MA52231A - Combinaison d'inhibiteurs de lif et d'inhibiteurs de l'axe pd-1 pour une utilisation dans le traitement du cancer - Google Patents
Combinaison d'inhibiteurs de lif et d'inhibiteurs de l'axe pd-1 pour une utilisation dans le traitement du cancerInfo
- Publication number
- MA52231A MA52231A MA052231A MA52231A MA52231A MA 52231 A MA52231 A MA 52231A MA 052231 A MA052231 A MA 052231A MA 52231 A MA52231 A MA 52231A MA 52231 A MA52231 A MA 52231A
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- cancer
- treatment
- combination
- lif
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18382248 | 2018-04-12 | ||
| EP18382326 | 2018-05-14 | ||
| EP18382360 | 2018-05-25 | ||
| EP19382132 | 2019-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA52231A true MA52231A (fr) | 2021-02-17 |
Family
ID=67060425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA052231A MA52231A (fr) | 2018-04-12 | 2019-04-11 | Combinaison d'inhibiteurs de lif et d'inhibiteurs de l'axe pd-1 pour une utilisation dans le traitement du cancer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20210130453A1 (fr) |
| EP (1) | EP3774895A1 (fr) |
| JP (2) | JP7423598B2 (fr) |
| KR (1) | KR20210021287A (fr) |
| CN (1) | CN112585164A (fr) |
| AU (1) | AU2019251289B2 (fr) |
| CA (1) | CA3096779A1 (fr) |
| IL (1) | IL277918A (fr) |
| MA (1) | MA52231A (fr) |
| SG (1) | SG11202009966SA (fr) |
| WO (1) | WO2019197903A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3555132T1 (sl) * | 2016-12-19 | 2024-04-30 | Medimmune Limited | Protitelesa proti LIF in njihove uporabe |
| WO2019220204A2 (fr) * | 2018-05-14 | 2019-11-21 | Mosaic Biomedicals Slu | Anticorps anti-lif et leurs formes galéniques |
| CN114929741A (zh) * | 2019-12-04 | 2022-08-19 | 免疫医疗有限公司 | 针对lif的抗体及其用途 |
| CN115551497B (zh) * | 2020-03-11 | 2024-11-08 | 普渡研究基金会 | 具有免疫调节活性的化合物及其治疗用途 |
| WO2023159152A2 (fr) * | 2022-02-17 | 2023-08-24 | Immune-Onc Therapeutics, Inc. | Polythérapie d'un antagoniste de lilrb et d'un inhibiteur d'axe pd -1/pd-l1 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| EP0940468A1 (fr) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Domaine variable d'un anticorps humanisé |
| AU4231393A (en) * | 1992-05-08 | 1993-12-13 | Genentech Inc. | Antibodies to leukemia inhibitory factor |
| WO1994029351A2 (fr) | 1993-06-16 | 1994-12-22 | Celltech Limited | Anticorps |
| KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| EP2371860A1 (fr) * | 2010-04-05 | 2011-10-05 | Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron | Anticorps reconnaissant le facteur d'inhibition de la leucémie humaine (LIF) et utilisation d'anticorps anti-LIF pour le traitement de maladies associées à la prolifération de cellules indésirables |
| EP3191129A4 (fr) * | 2014-09-10 | 2018-03-14 | The Regents of The University of California | Ciblage de voies de signalisation médiées par k-ras et de malignité par des anticorps anti-hlif |
| EP3173483A1 (fr) * | 2015-11-27 | 2017-05-31 | Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron | Agents pour le traitement de maladies associées à une prolifération cellulaire indésirable |
| US10583191B2 (en) * | 2016-12-19 | 2020-03-10 | Mosaic Biomedicals Slu | Antibodies against LIF and uses thereof |
| SI3555132T1 (sl) * | 2016-12-19 | 2024-04-30 | Medimmune Limited | Protitelesa proti LIF in njihove uporabe |
-
2019
- 2019-04-11 CN CN201980038348.0A patent/CN112585164A/zh active Pending
- 2019-04-11 EP EP19733546.6A patent/EP3774895A1/fr not_active Withdrawn
- 2019-04-11 JP JP2021504589A patent/JP7423598B2/ja active Active
- 2019-04-11 KR KR1020207032587A patent/KR20210021287A/ko not_active Ceased
- 2019-04-11 MA MA052231A patent/MA52231A/fr unknown
- 2019-04-11 AU AU2019251289A patent/AU2019251289B2/en not_active Ceased
- 2019-04-11 US US17/046,599 patent/US20210130453A1/en not_active Abandoned
- 2019-04-11 SG SG11202009966SA patent/SG11202009966SA/en unknown
- 2019-04-11 CA CA3096779A patent/CA3096779A1/fr active Pending
- 2019-04-11 WO PCT/IB2019/000423 patent/WO2019197903A1/fr not_active Ceased
-
2020
- 2020-10-11 IL IL277918A patent/IL277918A/en unknown
-
2024
- 2024-01-17 JP JP2024005463A patent/JP2024054138A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA3096779A1 (fr) | 2019-10-17 |
| JP2021521274A (ja) | 2021-08-26 |
| AU2019251289A1 (en) | 2020-11-26 |
| SG11202009966SA (en) | 2020-11-27 |
| CN112585164A (zh) | 2021-03-30 |
| JP7423598B2 (ja) | 2024-01-29 |
| AU2019251289A8 (en) | 2021-01-14 |
| WO2019197903A1 (fr) | 2019-10-17 |
| WO2019197903A8 (fr) | 2020-02-20 |
| KR20210021287A (ko) | 2021-02-25 |
| EP3774895A1 (fr) | 2021-02-17 |
| AU2019251289B2 (en) | 2024-01-18 |
| US20210130453A1 (en) | 2021-05-06 |
| IL277918A (en) | 2020-11-30 |
| JP2024054138A (ja) | 2024-04-16 |
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