MA52556B1 - Compositions solides comportant un agoniste glp-1 et du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate - Google Patents

Compositions solides comportant un agoniste glp-1 et du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate

Info

Publication number
MA52556B1
MA52556B1 MA52556A MA52556A MA52556B1 MA 52556 B1 MA52556 B1 MA 52556B1 MA 52556 A MA52556 A MA 52556A MA 52556 A MA52556 A MA 52556A MA 52556 B1 MA52556 B1 MA 52556B1
Authority
MA
Morocco
Prior art keywords
hydroxybenzoyl
glp
agonist
amino
acid salt
Prior art date
Application number
MA52556A
Other languages
English (en)
Other versions
MA52556A (fr
Inventor
Andreas VEGGE
Simon Bjerregaard
RAHBEK Ulrik LYTT
SASSENE Philip JONAS
WATER Jorrit JEROEN
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of MA52556A publication Critical patent/MA52556A/fr
Publication of MA52556B1 publication Critical patent/MA52556B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions pharmaceutiques comprenant un agoniste de GLP-1 et un sel d'acide N-(8-(2-hydroxybenzoyl)amino)caprylique. L'invention concerne en outre des procédés pour la préparation de telles compositions, et leur utilisation en médecine.
MA52556A 2018-05-07 2019-05-06 Compositions solides comportant un agoniste glp-1 et du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate MA52556B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18171046 2018-05-07
PCT/EP2019/061502 WO2019215063A1 (fr) 2018-05-07 2019-05-06 Compositions solides comprenant un agoniste de glp-1 et un sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylique
EP19720693.1A EP3790575B1 (fr) 2018-05-07 2019-05-06 Compositions solides comportant un agoniste glp-1 et du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate

Publications (2)

Publication Number Publication Date
MA52556A MA52556A (fr) 2021-03-17
MA52556B1 true MA52556B1 (fr) 2025-09-30

Family

ID=62134107

Family Applications (1)

Application Number Title Priority Date Filing Date
MA52556A MA52556B1 (fr) 2018-05-07 2019-05-06 Compositions solides comportant un agoniste glp-1 et du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate

Country Status (25)

Country Link
US (2) US11622996B2 (fr)
EP (2) EP3790575B1 (fr)
JP (2) JP7164628B2 (fr)
KR (2) KR102835312B1 (fr)
CN (1) CN112153979A (fr)
AR (1) AR115283A1 (fr)
AU (2) AU2019264783B2 (fr)
BR (1) BR112020021717A2 (fr)
CA (1) CA3097944A1 (fr)
CL (1) CL2020002797A1 (fr)
CO (1) CO2020014570A2 (fr)
ES (1) ES3041298T3 (fr)
HR (1) HRP20251112T1 (fr)
HU (1) HUE073123T2 (fr)
IL (2) IL312620A (fr)
MA (1) MA52556B1 (fr)
MX (1) MX2020011308A (fr)
MY (1) MY206098A (fr)
PE (1) PE20211794A1 (fr)
PH (1) PH12020551691A1 (fr)
PL (1) PL3790575T3 (fr)
RS (1) RS67212B1 (fr)
SG (1) SG11202009978WA (fr)
TW (1) TWI829687B (fr)
WO (1) WO2019215063A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS58039B1 (sr) 2013-05-02 2019-02-28 Novo Nordisk As Oralno doziranje glp-1 jedinjenja
AR114353A1 (es) 2018-02-02 2020-08-26 Novo Nordisk As Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
CN110642935A (zh) * 2019-09-25 2020-01-03 成都奥达生物科技有限公司 一种替瑞帕肽类似物
JP2023502004A (ja) * 2019-11-07 2023-01-20 ノヴォ ノルディスク アー／エス Ｇｌｐ－１作動薬、ｓｇｌｔ２阻害剤、およびｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩を含む固形組成物
AU2020418207A1 (en) 2019-12-30 2022-08-25 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting GLP-1 compound
US12605426B2 (en) 2020-02-14 2026-04-21 G2Gbio, Inc. Pharmaceutical comprising sustained-release microspheres including GLP-1 analogue or pharmaceutically acceptable salt thereof
CN115461044B (zh) 2020-04-29 2025-06-10 诺和诺德股份有限公司 包含glp-1激动剂和组氨酸的固体组合物
TW202620039A (zh) 2020-12-18 2026-05-16 丹麥商諾佛 儂迪克股份有限公司 Ｇｌｐ－１及澱粉素受體之共促效劑之用途
CN113171446B (zh) * 2021-05-06 2022-03-29 合肥天汇孵化科技有限公司 利拉鲁肽组合物及其用途
CN117561072A (zh) * 2021-06-25 2024-02-13 甘李药业股份有限公司 含glp-1化合物的药物组合物
WO2023065231A1 (fr) * 2021-10-21 2023-04-27 Guangzhou Dazhou Biomedicine Ltd. Administration orale d'agents thérapeutiques
US20250304645A1 (en) 2022-05-10 2025-10-02 Novo Nordisk A/S Prodrugs of GLP-1 Polypeptide and Uses Thereof
US12098400B2 (en) 2022-07-08 2024-09-24 Novo Nordisk A/S Highly potent ISVD compounds capable of substituting for FVIII(A)
MA71385A (fr) * 2022-07-08 2025-04-30 Novo Nordisk A/S Composés isvd hautement puissants capables de remplacer fviii(a)
US12116388B2 (en) 2022-12-22 2024-10-15 Novo Nordisk A/S Amylin receptor agonists
PE20251949A1 (es) 2022-12-22 2025-08-12 Novo Nordisk As Agonistas del receptor de amilina
US20260007869A1 (en) 2023-06-23 2026-01-08 Vaxess Technologies, Inc. Microneedle array patches (maps), systems, and methods for manufacturing and using same
KR20250039299A (ko) 2023-09-11 2025-03-20 노보 노르디스크 에이/에스 항-il-6 도메인 항체
TWI926512B (zh) 2023-11-30 2026-05-21 丹麥商諾佛 儂迪克股份有限公司 Glp-1、gip及澱粉素受體之三重促效劑
KR102991397B1 (ko) 2024-11-29 2026-07-21 노보 노르디스크 에이/에스 Glp-1, gip, 및 아밀린 수용체의 삼중작용제 및 이의 용도

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5382574A (en) 1989-12-21 1995-01-17 Novo Nordisk A/S Insulin preparations containing nicotinic acid or nicotinamide
DK39892D0 (da) 1992-03-25 1992-03-25 Bernard Thorens Peptid
US6284727B1 (en) 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
DE69529998D1 (de) * 1994-12-23 2003-04-24 Novo Nordisk As Glp-1 zusammensetzungen mit verlängerter wirkdauer
US5869602A (en) 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
DE19530865A1 (de) 1995-08-22 1997-02-27 Michael Dr Med Nauck Wirkstoff sowie Mittel zur parenteralen Ernährung
DE122009000079I2 (de) 1996-08-30 2011-06-16 Novo Nordisk As Novo Alle Glp-1 derivate
EP0880969A1 (fr) 1997-05-28 1998-12-02 Applied Research Systems ARS Holdings N.V. Compositions pharmaceutiques de peptides de faible solubilité dans un milieu physioloqique
AU2610899A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S N-terminally modified glp-1 derivatives
DE69916811T2 (de) 1998-02-27 2005-04-14 Novo Nordisk A/S Glp-1 derivate mit einem helix-gehalt über 25 %, die partiell strukturierte mizellenartige aggregate bilden
AU3247799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
EP1060191B1 (fr) 1998-02-27 2010-04-28 Novo Nordisk A/S Derives d'analogues de glp-1
WO2000015224A1 (fr) * 1998-09-17 2000-03-23 Eli Lilly And Company Preparation a base de proteines
AU3357800A (en) 1999-02-05 2000-08-25 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides
AU3957400A (en) 1999-04-16 2000-11-02 Novo Nordisk A/S Dry, mouldable drug formulation
AU2001275231A1 (en) 2000-06-02 2001-12-11 Emisphere Technologies, Inc. Method of preparing salicylamides
US6573237B2 (en) 2001-03-16 2003-06-03 Eli Lilly And Company Protein formulations
JP2005506956A (ja) 2001-06-01 2005-03-10 イーライ・リリー・アンド・カンパニー 長時間作用性ｇｌｐ−１製剤
AU2003208945B2 (en) 2002-02-20 2008-05-01 Emisphere Technologies, Inc Method for administering GLP-1 molecules
CN1787830A (zh) * 2003-05-14 2006-06-14 爱密斯菲尔科技公司 用于传送肽yy和pyy激动剂的组合物
MXPA05012278A (es) * 2003-05-14 2006-02-10 Emisphere Tech Inc Composiciones para suministrar peptido yy y combatientes pyy.
EP1670515A2 (fr) 2003-09-19 2006-06-21 Novo Nordisk A/S Derives de peptides therapeutiques liant l'albumine
CN101665538A (zh) 2003-12-18 2010-03-10 诺沃挪第克公司 与白蛋白样物质相连的新glp-1类似物
JP2007537141A (ja) 2003-12-18 2007-12-20 ノボ　ノルディスク　アクティーゼルスカブ 新規なｇｌｐ−１化合物
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
EP1750754A4 (fr) 2004-03-31 2010-09-22 Centocor Ortho Biotech Inc Corps mimetiques glp-1 humains, compositions, procedes et utilisations
CN1968919A (zh) * 2004-04-16 2007-05-23 爱密斯菲尔科技公司 用于递送活性剂的8－（2－羟基苯氧基）辛基二乙醇胺和其盐
CA2563335A1 (fr) 2004-04-16 2005-12-08 Emisphere Technologies, Inc. 8-(2-hydroxyphenoxy)octyldiethanolamine et ses sels utile dans l'administration d'agents actifs
NZ550894A (en) * 2004-05-06 2011-02-25 Emisphere Tech Inc Solid dosage form of wetted heparin
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
ES2542228T3 (es) 2004-07-08 2015-08-03 Novo Nordisk A/S Marcas de prolongación polipeptídica que comprenden un resto de tetrazol
CN105708787A (zh) 2004-07-12 2016-06-29 爱密斯菲尔科技公司 用于递送肽yy和pyy激动剂的组合物
JP2008515856A (ja) 2004-10-07 2008-05-15 ノボ ノルディスク アクティーゼルスカブ 遅延性ｇｌｐ−１化合物
JP5107713B2 (ja) 2004-10-07 2012-12-26 ノヴォ ノルディスク アー／エス 遅延性のエキセンディン−４化合物
EP1817008B1 (fr) 2004-11-09 2020-04-01 Board of Regents, The University of Texas System Composition de petites particules medicamenteuses chauffee et stabilisee
JP2008525452A (ja) 2004-12-22 2008-07-17 イーライ リリー アンド カンパニー Ｇｌｐ−１類似体融合蛋白質製剤
KR20070090036A (ko) 2004-12-22 2007-09-04 센토코 인코포레이티드 Ｇｌｐ-1 작용제, 조성물, 방법 및 용도
JP5175553B2 (ja) * 2005-02-01 2013-04-03 エミスフェアー・テクノロジーズ・インク 胃内滞留および制御放出型送達系
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
ES2484796T3 (es) 2005-03-18 2014-08-12 Novo Nordisk A/S Compuestos de GLP-1 extendidos
EP1909824B1 (fr) 2005-04-08 2011-05-18 Amylin Pharmaceuticals, Inc. Formulations pharmaceutiques comprenant un peptide incretine et un solvant polaire aprotique
JP2009526750A (ja) 2005-12-22 2009-07-23 セントカー・インコーポレーテツド Ｇｌｐ−１アゴニスト、組成物、方法および使用
WO2007121318A2 (fr) 2006-04-12 2007-10-25 Emisphere Technologies, Inc. Préparations destinées à l'administration d'insuline
US8679540B2 (en) 2006-06-09 2014-03-25 Flamel Technologies Pharmaceutical formulations for the prolonged release of active principle(s), and their applications, especially therapeutic applications
KR20090039787A (ko) 2006-07-18 2009-04-22 센토코 인코포레이티드 인간 ｇｌｐ-1 모방체, 조성물, 방법 및 용도
EP2068910A2 (fr) 2006-08-04 2009-06-17 Amylin Pharmaceuticals, Inc. Utilisation d'exendines et d'agonistes d'exendines et d'agonistes du récepteur glp-1 pour modifier la dimension de particule et la composition de sous-classe de lipoprotéines
EP2066337A2 (fr) 2006-08-04 2009-06-10 Amylin Pharmaceuticals, Inc. Utilisation d'exendines et d'agonistes d'exendines et d'agonistes des récepteurs du glp-1 pour modifier la concentration de fibrinogène
US20090318353A1 (en) 2006-08-25 2009-12-24 Novo Nordisk A/S Acylated Exendin-4 Compounds
MX2009002121A (es) 2006-09-07 2009-05-20 Hoffmann La Roche Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico.
WO2008070543A1 (fr) * 2006-12-01 2008-06-12 Emisphere Technologies Inc. Formulations améliorées à base d'aciclovir
AR064623A1 (es) 2006-12-21 2009-04-15 Centocor Inc Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos
US20100080829A1 (en) 2007-04-11 2010-04-01 Cephalon France Lyophilized pharmaceutical compositions and methods of making and using same
EP1980245A1 (fr) 2007-04-11 2008-10-15 Cephalon France Composition pharmaceutique bicouche lyophilisée et ses procédés de fabrication et d'utilisation
GB0707662D0 (en) * 2007-04-20 2007-05-30 Astrazeneca Ab Chemical compounds
US20100292133A1 (en) 2007-09-05 2010-11-18 Novo Nordisk A/S Truncated glp-1 derivaties and their therapeutical use
US20100261637A1 (en) 2007-09-05 2010-10-14 Novo Nordisk A/S Peptides derivatized with a-b-c-d- and their therapeutical use
EP2190872B1 (fr) 2007-09-05 2018-03-14 Novo Nordisk A/S Dérivés de glucagon-like peptide-1 et leur utilisation pharmaceutique
JP2011506442A (ja) 2007-12-11 2011-03-03 コンジュケム バイオテクノロジーズ インコーポレイテッド インスリン分泌性ペプチド結合体の製剤
JP2009274983A (ja) 2008-05-14 2009-11-26 Kowa Co ニコチン酸アミドを含有する経口医薬組成物
US8071537B2 (en) 2008-06-25 2011-12-06 Endo Pharmaceuticals Solutions Inc. Implantable device for the sustained release of a polypeptide
CN102123697B (zh) 2008-08-18 2015-06-10 安特拉贝欧有限公司 用于口服给予蛋白质的方法和组合物
EP3685837A1 (fr) 2008-09-04 2020-07-29 Amylin Pharmaceuticals, LLC Formulations à libération prolongée à base de supports non aqueux
US8425968B2 (en) 2009-06-19 2013-04-23 Pepsico., Inc. Beverage preservative system containing pimaricin-cyclodextrin complex
US20120065255A1 (en) * 2009-10-19 2012-03-15 Nagesh Palepu Cabazitaxel formulations and methods of preparing thereof
JP5832439B2 (ja) 2009-11-13 2015-12-16 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｇｌｐ−１アゴニスト、インスリン及びメチオニンを含む薬学的組成物
SG10201500871TA (en) 2009-11-13 2015-04-29 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
US20120329711A1 (en) 2009-12-16 2012-12-27 Nordisk A/S Glp-1 receptor agonist compounds with a modified n-terminus
EP2512454A2 (fr) 2009-12-16 2012-10-24 Nod Pharmaceuticals, Inc. Compositions et procedes d'administration de medicaments par voie orale
EP2538945A4 (fr) * 2010-02-24 2013-07-24 Emisphere Tech Inc Thérapie orale à la vitamine b12
WO2011109784A1 (fr) 2010-03-05 2011-09-09 Conjuchem, Llc Formulation de conjugués peptidiques insulinotropiques
JP6231386B2 (ja) 2010-11-09 2017-11-15 ノヴォ ノルディスク アー／エス リンカーを有する二重アシル化されたｇｌｐ−１誘導体
MX377589B (es) 2010-12-16 2025-03-10 Novo Nordisk As Composiciones sólidas que comprenden agonista de glp-1 y sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico.
CN102718858B (zh) 2011-03-29 2014-07-02 天津药物研究院 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
AU2012241894B2 (en) 2011-04-12 2015-12-03 Novo Nordisk A/S Double-acylated GLP-1 derivatives
US20140220134A1 (en) 2011-06-24 2014-08-07 Astrazeneca Pharamceuticals LP Method for treating diabetes with extended release formulation of glp-1 receptor agonists
JP6006309B2 (ja) 2011-07-08 2016-10-12 アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド
HUE064694T2 (hu) * 2012-03-22 2024-04-28 Novo Nordisk As Továbbítószert tartalmazó készítmények és elõállításuk
KR102072202B1 (ko) * 2012-03-22 2020-01-31 노보 노르디스크 에이/에스 Ｇｌｐ-1 펩티드의 조성물 및 그것의 제조
WO2013189988A1 (fr) * 2012-06-20 2013-12-27 Novo Nordisk A/S Formulation de comprimés comprenant un peptide et un agent d'administration
US20150157619A1 (en) 2012-07-10 2015-06-11 Takeda Pharmaceutical Company Limited Pharmaceutical preparation for injection
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
HUE035803T2 (en) 2012-12-21 2018-05-28 Sanofi Sa Dual GLP1 / GIP or trigonal GLP1 / GIP / glucagon agonists
RS58039B1 (sr) 2013-05-02 2019-02-28 Novo Nordisk As Oralno doziranje glp-1 jedinjenja
CN103405753B (zh) 2013-08-13 2016-05-11 上海仁会生物制药股份有限公司 稳定的促胰岛素分泌肽水针药物组合物
TW201609798A (zh) 2013-12-13 2016-03-16 賽諾菲公司 Ｅｘｅｎｄｉｎ－４胜肽類似物
EP3080154B1 (fr) 2013-12-13 2018-02-07 Sanofi Agonistes doubles du récepteur glp-1/gip
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2015155151A1 (fr) 2014-04-07 2015-10-15 Novo Nordisk A/S Composés glp -1 à double acylation
DK3006045T3 (en) 2014-10-07 2017-07-17 Cyprumed Gmbh Pharmaceutical formulations for oral administration of peptide or protein drugs
WO2016120380A1 (fr) 2015-01-29 2016-08-04 Novo Nordisk A/S Composition pharmaceutique pour l'administration de glp-1 par voie orale, comprenant un noyau de comprimé et un revêtement à libération conventionnelle
WO2016203495A1 (fr) 2015-06-16 2016-12-22 Sun Pharma Advanced Research Company Limited Compositions de liraglutide à action prolongée
EP3359181A1 (fr) 2015-10-07 2018-08-15 Cyprumed GmbH Formulations pharmaceutiques pour l'administration par voie orale de médicaments peptidiques
WO2017149070A1 (fr) 2016-03-03 2017-09-08 Novo Nordisk A/S Dérivés de glp-1 et utilisations correspondantes
WO2018065634A1 (fr) 2016-10-07 2018-04-12 Cyprumed Gmbh Compositions pharmaceutiques pour l'administration par voie nasale de médicaments de type peptide ou protéine
US11458201B2 (en) * 2016-10-31 2022-10-04 Suda Ltd. Mucosal active agent delivery
AR112015A1 (es) 2017-06-09 2019-09-11 Novo Nordisk As Composiciones sólidas para administración oral
AR114353A1 (es) 2018-02-02 2020-08-26 Novo Nordisk As Composiciones sólidas que comprenden un agonista del glp-1 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico
SMT202200352T1 (it) 2018-04-05 2022-09-14 Sun Pharmaceutical Ind Ltd Analoghi del glp-1 innovativi
TWI829687B (zh) * 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物

Also Published As

Publication number Publication date
SG11202009978WA (en) 2020-11-27
EP4674479A2 (fr) 2026-01-07
US20210236601A1 (en) 2021-08-05
EP3790575C0 (fr) 2025-07-30
MY206098A (en) 2024-11-28
JP7164628B2 (ja) 2022-11-01
IL277857B2 (en) 2024-10-01
HRP20251112T1 (hr) 2025-11-07
IL277857A (en) 2020-11-30
ES3041298T3 (en) 2025-11-11
JP2022191439A (ja) 2022-12-27
IL312620A (en) 2024-07-01
CO2020014570A2 (es) 2021-03-08
US20230087952A1 (en) 2023-03-23
US11622996B2 (en) 2023-04-11
MX2020011308A (es) 2020-11-18
KR102835312B1 (ko) 2025-07-18
WO2019215063A1 (fr) 2019-11-14
IL277857B1 (en) 2024-06-01
AU2025204852A1 (en) 2025-07-24
MA52556A (fr) 2021-03-17
JP2021523149A (ja) 2021-09-02
US12616738B2 (en) 2026-05-05
AU2019264783A1 (en) 2020-12-10
EP3790575A1 (fr) 2021-03-17
RS67212B1 (sr) 2025-10-31
CA3097944A1 (fr) 2019-11-14
BR112020021717A2 (pt) 2021-01-26
TW202015722A (zh) 2020-05-01
EP3790575B1 (fr) 2025-07-30
JP7529743B2 (ja) 2024-08-06
EP4674479A3 (fr) 2026-01-28
PH12020551691A1 (en) 2021-07-19
CL2020002797A1 (es) 2021-02-19
PL3790575T3 (pl) 2025-11-17
TWI829687B (zh) 2024-01-21
PE20211794A1 (es) 2021-09-09
AU2019264783B2 (en) 2025-04-03
HUE073123T2 (hu) 2026-01-28
KR20250111399A (ko) 2025-07-22
AR115283A1 (es) 2020-12-16
KR20210008353A (ko) 2021-01-21
CN112153979A (zh) 2020-12-29
WO2019215063A8 (fr) 2020-07-02

Similar Documents

Publication Publication Date Title
MA53076B1 (fr) Compositions solides comportant un agoniste glp-1, du sel d'acide n-(8-(2-hydroxybenzoyl)amino)caprylate et un lubrifiant
PH12020551691A1 (en) Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
MA41496B1 (fr) Compositions pharmaceutiques comprenant n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
EP4529952A3 (fr) Composés chimiques
MA40814A1 (fr) Compositions pharmaceutiques pour thérapie combinée
PH12022550007A1 (en) Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
MA37850A1 (fr) Inhibiteurs de nep pour le traitement de maladies caractérisées par un agrandissement atrial ou une remodélisation atriale
EA202190960A1 (ru) Конденсированные пирролины, которые действуют как ингибиторы убиквитин-специфической протеазы 30 (usp30)
MA33467B1 (fr) Promédicaments comprenant un conjugué insuline-lieur
CL2017003208A1 (es) Unidad de dosificación orodispersable que contiene un componente estetrol
MA52154B1 (fr) Composition pharmaceutique pour l'anémie
MA45972B1 (fr) Unité posologique orodispersible contenant un composant d'estétrol
EA202192322A1 (ru) Фармацевтические составы
MA37777B1 (fr) Préparation pharmaceutique
WO2017093810A3 (fr) Composition destinée à une administration intra-orale de peptides et de protéines biologiquement actifs
MA41985B1 (fr) Composition pour le nettoyage du côlon et le traitement de troubles gastro-intestinaux
FI3998067T3 (fi) Koostumukset ja menetelmät homokystinurian hoitoon
MX2026000979A (es) Una forma farmaceutica solida de dosificacion bucodispersable de safinamida
PH12022550008A1 (en) Solid compositions comprising an egf(a) derivative and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
EA202191130A1 (ru) Фармацевтическая композиция для лечения апластической анемии
MA41102A (fr) Compositions contenant de la curcumine à biodisponibilité améliorée
MA33455B1 (fr) Otamixaban pour le traitement de patients atteints d'infarctus du myocarde sans élévation du st ages et insuffisants renaux
MA43793B1 (fr) Procédé de préparation de formulations solides de mésalazine
AR122297A1 (es) Composiciones sólidas que comprenden un agonista del glp-1, un inhibidor del sglt2 y una sal del ácido n-(8-(2-hidroxibenzoil)amino)caprílico
MX2021004412A (es) Cocristales que comprenden levotiroxina y un acido dicarboxilico.