MA54550A - Inhibiteurs de kif18a - Google Patents

Inhibiteurs de kif18a

Info

Publication number
MA54550A
MA54550A MA054550A MA54550A MA54550A MA 54550 A MA54550 A MA 54550A MA 054550 A MA054550 A MA 054550A MA 54550 A MA54550 A MA 54550A MA 54550 A MA54550 A MA 54550A
Authority
MA
Morocco
Prior art keywords
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054550A
Other languages
English (en)
Inventor
John Gordon Allen
Abhisek Banerjee
Matthew Paul Bourbeau
James Alexander Brown
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Kexue Li
Qingyian Liu
Jonathan Dante Low
Vu Ma
Ana Elena Minatti
Thomas T Nguyen
Nobuko Nishimura
Liping H Pettus
Nuria A Tamayo
Mary Catherine Walton
Qiufen May Xue
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54550A publication Critical patent/MA54550A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treating Waste Gases (AREA)
MA054550A 2018-12-20 2019-12-20 Inhibiteurs de kif18a MA54550A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783069P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54550A true MA54550A (fr) 2022-03-30

Family

ID=69411509

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054550A MA54550A (fr) 2018-12-20 2019-12-20 Inhibiteurs de kif18a

Country Status (9)

Country Link
US (1) US12459932B2 (fr)
EP (1) EP3897855B1 (fr)
JP (1) JP7686559B2 (fr)
AU (1) AU2019403488B2 (fr)
CA (1) CA3123042A1 (fr)
ES (1) ES2953821T3 (fr)
MA (1) MA54550A (fr)
MX (1) MX2021007104A (fr)
WO (1) WO2020132651A1 (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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MA54543A (fr) 2018-12-20 2022-03-30 Amgen Inc Inhibiteurs de kif18a
JP7686559B2 (ja) 2018-12-20 2025-06-02 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤
JP2022513967A (ja) 2018-12-20 2022-02-09 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド
AU2019401495B2 (en) * 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
EP4007638A1 (fr) 2019-08-02 2022-06-08 Amgen Inc. Dérivés de pyridine en tant qu'inhibiteurs de kif18a
EP4007752B1 (fr) * 2019-08-02 2025-09-24 Amgen Inc. Inhibiteurs de kif18a
EP4007753B1 (fr) 2019-08-02 2025-09-24 Amgen Inc. Inhibiteurs de kif18a
US20230233565A1 (en) * 2020-05-11 2023-07-27 University Of Vermont A treatment approach involving kif18a inhibition for chromosomally unstable tumors
US20240059703A1 (en) 2020-10-20 2024-02-22 Amgen Inc. Heterocyclic spiro compounds and methods of use
WO2022093856A1 (fr) 2020-10-27 2022-05-05 Amgen Inc. Composés spiro hétérocycliques et procédés d'utilisation
MX2023012725A (es) 2021-04-29 2024-09-23 Amgen Inc Compuestos de 2-aminobenzotiazol y metodos de uso de los mismos.
US20250214965A1 (en) * 2021-06-25 2025-07-03 Hangzhou Innogate Pharma Co., Ltd. Compound as kif18a inhibitor
IL310863A (en) 2021-08-26 2024-04-01 Volastra Therapeutics Inc Spiro indoline inhibitors of kif18a
WO2023041055A1 (fr) * 2021-09-16 2023-03-23 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
AU2022389558A1 (en) * 2021-11-19 2024-05-23 Wigen Biomedicine Technology (shanghai) Co., Ltd. Kif18a inhibitor
EP4479398A1 (fr) 2022-02-16 2024-12-25 Amgen Inc. Composés quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
MX2024010045A (es) 2022-02-16 2024-08-26 Amgen Inc Compuestos de quinazolina y uso de los mismos como inhibidores de proteinas mutantes kras.
JP2025508192A (ja) * 2022-03-17 2025-03-21 ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド Ｋｉｆ１８ａ阻害剤
TW202400582A (zh) * 2022-05-13 2024-01-01 大陸商上海湃隆生物科技有限公司 驅動蛋白kif18a抑制劑及其應用
CN116789637B (zh) * 2022-05-13 2024-08-02 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
KR20250027560A (ko) * 2022-06-30 2025-02-26 쑤저우 젠하우스 바이오 컴퍼니 리미티드 질소 함유 화합물 및 이의 용도
WO2024022508A1 (fr) * 2022-07-29 2024-02-01 武汉人福创新药物研发中心有限公司 Inhibiteur de la kif18a et utilisation
CN117510463A (zh) * 2022-08-05 2024-02-06 长春金赛药业有限责任公司 Kif18a抑制剂化合物、药物组合物及其制备方法和应用
WO2024035950A1 (fr) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
TW202416973A (zh) 2022-08-18 2024-05-01 美商雅客森醫療公司 Ｋｉｆ１８ａ抑制劑及其用途
KR20250044780A (ko) * 2022-09-08 2025-04-01 장춘 진사이언스 파마슈티컬 씨오., 엘티디. Kif18a 억제제 화합물, 약제학적 조성물 및 이의 제조 방법과 적용
CN119907796A (zh) * 2022-09-09 2025-04-29 海南先声再明医药股份有限公司 酰胺类化合物、其组合物及用途
CN119072473A (zh) * 2022-09-30 2024-12-03 长春金赛药业有限责任公司 稠环类kif18a抑制剂化合物、药物组合物及其制备方法和应用
CN119894878A (zh) * 2022-10-13 2025-04-25 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和用途
WO2024083208A1 (fr) * 2022-10-21 2024-04-25 杭州邦顺制药有限公司 Inhibiteur de protéine kif18a
WO2024099398A1 (fr) * 2022-11-10 2024-05-16 南京明德新药研发有限公司 Classe de composés sulfonamide contenant un hétérocycle ortho-condensé et leur utilisation
AU2023382606A1 (en) 2022-11-14 2025-05-08 Amgen Inc. Macrocyclic kras inhibitors and methods of use
JP2025538601A (ja) * 2022-11-24 2025-11-28 インベンティスバイオ カンパニー リミテッド 複素環化合物、その製造方法および用途
WO2024114730A1 (fr) * 2022-11-30 2024-06-06 微境生物医药科技(上海)有限公司 Composition pharmaceutique pour le traitement du cancer
EP4628486A1 (fr) * 2022-12-02 2025-10-08 Shenzhen Zhongge Biological Technology Co., Ltd. Composé amide ou urée
CN120265626A (zh) * 2022-12-14 2025-07-04 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
WO2024140799A1 (fr) * 2022-12-28 2024-07-04 Insilico Medicine Ip Limited Inhibiteurs de kif18a et utilisations associées
CN120569373A (zh) * 2023-01-05 2025-08-29 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和医药上的用途
CN120548308A (zh) * 2023-01-20 2025-08-26 英矽智能科技知识产权有限公司 Kif18a的抑制剂及其用途
WO2024156288A1 (fr) * 2023-01-29 2024-08-02 Shanghai Kygent Pharmaceutical Co., Ltd Inhibiteurs de dnmt1, compositions pharmaceutiques et applications thérapeutiques
WO2024183710A1 (fr) * 2023-03-06 2024-09-12 武汉人福创新药物研发中心有限公司 Composé inhibiteur de kif18a et son utilisation
MX2025012140A (es) * 2023-04-13 2026-02-03 Ideaya Biosciences Inc Terapia combinada que comprende un inhibidor de mat2a y un inhibidor de la topoisomerasa, un inhibidor del empalme sulfonamida, o un inhibidor de kif18
WO2025067239A1 (fr) * 2023-09-26 2025-04-03 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son application
WO2025194054A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés spirocycliques utilisés en tant que modulateurs de kras et leurs utilisations
TW202602882A (zh) 2024-03-14 2026-01-16 美商安進公司 作為ｋｒａｓ調節劑的大環化合物及其用途
WO2025217247A1 (fr) 2024-04-10 2025-10-16 Amgen Inc. Inhibiteurs spiro-hétérocycliques ancrés de protéines mutantes kras g12c et leurs utilisations
WO2025230862A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés aminés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025230878A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025240582A1 (fr) 2024-05-14 2025-11-20 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025242166A1 (fr) * 2024-05-22 2025-11-27 InventisBio Co., Ltd. Composés hétérocycliques, leurs procédés de préparation et leurs utilisations
WO2026055477A1 (fr) 2024-09-06 2026-03-12 Amgen Inc. Composés macrocycliques constituant des modulateurs de kras et leurs utilisations
CN120665073B (zh) * 2025-08-18 2025-10-28 山东绿叶制药有限公司 作为kif18a抑制剂的化合物及其用途

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EP3897855A1 (fr) 2021-10-27
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