MA51633A - Identification par résolution de base sans bisulfite de modifications de cytosine - Google Patents
Identification par résolution de base sans bisulfite de modifications de cytosineInfo
- Publication number
- MA51633A MA51633A MA051633A MA51633A MA51633A MA 51633 A MA51633 A MA 51633A MA 051633 A MA051633 A MA 051633A MA 51633 A MA51633 A MA 51633A MA 51633 A MA51633 A MA 51633A
- Authority
- MA
- Morocco
- Prior art keywords
- bisulphite
- resolution identification
- basic resolution
- cytosine modifications
- cytosine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01026—DNA alpha-glucosyltransferase (2.4.1.26)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/01—Hexosyltransferases (2.4.1)
- C12Y204/01027—DNA beta-glucosyltransferase (2.4.1.27)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/186—Modifications characterised by incorporating a non-extendable or blocking moiety
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862614798P | 2018-01-08 | 2018-01-08 | |
| US201862660523P | 2018-04-20 | 2018-04-20 | |
| US201862771409P | 2018-11-26 | 2018-11-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA51633A true MA51633A (fr) | 2020-11-18 |
Family
ID=67143801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA051633A MA51633A (fr) | 2018-01-08 | 2019-01-08 | Identification par résolution de base sans bisulfite de modifications de cytosine |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US12071660B2 (fr) |
| EP (1) | EP3737748A4 (fr) |
| JP (3) | JP7136899B2 (fr) |
| KR (3) | KR20250026369A (fr) |
| CN (2) | CN111971386A (fr) |
| AU (3) | AU2019205416B2 (fr) |
| BR (1) | BR112020013718A2 (fr) |
| CA (1) | CA3087915C (fr) |
| IL (2) | IL275850B2 (fr) |
| MA (1) | MA51633A (fr) |
| MX (2) | MX395068B (fr) |
| NZ (1) | NZ765943A (fr) |
| SG (1) | SG11202006511YA (fr) |
| WO (1) | WO2019136413A1 (fr) |
| ZA (1) | ZA202004769B (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440B1 (fr) | 2015-03-27 | 2026-03-04 | Exact Sciences Corporation | Détection de troubles de l' oesophage |
| MA51633A (fr) | 2018-01-08 | 2020-11-18 | Ludwig Inst For Cancer Res Ltd | Identification par résolution de base sans bisulfite de modifications de cytosine |
| US11634748B2 (en) | 2018-02-14 | 2023-04-25 | Clearnote Health, Inc. | Methods for the epigenetic analysis of DNA, particularly cell-free DNA |
| ES3013495T3 (en) | 2019-01-31 | 2025-04-14 | Guardant Health Inc | Method for isolating and sequencing cell-free dna |
| JP7717608B2 (ja) * | 2019-05-31 | 2025-08-04 | フリーノム ホールディングス,インク. | メチル化核酸の高深度シーケンシングのための方法とシステム |
| WO2021005537A1 (fr) | 2019-07-08 | 2021-01-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Analyse de méthylation du génome entier sans bisulfite |
| EP4028550B1 (fr) * | 2019-09-09 | 2024-11-06 | University of Utah Research Foundation | Séquençage ciblé pour détecter et quantifier de faibles taux d'adn méthylé |
| EP4041888A4 (fr) | 2019-10-11 | 2023-11-01 | Guardant Health, Inc. | Utilisation d'acides nucléiques bactériens acellulaires pour la détection du cancer |
| CN110669824A (zh) * | 2019-10-11 | 2020-01-10 | 广州迈森致远基因科技有限公司 | 低起始量血浆游离dna甲基化建库试剂盒及方法 |
| WO2021087615A1 (fr) * | 2019-11-06 | 2021-05-14 | University Health Network | Témoins synthétiques de type « spike-in » dans un séquençage medip acellulaire et leurs procédés d'utilisation |
| CN110820050A (zh) * | 2019-11-22 | 2020-02-21 | 北京吉因加科技有限公司 | 全基因组甲基化非重亚硫酸氢盐测序文库及构建 |
| US20230076949A1 (en) * | 2020-02-11 | 2023-03-09 | Ludwig Institute For Cancer Research Ltd | Targeted, long-read nucleic acid sequencing for the determination of cytosine modifications |
| CN113373207A (zh) * | 2020-02-25 | 2021-09-10 | 深圳华大基因科技服务有限公司 | 确定胞嘧啶修饰的方法 |
| US11946044B2 (en) | 2020-07-30 | 2024-04-02 | Guardant Health, Inc. | Methods for isolating cell-free DNA |
| IL300238A (en) | 2020-07-30 | 2023-03-01 | Cambridge Epigenetix Ltd | Compositions and Methods for Nucleic Acid Analysis |
| CN116670299A (zh) | 2020-08-19 | 2023-08-29 | 梅约医学教育与研究基金会 | 检测非霍奇金淋巴瘤 |
| US20230357833A1 (en) * | 2020-09-14 | 2023-11-09 | Ludwig Institute For Cancer Research Ltd | Cytosine modification analysis |
| EP4232599A1 (fr) * | 2020-10-23 | 2023-08-30 | Guardant Health, Inc. | Compositions et procédés d'analyse d'adn par division et conversion de base |
| GB202017653D0 (en) | 2020-11-09 | 2020-12-23 | Cambridge Entpr Ltd | Methods for detection of nucleotide modification |
| CA3206781A1 (fr) | 2021-01-29 | 2022-08-04 | John B. Kisiel | Detection de la presence ou de l'absence de multiples types de cancer |
| EP4291677A2 (fr) * | 2021-02-09 | 2023-12-20 | F. Hoffmann-La Roche AG | Procédés de détection de méthylation de base dans des acides nucléiques |
| JP2024510329A (ja) * | 2021-03-15 | 2024-03-06 | イルミナ インコーポレイテッド | S-アデノシル-l-メチオニン類似体(xsams)を用いたメチルシトシン及びその誘導体の検出 |
| GB202109469D0 (en) | 2021-06-30 | 2021-08-11 | Cambridge Entpr Ltd | Methods for detecting modified nucleotides |
| JP2024529488A (ja) * | 2021-07-27 | 2024-08-06 | ザ チャンセラー,マスターズ アンド スカラーズ オブ ザ ユニバーシティ オブ オックスフォード | 無細胞dnaのためのtet支援ピリジンボラン配列決定に関する組成物及び方法 |
| CN113846160B (zh) * | 2021-09-14 | 2024-08-20 | 翌圣生物科技(上海)股份有限公司 | 正向筛选的胞嘧啶甲基化快速检测方法及过氧钨酸盐在将5hmC氧化为thT中的应用 |
| CN114085894A (zh) * | 2021-11-03 | 2022-02-25 | 翌圣生物科技(上海)股份有限公司 | 核酸甲基化胞嘧啶转化方法 |
| WO2023082240A1 (fr) * | 2021-11-15 | 2023-05-19 | 深圳华大智造科技股份有限公司 | Procédé de détection de modification de méthylation d'adn à l'échelle du génome |
| JP2025502811A (ja) * | 2021-12-29 | 2025-01-28 | ファウンデーション・メディシン・インコーポレイテッド | 単一ワークフローにおける遺伝子情報及びエピジェネティック情報の検出 |
| CN114045345B (zh) * | 2022-01-07 | 2022-04-29 | 臻和(北京)生物科技有限公司 | 基于游离dna的基因组癌变信息检测系统和检测方法 |
| AU2023234670A1 (en) * | 2022-03-15 | 2024-01-18 | Illumina, Inc. | Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection |
| WO2023183841A2 (fr) * | 2022-03-23 | 2023-09-28 | Exact Sciences Corporation | Compositions et méthodes d'oxydation assistée par tet de bases nucléotidiques méthylées |
| US20250333782A1 (en) | 2022-03-31 | 2025-10-30 | Illumina, Inc. | Compositions including aqueous amine borane complexes and polynucleotides, and methods of using the same to detect methylcytosine or hydroxymethylcytosine |
| US20250320549A1 (en) | 2022-08-25 | 2025-10-16 | Illumina, Inc. | Methods of modifying methylcytosine or derivative thereof using a nucleophilic molecule, and methods of using the same to detect the methylcytosine or derivative thereof in a polynucleotide |
| US20250388894A1 (en) | 2022-09-30 | 2025-12-25 | Illumina, Inc. | Methods of using cpg binding proteins in mapping modified cytosine nucleotides |
| US20250313589A1 (en) | 2023-02-01 | 2025-10-09 | Illumina, Inc. | Methods of modifying methylcytosine or derivative thereof using a photoredox reaction, and methods of using the same to detect the methylcytosine or derivative thereof in a polynucleotide |
| WO2024164173A1 (fr) * | 2023-02-08 | 2024-08-15 | Peking University | Séquençage de 5-hydroxyméthylcytosine |
| CN116287166A (zh) * | 2023-04-19 | 2023-06-23 | 纳昂达(南京)生物科技有限公司 | 甲基化测序接头及其应用 |
| WO2024224324A1 (fr) | 2023-04-28 | 2024-10-31 | Exact Sciences Innovation Ltd. | Enzymes tet modifiées et utilisation dans l'épigénétique et le séquençage de nouvelle génération (ngs), tels que le séquençage de borane-pyridine assisté par tet (taps). |
| WO2024249061A1 (fr) * | 2023-05-31 | 2024-12-05 | Illumina, Inc. | Détection d'un nucléotide méthylé à l'aide d'un extincteur |
| WO2025054389A1 (fr) * | 2023-09-07 | 2025-03-13 | Illumina, Inc. | Identification de la cytosine méthylée par l'utilisation de points de repère |
| WO2025085492A1 (fr) * | 2023-10-17 | 2025-04-24 | Exact Sciences Corporation | Agents réducteurs boranes |
| WO2026055641A1 (fr) | 2024-09-06 | 2026-03-12 | Exact Sciences Corporation | Procédés et compositions pour préparer des analytes biomoléculaires à partir d'échantillons complexes |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| WO2011127136A1 (fr) | 2010-04-06 | 2011-10-13 | University Of Chicago | Compositions et procédés liés à la modification de 5-hydroxyméthylcytosine (5-hmc) |
| EP2694686B2 (fr) | 2011-04-06 | 2023-07-19 | The University of Chicago | Composition et procédés se rapportant à la modification de la 5-méthylcytosine (5-mc) |
| EP3141616B1 (fr) * | 2011-07-29 | 2020-05-13 | Cambridge Epigenetix Limited | Méthode pour détecter des modifications nucléotidiques |
| EP3124605A1 (fr) | 2012-03-15 | 2017-02-01 | New England Biolabs, Inc. | Procedes et compositions pour la discrimination entre la cytosine et leurs modifications et pour l'analyse des methylomes |
| US9267117B2 (en) | 2012-03-15 | 2016-02-23 | New England Biolabs, Inc. | Mapping cytosine modifications |
| WO2014165770A1 (fr) | 2013-04-05 | 2014-10-09 | The University Of Chicago | Séquençage avec une résolution de l'ordre de la base de la 5-formylcytosine (5fc) et de la 5-carboxylcytosine (5cac) |
| US20160194696A1 (en) | 2013-08-09 | 2016-07-07 | New England Biolabs, Inc. | Detecting, Sequencing and/or Mapping 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution |
| US20180251815A1 (en) | 2015-09-04 | 2018-09-06 | The University Of Tokyo | Oxidizing agent for 5-hydroxymethylcytosine and method for analyzing 5-hydroxymethylcytosine |
| US11162139B2 (en) | 2016-03-02 | 2021-11-02 | Shanghai Epican Genetech Co. Ltd. | Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine |
| PL3440205T3 (pl) | 2016-04-07 | 2021-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowego |
| MA51633A (fr) | 2018-01-08 | 2020-11-18 | Ludwig Inst For Cancer Res Ltd | Identification par résolution de base sans bisulfite de modifications de cytosine |
| US11634748B2 (en) | 2018-02-14 | 2023-04-25 | Clearnote Health, Inc. | Methods for the epigenetic analysis of DNA, particularly cell-free DNA |
-
2019
- 2019-01-08 MA MA051633A patent/MA51633A/fr unknown
- 2019-01-08 EP EP19736010.0A patent/EP3737748A4/fr active Pending
- 2019-01-08 CN CN201980011272.2A patent/CN111971386A/zh active Pending
- 2019-01-08 JP JP2020537593A patent/JP7136899B2/ja active Active
- 2019-01-08 BR BR112020013718-9A patent/BR112020013718A2/pt unknown
- 2019-01-08 SG SG11202006511YA patent/SG11202006511YA/en unknown
- 2019-01-08 MX MX2020007259A patent/MX395068B/es unknown
- 2019-01-08 AU AU2019205416A patent/AU2019205416B2/en active Active
- 2019-01-08 IL IL275850A patent/IL275850B2/en unknown
- 2019-01-08 CA CA3087915A patent/CA3087915C/fr active Active
- 2019-01-08 IL IL296932A patent/IL296932B2/en unknown
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- 2019-01-08 KR KR1020257004045A patent/KR20250026369A/ko active Pending
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- 2019-01-08 KR KR1020237005878A patent/KR102768046B1/ko active Active
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2020
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2021
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2022
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2024
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2025
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