明生物医药有限公司	一种优化的Fc变体及其应用
KR20250069606A (ko)	2022-09-15	2025-05-19	보이저 테라퓨틱스, 인크.	타우 결합 화합물
WO2025122634A1 (fr)	2023-12-05	2025-06-12	Voyager Therapeutics, Inc.	Compositions et méthodes pour le traitement de troubles liés à la protéine tau
WO2025207501A1 (fr) *	2024-03-26	2025-10-02	Merck Sharp & Dohme Llc	Cristaux d'anticorps monoclonal anti-tau humain
CN119080924B (zh) *	2024-07-04	2025-02-25	上海交通大学医学院附属第九人民医院	一种单克隆免疫球蛋白及其用途

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JPS587390B2 (ja)	1975-03-11	1983-02-09	ツキシマキカイカブシキガイシヤ	ア−クヨウセツホウホウ
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US5859205A (en)	1989-12-21	1999-01-12	Celltech Limited	Humanised antibodies
EP1400536A1 (fr)	1991-06-14	2004-03-24	Genentech Inc.	Procédé pour fabriquer des anticorps humanisés
WO1994004679A1 (fr)	1991-06-14	1994-03-03	Genentech, Inc.	Procede pour fabriquer des anticorps humanises
JP3587390B2 (ja)	1994-03-17	2004-11-10	タカラバイオ株式会社	リン酸化アミノ酸誘導体及びリン酸化ペプチド合成方法
JP4754352B2 (ja)	2003-08-29	2011-08-24	株式会社リバース・プロテオミクス研究所	タンパク質の固定化方法
AU2004297616B2 (en)	2003-12-04	2008-12-18	Xencor, Inc.	Methods of generating variant proteins with increased host string content and compositions thereof
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MY164376A (en)	2010-10-07	2017-12-15	Univ Leuven Kath	Phosphospecific antibodies recognizing tau
CA2813493C (fr)	2010-10-11	2019-07-09	University Of Zurich	Anticorps anti-tau humain
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PL2857039T3 (pl) *	2012-05-31	2020-05-18	Osaka City University	Środek terapeutyczny lub środek profilaktyczny na otępienie
NZ630542A (en) *	2012-08-16	2017-06-30	Ipierian Inc	Methods of treating a tauopathy
CA2896066C (fr)	2012-12-21	2022-07-12	Biogen Ma Inc.	Anticorps anti-tau humains
BR112015030356A2 (pt)	2013-06-10	2017-12-05	Ipierian Inc	métodos de tratamento de uma taupatia
AU2014368696A1 (en)	2013-12-20	2016-06-02	F. Hoffmann-La Roche Ag	Humanized anti-Tau(pS422) antibodies and methods of use
AR100978A1 (es) *	2014-06-26	2016-11-16	Hoffmann La Roche	LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
TWI734975B (zh) *	2014-06-27	2021-08-01	美商Ｃ２Ｎ醫療診斷有限責任公司	人類化抗-tau抗體
CA2961439A1 (fr)	2014-11-05	2016-05-12	Genentech, Inc.	Anticorps anti-fgfr2/3 et procedes d'utilisation de ceux-ci
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US10344081B2 (en)	2015-07-06	2019-07-09	Ucb Biopharma Sprl	Tau-binding antibodies
WO2017005734A1 (fr)	2015-07-06	2017-01-12	Ucb Biopharma Sprl	Anticorps se liant à tau
JO3711B1 (ar)	2015-07-13	2021-01-31	H Lundbeck As	أجسام مضادة محددة لبروتين تاو وطرق استعمالها
JP2018139530A (ja)	2017-02-27	2018-09-13	帝人ファーマ株式会社	認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤

2017
- 2017-02-27 JP JP2017035594A patent/JP2018139530A/ja active Pending
2018
- 2018-02-25 WO PCT/IB2018/000267 patent/WO2018154392A1/fr not_active Ceased
- 2018-02-26 TW TW107106444A patent/TWI848904B/zh active
- 2018-02-26 TW TW113125487A patent/TW202506718A/zh unknown
- 2018-02-27 KR KR1020197024146A patent/KR102701634B1/ko active Active
- 2018-02-27 MY MYPI2019004787A patent/MY193821A/en unknown
- 2018-02-27 AR ARP180100454A patent/AR110875A1/es unknown
- 2018-02-27 MA MA047608A patent/MA47608A/fr unknown
- 2018-02-27 CR CR20190363A patent/CR20190363A/es unknown
- 2018-02-27 PE PE2019001541A patent/PE20191614A1/es unknown
- 2018-02-27 US US15/906,773 patent/US10556950B2/en active Active
- 2018-02-27 JO JOP/2018/0014A patent/JOP20180014A1/ar unknown
- 2018-02-27 BR BR112019016490A patent/BR112019016490A2/pt unknown
- 2018-02-27 IL IL267945A patent/IL267945B2/en unknown
- 2018-02-27 SG SG10201913419TA patent/SG10201913419TA/en unknown
- 2018-02-27 WO PCT/IB2018/000249 patent/WO2018154390A1/fr not_active Ceased
- 2018-02-27 JP JP2019545918A patent/JP7165996B2/ja active Active
- 2018-02-27 AU AU2018224390A patent/AU2018224390C1/en active Active
- 2018-02-27 PE PE2024001024A patent/PE20241514A1/es unknown
- 2018-02-27 ES ES18718907T patent/ES3063126T3/es active Active
- 2018-02-27 GE GEAP201815170A patent/GEP20227392B/en unknown
- 2018-02-27 CN CN202010117151.0A patent/CN111320695B/zh active Active
- 2018-02-27 SG SG11201907548PA patent/SG11201907548PA/en unknown
- 2018-02-27 CN CN201880008302.XA patent/CN110382528A/zh active Pending
- 2018-02-27 EP EP18718907.1A patent/EP3585810B1/fr active Active
- 2018-02-27 MX MX2019009945A patent/MX2019009945A/es unknown
- 2018-02-27 EA EA201991726A patent/EA201991726A1/ru unknown
- 2018-02-27 CA CA3052538A patent/CA3052538A1/fr active Pending
- 2018-02-27 GE GEAP202215170A patent/GEAP202215170A/en unknown
2019
- 2019-08-09 NI NI201900086A patent/NI201900086A/es unknown
- 2019-08-13 CO CONC2019/0008786A patent/CO2019008786A2/es unknown
- 2019-08-13 CL CL2019002296A patent/CL2019002296A1/es unknown
- 2019-08-15 DO DO2019000215A patent/DOP2019000215A/es unknown
- 2019-08-20 MX MX2023013246A patent/MX2023013246A/es unknown
- 2019-08-20 PH PH12019501929A patent/PH12019501929A1/en unknown
- 2019-08-22 AR ARP190102386A patent/AR117952A2/es unknown
2020
- 2020-01-17 US US16/746,725 patent/US10894829B2/en active Active
- 2020-12-15 US US17/122,325 patent/US11739143B2/en active Active
2021
- 2021-09-13 CL CL2021002389A patent/CL2021002389A1/es unknown
2022
- 2022-10-18 JP JP2022166859A patent/JP2023002670A/ja active Pending
2024
- 2024-02-02 CL CL2024000339A patent/CL2024000339A1/es unknown
- 2024-08-28 JP JP2024146101A patent/JP2024170459A/ja active Pending

Also Published As

Publication number	Publication date
AR117952A2 (es)	2021-09-08
EA201991726A1 (ru)	2020-01-30
TW202506718A (zh)	2025-02-16
CL2021002389A1 (es)	2022-04-22
AU2018224390A1 (en)	2019-07-11
MY193821A (en)	2022-10-27
JP2018139530A (ja)	2018-09-13
MX2023013246A (es)	2023-11-21
CL2019002296A1 (es)	2019-11-29
JP2020508666A (ja)	2020-03-26
CN111320695B (zh)	2021-09-03
CL2024000339A1 (es)	2024-08-16
CN110382528A (zh)	2019-10-25
AR110875A1 (es)	2019-05-08
US10894829B2 (en)	2021-01-19
CO2019008786A2 (es)	2019-08-20
JOP20180014A1 (ar)	2019-01-30
CR20190363A (es)	2019-11-05
JP2023002670A (ja)	2023-01-10
GEP20227392B (en)	2022-06-27
AU2018224390C1 (en)	2025-04-17
BR112019016490A2 (pt)	2020-04-07
GEAP202215170A (en)	2022-02-10
ES3063126T3 (en)	2026-04-15
TWI848904B (zh)	2024-07-21
SG10201913419TA (en)	2020-03-30
JP7165996B2 (ja)	2022-11-07
CA3052538A1 (fr)	2018-08-30
WO2018154392A1 (fr)	2018-08-30
IL267945B1 (en)	2025-06-01
AU2018224390B2 (en)	2024-10-31
NI201900086A (es)	2019-10-08
US20210380677A1 (en)	2021-12-09
US20180346564A1 (en)	2018-12-06
US10556950B2 (en)	2020-02-11
CN111320695A (zh)	2020-06-23
DOP2019000215A (es)	2019-09-30
US20200223916A1 (en)	2020-07-16
EP3585810B1 (fr)	2025-11-26
JP2024170459A (ja)	2024-12-10
US11739143B2 (en)	2023-08-29
PH12019501929A1 (en)	2020-06-29
EP3585810A1 (fr)	2020-01-01
KR20190122674A (ko)	2019-10-30
IL267945A (en)	2019-09-26
WO2018154390A1 (fr)	2018-08-30
IL267945B2 (en)	2025-10-01
TW201843179A (zh)	2018-12-16
PE20191614A1 (es)	2019-11-05
SG11201907548PA (en)	2019-09-27
MX2019009945A (es)	2019-11-05
PE20241514A1 (es)	2024-07-19
KR102701634B1 (ko)	2024-08-30

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EP3819284A4 (fr)	2022-04-20	Catalyseur pour la préparation de 1,2-pentanediol et procédé de préparation de 1,2-pentanediol l'utilisant
EP3778619A4 (fr)	2021-06-30	Segment pour la synthèse d'oligonucléotides, procédé de production correspondant et procédé de synthèse d'oligonucléotides l'utilisant
EP3421506A4 (fr)	2019-05-29	Catalyseur supporté de type métallocène et procédé de production de polypropylène l'utilisant
EP3606520A4 (fr)	2021-01-06	Inhibiteurs de l'activité de la déshydrogénase à chaîne courte pour le traitement des troubles coronaires
EP3496715A4 (fr)	2020-01-22	Composés utiles pour modifier les taux d'acides biliaires pour le traitement du diabète et de maladies cardiométaboliques.
EP3728567A4 (fr)	2021-09-22	Procédés pour le développement de produits pharmaceutiques pour le traitement d'affections neurodégénératives
EP3529234A4 (fr)	2020-03-11	Composés, procédé d'obtention des composés, composition pharmaceutique, utilisation des composés et procédé de traitement de troubles psychiatriques et/ou de troubles du sommeil
EP3858483A4 (fr)	2022-01-19	Catalyseur pour ammoxydation de propylène, son procédé de préparation et procédé d'ammoxydation de propylène l'utilisant
EP3573616C0 (fr)	2025-12-10	Nouvel inhibiteur du protéasome spiro et cyclique bis-benzylidine pour le traitement du cancer, du diabète et de troubles neurologiques
EP3730144A4 (fr)	2021-09-01	Agent pour le traitement d'une maladie du système nerveux
EP3398614A4 (fr)	2019-12-25	Agent pour la prévention et/ou le traitement de la maladie d'alzheimer
EP3710015A4 (fr)	2021-11-10	Utilisation d'agents srsf3 pour le traitement et/ou la prévention d'affections neurologiques, du cancer, d'infections bactériennes ou d'infections virales
EP3496716A4 (fr)	2020-01-22	Composés utiles pour modifier les taux d'acides biliaires pour le traitement du diabète et de maladies cardiométaboliques.