MA52812A - Inhibiteurs de sarm1 - Google Patents

Inhibiteurs de sarm1

Info

Publication number
MA52812A
MA52812A MA052812A MA52812A MA52812A MA 52812 A MA52812 A MA 52812A MA 052812 A MA052812 A MA 052812A MA 52812 A MA52812 A MA 52812A MA 52812 A MA52812 A MA 52812A
Authority
MA
Morocco
Prior art keywords
sarm1 inhibitors
sarm1
inhibitors
Prior art date
Application number
MA052812A
Other languages
English (en)
Inventor
Jonathan Bentley
Todd Bosanac
Andrew Simon Brearley
Rajesh Devraj
Robert Owen Hughes
Richard Andrew Jarjes-Pike
Original Assignee
Disarm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Disarm Therapeutics Inc filed Critical Disarm Therapeutics Inc
Publication of MA52812A publication Critical patent/MA52812A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/022Boron compounds without C-boron linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MA052812A 2018-06-07 2019-06-06 Inhibiteurs de sarm1 MA52812A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862682054P 2018-06-07 2018-06-07

Publications (1)

Publication Number Publication Date
MA52812A true MA52812A (fr) 2021-04-14

Family

ID=68770700

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052812A MA52812A (fr) 2018-06-07 2019-06-06 Inhibiteurs de sarm1

Country Status (7)

Country Link
US (1) US20210261537A1 (fr)
EP (1) EP3801503A4 (fr)
JP (1) JP7481329B2 (fr)
CN (2) CN120398784A (fr)
CA (1) CA3108669A1 (fr)
MA (1) MA52812A (fr)
WO (1) WO2019236890A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019236884A1 (fr) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibiteurs de sarm1
CN112839647B (zh) 2018-06-07 2025-09-23 达萨玛治疗公司 Sarm1抑制剂
JP7273954B2 (ja) * 2018-10-19 2023-05-15 ディスアーム セラピューティクス, インコーポレイテッド Nad+またはnad+前駆体と組み合わせたsarm1の阻害
CA3123215C (fr) 2018-12-19 2024-04-02 Disarm Therapeutics, Inc. Inhibiteurs de sarm1 en combinaison avec des agents neuroprotecteurs
CA3140578C (fr) * 2019-06-06 2025-06-17 Disarm Therapeutics, Inc. Inhibiteurs de sarm1
EP4028013A4 (fr) 2019-09-12 2023-10-18 Disarm Therapeutics, Inc. Inhibiteurs de sarm1
WO2021108602A1 (fr) * 2019-11-26 2021-06-03 Disarm Therapeutics, Inc. Méthodes et compositions pour la neuroprotection
EP4083037A4 (fr) * 2019-12-26 2024-01-24 Yonsei University, University-Industry Foundation(UIF). Dérivé de pyrrolidine et composition pharmaceutique de prévention ou de traitement de maladies associées à la protéine bêta-amyloïde ou tau contenant ce dernier
JP7490781B2 (ja) * 2020-01-07 2024-05-27 ディスアーム セラピューティクス, インコーポレイテッド Sarm1の阻害剤
EP4132920B1 (fr) 2020-04-09 2025-08-13 Disarm Therapeutics, Inc. Dérivés d' indazole comme inhibiteurs de sarm1
US12404265B2 (en) 2020-08-04 2025-09-02 Nura Bio, Inc. Substituted pyridine derivatives as SARM1 inhibitors
TWI904906B (zh) 2020-08-24 2025-11-11 美商達薩瑪治療公司 Sarm1之抑制劑
EP4214197A1 (fr) 2020-09-16 2023-07-26 Nura Bio, Inc. Dérivés de pyridine substitués utiles comme inhibiteurs de sarm1
CN114470215A (zh) * 2020-11-12 2022-05-13 北京科辉智药生物科技有限责任公司 Sarm1酶活性抑制剂及其在神经退行性疾病中的应用
CA3200439A1 (fr) * 2020-12-08 2022-06-16 Disarm Therapeutics, Inc. Inhibiteurs de sarm1 a base de benzopyrazole
KR20240041987A (ko) 2021-07-28 2024-04-01 누라 바이오, 인크. Sarm1 억제제로서 치환된 피리딘 유도체
CN118946553A (zh) * 2022-04-08 2024-11-12 深圳众格生物科技有限公司 Sarm1抑制剂化合物、包含其的药物组合物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2443918C (fr) * 2001-04-11 2012-06-05 Senju Pharmaceutical Co., Ltd. Agents contenant des inhibiteurs de la kinase rho ameliorant les troubles de la fonction visuelle
US6989451B2 (en) * 2002-06-04 2006-01-24 Valeant Research & Development Heterocyclic compounds and uses thereof
US6727241B2 (en) * 2002-06-12 2004-04-27 Chemocentryx Anti-inflammatory compositions and methods of use
US20060217390A1 (en) * 2005-02-24 2006-09-28 Esmir Gunic Cycloalkl, aryl and heteroaryl amino isothiazoles for the treatment of Hepatitis C virus
WO2006133417A1 (fr) * 2005-06-07 2006-12-14 Valeant Pharmaceuticals International Phenylamino isothiazole carboxamidines comme inhibiteurs de mek
EP2152079A4 (fr) * 2007-06-04 2011-03-09 Avila Therapeutics Inc Composés hétérocycliques et utilisations de ceux-ci
IL251949A0 (en) 2017-04-26 2017-07-31 Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct Small organic molecules for use in the treatment of neuro-inflammatory diseases
CA3123215C (fr) * 2018-12-19 2024-04-02 Disarm Therapeutics, Inc. Inhibiteurs de sarm1 en combinaison avec des agents neuroprotecteurs

Also Published As

Publication number Publication date
WO2019236890A1 (fr) 2019-12-12
CA3108669A1 (fr) 2019-12-12
JP7481329B2 (ja) 2024-05-10
CN112867489A (zh) 2021-05-28
CN120398784A (zh) 2025-08-01
EP3801503A1 (fr) 2021-04-14
EP3801503A4 (fr) 2021-12-08
JP2021527126A (ja) 2021-10-11
US20210261537A1 (en) 2021-08-26

Similar Documents

Publication Publication Date Title
IL283639A (en) Kif18a inhibitors
MA54550A (fr) Inhibiteurs de kif18a
EP4007752C0 (fr) Inhibiteurs de kif18a
EP4007753C0 (fr) Inhibiteurs de kif18a
EP4007756C0 (fr) Inhibiteurs de kif18a
IL269196A (en) Novel inhibitors
EP3801503A4 (fr) Inhibiteurs de sarm1
EP3843714A4 (fr) Inhibiteurs de cd73
EP3833355A4 (fr) Inhibiteurs de prmt5
DK3740479T3 (da) Dna-pk-hæmmere
EP3788042A4 (fr) Inhibiteurs de bcl-2
MA52413A (fr) Inhibiteurs de cd73
EP3541932A4 (fr) Inhibiteurs de crispr-cas9
MA52813A (fr) Inhibiteurs de sarm1
EP3793547A4 (fr) Inhibiteurs de magl
DK3571192T3 (da) Jak1-selektive inhibitorer
EP3817736A4 (fr) Inhibiteurs de pikfyve
EP3856176A4 (fr) Inhibiteurs de vap-1
EP3787635A4 (fr) Inhibiteurs de cd73
MA52809A (fr) Inhibiteurs de sarm1
EP3980011A4 (fr) Inhibiteurs de sarm1
EP3773537A4 (fr) Inhibiteurs de stat3
DK3630744T3 (da) Pyrazol-magl-inhibitorer
MA51611A (fr) Inhibiteurs de pi4kiiibêta
EP3833664A4 (fr) Inhibiteurs de smad3