CU20200096A7 - N-benzisoxazolil sulfonamidas como inhibidores de kat - Google Patents
N-benzisoxazolil sulfonamidas como inhibidores de katInfo
- Publication number
- CU20200096A7 CU20200096A7 CU2020000096A CU20200096A CU20200096A7 CU 20200096 A7 CU20200096 A7 CU 20200096A7 CU 2020000096 A CU2020000096 A CU 2020000096A CU 20200096 A CU20200096 A CU 20200096A CU 20200096 A7 CU20200096 A7 CU 20200096A7
- Authority
- CU
- Cuba
- Prior art keywords
- benzisoxazolyl
- sulfonamides
- kat
- inhibitors
- kat inhibitors
- Prior art date
Links
- -1 N-BENZISOXAZOLYL SULFONAMIDES Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
<p>Un compuesto de la fórmula (I), o una sal farmacéutica del mismo.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1810092.5A GB201810092D0 (en) | 2018-06-20 | 2018-06-20 | Compounds |
| PCT/EP2019/066337 WO2019243491A1 (en) | 2018-06-20 | 2019-06-20 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20200096A7 true CU20200096A7 (es) | 2021-08-06 |
Family
ID=63042663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2020000096A CU20200096A7 (es) | 2018-06-20 | 2019-06-20 | N-benzisoxazolil sulfonamidas como inhibidores de kat |
Country Status (41)
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| EP3471271A1 (en) | 2017-10-16 | 2019-04-17 | Acoustical Beauty | Improved convolutions of digital signals using a bit requirement optimization of a target digital signal |
| GB201810092D0 (en) | 2018-06-20 | 2018-08-08 | Ctxt Pty Ltd | Compounds |
| LT4299135T (lt) * | 2019-06-18 | 2025-09-10 | Pfizer Inc. | Benzizoksazolo sulfonamido dariniai |
| AU2020295006B2 (en) * | 2019-06-19 | 2023-11-09 | Ctxt Pty Ltd | Cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives |
| US12012373B2 (en) | 2019-07-12 | 2024-06-18 | Canopy Growth Corporation | Cannabinoid derivatives |
| EP4667055A3 (en) | 2020-07-15 | 2026-02-25 | Pfizer Inc. | Kat6 inhibitor methods and combinations for cancer treatment |
| JP2024521141A (ja) * | 2021-05-21 | 2024-05-28 | アウリジーン オンコロジー リミテッド | Ｋａｔ６ａ阻害剤としての縮合イソオキサゾリル化合物 |
| CN118382622A (zh) * | 2021-07-05 | 2024-07-23 | 杭州英创医药科技有限公司 | 作为kat6抑制剂的化合物 |
| CN117597341A (zh) * | 2021-08-10 | 2024-02-23 | 江苏恒瑞医药股份有限公司 | 磺酰胺衍生物、其制备方法及其在医药上的应用 |
| JP2024543512A (ja) | 2021-11-16 | 2024-11-21 | インシリコ メディシン アイピー リミテッド | リジンアセチルトランスフェラーゼ６ａ（ｋａｔ６ａ）阻害剤およびその使用 |
| US20250059204A1 (en) * | 2021-12-13 | 2025-02-20 | Aurigene Oncology Limited | Fused benzoisoxazolyl compounds as kat6a inhibitors |
| CN116621859A (zh) * | 2022-02-18 | 2023-08-22 | 山东轩竹医药科技有限公司 | 三并环类kat6抑制剂 |
| JP2025511122A (ja) * | 2022-03-28 | 2025-04-15 | アイソステリックス， インコーポレイテッド | リジンアセチルトランスフェラーゼのｍｙｓｔファミリーの阻害剤 |
| IL317668A (en) * | 2022-06-16 | 2025-02-01 | Prelude Therapeutics Inc | KAT6-targeted compounds with a ubiquitin ligase-binding residue |
| CN119604288A (zh) | 2022-07-29 | 2025-03-11 | 辉瑞大药厂 | 用于治疗癌症的包含kat6抑制剂的给药方案 |
| KR20250143814A (ko) | 2023-02-10 | 2025-10-02 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 설폰아미드 유도체 결정 형태 및 이의 제조 방법 |
| CN120981721A (zh) | 2023-03-30 | 2025-11-18 | 辉瑞大药厂 | Kat6a作为用kat6a抑制剂治疗的预测性生物标志物和相关治疗方法 |
| TW202446378A (zh) * | 2023-04-19 | 2024-12-01 | 香港商英矽智能科技知識產權有限公司 | 離胺酸乙醯基轉移酶6a(kat6a)抑制劑、其組合及其用途 |
| AU2024262206A1 (en) * | 2023-04-25 | 2025-12-04 | Insilico Medicine Ip Limited | Crystalline lysine acetyltransferase 6a (kat6a) inhibitor and uses thereof |
| TW202504580A (zh) * | 2023-07-04 | 2025-02-01 | 大陸商上海齊魯製藥研究中心有限公司 | Kat6抑制劑 |
| WO2025036382A1 (zh) * | 2023-08-14 | 2025-02-20 | 上海复宏汉霖生物医药有限公司 | 一种磺酰胺类化合物、其制备方法及用途 |
| WO2025098417A1 (zh) * | 2023-11-08 | 2025-05-15 | 再和医药科技（苏州）有限公司 | 磺酰胺类化合物及其应用 |
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