MA50908A - Formulations de protéines de fusion vegfr-fc - Google Patents
Formulations de protéines de fusion vegfr-fcInfo
- Publication number
- MA50908A MA50908A MA050908A MA50908A MA50908A MA 50908 A MA50908 A MA 50908A MA 050908 A MA050908 A MA 050908A MA 50908 A MA50908 A MA 50908A MA 50908 A MA50908 A MA 50908A
- Authority
- MA
- Morocco
- Prior art keywords
- vegfr
- fusion protein
- protein formulations
- formulations
- fusion
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762587733P | 2017-11-17 | 2017-11-17 | |
| US201862618904P | 2018-01-18 | 2018-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA50908A true MA50908A (fr) | 2020-09-23 |
Family
ID=65041879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA050908A MA50908A (fr) | 2017-11-17 | 2018-11-16 | Formulations de protéines de fusion vegfr-fc |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US12156900B2 (fr) |
| EP (1) | EP3709971A2 (fr) |
| JP (2) | JP7536640B2 (fr) |
| AU (2) | AU2018368466B2 (fr) |
| CA (1) | CA3082899A1 (fr) |
| MA (1) | MA50908A (fr) |
| MX (2) | MX2020005170A (fr) |
| WO (1) | WO2019099921A2 (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020005170A (es) | 2017-11-17 | 2020-10-16 | Amgen Inc | Formulaciones de proteinas de fusion vegfr-fc. |
| EP4495136A3 (fr) | 2018-01-26 | 2025-04-23 | The Regents of the University of California | Méthodes et compositions pour le traitement de troubles angiogéniques à l'aide d'agents anti-vegf |
| EP3761953A1 (fr) * | 2018-03-08 | 2021-01-13 | Coherus Biosciences, Inc. | Formulations aqueuses stables d'aflibercept |
| US11426446B2 (en) | 2018-03-08 | 2022-08-30 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
| SG11202010684YA (en) | 2018-05-10 | 2020-11-27 | Regeneron Pharma | High concentration vegf receptor fusion protein containing formulations |
| WO2020055123A1 (fr) * | 2018-09-10 | 2020-03-19 | 삼성바이오에피스 주식회사 | Composition liquide comprenant une protéine |
| WO2021050687A1 (fr) * | 2019-09-10 | 2021-03-18 | Coherus Biosciences, Inc. | Formulations aqueuses stables d'aflibercept |
| BR112022010113A2 (pt) | 2019-11-25 | 2022-09-06 | Univ California | Inibidores de vegf de longa ação para neovascularização intraocular |
| CA3190325A1 (fr) * | 2020-07-31 | 2022-02-03 | Celltrion Inc. | Preparation pharmaceutique stable |
| US20240166718A1 (en) * | 2021-02-17 | 2024-05-23 | Arecor Limited | Aqueous composition of an engineered protein construct comprising an fc domain |
| US11723955B1 (en) | 2022-05-13 | 2023-08-15 | Allgenesis Biotherapeutics Inc. | VEGFR fusion protein pharmaceutical composition |
| US12240888B1 (en) * | 2024-04-29 | 2025-03-04 | QILU Pharmaceutical, Co., Ltd. | Composition comprising aflibercept and a variant thereof, and related methods and uses |
| WO2025227916A1 (fr) * | 2024-04-29 | 2025-11-06 | 齐鲁制药有限公司 | Composition comprenant de l'aflibercept et un variant de celui-ci, son procédé associé et son utilisation |
| DE102025103344A1 (de) | 2024-09-17 | 2026-03-19 | Kioxia Corporation | Speichersystem und verfahren zur steuerung eines nichtflüchtigen speichers |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL215168B1 (pl) | 2002-02-27 | 2013-10-31 | Immunex Corp | Formulacja polipeptydowa |
| HRP20050934B1 (hr) | 2003-04-04 | 2014-09-26 | Genentech, Inc. | Formulacije s visokom koncentracijom antitijela i proteina |
| EP1877438A2 (fr) | 2005-02-02 | 2008-01-16 | Regeneron Pharmaceuticals, Inc. | Methode de traitement de lesion oculaire par l'administration locale d'un inhibiteur de vegf |
| EP2586459B1 (fr) | 2005-03-25 | 2017-05-24 | Regeneron Pharmaceuticals, Inc. | Formulations antagonistes du VEGF |
| ES2776657T3 (es) | 2005-06-14 | 2020-07-31 | Amgen Inc | Formulaciones de proteínas autotamponantes |
| US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
| EP3753548A1 (fr) | 2006-06-16 | 2020-12-23 | Regeneron Pharmaceuticals, Inc. | Formulations antagonistes vegf appropriées pour l'administration intravitréenne |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| CN103816115B (zh) | 2010-08-31 | 2017-06-27 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| EP2790681B9 (fr) | 2011-11-18 | 2023-07-26 | Regeneron Pharmaceuticals, Inc. | Procédé de préparation d'une formulation pharmaceutique à libération prolongée comprenant microparticules de protéine revêtues de polymère en utilisant séchage par atomisation |
| ES2751386T3 (es) | 2011-12-21 | 2020-03-31 | Amgen Inc | Polipéptidos Fc variantes con unión potenciada al receptor de Fc neonatal |
| CN107115294B (zh) | 2012-01-19 | 2019-10-18 | 北京康弘生物医药有限公司 | 一种含有vegf拮抗剂的滴眼液 |
| AR091237A1 (es) | 2012-06-01 | 2015-01-21 | Ophthotech Corp | Composiciones que comprenden un aptamero anti factor de crecimiento derivado de plaquetas (anti-pdgf) y un antagonista de factor de crecimiento de endotelio vascular (vegf) |
| US20130323242A1 (en) * | 2012-06-01 | 2013-12-05 | Ophthotech Corp. | Compositions comprising an anti-pdgf aptamer and a vegf antagonist |
| UA115789C2 (uk) * | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
| US9649383B2 (en) | 2012-11-19 | 2017-05-16 | Merck Sharp & Dohme Corp. | Liquid formulations for TNFR:Fc fusion proteins |
| CN105636986B (zh) | 2013-10-18 | 2020-05-12 | 瑞泽恩制药公司 | 包含vegf拮抗剂和抗-ctla-4抗体的组合的方法和组合物 |
| CN105435222B (zh) | 2014-09-25 | 2018-05-29 | 信达生物制药(苏州)有限公司 | 重组融合蛋白制剂 |
| KR101808234B1 (ko) * | 2015-06-23 | 2017-12-12 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제 |
| CA3001346A1 (fr) * | 2015-10-16 | 2017-04-20 | Regeneron Pharmaceuticals, Inc. | Compositions proteiniques stables |
| EA201891164A1 (ru) * | 2015-12-16 | 2018-11-30 | Ридженерон Фармасьютикалз, Инк. | Композиции и способы получения белковых микрочастиц |
| AU2017213103B2 (en) * | 2016-01-26 | 2022-08-11 | Formycon Ag | Liquid formulation of a VEGF antagonist |
| WO2017168296A1 (fr) | 2016-03-29 | 2017-10-05 | Navya Biologicals Pvt. Ltd | Procédé de purification de protéines de fusion fc |
| KR101685532B1 (ko) | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
| CA3038894A1 (fr) | 2016-09-28 | 2018-04-05 | Board Of Regents, The University Of Texas System | Formulations therapeutiques d'anticorps et de proteines et leurs utilisations |
| EP3528787B1 (fr) | 2016-10-21 | 2026-01-07 | Amgen Inc. | Formulations pharmaceutiques et leurs procédés de préparation |
| EP3541365A1 (fr) | 2016-11-21 | 2019-09-25 | Just Biotherapeutics, Inc. | Formulations d'aflibercecept et leurs utilisations |
| US20200131251A1 (en) | 2016-12-23 | 2020-04-30 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
| KR101861163B1 (ko) | 2017-04-26 | 2018-05-25 | 삼천당제약주식회사 | 안과용 약학 조성물 |
| WO2019020777A1 (fr) | 2017-07-26 | 2019-01-31 | Formycon Ag | Formulation liquide d'un antagoniste du vegf |
| WO2019055902A1 (fr) | 2017-09-18 | 2019-03-21 | Amgen Inc. | Formules de protéines de fusion vegfr-fc |
| CN107595765A (zh) | 2017-09-22 | 2018-01-19 | 沈阳兴齐眼药股份有限公司 | 一种眼用缓释药物递送系统及其制备方法 |
| MX2020005170A (es) | 2017-11-17 | 2020-10-16 | Amgen Inc | Formulaciones de proteinas de fusion vegfr-fc. |
| WO2019099965A1 (fr) | 2017-11-20 | 2019-05-23 | Just Biotherapeutics, Inc. | Formulations d'aflibercept contenant un sel de lysine en tant qu'agent de tonicification et leurs utilisations |
| JP7692699B2 (ja) | 2017-12-22 | 2025-06-16 | サムスン バイオエピス カンパニー リミテッド | Vegfアンタゴニストを含む液体組成物 |
| US11426446B2 (en) | 2018-03-08 | 2022-08-30 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
| EP3761953A1 (fr) | 2018-03-08 | 2021-01-13 | Coherus Biosciences, Inc. | Formulations aqueuses stables d'aflibercept |
| SG11202010684YA (en) | 2018-05-10 | 2020-11-27 | Regeneron Pharma | High concentration vegf receptor fusion protein containing formulations |
| WO2020055123A1 (fr) | 2018-09-10 | 2020-03-19 | 삼성바이오에피스 주식회사 | Composition liquide comprenant une protéine |
| US20210353713A1 (en) | 2018-10-26 | 2021-11-18 | Amgen Inc. | Formulations comprising a tris buffer and a protein |
| WO2020165132A1 (fr) | 2019-02-13 | 2020-08-20 | Novaliq Gmbh | Compositions et procédés pour le traitement de la néovascularisation oculaire |
| GB201911461D0 (en) | 2019-08-09 | 2019-09-25 | Arecor Ltd | Novel composition |
| WO2021050687A1 (fr) | 2019-09-10 | 2021-03-18 | Coherus Biosciences, Inc. | Formulations aqueuses stables d'aflibercept |
-
2018
- 2018-11-16 MX MX2020005170A patent/MX2020005170A/es unknown
- 2018-11-16 JP JP2020527828A patent/JP7536640B2/ja active Active
- 2018-11-16 MA MA050908A patent/MA50908A/fr unknown
- 2018-11-16 WO PCT/US2018/061644 patent/WO2019099921A2/fr not_active Ceased
- 2018-11-16 EP EP18836718.9A patent/EP3709971A2/fr active Pending
- 2018-11-16 AU AU2018368466A patent/AU2018368466B2/en active Active
- 2018-11-16 US US16/764,463 patent/US12156900B2/en active Active
- 2018-11-16 CA CA3082899A patent/CA3082899A1/fr active Pending
-
2020
- 2020-07-13 MX MX2025004779A patent/MX2025004779A/es unknown
-
2024
- 2024-07-31 AU AU2024205240A patent/AU2024205240A1/en active Pending
- 2024-08-06 JP JP2024129687A patent/JP2024160287A/ja active Pending
- 2024-11-25 US US18/959,137 patent/US20250082726A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019099921A2 (fr) | 2019-05-23 |
| AU2018368466B2 (en) | 2024-06-20 |
| US20200338164A1 (en) | 2020-10-29 |
| EP3709971A2 (fr) | 2020-09-23 |
| US12156900B2 (en) | 2024-12-03 |
| AU2018368466A1 (en) | 2020-06-18 |
| JP2024160287A (ja) | 2024-11-13 |
| AU2024205240A1 (en) | 2024-08-22 |
| US20250082726A1 (en) | 2025-03-13 |
| WO2019099921A3 (fr) | 2019-06-27 |
| JP2021503485A (ja) | 2021-02-12 |
| MX2020005170A (es) | 2020-10-16 |
| JP7536640B2 (ja) | 2024-08-20 |
| MX2025004779A (es) | 2025-05-02 |
| CA3082899A1 (fr) | 2019-05-23 |
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