MA52648A - Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation - Google Patents

Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Info

Publication number
MA52648A
MA52648A MA052648A MA52648A MA52648A MA 52648 A MA52648 A MA 52648A MA 052648 A MA052648 A MA 052648A MA 52648 A MA52648 A MA 52648A MA 52648 A MA52648 A MA 52648A
Authority
MA
Morocco
Prior art keywords
compounds
pharmaceutical compositions
ppar agonists
use procedures
procedures
Prior art date
Application number
MA052648A
Other languages
English (en)
Inventor
Michael Downes
Ronald M Evans
Arthur Kluge
Bharat Lagu
Masanori Miura
Sunil Kumar Panigrahi
Michael Patane
Susanta Samajdar
Ramesh Senaiar
Taisuke Takahashi
Original Assignee
Mitobridge Inc
Salk Inst Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57200096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA52648(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitobridge Inc, Salk Inst Biological Studies filed Critical Mitobridge Inc
Publication of MA52648A publication Critical patent/MA52648A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA052648A 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation MA52648A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562238629P 2015-10-07 2015-10-07
US201562243263P 2015-10-19 2015-10-19
US201662352348P 2016-06-20 2016-06-20

Publications (1)

Publication Number Publication Date
MA52648A true MA52648A (fr) 2021-10-13

Family

ID=57200096

Family Applications (2)

Application Number Title Priority Date Filing Date
MA052648A MA52648A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation
MA052098A MA52098A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA052098A MA52098A (fr) 2015-10-07 2016-10-05 Agonistes de ppar, composés, compositions pharmaceutiques et leurs procédés d'utilisation

Country Status (26)

Country Link
US (6) US10399958B2 (fr)
EP (3) EP3770146B1 (fr)
JP (2) JP6657413B2 (fr)
KR (2) KR102667386B1 (fr)
CN (3) CN113004205B (fr)
AU (3) AU2016333963C1 (fr)
BR (1) BR112018006866B1 (fr)
CA (1) CA3000431A1 (fr)
CO (1) CO2018004473A2 (fr)
DK (1) DK3359528T3 (fr)
EA (1) EA037371B1 (fr)
ES (3) ES2949852T3 (fr)
HU (1) HUE058154T2 (fr)
IL (3) IL258225B (fr)
JO (3) JO3738B1 (fr)
MA (2) MA52648A (fr)
MX (3) MX392524B (fr)
MY (1) MY203081A (fr)
PH (1) PH12018500762A1 (fr)
PL (1) PL3359528T3 (fr)
PT (1) PT3359528T (fr)
SG (1) SG10201906400SA (fr)
TW (3) TWI742479B (fr)
UA (1) UA122237C2 (fr)
WO (1) WO2017062468A1 (fr)
ZA (4) ZA201802029B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037371B1 (ru) * 2015-10-07 2021-03-19 Митобридж, Инк. Агонисты ppar, соединения, фармацевтические композиции и способы их применения
US11358954B2 (en) 2016-04-13 2022-06-14 Mitobridge, Inc. PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
ES2859487T3 (es) * 2016-10-05 2021-10-04 Mitobridge Inc Métodos para tratar las lesiones renales agudas
ES2887008T3 (es) 2016-10-05 2021-12-21 Mitobridge Inc Formas cristalinas y de sal de compuestos agonistas del PPAR
US20220331267A1 (en) * 2019-09-05 2022-10-20 Rush University Medical Center Methods and compositions for treatment of demyelinating disorders
US11634387B2 (en) 2019-09-26 2023-04-25 Abionyx Pharma Sa Compounds useful for treating liver diseases
WO2022189856A1 (fr) 2021-03-08 2022-09-15 Abionyx Pharma Sa Composés utiles pour le traitement des maladies du foie
MX2023010537A (es) * 2021-03-08 2023-11-28 Abionyx Pharma Sa Compuestos útiles para tratar enfermedades del hígado.
BR112023025221A2 (pt) 2021-06-02 2024-02-27 Astellas Pharma Inc Métodos de uso de compostos agonistas de ppar e composições farmacêuticas dos mesmos
WO2023147309A1 (fr) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Utilisation d'agonistes ppar-delta dans le traitement d'une maladie
EP4230196A1 (fr) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Composés à utiliser dans le traitement des dystrophinopathies
WO2025207099A1 (fr) 2024-03-28 2025-10-02 Astellas Pharma Inc. Inhibiteurs de ppar-delta pour prévenir une fibrillation auriculaire post-opératoire

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DE4123341A1 (de) 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9511694D0 (en) 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
NZ514453A (en) 1999-02-26 2003-04-29 Merck & Co Inc Novel sulfonamide compounds and uses thereof
GB9919413D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
ATE447557T1 (de) 2000-08-17 2009-11-15 Pfizer Ltd Substitutuierte imidazole als tafia inhibitoren
CN100457730C (zh) * 2002-08-29 2009-02-04 默克公司 具有抗糖尿病活性的吲哚化合物
US7820682B2 (en) 2002-10-03 2010-10-26 Ono Pharmaceutical Co., Ltd. LPA receptor antagonist
WO2004060367A1 (fr) 2002-12-30 2004-07-22 Fujisawa Pharmaceutical Co., Ltd. Derives d'imidazole et de triazole utiles en tant qu'inhibiteurs de cox-1 selectifs
MXPA06003357A (es) 2003-09-26 2006-06-08 Japan Tobacco Inc Metodo para inhibir la produccion de lipoproteina remanente.
BRPI0515140A (pt) 2004-09-06 2008-07-08 Hoffmann La Roche derivados de benzamidina de 4-aminometila e seu emprego como inibidores do fator viia
CA2597148A1 (fr) 2005-02-15 2007-03-15 F. Hoffmann-La Roche Ag Derives d'amides en tant qu'activateurs de ppar
BRPI0615948A2 (pt) 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
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MX2008012404A (es) 2006-03-28 2008-10-09 Novartis Ag Derivados de amida y su aplicacion para el tratamiento de enfermedades relacionadas con proteina-g.
CN101466687B (zh) 2006-04-18 2012-04-11 日本化学医药株式会社 过氧化物酶体增殖剂激活受体δ的激活剂
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CN101085772A (zh) 2006-06-07 2007-12-12 上海艾力斯医药科技有限公司 一类具有PPARγ激动剂活性的化合物及其应用
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EP2981522A4 (fr) 2013-04-05 2016-08-31 Salk Inst For Biological Studi Antagonistes de ppar
WO2015035171A1 (fr) 2013-09-09 2015-03-12 High Point Pharmaceuticals, Llc Utilisation d'un agoniste de ppar-delta pour le traitement d'une amyotrophie
WO2016057322A1 (fr) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Agonistes de ppar et leurs méthodes d'utilisation
US20170305894A1 (en) 2014-10-08 2017-10-26 Mitobridge, Inc. Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof
EA037371B1 (ru) 2015-10-07 2021-03-19 Митобридж, Инк. Агонисты ppar, соединения, фармацевтические композиции и способы их применения
US11358954B2 (en) 2016-04-13 2022-06-14 Mitobridge, Inc. PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
ES2887008T3 (es) * 2016-10-05 2021-12-21 Mitobridge Inc Formas cristalinas y de sal de compuestos agonistas del PPAR
ES2859487T3 (es) 2016-10-05 2021-10-04 Mitobridge Inc Métodos para tratar las lesiones renales agudas
SMT202100321T1 (it) * 2016-12-30 2021-07-12 Mitobridge Inc Inibitori della poli-adp ribosio polimerasi (parp)

Also Published As

Publication number Publication date
CN113004205A (zh) 2021-06-22
ZA202003663B (en) 2022-08-31
EP3770146B1 (fr) 2024-07-24
MX380281B (es) 2025-03-12
ZA201802029B (en) 2022-01-26
US20200157074A1 (en) 2020-05-21
US10399958B2 (en) 2019-09-03
TWI742479B (zh) 2021-10-11
AU2020281069B2 (en) 2022-10-27
MX392523B (es) 2025-03-24
KR20210126150A (ko) 2021-10-19
EA201890776A1 (ru) 2018-09-28
IL258225B (en) 2021-08-31
CA3000431A1 (fr) 2017-04-13
KR102667385B1 (ko) 2024-05-21
US11578052B2 (en) 2023-02-14
IL275392B (en) 2022-05-01
PT3359528T (pt) 2022-04-07
HK1257907A1 (zh) 2019-11-01
AU2016333963A1 (en) 2018-04-12
TW202012375A (zh) 2020-04-01
PL3359528T3 (pl) 2022-05-30
EP3359528B1 (fr) 2022-01-12
IL275387A (en) 2020-07-30
MX2020011100A (es) 2022-05-23
CN113004205B (zh) 2024-07-02
UA122237C2 (uk) 2020-10-12
KR20180095797A (ko) 2018-08-28
TWI730006B (zh) 2021-06-11
NZ740846A (en) 2024-12-20
EP3770146C0 (fr) 2024-07-24
JP6657413B2 (ja) 2020-03-04
BR112018006866A2 (pt) 2018-10-16
EP3359528A1 (fr) 2018-08-15
JO3738B1 (ar) 2021-01-31
TW201722919A (zh) 2017-07-01
JOP20200230A1 (ar) 2022-10-30
TW201943705A (zh) 2019-11-16
PH12018500762A1 (en) 2018-10-29
US10906885B2 (en) 2021-02-02
CN108349904A (zh) 2018-07-31
DK3359528T3 (en) 2022-03-07
WO2017062468A8 (fr) 2017-05-11
TWI730408B (zh) 2021-06-11
SG10201906400SA (en) 2019-08-27
EP3795566A1 (fr) 2021-03-24
MX392524B (es) 2025-03-24
MX2018004295A (es) 2018-08-09
BR112018006866B1 (pt) 2023-11-21
AU2019283837A1 (en) 2020-01-16
IL258225A (en) 2018-05-31
HUE058154T2 (hu) 2022-07-28
JP2020075939A (ja) 2020-05-21
AU2016333963C1 (en) 2021-05-27
JOP20200230B1 (ar) 2024-04-18
EP3795566B1 (fr) 2023-04-19
ZA202003662B (en) 2022-08-31
US10479775B1 (en) 2019-11-19
US20240417383A1 (en) 2024-12-19
IL275392A (en) 2020-07-30
JOP20200231B1 (ar) 2022-03-14
JP2018534355A (ja) 2018-11-22
CN108349904B (zh) 2021-08-31
AU2019283837B2 (en) 2020-12-24
CO2018004473A2 (es) 2018-09-20
ES2988059T3 (es) 2024-11-19
EA037371B1 (ru) 2021-03-19
ES2949852T3 (es) 2023-10-03
CN113024467A (zh) 2021-06-25
IL275387B (en) 2021-08-31
MA52098A (fr) 2021-01-27
JP6866514B2 (ja) 2021-04-28
AU2016333963B2 (en) 2021-01-07
US20190337920A1 (en) 2019-11-07
AU2020281069A1 (en) 2021-01-07
US20190084958A1 (en) 2019-03-21
US20230373948A1 (en) 2023-11-23
KR102667386B1 (ko) 2024-05-21
MX2020011099A (es) 2022-05-23
MY203081A (en) 2024-06-07
ZA202003664B (en) 2022-08-31
CN113024467B (zh) 2024-08-06
ES2906379T3 (es) 2022-04-18
JOP20200231A1 (ar) 2022-10-30
EP3770146A1 (fr) 2021-01-27
US20210253549A1 (en) 2021-08-19
WO2017062468A1 (fr) 2017-04-13

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