DK4364724T3 - Formuleringer med høj koncentration af VEGF-receptorfusionsprotein - Google Patents

Formuleringer med høj koncentration af VEGF-receptorfusionsprotein

Info

Publication number
DK4364724T3
DK4364724T3 DK24156902.9T DK24156902T DK4364724T3 DK 4364724 T3 DK4364724 T3 DK 4364724T3 DK 24156902 T DK24156902 T DK 24156902T DK 4364724 T3 DK4364724 T3 DK 4364724T3
Authority
DK
Denmark
Prior art keywords
formulations
fusion protein
high concentration
vegf receptor
receptor fusion
Prior art date
Application number
DK24156902.9T
Other languages
English (en)
Inventor
Kenneth S Graham
Saurabh Wadhwa
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66669104&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK4364724(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK4364724T3 publication Critical patent/DK4364724T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK24156902.9T 2018-05-10 2019-05-10 Formuleringer med høj koncentration af VEGF-receptorfusionsprotein DK4364724T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862669506P 2018-05-10 2018-05-10
US201862752127P 2018-10-29 2018-10-29
US201862769876P 2018-11-20 2018-11-20
US201962813882P 2019-03-05 2019-03-05
EP19727219.8A EP3790532A1 (en) 2018-05-10 2019-05-10 High concentration vegf receptor fusion protein containing formulations

Publications (1)

Publication Number Publication Date
DK4364724T3 true DK4364724T3 (da) 2025-12-22

Family

ID=66669104

Family Applications (1)

Application Number Title Priority Date Filing Date
DK24156902.9T DK4364724T3 (da) 2018-05-10 2019-05-10 Formuleringer med høj koncentration af VEGF-receptorfusionsprotein

Country Status (28)

Country Link
US (4) US11103552B2 (da)
EP (3) EP4364724B1 (da)
JP (3) JP7235770B2 (da)
KR (1) KR20210021299A (da)
CN (5) CN116585466A (da)
AU (3) AU2019265005B2 (da)
BR (1) BR112020022610A2 (da)
CA (2) CA3099551C (da)
CL (3) CL2020002872A1 (da)
CO (1) CO2020014427A2 (da)
DK (1) DK4364724T3 (da)
ES (1) ES3056525T3 (da)
FI (1) FI4364724T3 (da)
HR (1) HRP20260001T1 (da)
IL (2) IL278375B2 (da)
JO (1) JOP20200275A1 (da)
LT (1) LT4364724T (da)
MA (1) MA52570A (da)
MX (3) MX421310B (da)
MY (1) MY204232A (da)
NZ (1) NZ770284A (da)
PH (1) PH12020551839A1 (da)
PL (1) PL4364724T3 (da)
PT (1) PT4364724T (da)
RS (1) RS67656B1 (da)
SG (1) SG11202010684YA (da)
SI (1) SI4364724T1 (da)
WO (1) WO2019217927A1 (da)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101482483B1 (ko) 2006-04-07 2015-01-15 에르피오 세러퓨틱스 인코포레이티드 인간 단백질 타이로신 포스파타아제 베타(ｈｐｔｐ베타)에 결합하는 항체 및 그의 용도
CA2838246C (en) 2011-06-13 2018-07-10 Csl Limited Antibodies against g-csfr and uses thereof
CA2850830A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome and cancer
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
KR20250057128A (ko) 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
DK3619324T3 (da) 2017-05-05 2025-09-22 Trefoil Therapeutics Inc Rekombinante modificerede fibroblast-vækstfaktorer og terapeutiske anvendelser heraf
MA50908A (fr) 2017-11-17 2020-09-23 Amgen Inc Formulations de protéines de fusion vegfr-fc
JP7465210B2 (ja) 2017-11-29 2024-04-10 シーエスエル リミティド 虚血－再灌流障害の治療又は予防方法
AU2018375398C1 (en) 2017-11-30 2026-01-15 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
EP3730126B1 (en) * 2017-12-22 2025-05-14 Samsung Bioepis Co., Ltd. Liquid composition comprising vegf antagonist
US11524053B2 (en) 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
WO2019154776A1 (en) 2018-02-06 2019-08-15 F. Hoffmann-La Roche Ag Treatment of ophthalmologic diseases
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
JP7235770B2 (ja) 2018-05-10 2023-03-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 高濃度ｖｅｇｆ受容体融合タンパク質を含む製剤
US10894824B2 (en) 2018-09-24 2021-01-19 Aerpio Pharmaceuticals, Inc. Multispecific antibodies that target HPTP-β (VE-PTP) and VEGF
SG11202103064YA (en) 2018-10-29 2021-05-28 Hoffmann La Roche Antibody formulation
SG11202108627SA (en) 2019-02-18 2021-09-29 Lilly Co Eli Therapeutic antibody formulation
MA54325A (fr) 2019-06-05 2022-05-11 Regeneron Pharma Dispositifs et procédés pour l'administration précise de doses
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
AU2020393842A1 (en) * 2019-11-25 2022-06-16 The Regents Of The University Of California Long-acting VEGF inhibitors for intraocular neovascularization
KR20240007293A (ko) 2019-12-06 2024-01-16 리제너론 파아마슈티컬스, 인크. 항-vegf 단백질 조성물 및 이를 생산하는 방법
CN115698245A (zh) * 2020-01-27 2023-02-03 百时美施贵宝公司 等电聚焦样品基质
AU2021262609A1 (en) 2020-05-01 2022-12-22 Kashiv Biosciences, Llc An improved process of purification of protein
MX2022013812A (es) 2020-05-08 2022-12-15 Regeneron Pharma Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer.
CN115768475A (zh) 2020-06-04 2023-03-07 Csl创新私人有限公司 治疗或预防急性呼吸窘迫综合征的方法
JP2023532046A (ja) * 2020-06-26 2023-07-26 トレフォイル セラピューティクス，インク． 組換え修飾線維芽細胞増殖因子およびそれを使用した治療
KR20220001106A (ko) * 2020-06-29 2022-01-05 (주)메디톡스 고농도 항-ｖｅｇｆ 항체 제제 및 이에 사용하기 위한 항-ｖｅｇｆ 항체
JP7560185B2 (ja) * 2020-07-07 2024-10-02 カナプ セラピューティクス インコーポレイテッド 補体経路阻害剤及び血管新生阻害剤を含む融合タンパク質並びにその使用
US20230340529A1 (en) * 2020-09-03 2023-10-26 University Of Massachusetts Adeno-associated virus for delivery of kh902 (conbercept) and uses thereof
EP4225330A1 (en) 2020-10-06 2023-08-16 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022125788A1 (en) * 2020-12-10 2022-06-16 Stemline Therapeutics, Inc. Improved lyophilized formulation
JP2023554087A (ja) * 2020-12-16 2023-12-26 シーエスエル イノベーション プロプライアタリー リミティド タンパク質製剤及びその使用
CN114681592A (zh) * 2020-12-31 2022-07-01 天境生物科技(杭州)有限公司 包含可溶性gp130二聚体的制剂和使用方法
CN116867481A (zh) * 2021-02-17 2023-10-10 艾瑞克有限公司 包含Fc结构域的工程化蛋白质构建体的水性组合物
CA3213505A1 (en) * 2021-03-16 2022-09-22 Kashiv Biosciences, Llc Novel formulation of fusion protein
WO2022199603A1 (en) * 2021-03-25 2022-09-29 Nanjing GenScript Biotech Co., Ltd. Antibody fusion proteins and uses thereof
PL4185318T3 (pl) 2021-05-17 2026-01-12 Regeneron Pharmaceuticals, Inc. Rozszerzone schematy leczenia dużymi dawkami antagonistów vegf w leczeniu angiogennych zaburzeń oka
CN113289029B (zh) * 2021-05-20 2023-09-05 上海赛金生物医药有限公司 一种单克隆抗体-细胞因子融合蛋白制剂
EP4398877A1 (en) * 2021-09-06 2024-07-17 LEK Pharmaceuticals d.d. Formulations for vegf receptor fusion proteins
JP2023135646A (ja) 2022-03-15 2023-09-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 血管新生性眼障害の処置のための長期高用量ｖｅｇｆアンタゴニストレジメン
AU2023234355A1 (en) * 2022-03-15 2024-09-19 Bayer Healthcare Llc Extended, high dose vegf antagonist regimens for treatment of angiogenic eye disorders
WO2023206134A1 (en) * 2022-04-27 2023-11-02 Beijing Sightnovo Medical Technology Co., Ltd Compositions and methods for eye diseases
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition
CA3265082A1 (en) * 2022-09-01 2024-03-07 Vegenics Pty Limited PHARMACEUTICAL COMPOSITION AND METHOD OF USE
TW202412840A (zh) * 2022-09-16 2024-04-01 大陸商齊魯製藥有限公司 一種穩定的高濃度自緩衝藥物組合物
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
AU2024218755A1 (en) * 2023-02-10 2025-09-11 Innovent Biologics (Suzhou) Co., Ltd. Pharmaceutical preparation containing anti-vegfa and anti-vegfc bispecific binding protein
JP2025003405A (ja) 2023-06-23 2025-01-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 眼内血管新生性疾患の治療のための、ｖｅｇｆアンタゴニストの延長された高用量レジメン
WO2025122670A1 (en) * 2023-12-05 2025-06-12 Kodiak Sciences Inc. Formulations for dual vegf/il-6 inhibitors, anti-vegf antibodies, and conjugates thereof
WO2025177156A1 (en) * 2024-02-20 2025-08-28 Lupin Limited Stable ophthalmic pharmaceutical formulation of aflibercept
WO2025217334A1 (en) * 2024-04-09 2025-10-16 Regeneron Pharmaceuticals, Inc. Low concentration vegf receptor fusion protein containing formulations
WO2025217676A1 (en) * 2024-04-15 2025-10-23 CSL Innovation Pty Ltd Protein formulations and uses thereof
WO2025219484A1 (en) 2024-04-16 2025-10-23 Alvotech Hf High concentration aflibercept formulations
CN118108862B (zh) * 2024-04-29 2024-08-09 上海鼎新基因科技有限公司 抗血管新生的融合蛋白及其应用

Family Cites Families (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580856A (en) 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
KR19980703876A (ko) 1995-04-14 1998-12-05 스티븐 엘. 허스트 분산성이 개선된 분말화된 약학적 조성물
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
IL132240A0 (en) 1997-04-07 2001-03-19 Genentech Inc Anti-vegf antibodies
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
AUPP494798A0 (en) 1998-07-29 1998-08-20 Pacific Biolink Pty Limited Protective protein formulation
US6833349B2 (en) 1999-06-08 2004-12-21 Regeneron Pharmaceuticals, Inc. Methods of treating inflammatory skin diseases
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7303746B2 (en) 1999-06-08 2007-12-04 Regeneron Pharmaceuticals, Inc. Methods of treating eye disorders with modified chimeric polypeptides
MXPA01012630A (es) 1999-06-08 2002-07-22 Regeneron Pharma Polipeptidos quimericos modificados con propiedades farmacocineticas mejoradas.
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
US6586574B1 (en) 1999-08-17 2003-07-01 Nn A/S Stabilization of freeze-dried cake
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
JP4340062B2 (ja) 2000-10-12 2009-10-07 ジェネンテック・インコーポレーテッド 粘度の減少した濃縮タンパク質製剤
AU2002324556A1 (en) 2001-07-25 2003-02-17 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
AU2002335046A1 (en) 2001-10-19 2003-05-06 Inhale Therapeutic Systems, Inc. The use of proton sequestering agents in drug formulations
US20050123509A1 (en) 2001-10-19 2005-06-09 Lehrman S. R. Modulating charge density to produce improvements in the characteristics of spray-dried proteins
ES2392073T3 (es) 2001-11-08 2012-12-04 Abbott Biotherapeutics Corp. Formulación farmacéutica líquida estable de anticuerpos IGG
SI1478394T1 (sl) 2002-02-27 2008-12-31 Immunex Corp STABILIZIRAN TNFR-Fc SESTAVEK Z ARGININOM
AU2004229335C1 (en) 2003-04-04 2010-06-17 Genentech, Inc. High concentration antibody and protein formulations
US7399612B2 (en) 2003-06-30 2008-07-15 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
AR046510A1 (es) 2003-07-25 2005-12-14 Regeneron Pharma Composicion de un antagonista de vegf y un agente anti-proliferativo
US20050112061A1 (en) 2003-08-06 2005-05-26 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
US20050196340A1 (en) 2003-08-06 2005-09-08 Jocelyn Holash Use of a VEGF antagonist in combination with radiation therapy
NZ592039A (en) 2003-08-27 2013-03-28 Ophthotech Corp Combination therapy for the treatment of ocular neovascular disorders
PL1767546T3 (pl) 2004-06-08 2012-07-31 Chengdu Kanghong Biotechnologies Co Ltd Hamujące angiogenezę białka chimeryczne i ich zastosowanie
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
EP1802334B1 (en) 2004-10-21 2012-08-29 Genentech, Inc. Method for treating intraocular neovascular diseases
HUE034109T2 (en) 2005-03-25 2018-01-29 Regeneron Pharma VEGF antagonist formulations
WO2006138181A2 (en) 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
EP2377554A1 (en) 2005-07-22 2011-10-19 Amgen, Inc Concentrated protein lyophilates, methods and uses
AU2006272714A1 (en) 2005-07-25 2007-02-01 Trubion Pharmaceuticals, Inc. Compositions and methods for protein deaggregation
KR20080071192A (ko) 2005-11-22 2008-08-01 와이어쓰 면역글로불린 융합 단백질 제형
JP5405122B2 (ja) 2005-12-21 2014-02-05 ワイス・エルエルシー 低粘度のタンパク質製剤およびその用途
FR2895258B1 (fr) 2005-12-22 2008-03-21 Aventis Pharma Sa Combinaison comprenant de la combretastatine et des agents anticancereux
JP2009525986A (ja) 2006-02-03 2009-07-16 メディミューン，エルエルシー タンパク質製剤
TW200806317A (en) 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
US8216575B2 (en) 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
CN100502945C (zh) 2006-03-31 2009-06-24 成都康弘生物科技有限公司 Vegf受体融合蛋白在治疗眼睛疾病中的应用
SI2944306T1 (sl) 2006-06-16 2021-04-30 Regeneron Pharmaceuticals, Inc. Formulacije antagonista VEGF, primerne za intravitrealno dajanje
WO2009015345A1 (en) 2007-07-25 2009-01-29 Amgen Inc. Pharmaceutical compositions comprising fc fusion proteins
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
ES2968301T3 (es) 2008-08-05 2024-05-08 Wyeth Llc Liofilización por encima del colapso
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2010148321A1 (en) 2009-06-18 2010-12-23 Wyeth Llc Slow dissolution method for reconstitution of lyophilized material
CA2764180A1 (en) 2009-06-18 2010-12-23 Wyeth Llc Lyophilized formulations for small modular immunopharmaceuticals
EP2453874A2 (en) 2009-07-14 2012-05-23 Biogen Idec MA Inc. Methods for inhibiting yellow color and peroxide formation in a composition
EP2458990B1 (en) 2009-07-28 2016-03-30 Merck Sharp & Dohme Corp. Methods for producing high concentration lyophilized pharmaceutical formulations
WO2011017330A1 (en) 2009-08-04 2011-02-10 Genentech Inc Concentrated polypeptide formulations with reduced viscosity
US20130029909A1 (en) 2009-09-15 2013-01-31 John Ryan Treatment of cancer
EP3409289B1 (en) 2010-02-26 2020-09-30 Novo Nordisk A/S Stable antibody containing compositions
BR112012022223B1 (pt) 2010-03-01 2022-08-09 Cytodyn Inc Formulação de proteína concentrada, uso e método de preparação da mesma
CN102958538A (zh) 2010-05-03 2013-03-06 弗·哈夫曼-拉罗切有限公司 用于降低含有蛋白质的制剂的粘度的组合物和方法
MX2012014523A (es) 2010-07-02 2013-01-29 Genentech Inc Tratamiento de desprendimiento epitelial de pigmento vascularizado con terapia anti-vegf.
WO2012019047A2 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Subconjunctival implant for posterior segment drug delivery
CN103816115B (zh) * 2010-08-31 2017-06-27 成都康弘生物科技有限公司 一种含有抑制血管增生的融合蛋白的药物组合物及用途
CN102380096B (zh) 2010-08-31 2014-04-30 成都康弘生物科技有限公司 一种含有抑制血管增生的融合蛋白的药物组合物及用途
CN103533950A (zh) 2011-01-13 2014-01-22 瑞泽恩制药公司 Vegf拮抗剂在治疗血管生成眼病中的用途
DK2701773T3 (da) 2011-04-25 2019-05-20 Icon Bioscience Inc Dosisstyredele til injektionssprøjte
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
WO2013012022A1 (ja) 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
WO2013063510A1 (en) 2011-10-28 2013-05-02 Integritybio Inc. Protein formulations containing amino acids
GB201122408D0 (en) 2011-12-23 2012-02-08 Univ Strathclyde Method for preparing dry protein formulations
NZ627859A (en) 2012-01-23 2015-09-25 Regeneron Pharma Stabilized formulations containing anti-ang2 antibodies
TWI775096B (zh) 2012-05-15 2022-08-21 澳大利亞商艾佛蘭屈澳洲私營有限公司 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
PT3858405T (pt) 2012-06-01 2023-06-26 Novartis Ag Seringa
US20130323242A1 (en) 2012-06-01 2013-12-05 Ophthotech Corp. Compositions comprising an anti-pdgf aptamer and a vegf antagonist
EA201492289A1 (ru) 2012-06-01 2015-05-29 Офтотек Корпорейшн Композиции, содержащие аптамер против pdgf и антагонист vegf
US20150150982A1 (en) 2012-06-12 2015-06-04 Boehringer Ingelheim International Gmbh Pharmaceutical formulation for a therapeutic antibody
DE202013000688U1 (de) 2012-07-03 2013-03-05 Novartis Ag Glas-Spritze
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
KR102467714B1 (ko) 2012-11-08 2022-11-16 클리어사이드 바이오메디컬, 인코포레이드 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치
US9474803B2 (en) 2012-11-27 2016-10-25 Alteogen Inc. Composition for stabilizing fusion protein in which protein and FC domain are fused
EP2956468B1 (en) 2013-02-12 2020-06-10 Bristol-Myers Squibb Company Tangential flow filtration based protein refolding methods
US10274503B2 (en) 2013-05-08 2019-04-30 Vegenics Pty Limited Methods of using VEGF-C biomarkers for age-related macular degeneration (AMD) diagnosis
EP3003369A4 (en) 2013-05-28 2017-04-26 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions comprising pyrophosphate
KR102465025B1 (ko) 2013-07-18 2022-11-09 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
EP3628324A1 (en) 2013-11-05 2020-04-01 Allergan, Inc. Method of treating conditions of the eye with an anti-vegf darpin
RU2702748C2 (ru) 2014-05-12 2019-10-11 Формикон Аг Предварительно заполненный пластиковый шприц, содержащий антагонист vegf
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
CA2952609A1 (en) 2014-06-26 2015-12-30 Amgen Inc. Solid protein formulations comprising stabilizer, sugar alcohol, sugar and surfactant
WO2016008975A1 (en) 2014-07-18 2016-01-21 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
CN105435222B (zh) 2014-09-25 2018-05-29 信达生物制药(苏州)有限公司 重组融合蛋白制剂
CN104940926B (zh) 2014-09-25 2017-09-22 信达生物制药(苏州)有限公司 重组融合蛋白制剂
TWI738632B (zh) 2014-11-07 2021-09-11 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
US20160144025A1 (en) 2014-11-25 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and formulations for treating vascular eye diseases
HUE057653T2 (hu) 2014-12-11 2022-05-28 Bayer Healthcare Llc Kis aktív choroidális neurovaszkularizáció lézióval jellemzett idõskori makuladegeneráció kezelése
BR112017020948A2 (pt) * 2015-03-31 2018-07-10 Ildong Pharm Co., Ltd. composição farmacêutica, método para preparar um agente, método para tratar uma doença ocular e uso de uma proteína de fusão
RU2766890C2 (ru) 2015-06-16 2022-03-16 Мерк Патент Гмбх Комбинированные способы лечения антагонистами pd-l1
KR101808234B1 (ko) * 2015-06-23 2017-12-12 (주)알테오젠 IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제
MX2018000869A (es) 2015-07-22 2018-07-06 Iconic Therapeutics Inc Metodos para tratar trastornos asociados con la angiogenesis y la neovascularizacion.
AU2016329034B2 (en) 2015-09-22 2019-05-23 Pfizer Inc. Method of preparing a therapeutic protein formulation and antibody formulation produced by such a method
JP6959912B2 (ja) 2015-09-23 2021-11-05 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
CA3001346A1 (en) 2015-10-16 2017-04-20 Regeneron Pharmaceuticals, Inc. Stable protein compositions
HK1257422A1 (zh) 2015-10-30 2019-10-18 豪夫迈‧罗氏有限公司 抗-因子d抗体变体缀合物及其用途
RU2734958C2 (ru) 2015-11-18 2020-10-26 Формикон Аг Предварительно заполненная фармацевтическая упаковка, содержащая жидкий состав на основе антагониста vegf
WO2017085253A1 (en) 2015-11-18 2017-05-26 Formycon Ag Pre-filled plastic syringe containing a vegf antagonist
EP3383435A4 (en) 2015-11-30 2019-07-10 Medimmune, LLC OPTIMIZED RATES OF AMINO ACIDS AND SUGARS AS AMORPHOUS STABILIZING COMPOUNDS IN PHARMACEUTICAL COMPOSITIONS HAVING HIGH CONCENTRATIONS IN PROTEIN-BASED THERAPEUTICS
PT3384049T (pt) 2015-12-03 2023-08-18 Regeneron Pharma Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf
EP3400014A1 (en) 2016-01-08 2018-11-14 Clearside Biomedical, Inc. Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics
ES2824574T3 (es) 2016-01-25 2021-05-12 Sanofi Sa Método de predicción del resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer midiendo el nivel de un biomarcador de plasma
WO2017129685A1 (en) * 2016-01-26 2017-08-03 Formycon Ag Liquid formulation of a vegf antagonist
EP3443346B1 (en) 2016-04-13 2023-08-30 Medimmune, LLC Use of amino acids as stabilizing compounds in pharmaceutical compositions containing high concentrations of protein-based therapeutic agents
SI3471780T1 (sl) 2016-06-16 2021-03-31 Adverum Biotechnologies, Inc. Zdravljenje SDM-ja z uporabo različice AAV2 z afliberceptom
CA3030422C (en) 2016-07-13 2021-10-26 Reform Biologics, Llc Stabilizing excipients for therapeutic protein formulations
SG11201901081XA (en) 2016-08-17 2019-03-28 Boehringer Ingelheim Int Process for the preparation of highly concentrated liquid formulations containing biomolecules
IL264640B2 (en) 2016-08-18 2024-03-01 Regeneron Pharma Assay for determining potential to self-association of a protein using concentration-dependent self-interaction nanoparticle spectroscopy
CN109689042B (zh) 2016-08-24 2022-07-12 北京生命科学研究所 用于治疗黄斑变性的与恩他卡朋相关的化合物
WO2018063963A1 (en) 2016-09-28 2018-04-05 Board Of Regents, The University Of Texas System Antibody and protein therapeutic formulations and uses thereof
IL310367A (en) * 2016-10-07 2024-03-01 Regeneron Pharma A stable protein at room temperature that has been lyophilized
CA3043487A1 (en) 2016-11-21 2018-05-24 Just-Evotec Biologics Inc Aflibercept formulations and uses thereof
CN108778336A (zh) 2016-12-01 2018-11-09 江苏恒瑞医药股份有限公司 一种vegfr抑制剂与parp抑制剂联合在制备治疗胃癌的药物中的用途
US20200368331A1 (en) 2016-12-08 2020-11-26 Gary E. Borodic Novel Method of Treating Macular Degeneration Using Botulinum Toxin-Based Pharmaceuticals
US11123411B2 (en) 2016-12-08 2021-09-21 Gary E. Borodic Method of treating macular degeneration using botulinum toxin-based pharmaceuticals
GEAP202315128A (en) 2016-12-23 2023-02-10 Serum Institute Of India Pvt Ltd Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof
US10617756B2 (en) 2017-01-05 2020-04-14 Shimojani, LLC Drug regimen for treatment of cerebral ischemia
US10426817B2 (en) 2017-01-24 2019-10-01 Macregen, Inc. Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics
KR101861163B1 (ko) 2017-04-26 2018-05-25 삼천당제약주식회사 안과용 약학 조성물
WO2018201007A2 (en) 2017-04-27 2018-11-01 The Johns Hopkins University Dendrimer compositions for use in angiography
WO2018211517A1 (en) 2017-05-16 2018-11-22 Bhami's Research Laboratory, Pvt. Ltd. High concentration protein formulations with reduced viscosity
EP3630043A1 (en) 2017-05-24 2020-04-08 Formycon AG Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
US20200108064A1 (en) 2017-06-08 2020-04-09 Eye Therapies, Llc Low-dose brimonidine combinations and uses thereof
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
WO2019023392A1 (en) 2017-07-25 2019-01-31 Elektrofi, Inc. FORMATION OF PARTICLES COMPRISING AGENTS
WO2019020777A1 (en) 2017-07-26 2019-01-31 Formycon Ag LIQUID FORMULATION OF A VEGF ANTAGONIST
WO2019036619A1 (en) 2017-08-18 2019-02-21 Reform Biologics, Llc STABILIZING EXCIPIENTS FOR FORMULATIONS OF THERAPEUTIC PROTEIN
IT201700101582A1 (it) 2017-09-12 2019-03-12 Milano Politecnico Dispositivo per rilascio intraoculare
KR20250093620A (ko) 2017-09-15 2025-06-24 암젠 인크 치료 단백질의 동결건조된 약학적 제형을 위한 방법
EP3684332A1 (en) 2017-09-18 2020-07-29 Amgen Inc. Vegfr-fc fusion protein formulations
JP2020535199A (ja) 2017-09-29 2020-12-03 ハンミ ファーマシューティカル カンパニー リミテッド 効力が向上した持続性タンパク質結合体
US11246846B2 (en) 2017-10-23 2022-02-15 Michael S. Tempesta Trisodium citrate compositions having enhanced uptake across digestive mucosa
WO2019099786A1 (en) 2017-11-16 2019-05-23 Ophthotech Corporation A method for treating or preventing idiopathic polypoidal choroidal vasculopathy (ipcv)
MA50908A (fr) 2017-11-17 2020-09-23 Amgen Inc Formulations de protéines de fusion vegfr-fc
WO2019099965A1 (en) 2017-11-20 2019-05-23 Just Biotherapeutics, Inc. Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof
AU2018375398C1 (en) 2017-11-30 2026-01-15 Regeneron Pharmaceuticals, Inc. Use of a VEGF antagonist to treat angiogenic eye disorders
CN111093706B (zh) 2017-12-06 2022-06-21 江苏恒瑞医药股份有限公司 Parp抑制剂用于治疗化疗耐药的卵巢癌或乳腺癌的用途
EP3730126B1 (en) 2017-12-22 2025-05-14 Samsung Bioepis Co., Ltd. Liquid composition comprising vegf antagonist
US11524053B2 (en) 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
US11426446B2 (en) 2018-03-08 2022-08-30 Coherus Biosciences, Inc. Stable aqueous formulations of aflibercept
WO2019173767A1 (en) 2018-03-08 2019-09-12 Coherus Biosciences Inc. Stable aqueous formulations of aflibercept
MA52204A (fr) 2018-04-12 2021-02-17 Amgen Inc Procédés de préparation de compositions protéiques stables
US20210379012A1 (en) 2018-04-30 2021-12-09 Indiana University Research And Technology Corporation Antiangiogenic chromane derivative and uses thereof
CN108671229B (zh) 2018-05-08 2022-03-25 华博生物医药技术（上海）有限公司 一种重组人血管内皮生长因子受体-抗体融合蛋白的药物组合制剂
JP7235770B2 (ja) 2018-05-10 2023-03-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 高濃度ｖｅｇｆ受容体融合タンパク質を含む製剤
US11519020B2 (en) 2018-05-25 2022-12-06 Regeneron Pharmaceuticals, Inc. Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
TW202011995A (zh) 2018-07-03 2020-04-01 比利時商葛萊伯格有限公司 高濃度液體抗體配製物
EP3851096A4 (en) 2018-09-10 2022-07-06 Samsung Bioepis Co., Ltd. LIQUID COMPOSITION WITH PROTEIN
EP3636657A1 (en) 2018-10-08 2020-04-15 Ablynx N.V. Chromatography-free antibody purification method
WO2020087003A1 (en) 2018-10-26 2020-04-30 Amgen Inc. Formulations comprising a tris buffer and a protein
CN110664757B (zh) 2018-11-19 2022-08-02 成都瑞沐生物医药科技有限公司 纳米晶滴眼剂、其制备方法及其应用
WO2020106948A1 (en) 2018-11-21 2020-05-28 Regeneron Pharmaceuticals, Inc. High concentration protein formulation
EP3897595B1 (fr) 2018-12-20 2023-03-15 Laboratoires THEA Composition ophtalmique nutraceutique pour le traitement de pathologies retiniennes a composante neovasculaire
US20220098279A1 (en) 2019-01-30 2022-03-31 Amgen Inc. Aflibercept attributes and methods of characterizing and modifying thereof
WO2020167848A1 (en) 2019-02-11 2020-08-20 Surrozen, Inc. Modulation of wnt signalling in ocular disorders
EP3923907B1 (en) 2019-02-13 2024-09-25 Novaliq GmbH Compositions and methods for the treatment of ocular neovascularization
US20200390725A1 (en) 2019-06-17 2020-12-17 Sol-Gel Technologies Ltd. Treatment of ocular diseases with ophthalmic tapinarof compositions
WO2020255135A1 (en) 2019-06-17 2020-12-24 Sol-Gel Technologies Ltd. Treatment of ocular inflammatory diseases with topical ophthalmic tapinarof compositions
US20200390724A1 (en) 2019-06-17 2020-12-17 Sol-Gel Technologies Ltd. Treatment of ocular diseases with ophthalmic tapinarof compositions
CN112203642B (zh) 2019-03-25 2025-03-07 阿特根公司 用于皮下注射的包含人透明质酸酶ph20变体和药物的药物组合物
AU2020254582B2 (en) 2019-04-01 2025-12-18 Genentech, Inc. Compositions and methods for stabilizing protein-containing formulations
CA3134538A1 (en) 2019-04-03 2020-10-08 Denali Therapeutics Inc. Formulations of protein molecules comprising iduronate 2-sulfatase
US12599669B2 (en) 2019-04-23 2026-04-14 Amgen Inc. Use of low molecular weight polyvinylpyrrolidone (PVP) to reduce viscosity of high concentration protein formulations
EP3736574A1 (en) 2019-05-07 2020-11-11 Atlas Antibodies AB A formulation comprising an isotope labeled fusion polypeptide
WO2020239051A1 (zh) 2019-05-30 2020-12-03 江苏恒瑞医药股份有限公司 Cdk4/6抑制剂与vegfr抑制剂联合在制备治疗肿瘤的药物中的用途
JP2022540148A (ja) 2019-07-10 2022-09-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 低減したレベルの宿主細胞タンパク質を含む方法および組成物
MX2022001433A (es) 2019-08-06 2022-02-22 Hoffmann La Roche Tratamiento personalizado de enfermedades oftalmologicas.
US20210100856A1 (en) 2019-09-11 2021-04-08 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
AU2020345174A1 (en) 2019-09-12 2022-03-31 Lupin Limited Modified dosing of VEGF inhibitors for ophthalmic use
US20220340630A1 (en) 2019-09-13 2022-10-27 National Science And Technology Development Agency Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof
US20220331430A1 (en) 2019-09-17 2022-10-20 Merck Patent Gmbh Camphorsulfonic acid and combinations thereof with cationic excipients as viscosity reducing agents in high concentrated protein formulations
EP4057980A1 (en) 2019-11-15 2022-09-21 F. Hoffmann-La Roche AG Prevention of visible particle formation in aqueous protein solutions
JP2023504821A (ja) 2019-12-03 2023-02-07 四川弘合生物科技有限公司 エレメンを含む医薬組成物、その調製方法、及びその使用
KR20220110555A (ko) 2019-12-06 2022-08-08 리제너론 파마슈티칼스 인코포레이티드 Vegf 미니-트랩 및 그의 사용 방법
KR20240007293A (ko) 2019-12-06 2024-01-16 리제너론 파아마슈티컬스, 인크. 항-vegf 단백질 조성물 및 이를 생산하는 방법
KR20210077645A (ko) 2019-12-17 2021-06-25 주식회사 프로젠 신규 주사제 제형
WO2021146328A1 (en) 2020-01-13 2021-07-22 Aptevo Research And Development Llc Formulations for protein therapeutics
CN115697333A (zh) 2020-02-19 2023-02-03 科尼尔赛德生物医学公司 包含阿西替尼的组合物和治疗眼部疾病的方法
PT3884929T (pt) 2020-03-25 2023-08-09 Ocular Therapeutix Inc Implante ocular contendo um inibidor da tirosina cinase
WO2021203769A1 (zh) 2020-04-10 2021-10-14 江苏恒瑞医药股份有限公司 一种抗pd-1抗体在制备治疗肢端黑色素瘤的药物中的用途
EP4138778A1 (en) 2020-04-22 2023-03-01 Dragonfly Therapeutics, Inc. Formulation, dosage regimen, and manufacturing process for heterodimeric fc-fused proteins
CA3180401A1 (en) 2020-06-11 2021-12-16 Bartosz SIKORSKI Methods of improving retina-associated disease outcome using ccr3-inhibitors
US11944663B2 (en) 2020-06-18 2024-04-02 Chengdu Kanghong Biotechnologies Co. Ltd. Method for treating angiogenic eye disorders using VEGF antagonists
CN115803010A (zh) 2020-07-09 2023-03-14 豪夫迈·罗氏有限公司 浓缩的蛋白质组合物、它们的制备及其用途
WO2022011323A1 (en) 2020-07-10 2022-01-13 Iconic Therapeutics, Inc. Ocular disease treatment using anti-tissue factor antibodies
IL299671A (en) 2020-07-13 2023-03-01 Merck Patent Gmbh Viscosity-reducing excipients and their combinations for high-concentration protein formulations
US11524998B2 (en) 2020-07-16 2022-12-13 Novartis Ag Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
KR20230047359A (ko) 2020-07-29 2023-04-07 시아겐 인크. 트라스투주맙, 탁산 및 vegfr-2 길항제와 병용하여 투카티닙을 이용하는 her2 양성 암의 치료 방법
KR20220015976A (ko) 2020-07-31 2022-02-08 (주)셀트리온 안정한 약제학적 제제
DE102020005002A1 (de) 2020-08-17 2022-02-17 Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh Mittel zur Therapie von Tumorerkrankungen
WO2022056326A1 (en) 2020-09-11 2022-03-17 Elixir Medical Corporation Anticoagulant compounds, methods and devices for ophthalmic use
MX2023004839A (es) 2020-10-30 2023-06-29 Eluminex Biosciences Suzhou Ltd Inhibidores de factores angiogenicos.
US20240024416A1 (en) 2020-10-30 2024-01-25 Gemini Therapeutics Sub, Inc. Methods for treating inflammatory ocular diseases with complement factor h
EP4243780A1 (en) 2020-11-13 2023-09-20 AstraZeneca UK Limited Pharmaceutical formulation
US20220151920A1 (en) 2020-11-18 2022-05-19 Bend Research, Inc. Inhalable dry powder formulations comprising angiogenesis inhibitors
FI20215186A1 (en) 2021-02-19 2022-08-20 Rebio Tech Oy Compositions for ophthalmic treatment
CA3213505A1 (en) 2021-03-16 2022-09-22 Kashiv Biosciences, Llc Novel formulation of fusion protein
WO2022201084A1 (en) 2021-03-26 2022-09-29 Novartis Ag Methods for treating ocular diseases
KR20230167100A (ko) 2021-04-09 2023-12-07 에이버맥스 바이오파마 인크. 안구 트랜스진 발현을 위한 조성물 및 방법
BR112023019056A2 (pt) 2021-04-27 2024-01-16 Adverum Biotechnologies Inc Métodos para tratar doenças oculares usando variantes de aav2 que codificam aflibercepte
WO2022229932A1 (en) 2021-04-29 2022-11-03 Einar Stefansson Hypoxia inducible factor (hif) inhibitors for treatment of atrophy associated with retinal hypoxia
PL4185318T3 (pl) 2021-05-17 2026-01-12 Regeneron Pharmaceuticals, Inc. Rozszerzone schematy leczenia dużymi dawkami antagonistów vegf w leczeniu angiogennych zaburzeń oka
WO2023001288A1 (zh) 2021-07-23 2023-01-26 百奥泰生物制药股份有限公司 整合素GPIIb/IIIa拮抗剂及其和抗VEGF抗体联合用药的应用
WO2023023278A2 (en) 2021-08-18 2023-02-23 University Of Utah Research Foundation Multigene constructs for treatment of age-related macular degeneration and other complement dysregulation-related conditions
EP4398877A1 (en) 2021-09-06 2024-07-17 LEK Pharmaceuticals d.d. Formulations for vegf receptor fusion proteins
EP4147709A1 (en) 2021-09-14 2023-03-15 The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth A composition comprising il-36 and/or il-18 for use in treating ocular disorders
US20250009850A1 (en) 2021-10-29 2025-01-09 Alteogen, Inc. Pharmaceutical composition comprising human hyaluronidase ph20 and drug

Also Published As

Publication number Publication date
CA3099551C (en) 2025-08-19
US20210353714A1 (en) 2021-11-18
AU2024100037B4 (en) 2025-04-10
AU2025204229A1 (en) 2025-06-26
HRP20260001T1 (hr) 2026-02-27
MX421310B (es) 2025-03-14
AU2024100037A4 (en) 2024-10-24
EP4684776A3 (en) 2026-04-22
JP2026058347A (ja) 2026-04-03
CN118948760A (zh) 2024-11-15
JP7235770B2 (ja) 2023-03-08
PT4364724T (pt) 2025-12-16
US20250121030A1 (en) 2025-04-17
AU2019265005A1 (en) 2020-12-17
US11103552B2 (en) 2021-08-31
EP4364724B1 (en) 2025-11-26
IL278375B2 (en) 2025-07-01
FI4364724T3 (fi) 2026-01-05
MX2020011848A (es) 2021-03-29
JP2021523162A (ja) 2021-09-02
CN121421956A (zh) 2026-01-30
IL278375A (da) 2020-12-31
JP7791125B2 (ja) 2025-12-23
EP3790532A1 (en) 2021-03-17
ES3056525T3 (en) 2026-02-23
CN112739323A (zh) 2021-04-30
CN121570417A (zh) 2026-02-27
PH12020551839A1 (en) 2021-06-28
KR20210021299A (ko) 2021-02-25
SG11202010684YA (en) 2020-11-27
MY204232A (en) 2024-08-16
MA52570A (fr) 2021-03-17
CA3281979A1 (en) 2026-03-02
LT4364724T (lt) 2026-01-12
RS67656B1 (sr) 2026-02-27
IL318714A (en) 2025-03-01
CL2020002872A1 (es) 2021-03-26
SI4364724T1 (sl) 2026-01-30
PL4364724T3 (pl) 2026-02-23
US20190343918A1 (en) 2019-11-14
BR112020022610A2 (pt) 2021-02-09
EP4364724A3 (en) 2024-08-07
IL278375B1 (en) 2025-03-01
CN116585466A (zh) 2023-08-15
CN112739323B (zh) 2025-11-25
AU2019265005B2 (en) 2025-03-13
WO2019217927A1 (en) 2019-11-14
CL2021001957A1 (es) 2022-04-08
NZ770284A (en) 2025-11-28
CA3099551A1 (en) 2019-11-14
JOP20200275A1 (ar) 2020-11-02
EP4364724A2 (en) 2024-05-08
US20240058418A1 (en) 2024-02-22
EP4684776A2 (en) 2026-01-28
CO2020014427A2 (es) 2020-12-21
MX2024014765A (es) 2025-01-09
CL2023003448A1 (es) 2024-07-19
US12168036B2 (en) 2024-12-17
JP2023071798A (ja) 2023-05-23
MX2025001448A (es) 2025-03-07

Similar Documents

Publication Publication Date Title
HRP20260001T1 (hr) Formulacije koje sadrže visoke koncentracije fuzijskog proteina vegf receptora
IL281954A (en) Heterodimeric fc-fused proteins
IL284216A (en) Anti-transferrin receptor antibodies and uses thereof
IL280087B (en) Stable protein solution formulation containing high concentration of an anti-vegf antibody
MA46534A (fr) Protéines de fusion fc hétérodimères il15/il15r
PL3445787T3 (pl) Kompozycje i sposoby reprogramowania receptorów limfocytów t przy użyciu białek fuzyjnych
EP3880814A4 (en) FUSION PROTEIN
EP3609891A4 (en) SYNTHESIS OF CONDENSED GAMMA CARBOLINE WITH SUBSTITUTED HETEROCYCLE
DK3280727T3 (da) Enkeltarmede type i- og type ii-receptorfusionsproteiner og anvendelser deraf
DK3313879T3 (da) Anti-transferrinreceptor-antistoffer med tilpasset affinitet
EP3402507A4 (en) MULTIVALENT AND MULTISPECIFIC OX40-BINDING FUSION PROTEINS
DK3298033T4 (da) Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner
DK3199179T3 (da) Formulering af rekombinant fusionsprotein
DK3299383T3 (da) Specifik modifikation af antistof med igg-bindende peptid
MA50908A (fr) Formulations de protéines de fusion vegfr-fc
PL3765489T3 (pl) Terapeutyczne połączenie agonistów 4-1BB z przeciwciałami anty-CD20
DK3538554T3 (da) Antigenbindende proteiner som antagonister af leptinreceptor
EP3749357A4 (en) POLYVALENT PNEUMOCOCCAL POLYSACCHARIDE PROTEIN CONJUGATE COMPOSITION
EP3548073A4 (en) FUSION PROTEINS FOR THE SELECTIVE DEPREVIRANT OF ANTIBODIES SPECIFIC TO AN ANTIGEN
IL281641A (en) Methods and uses of variant cd80 fusion proteins and related constructs
EP3561058A4 (en) Fusion protein including bdnf
MA40763A (fr) Anticorps stables à affinité élevée et agrégatifs à base de domaines viraux vl et de dérivé de vhh
EP3898580A4 (en) SYNTHESIS OF CONDENSED GAMMA-CARBOLINES WITH SUBSTITUTED HETEROCYCLE
DK3517543T3 (da) Fremstilling af glucagonpeptider
EP3481412A4 (en) FUSION PROTEINS WITH EXTENDED SERUM HALF-VALUE