|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
US5844092A
(en)
|
1994-03-18 |
1998-12-01 |
Genentech, Inc. |
Human TRK receptors and neurotrophic factor inhibitors
|
|
KR100823764B1
(ko)
|
2000-06-22 |
2008-04-21 |
제넨테크, 인크. |
아고니스트 안티-티알케이-씨 모노클로날 항체
|
|
MY141220A
(en)
|
2003-11-17 |
2010-03-31 |
Astrazeneca Ab |
Pyrazole derivatives as inhibitors of receptor tyrosine kinases
|
|
DE102005003687A1
(de)
|
2005-01-26 |
2006-07-27 |
Sphingo Tec Gmbh |
Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
|
|
BRPI0610184A2
(pt)
|
2005-05-16 |
2012-09-25 |
Astrazeneca Ab |
composto, sal farmaceuticamente aceitável de um composto, processo para preparar um composto ou um sal farmaceuticamente aceitável do mesmo, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, métodos para a inibição da atividade de trk, para o tratamento ou profilaxia de cáncer e para a produção de um efeito anti-proliferativo em um animal de sanque quente, e, composição farmacêutica
|
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
|
RS53195B2
(sr)
|
2005-08-25 |
2018-08-31 |
Creabilis Therapeutics Spa |
Polimerni konjugati k-252a i njihovi derivati
|
|
EA019524B1
(ru)
|
2007-05-04 |
2014-04-30 |
Айрм Ллк |
СОЕДИНЕНИЯ И КОМПОЗИЦИИ КАК ИНГИБИТОРЫ КИНАЗЫ с-kit И PDGFR
|
|
EA018503B1
(ru)
|
2007-07-20 |
2013-08-30 |
НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. |
Замещенные производные индазола, активные как ингибиторы киназы
|
|
EA201000603A1
(ru)
|
2007-10-23 |
2010-12-30 |
Новартис Аг |
ПРИМЕНЕНИЕ АНТИТЕЛ К TrkB ДЛЯ ЛЕЧЕНИЯ РЕСПИРАТОРНЫХ НАРУШЕНИЙ
|
|
CN102015769B
(zh)
|
2008-01-17 |
2014-12-10 |
Irm责任有限公司 |
改进的抗-trkb抗体
|
|
ES2532732T3
(es)
|
2008-07-29 |
2015-03-31 |
Nerviano Medical Sciences S.R.L. |
Uso de un inhibidor de CDK para el tratamiento del glioma
|
|
DK2350075T3
(da)
|
2008-09-22 |
2014-05-26 |
Array Biopharma Inc |
Substituerede imidazo[1,2b]pyridazinforbindelser som trk-kinase-inhibitorer
|
|
PT3106463T
(pt)
|
2008-10-22 |
2018-05-18 |
Array Biopharma Inc |
Compostos de pirazolo[1,5-]pirimidina substituídos como inibidores de cinase trk
|
|
CN102223885B
(zh)
|
2008-11-24 |
2013-04-03 |
内尔维阿诺医学科学有限公司 |
用于治疗间皮瘤的cdk抑制剂
|
|
AR077468A1
(es)
|
2009-07-09 |
2011-08-31 |
Array Biopharma Inc |
Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
|
|
TWI619713B
(zh)
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
|
RU2735545C2
(ru)
|
2010-05-20 |
2020-11-03 |
Эррэй Биофарма Инк. |
Макроциклические соединения в качестве ингибиторов киназы trk
|
|
WO2012034095A1
(fr)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Composés et compositions comme inhibiteurs de trk
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
KR20140014184A
(ko)
|
2011-02-25 |
2014-02-05 |
아이알엠 엘엘씨 |
Trk 억제제로서의 화합물 및 조성물
|
|
MY173181A
(en)
|
2011-05-13 |
2020-01-02 |
Array Biopharma Inc |
Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors
|
|
EP2779833A4
(fr)
|
2011-11-14 |
2015-03-18 |
Tesaro Inc |
Modulation de certaines tyrosine kinases
|
|
WO2013088257A1
(fr)
|
2011-12-12 |
2013-06-20 |
Dr. Reddy's Laboratories Ltd. |
Composés hétérocycliques substitués en tant qu'inhibiteurs du récepteur kinase a lié à la tropomyosine (trka)
|
|
EP2842955B1
(fr)
|
2012-04-26 |
2016-10-05 |
ONO Pharmaceutical Co., Ltd. |
Composé inhibiteur de trk
|
|
JP6231556B2
(ja)
|
2012-05-23 |
2017-11-15 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
N−[5−(3,5−ジフルオロ−ベンジル)−1h−インダゾール−3−イル]−4−(4−メチル−ピペラジン−1−イル)−2−(テトラヒドロ−ピラン−4−イルアミノ)−ベンズアミドの調製方法
|
|
TWI585088B
(zh)
|
2012-06-04 |
2017-06-01 |
第一三共股份有限公司 |
作爲激酶抑制劑之咪唑并[1,2-b]嗒衍生物
|
|
WO2014078325A1
(fr)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Composés de n-aryle monocycliques, n'-pyrazolyl-urée, thiourée, guanidine et cyanoguanidine utiles comme inhibiteurs de trka kinase
|
|
US9790178B2
(en)
|
2012-11-13 |
2017-10-17 |
Array Biopharma Inc. |
Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
EP2922844B1
(fr)
|
2012-11-13 |
2018-01-10 |
Array Biopharma, Inc. |
Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
|
|
WO2014078328A1
(fr)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Composés de n-pyrrolidinyle, n'-pyrazolyl-urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
|
|
WO2014078331A1
(fr)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Composés de n-(arylalkyle)-n'-pyrazolyle-urée, de thiourée, de guanidine et de cyanoguanidine en tant qu'inhibiteurs de la kinase trka
|
|
WO2014078378A1
(fr)
|
2012-11-13 |
2014-05-22 |
Array Biopharma Inc. |
Composés de n-pyrrolidinyle urée, thio-urée,guanidine et cyanoguanidine en tant qu'inhibiteurs de la kinase trka
|
|
US9809578B2
(en)
|
2012-11-13 |
2017-11-07 |
Array Biopharma Inc. |
Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors
|
|
US9822118B2
(en)
|
2012-11-13 |
2017-11-21 |
Array Biopharma Inc. |
Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
US9981959B2
(en)
|
2012-11-13 |
2018-05-29 |
Array Biopharma Inc. |
Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
|
|
EP2920166B1
(fr)
|
2012-11-13 |
2016-11-02 |
Array Biopharma, Inc. |
Composes bicycliques a base d' uree, thiouree, guanidine ou cyanoguanidine utiles dans le traitement de la douleur
|
|
HUE042591T2
(hu)
|
2013-02-19 |
2019-07-29 |
Ono Pharmaceutical Co |
TRK-gátló vegyület
|
|
WO2015017533A1
(fr)
|
2013-07-30 |
2015-02-05 |
Blueprint Medicines Corporation |
Fusions de ntrk2
|
|
HRP20191283T1
(hr)
|
2014-01-24 |
2019-10-18 |
Turning Point Therapeutics, Inc. |
Diaril makrocikli kao modulatori protein kinaze
|
|
HUE055357T2
(hu)
|
2014-02-05 |
2021-11-29 |
VM Oncology LLC |
Vegyületek kompozíciói és azok alkalmazásai
|
|
TWI672141B
(zh)
|
2014-02-20 |
2019-09-21 |
美商醫科泰生技 |
投予ros1突變癌細胞之分子
|
|
LT3154959T
(lt)
|
2014-05-15 |
2019-09-25 |
Array Biopharma, Inc. |
1-((3s,4r)-4-(3-fluorfenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)karbamidas kaip trka kinazės inhibitorius
|
|
BR122017020365A2
(pt)
|
2014-08-18 |
2019-09-10 |
Ono Pharmaceutical Co |
sal de adição de ácido do composto inibidor de trk
|
|
EP3218380B1
(fr)
|
2014-11-16 |
2021-03-17 |
Array Biopharma, Inc. |
Préparation d'une forme cristalline d'hydrogénosulfate de (s)-n-(5-((r)-2-(2,5-difluorophényl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
|
|
CN107207514B
(zh)
|
2014-12-15 |
2020-01-24 |
康联制药有限公司 |
稠环杂芳基化合物及其作为trk抑制剂的用途
|
|
TN2019000271A1
(en)
*
|
2015-10-26 |
2021-01-07 |
Univ Colorado Regents |
Point mutations in trk inhibitor-resistant cancer and methods relating to the same
|
|
EP3445361A1
(fr)
*
|
2016-04-19 |
2019-02-27 |
Exelixis, Inc. |
Procédé de traitement du cancer du sein négatif triple
|
|
WO2017201156A1
(fr)
*
|
2016-05-18 |
2017-11-23 |
Duke University |
Méthode de traitement du cancer colorectal métastatique kras sauvage au moyen de cabozantinib et de panitumumab
|
|
WO2018157032A1
(fr)
|
2017-02-26 |
2018-08-30 |
Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center |
Mutations somatiques egfr et ntrk fréquentes dans le cancer colorectal (crc) avec instabilité des microsatellites (msi)
|