MA52762A - Lipides cationiques comprenant une fraction stéroïdienne - Google Patents

Lipides cationiques comprenant une fraction stéroïdienne

Info

Publication number
MA52762A
MA52762A MA052762A MA52762A MA52762A MA 52762 A MA52762 A MA 52762A MA 052762 A MA052762 A MA 052762A MA 52762 A MA52762 A MA 52762A MA 52762 A MA52762 A MA 52762A
Authority
MA
Morocco
Prior art keywords
fat containing
cationic fat
steroid fraction
steroid
fraction
Prior art date
Application number
MA052762A
Other languages
English (en)
Inventor
Frank Derosa
Michael Heartlein
Shrirang Karve
Yi Zhang
Original Assignee
Translate Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Translate Bio Inc filed Critical Translate Bio Inc
Publication of MA52762A publication Critical patent/MA52762A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/52—Isomerases (5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA052762A 2018-05-30 2019-05-30 Lipides cationiques comprenant une fraction stéroïdienne MA52762A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862677821P 2018-05-30 2018-05-30

Publications (1)

Publication Number Publication Date
MA52762A true MA52762A (fr) 2021-04-14

Family

ID=67003655

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052762A MA52762A (fr) 2018-05-30 2019-05-30 Lipides cationiques comprenant une fraction stéroïdienne

Country Status (9)

Country Link
US (1) US11547666B2 (fr)
EP (2) EP4442831A3 (fr)
JP (2) JP7463006B2 (fr)
CN (1) CN112424214A (fr)
AU (1) AU2019278813B2 (fr)
CA (1) CA3100214A1 (fr)
ES (1) ES2989886T3 (fr)
MA (1) MA52762A (fr)
WO (1) WO2019232208A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853377B2 (en) * 2010-11-30 2014-10-07 Shire Human Genetic Therapies, Inc. mRNA for use in treatment of human genetic diseases
EP3793689A1 (fr) * 2018-05-15 2021-03-24 Translate Bio, Inc. Administration sous-cutanée d'arn messager
CN118436618A (zh) 2018-05-30 2024-08-06 川斯勒佰尔公司 信使rna疫苗及其用途
EP3986452A1 (fr) 2019-06-18 2022-04-27 CureVac AG Vaccin à arnm rotavirus
CA3146369A1 (fr) 2019-07-08 2021-01-14 Translate Bio, Inc. Nanoparticules lipidiques chargees d'arn messager ameliorees et leurs procedes de fabrication
US12194089B2 (en) 2020-02-04 2025-01-14 CureVac SE Coronavirus vaccine
DE202021004130U1 (de) 2020-02-04 2022-10-26 Curevac Ag Coronavirus-Vakzine
WO2021239880A1 (fr) 2020-05-29 2021-12-02 Curevac Ag Vaccins combinés à base d'acide nucléique
EP4172194A1 (fr) 2020-07-31 2023-05-03 CureVac SE Mélanges d'anticorps codés par des acides nucléiques
WO2022043551A2 (fr) 2020-08-31 2022-03-03 Curevac Ag Vaccins contre le coronavirus à base d'acides nucléiques multivalents
MX2023004371A (es) 2020-10-14 2023-07-26 George Mason Res Foundation Inc Lípidos ionizables, y métodos de fabricación y uso de los mismos.
MX2023007574A (es) 2020-12-22 2023-09-29 CureVac SE "vacuna de arn contra variantes de sars-cov-2.
US20240299309A1 (en) 2020-12-22 2024-09-12 CureVac SE Pharmaceutical composition comprising lipid-based carriers encapsulating rna for multidose administration
CA3170747A1 (fr) 2021-01-27 2022-08-04 Moritz THRAN Procede de reduction des proprietes immunostimulatrices d'arn transcrit in vitro
EP4312988A2 (fr) 2021-03-31 2024-02-07 CureVac SE Seringues contenant des compositions pharmaceutiques comprenant de l'arn
CA3215606A1 (fr) * 2021-04-19 2022-10-27 Shrirang KARVE Compositions ameliorees pour l'administration d'arnm
CA3171589A1 (fr) 2021-05-03 2022-11-03 Moritz THRAN Sequence d'acide nucleique amelioree pour l'expression specifique de type cellulaire
EP4763287A2 (fr) 2021-09-03 2026-06-24 CureVac SE Nouvelles nanoparticules lipidiques pour l'administration d'acides nucléiques
EP4422698A1 (fr) 2021-10-29 2024-09-04 CureVac SE Arn circulaire amélioré pour exprimer des protéines thérapeutiques
EP4469091A1 (fr) 2022-01-28 2024-12-04 CureVac SE Inhibiteurs de facteurs de transcription codés par un acide nucleique
CN117003807B (zh) * 2022-04-28 2026-05-26 北京科兴中维生物技术有限公司 一种结构脂质化合物及其制备方法和用途
CN117003808B (zh) * 2022-04-28 2026-05-29 北京科兴中维生物技术有限公司 一种阳离子脂质化合物及其制备方法和用途
CA3248209A1 (fr) 2022-05-25 2023-11-30 CureVac SE Vaccin à base d’acide nucléique codant pour un polypeptide antigénique fimh d’escherichia coli
WO2024012270A1 (fr) * 2022-07-11 2024-01-18 传信生物医药(苏州)有限公司 Composition pour l'administration spécifique à un organe d'acide nucléique
WO2024089638A1 (fr) 2022-10-28 2024-05-02 Glaxosmithkline Biologicals Sa Vaccin à base d'acide nucléique
WO2024140893A1 (fr) * 2022-12-29 2024-07-04 辽宁键凯科技有限公司 Composé lipidique cationique stéroïde et son utilisation
CN120641396A (zh) * 2023-01-29 2025-09-12 正基基因科技有限公司 阳离子脂质与脂质纳米颗粒
KR20250153298A (ko) 2023-03-08 2025-10-24 큐어백 에스이 핵산 전달을 위한 신규의 지질 나노입자 제형
EP4721759A1 (fr) 2023-04-29 2026-04-08 Cansino (Shanghai) Biological Research Co., Ltd. Nanoparticule lipidique pour administrer un médicament à base d'acide nucléique, son procédé de préparation et son utilisation
WO2024227430A1 (fr) 2023-04-29 2024-11-07 康希诺(上海)生物研发有限公司 Composé lipidique cationique stéroïdien et son utilisation
WO2024230934A1 (fr) 2023-05-11 2024-11-14 CureVac SE Acide nucléique thérapeutique pour le traitement de maladies ophtalmiques
CN117069785B (zh) * 2023-07-04 2026-08-11 中生复诺健生物科技(上海)有限公司 脂质化合物和脂质纳米颗粒组合物
WO2025113662A1 (fr) * 2023-12-01 2025-06-05 康希诺(上海)生物研发有限公司 Nanoparticule lipidique pour l'administration d'acide nucléique, son procédé de préparation et son utilisation
WO2026003582A2 (fr) 2024-06-27 2026-01-02 Axelyf ehf. Lipides et nanoparticules lipidiques
WO2026036296A1 (fr) * 2024-08-14 2026-02-19 康希诺(上海)生物研发有限公司 Nanoparticules lipidiques pour l'administration de médicament à base d'acide nucléique, son procédé de préparation et son utilisation
WO2026061417A1 (fr) * 2024-09-18 2026-03-26 北京茵诺医药科技有限公司 Dérivé de stérol ionisable pour l'administration d'un agent thérapeutique et son utilisation
WO2026102567A1 (fr) * 2024-11-12 2026-05-21 National University Of Singapore Nanoparticules lipidiques et méthodes correspondantes
CN120971717B (zh) * 2025-10-21 2026-02-06 上海交通大学医学院附属仁济医院 Serpinb10蛋白在制备嗜酸细胞性食管炎与反流性食管炎的鉴别诊断产品中的应用

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4192871A (en) * 1976-01-06 1980-03-11 Glaxo Laboratories Limited Chemical compounds
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US5132418A (en) 1980-02-29 1992-07-21 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4973679A (en) 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US4668777A (en) 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4401796A (en) 1981-04-30 1983-08-30 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US5047524A (en) 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5262530A (en) 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
US5334761A (en) 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
IT1304501B1 (it) * 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
IT1313617B1 (it) * 1999-08-31 2002-09-09 Bracco Spa Processo per la preparazione di derivati degli acidi biliari.
DE60325329D1 (de) * 2002-01-18 2009-01-29 Univ Minnesota Quaternäre terpensalze als biologisch aktive tenside
CA2569664C (fr) 2004-06-07 2013-07-16 Protiva Biotherapeutics, Inc. Arn interferant encapsule dans des lipides
EP2049665A2 (fr) 2006-07-28 2009-04-22 Applera Corporation ANALOGUES DE COIFFES DE NUCLÉOTIDE D'ARNm
WO2009058911A2 (fr) 2007-10-31 2009-05-07 Applied Biosystems Inc. Préparation et isolement d'un arnm coiffé en 5'
AU2009303345B2 (en) 2008-10-09 2015-08-20 Arbutus Biopharma Corporation Improved amino lipids and methods for the delivery of nucleic acids
WO2010053572A2 (fr) 2008-11-07 2010-05-14 Massachusetts Institute Of Technology Lipidoïdes aminoalcool et leurs utilisations
KR20220038506A (ko) 2009-06-10 2022-03-28 알닐람 파마슈티칼스 인코포레이티드 향상된 지질 조성물
EP4074693A1 (fr) 2011-06-08 2022-10-19 Translate Bio, Inc. Lipides clivables
US9512073B2 (en) 2011-10-27 2016-12-06 Massachusetts Institute Of Technology Amino acid-, peptide-and polypeptide-lipids, isomers, compositions, and uses thereof
BR112014024131A2 (pt) 2012-03-29 2017-07-25 Shire Human Genetic Therapies lipídios catiônicos ionizáveis
US20140275229A1 (en) * 2012-04-02 2014-09-18 Moderna Therapeutics, Inc. Modified polynucleotides encoding udp glucuronosyltransferase 1 family, polypeptide a1
US10266559B2 (en) 2013-03-14 2019-04-23 Translate Bio, Inc. Ribonucleic acids with 4′-thio-modified nucleotides and related methods
US10059655B2 (en) 2013-12-19 2018-08-28 Novartis Ag Lipids and lipid compositions for the delivery of active agents
WO2015184256A2 (fr) 2014-05-30 2015-12-03 Shire Human Genetic Therapies, Inc. Lipides biodégradables pour l'administration d'acides nucléiques
CA2953341C (fr) 2014-06-25 2023-01-24 Acuitas Therapeutics Inc. Lipides et formulations de nanoparticules de lipides pour l'administration d'acides nucleiques
WO2016004202A1 (fr) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Lipidoïdes dérivés de polyamine-acide gras et leurs utilisations
WO2016079685A1 (fr) * 2014-11-20 2016-05-26 Taplast S.P.A. Élément élastique pour dispositif pour la distribution de fluides ou de mélanges et procédé et moule pour la fabrication dudit élément élastique
WO2016118724A1 (fr) 2015-01-21 2016-07-28 Moderna Therapeutics, Inc. Compositions de nanoparticules lipidiques
EP3247398A4 (fr) 2015-01-23 2018-09-26 Moderna Therapeutics, Inc. Compositions de nanoparticules lipidiques
RS64331B1 (sr) 2015-06-19 2023-08-31 Massachusetts Inst Technology Alkenil supstituisani 2,5-piperazindioni i njihova primena u sastavima za isporuku agensa u organizam ili ćeliju subjekta
HUE067372T2 (hu) 2015-06-29 2024-10-28 Acuitas Therapeutics Inc Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
HRP20220156T1 (hr) 2015-09-17 2022-04-15 Modernatx, Inc. Spojevi i pripravci za unutarstaničnu isporuku terapeutskih sredstava
CN108368028B (zh) 2015-10-28 2021-09-03 爱康泰生治疗公司 用于递送核酸的新型脂质和脂质纳米颗粒制剂
US12678515B2 (en) 2015-12-30 2026-07-14 Acuitas Therapeutics, Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
ES3030658T3 (en) 2016-03-30 2025-07-01 Intellia Therapeutics Inc Lipid nanoparticle formulations for crispr/cas components
CN107281103A (zh) * 2016-04-11 2017-10-24 百奥迈科生物技术有限公司 具有高含量阳性脂质化合物的脂质体制剂及其应用
US20170325457A1 (en) * 2016-04-28 2017-11-16 Preceres Inc. Formulations for the delivery of active agents to insects, plants, and plant pathogens
US20180153822A1 (en) 2016-11-10 2018-06-07 Translate Bio, Inc. Process of Preparing mRNA-Loaded Lipid Nanoparticles
JP7256824B2 (ja) 2018-04-25 2023-04-12 エスリス ゲーエムベーハー 粒子状製剤用の凍結保護剤

Also Published As

Publication number Publication date
JP2021525744A (ja) 2021-09-27
US20210220273A1 (en) 2021-07-22
JP7463006B2 (ja) 2024-04-08
CN112424214A (zh) 2021-02-26
US11547666B2 (en) 2023-01-10
AU2019278813B2 (en) 2023-12-07
JP2024032912A (ja) 2024-03-12
EP3802558B1 (fr) 2024-09-11
CA3100214A1 (fr) 2019-12-05
EP4442831A3 (fr) 2024-10-30
ES2989886T3 (es) 2024-11-28
EP4442831A2 (fr) 2024-10-09
AU2019278813A1 (en) 2020-12-03
EP3802558C0 (fr) 2024-09-11
WO2019232208A1 (fr) 2019-12-05
EP3802558A1 (fr) 2021-04-14

Similar Documents

Publication Publication Date Title
MA52766A (fr) Lipides cationiques vitaminiques
EP3733641A4 (fr) Lipides cationiques
MA52625A (fr) Lipides cationiques de ribose
GB202206002D0 (en) Multi-tier tokenization platform
EP3851096A4 (fr) Composition liquide comprenant une protéine
EP3582603A4 (fr) Moissonneuse-batteuse comprenant une commande à rétroaction de machine
EP3844175A4 (fr) Thérapies combinées comprenant des protéines chimériques à base de pd -1
EP3874440A4 (fr) Plateforme de tokénisation
DK3835287T3 (da) Kationisk lipid
EP3613057A4 (fr) Interface utilisateur graphique pour la planification d'une intervention
EP3688097A4 (fr) Composition de silicone comprenant une charge
LT3849537T (lt) Kompleksinės terapijos
EP3275330A4 (fr) Chaussure comprenant un stabilisateur
EP3756071C0 (fr) Rétroaction haptique pour réalité virtuelle
FR3057768B1 (fr) Emulsions doubles comprenant une phase grasse gelifiee
EP3610371A4 (fr) Progiciels de diffusion de programmes comprenant des mises à jour de programmes
EP3510894A4 (fr) Pied à cinq étoiles pliable
EP3668321C0 (fr) Pain complet à teneur fodmap réduit
EP3897322A4 (fr) Agitateur
EP3764160A4 (fr) Pellicule comprenant un film de graphite
EP3317743A4 (fr) Charnière comprenant un verrou
IL278847A (en) Processor feature detection response for virtualization
EP3402699A4 (fr) Ensemble modulaire structural comprenant des renforcements électroconducteurs surmoulés
EP3733621A4 (fr) Film comprenant un circuit
EP3881865A4 (fr) Composition liquide stable comprenant une protéine