MA51285A - Dérivés d'azaindole comme inhibiteurs de rho-kinase - Google Patents

Dérivés d'azaindole comme inhibiteurs de rho-kinase

Info

Publication number
MA51285A
MA51285A MA051285A MA51285A MA51285A MA 51285 A MA51285 A MA 51285A MA 051285 A MA051285 A MA 051285A MA 51285 A MA51285 A MA 51285A MA 51285 A MA51285 A MA 51285A
Authority
MA
Morocco
Prior art keywords
rho
kinase inhibitors
azaindole derivatives
azaindole
derivatives
Prior art date
Application number
MA051285A
Other languages
English (en)
Inventor
Alessandro Accetta
Christine Edwards
Andrea Nuzzi
Fabio Rancati
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MA51285A publication Critical patent/MA51285A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA051285A 2017-12-18 2018-12-14 Dérivés d'azaindole comme inhibiteurs de rho-kinase MA51285A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17208193 2017-12-18

Publications (1)

Publication Number Publication Date
MA51285A true MA51285A (fr) 2021-04-28

Family

ID=60673855

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051285A MA51285A (fr) 2017-12-18 2018-12-14 Dérivés d'azaindole comme inhibiteurs de rho-kinase

Country Status (5)

Country Link
US (1) US11332468B2 (fr)
EP (1) EP3728248B1 (fr)
AR (1) AR113947A1 (fr)
MA (1) MA51285A (fr)
WO (1) WO2019121406A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230121812A (ko) 2020-12-15 2023-08-21 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체
KR20230121811A (ko) 2020-12-15 2023-08-21 키에시 파르마슈티시 엣스. 피. 에이. Rho-키나아제 억제제로서 다이하이드로퓨로피리딘 유도체
MX2023005867A (es) 2020-12-15 2023-06-05 Chiesi Farm Spa Derivados de dihidrofuropiridina como inhibidores de la cinasa rho.
WO2023110700A1 (fr) 2021-12-13 2023-06-22 Chiesi Farmaceutici S.P.A. Dérivés de dihydrofuropyridine utilisés comme inhibiteurs de la rho-kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE419239T1 (de) * 2000-10-20 2009-01-15 Eisai R&D Man Co Ltd Verfahren zur herstellung von 4-phenoxy chinolin derivaten
AU2003278088A1 (en) 2002-10-28 2004-05-25 Bayer Healthcare Ag Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
WO2006009889A1 (fr) 2004-06-17 2006-01-26 Smithkline Beecham Corporation Inhibiteurs novateurs de protéines rho-kinases
CA2709918A1 (fr) 2007-12-21 2009-06-25 The Scripps Research Institute Benzopyranes et analogues utilises comme inhibiteurs de la rho kinase
CN102159547A (zh) 2008-09-18 2011-08-17 安斯泰来制药株式会社 杂环甲酰胺化合物
MA34373B1 (fr) 2010-07-14 2013-07-03 Novartis Ag Composés hétérocycliques agonistes du récepteur ip
WO2014032755A2 (fr) * 2012-08-29 2014-03-06 Merck Patent Gmbh Inhibiteurs de ddr2 pour le traitement de l'arthrose
SI2951172T1 (sl) 2013-01-29 2017-08-31 Redx Pharma Plc Piridin derivati kot inhibitorji mehkih kamnov
TWI800498B (zh) 2016-12-21 2023-05-01 義大利商吉斯藥品公司 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
CA3047212A1 (fr) 2017-01-30 2018-08-02 Chiesi Farmaceutici S.P.A. Derives de tyrosine amide utilises en tant qu'inhibiteurs de la rho-kinase

Also Published As

Publication number Publication date
US20200392133A1 (en) 2020-12-17
US11332468B2 (en) 2022-05-17
AR113947A1 (es) 2020-07-01
EP3728248B1 (fr) 2022-02-02
WO2019121406A1 (fr) 2019-06-27
EP3728248A1 (fr) 2020-10-28

Similar Documents

Publication Publication Date Title
MA43753A (fr) Dérivés 1-cyano-pyrrolidine comme inhibiteurs de dbu
EP3478687A4 (fr) Dérivés de pyrazolopyrimidine comme inhibiteurs de kinase
MA45591A (fr) Dérivés de 1,3-dihydroxy-phényle utiles comme immunomodulateurs
EP3843714A4 (fr) Inhibiteurs de cd73
IL268004B (en) History of tyrosine amide as rho-kinase inhibitors
ME03404B (fr) Dérivés d'amides polycycliques comme inhibiteurs de la cdk9
MA41251A (fr) Dérivés de thiéno[2,3-c]pyrrol-4-one comme inhibiteurs erk
MA52413A (fr) Inhibiteurs de cd73
LT3768674T (lt) Aminopirimidino dariniai kaip ctps1 inhibitoriai
MA45646A (fr) Derives de benzimidazole comme des modulateurs de ror-gamma
EP3337787A4 (fr) Composés pyrazolo hétérocycliques condensés comme inhibiteurs d'erk
MA40774A (fr) Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
MA41140A (fr) Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
DK3324977T3 (da) Benzodiazepinderivater som rsv-inhibitorer
EP3277381C0 (fr) Dérivés de nitrobenzyle d'agents anticancéreux
EP3322409A4 (fr) Composés aza substitués comme inhibiteurs de l'irak-4
EP3416964A4 (fr) Dérivés de carboxamide utiles en tant qu'inhibiteurs de rsk
TWI800498B (zh) 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
EP3787635A4 (fr) Inhibiteurs de cd73
EP3999517A4 (fr) Inhibiteurs de cd73
MA46981A (fr) Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine
MA42597A (fr) 2-amino-3-fluoro-3-(fluorométhyl)-6-méthyl-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
EP3449001A4 (fr) Inhibition de l'arnmi mir-22 par apt-110
EP3302488A4 (fr) Nouvelle utilisation de dérivés aryl-quinoléine comme inhibiteurs de l'imitation de facteurs vasculogènes
EP3666770A4 (fr) Nouveaux composés hétérocycliques comme inhibiteurs de cdk8/19