MA52480A - Sels hautement solubles dans l'eau d'un agent bloquant les canaux calciques à base de phénylalkylamine à brève durée d'action et leurs utilisations - Google Patents

Sels hautement solubles dans l'eau d'un agent bloquant les canaux calciques à base de phénylalkylamine à brève durée d'action et leurs utilisations

Info

Publication number: MA52480A
Authority: MA; Morocco
Prior art keywords: phenylalkylamine; blocking agent; calcium channel; soluble salts; highly water
Prior art date: 2015-04-14

Application number

MA052480A

Other languages

English (en)

Inventor

Martin P Maguire

Original Assignee

Milestone Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-04-14

Filing date

2016-04-13

Publication date

2022-03-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57125495&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA52480(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2016-04-13 Application filed by Milestone Pharmaceuticals Inc filed Critical Milestone Pharmaceuticals Inc

2022-03-09 Publication of MA52480A publication Critical patent/MA52480A/fr

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Inorganic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

MA052480A 2015-04-14 2016-04-13 Sels hautement solubles dans l'eau d'un agent bloquant les canaux calciques à base de phénylalkylamine à brève durée d'action et leurs utilisations MA52480A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201562147427P	2015-04-14	2015-04-14

Publications (1)

Publication Number	Publication Date
MA52480A true MA52480A (fr)	2022-03-09

Family

ID=57125495

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
MA46679A MA46679B1 (fr)	2015-04-14	2016-04-13	Sels très hydrosolubles d'un inhibiteur des canaux calciques à base de phénylalkylamine à action courte et leurs utilisations
MA052480A MA52480A (fr)	2015-04-14	2016-04-13	Sels hautement solubles dans l'eau d'un agent bloquant les canaux calciques à base de phénylalkylamine à brève durée d'action et leurs utilisations

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
MA46679A MA46679B1 (fr)	2015-04-14	2016-04-13	Sels très hydrosolubles d'un inhibiteur des canaux calciques à base de phénylalkylamine à action courte et leurs utilisations

Country Status (28)

Country	Link
US (13)	US10117848B2 (fr)
EP (3)	EP3283067B1 (fr)
JP (1)	JP6785792B2 (fr)
KR (3)	KR102653347B1 (fr)
CN (2)	CN113694019A (fr)
AU (1)	AU2016249030B2 (fr)
BR (1)	BR112017021620B1 (fr)
CA (2)	CA2982622C (fr)
CY (1)	CY1122931T1 (fr)
DK (1)	DK3283067T3 (fr)
ES (2)	ES2986137T3 (fr)
HR (1)	HRP20200444T1 (fr)
HU (1)	HUE049570T2 (fr)
IL (1)	IL254889B (fr)
LT (1)	LT3283067T (fr)
MA (2)	MA46679B1 (fr)
MD (1)	MD3283067T2 (fr)
ME (1)	ME03679B (fr)
MX (1)	MX372659B (fr)
PL (2)	PL3689344T3 (fr)
PT (2)	PT3283067T (fr)
RS (1)	RS60154B1 (fr)
RU (1)	RU2731918C2 (fr)
SI (1)	SI3283067T1 (fr)
SM (1)	SMT202000149T1 (fr)
UA (1)	UA121330C2 (fr)
WO (1)	WO2016165014A1 (fr)
ZA (2)	ZA201706648B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12257224B2 (en)	2021-07-15	2025-03-25	Milestone Pharmaceuticals Inc.	Methods of administration for highly water-soluble salts of a short acting phenylalkylamine calcium channel blocker
TW202506649A (zh)	2023-03-31	2025-02-16	南韓商Ｌｇ化學股份有限公司	作為自分泌運動因子（ａｕｔｏｔａｘｉｎ）抑制劑的新穎苯並咪唑酮衍生化合物
WO2025215083A1 (fr)	2024-04-10	2025-10-16	Dipharma Francis S.R.L.	Procédé de préparation d'un médicament utilisé pour une tachycardie paroxystique supraventriculaire
WO2025229679A1 (fr) *	2024-04-30	2025-11-06	Cipla Limited	Procédé de synthèse d'étripamil

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9605074D0 (en) *	1996-03-11	1996-05-08	Chiroscience Ltd	Dosage forms and uses
CA2446904A1 (fr) *	2001-05-24	2003-04-03	Alexza Pharmaceuticals, Inc.	Administration d'esters medicamenteux par inhalation
US6831663B2 (en) *	2001-05-24	2004-12-14	Microsoft Corporation	System and process for automatically explaining probabilistic predictions
US20050191245A1 (en) *	2004-02-27	2005-09-01	Adams Christopher P.	Nasal administration of calcium channel, blockers for treatment of hypertension and other cardiovascular disorders
WO2008019106A1 (fr) *	2006-08-04	2008-02-14	Artesian Therapeutics, Inc.	Méthodes et compositions pour le traitement d'hypertension pulmonaire utilisant une combinaison d'un agent bloquant de canal calcium et un inhibiteur de phosphodiestérase
PL2170050T3 (pl) *	2007-06-20	2014-12-31	Milestone Pharmaceuticals Inc	Krótkodziałające fenyloalkiloaminowe blokery kanału wapniowego i ich zastosowania
US20090318413A1 (en) *	2008-06-18	2009-12-24	Universite Victor Segalen Bordeaux 2	Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
US8974828B2 (en) *	2009-03-18	2015-03-10	Incarda Therapeutics, Inc.	Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration

2016
- 2016-04-13 LT LTEP16779363.7T patent/LT3283067T/lt unknown
- 2016-04-13 BR BR112017021620-5A patent/BR112017021620B1/pt active IP Right Grant
- 2016-04-13 PL PL19218071.9T patent/PL3689344T3/pl unknown
- 2016-04-13 KR KR1020177031183A patent/KR102653347B1/ko active Active
- 2016-04-13 DK DK16779363.7T patent/DK3283067T3/da active
- 2016-04-13 EP EP16779363.7A patent/EP3283067B1/fr active Active
- 2016-04-13 EP EP24179715.8A patent/EP4428119A3/fr active Pending
- 2016-04-13 KR KR1020247010307A patent/KR20240044546A/ko not_active Ceased
- 2016-04-13 WO PCT/CA2016/050425 patent/WO2016165014A1/fr not_active Ceased
- 2016-04-13 RU RU2017134553A patent/RU2731918C2/ru active
- 2016-04-13 PT PT167793637T patent/PT3283067T/pt unknown
- 2016-04-13 PL PL16779363T patent/PL3283067T3/pl unknown
- 2016-04-13 MA MA46679A patent/MA46679B1/fr unknown
- 2016-04-13 CA CA2982622A patent/CA2982622C/fr active Active
- 2016-04-13 JP JP2017554520A patent/JP6785792B2/ja active Active
- 2016-04-13 MA MA052480A patent/MA52480A/fr unknown
- 2016-04-13 RS RS20200312A patent/RS60154B1/sr unknown
- 2016-04-13 ES ES19218071T patent/ES2986137T3/es active Active
- 2016-04-13 SM SM20200149T patent/SMT202000149T1/it unknown
- 2016-04-13 HR HRP20200444TT patent/HRP20200444T1/hr unknown
- 2016-04-13 EP EP19218071.9A patent/EP3689344B1/fr active Active
- 2016-04-13 AU AU2016249030A patent/AU2016249030B2/en active Active
- 2016-04-13 CN CN202111137477.0A patent/CN113694019A/zh active Pending
- 2016-04-13 MX MX2017013355A patent/MX372659B/es active IP Right Grant
- 2016-04-13 PT PT192180719T patent/PT3689344T/pt unknown
- 2016-04-13 ME MEP-2020-59A patent/ME03679B/fr unknown
- 2016-04-13 SI SI201630690T patent/SI3283067T1/sl unknown
- 2016-04-13 ES ES16779363T patent/ES2778673T3/es active Active
- 2016-04-13 CN CN201680031696.1A patent/CN107613970B/zh active Active
- 2016-04-13 UA UAA201711059A patent/UA121330C2/uk unknown
- 2016-04-13 US US15/566,122 patent/US10117848B2/en active Active
- 2016-04-13 KR KR1020257012308A patent/KR20250057109A/ko active Pending
- 2016-04-13 MD MDE20180191T patent/MD3283067T2/ro unknown
- 2016-04-13 HU HUE16779363A patent/HUE049570T2/hu unknown
- 2016-04-13 CA CA3203288A patent/CA3203288A1/fr active Pending
2017
- 2017-10-03 ZA ZA2017/06648A patent/ZA201706648B/en unknown
- 2017-10-03 IL IL254889A patent/IL254889B/en unknown
2018
- 2018-09-27 US US16/144,315 patent/US20190022048A1/en not_active Abandoned
- 2018-11-08 ZA ZA2018/07495A patent/ZA201807495B/en unknown
2019
- 2019-05-17 US US16/414,936 patent/US20190269643A1/en not_active Abandoned
- 2019-12-19 US US16/721,275 patent/US20200121631A1/en not_active Abandoned
2020
- 2020-03-30 CY CY20201100300T patent/CY1122931T1/el unknown
- 2020-08-13 US US16/992,328 patent/US20200368195A1/en not_active Abandoned
2021
- 2021-03-18 US US17/205,726 patent/US20210205258A1/en not_active Abandoned
- 2021-10-26 US US17/510,968 patent/US20220040139A1/en not_active Abandoned
2022
- 2022-06-02 US US17/830,496 patent/US20220296556A1/en not_active Abandoned
2023
- 2023-01-13 US US18/154,458 patent/US20230157990A1/en not_active Abandoned
- 2023-09-06 US US18/242,766 patent/US20230414553A1/en not_active Abandoned
2024
- 2024-04-18 US US18/639,354 patent/US20240277652A1/en not_active Abandoned
- 2024-11-27 US US18/961,725 patent/US20250090488A1/en not_active Abandoned
2025
- 2025-07-08 US US19/262,802 patent/US20250332137A1/en active Pending

Also Published As

Publication number	Publication date
UA121330C2 (uk)	2020-05-12
PL3283067T3 (pl)	2020-09-21
SI3283067T1 (sl)	2020-07-31
AU2016249030B2 (en)	2020-08-27
CA2982622A1 (fr)	2016-10-20
IL254889B (en)	2021-07-29
US20190269643A1 (en)	2019-09-05
US20180110752A1 (en)	2018-04-26
US20210205258A1 (en)	2021-07-08
EP4428119A2 (fr)	2024-09-11
KR20180019508A (ko)	2018-02-26
RS60154B1 (sr)	2020-05-29
MA46679A (fr)	2018-02-21
US20240277652A1 (en)	2024-08-22
EP3283067B1 (fr)	2020-01-01
HK1249417A1 (en)	2018-11-02
US20230157990A1 (en)	2023-05-25
MD3283067T2 (ro)	2020-05-31
US20190022048A1 (en)	2019-01-24
CN113694019A (zh)	2021-11-26
KR102653347B1 (ko)	2024-04-02
MX2017013355A (es)	2019-01-21
ES2778673T3 (es)	2020-08-11
US20250332137A1 (en)	2025-10-30
CN107613970A (zh)	2018-01-19
DK3283067T3 (da)	2020-03-30
HUE049570T2 (hu)	2020-10-28
EP3689344A1 (fr)	2020-08-05
JP6785792B2 (ja)	2020-11-18
US10117848B2 (en)	2018-11-06
US20250090488A1 (en)	2025-03-20
ZA201706648B (en)	2020-01-29
RU2017134553A3 (fr)	2019-11-13
CY1122931T1 (el)	2021-10-29
US20230414553A1 (en)	2023-12-28
US20200368195A1 (en)	2020-11-26
EP3689344B1 (fr)	2024-06-05
KR20250057109A (ko)	2025-04-28
ZA201807495B (en)	2024-04-24
ME03679B (fr)	2020-10-20
WO2016165014A1 (fr)	2016-10-20
RU2731918C2 (ru)	2020-09-09
AU2016249030A1 (en)	2017-10-26
RU2017134553A (ru)	2019-04-05
IL254889A0 (en)	2017-12-31
EP3283067A1 (fr)	2018-02-21
NZ736249A (en)	2024-07-05
MX372659B (es)	2020-03-26
CN107613970B (zh)	2021-10-19
SMT202000149T1 (it)	2020-05-08
CA3203288A1 (fr)	2016-10-20
ES2986137T3 (es)	2024-11-08
JP2018514527A (ja)	2018-06-07
CA2982622C (fr)	2023-08-22
LT3283067T (lt)	2020-06-25
MA46679B1 (fr)	2020-04-30
PL3689344T3 (pl)	2024-11-04
US20200121631A1 (en)	2020-04-23
US20220296556A1 (en)	2022-09-22
HRP20200444T1 (hr)	2020-06-12
PT3689344T (pt)	2024-09-04
EP4428119A3 (fr)	2024-11-13
EP3283067A4 (fr)	2018-12-05
KR20240044546A (ko)	2024-04-04
BR112017021620A2 (pt)	2018-07-03
US20220040139A1 (en)	2022-02-10
BR112017021620B1 (pt)	2023-10-03
PT3283067T (pt)	2020-03-31

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