MA53382A - Composés co-agonistes de gip/glp1 - Google Patents
Composés co-agonistes de gip/glp1Info
- Publication number
- MA53382A MA53382A MA053382A MA53382A MA53382A MA 53382 A MA53382 A MA 53382A MA 053382 A MA053382 A MA 053382A MA 53382 A MA53382 A MA 53382A MA 53382 A MA53382 A MA 53382A
- Authority
- MA
- Morocco
- Prior art keywords
- glp1
- gip
- agonist compounds
- agonist
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/56—Protease inhibitors from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862702072P | 2018-07-23 | 2018-07-23 | |
| US201862730563P | 2018-09-13 | 2018-09-13 | |
| US201862740596P | 2018-10-03 | 2018-10-03 | |
| EP19753218.7A EP3827015B1 (fr) | 2018-07-23 | 2019-07-22 | Composés co-agonistes de gip/glp1 |
| PCT/US2019/042822 WO2020023386A1 (fr) | 2018-07-23 | 2019-07-22 | Composés co-agonistes de gip/glp1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA53382A true MA53382A (fr) | 2021-06-02 |
| MA53382B1 MA53382B1 (fr) | 2026-04-30 |
Family
ID=67620523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA53382A MA53382B1 (fr) | 2018-07-23 | 2019-07-22 | Composés co-agonistes de gip/glp1 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US11084861B2 (fr) |
| EP (2) | EP4549454A3 (fr) |
| JP (3) | JP6920559B2 (fr) |
| KR (3) | KR20240051304A (fr) |
| CN (2) | CN112469731B (fr) |
| AU (2) | AU2019311000B2 (fr) |
| BR (1) | BR112020026671A2 (fr) |
| CA (3) | CA3107345C (fr) |
| CL (1) | CL2021000158A1 (fr) |
| CO (1) | CO2021000453A2 (fr) |
| CR (1) | CR20210040A (fr) |
| DK (1) | DK3827015T3 (fr) |
| DO (1) | DOP2021000016A (fr) |
| EC (1) | ECSP21004913A (fr) |
| FI (1) | FI3827015T3 (fr) |
| IL (1) | IL279827A (fr) |
| JO (2) | JOP20210016A1 (fr) |
| LT (1) | LT3827015T (fr) |
| MA (1) | MA53382B1 (fr) |
| MX (1) | MX2021000793A (fr) |
| MY (1) | MY197569A (fr) |
| PE (2) | PE20211637A1 (fr) |
| PH (1) | PH12021550154A1 (fr) |
| PT (1) | PT3827015T (fr) |
| SA (1) | SA521421080B1 (fr) |
| SG (1) | SG11202100128UA (fr) |
| TW (3) | TWI735917B (fr) |
| UA (1) | UA129537C2 (fr) |
| WO (1) | WO2020023386A1 (fr) |
| ZA (3) | ZA202100235B (fr) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102455171B1 (ko) | 2013-12-18 | 2022-10-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물 |
| TWI744579B (zh) * | 2017-12-21 | 2021-11-01 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| TWI735917B (zh) * | 2018-07-23 | 2021-08-11 | 美商美國禮來大藥廠 | Gip/glp1共促效劑化合物 |
| AU2019309798A1 (en) * | 2018-07-23 | 2021-02-11 | Eli Lilly And Company | Method of using a GIP/GLP1 co-agonist for diabetes |
| AR119471A1 (es) * | 2019-08-01 | 2021-12-22 | Lilly Co Eli | Compuestos agonistas de gipr |
| EP4017866A1 (fr) | 2019-08-19 | 2022-06-29 | Eli Lilly and Company | Procédés de fabrication d'analogues d'incrétine |
| CA3163507A1 (fr) | 2019-12-04 | 2021-06-10 | The Scripps Research Institute | Conjugues peptidiques et methodes d'utilisation |
| IL294955A (en) * | 2020-01-23 | 2022-09-01 | Lilly Co Eli | Cobalt-agonist gip/glp1 compounds |
| CN115884982A (zh) | 2020-03-06 | 2023-03-31 | 赛诺菲 | 作为选择性gip受体激动剂的肽 |
| JP7736315B2 (ja) | 2020-03-31 | 2025-09-09 | アンタロス メディカル アクティエボラーグ | イメージング及び治療目的のキレート部分を含む選択的ｇｉｐ受容体アゴニスト |
| TW202216746A (zh) * | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑 |
| AU2021312323A1 (en) | 2020-07-22 | 2023-02-02 | Novo Nordisk A/S | Co-agonists at GLP-1 and GIP receptors suitable for oral delivery |
| CA3184723A1 (fr) | 2020-07-22 | 2022-01-27 | Patrick J. KNERR | Co-agonistes de recepteurs de glp-1 et de gip |
| BR112023003668A2 (pt) | 2020-10-17 | 2023-04-25 | Sun Pharmaceutical Ind Ltd | Agonistas duplos de glp-1/gip |
| TWI901926B (zh) | 2020-12-18 | 2025-10-21 | 美商美國禮來大藥廠 | 雙重澱粉素及降鈣素受體促效劑及其用途 |
| PE20240116A1 (es) * | 2020-12-22 | 2024-01-22 | Lilly Co Eli | Formulaciones de peptidos terapeuticos |
| WO2022159395A1 (fr) | 2021-01-20 | 2022-07-28 | Viking Therapeutics, Inc. | Compositions et procédés pour le traitement de troubles métaboliques et hépatiques |
| JP2024508745A (ja) * | 2021-02-17 | 2024-02-28 | イーライ リリー アンド カンパニー | Ｇｉｐ／ｇｌｐ１デュアルアゴニスト治療方法 |
| TW202423476A (zh) * | 2021-03-23 | 2024-06-16 | 美商美國禮來大藥廠 | 含腸促胰島素(incretin)類似物之組合物及其用途 |
| US12215133B2 (en) | 2021-03-25 | 2025-02-04 | Brightgene Bio-Medical Technology Co., Ltd. | GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use |
| HRP20251468T1 (hr) * | 2021-03-25 | 2026-01-02 | Brightgene Bio-Medical Technology Co., Ltd. | Agonist dvostrukog receptora gip i glp-1, farmaceutski pripravak i upotreba |
| CN115181173A (zh) * | 2021-04-02 | 2022-10-14 | 深圳市健元医药科技有限公司 | 一种Tirzepatide的制备方法 |
| KR20240004943A (ko) | 2021-05-07 | 2024-01-11 | 일라이 릴리 앤드 캄파니 | 침식성 정제 |
| CN113332416B (zh) * | 2021-05-17 | 2022-02-22 | 宁波大学 | 丙谷二肽在制备治疗非酒精性脂肪肝药物中的应用 |
| CN117015551B (zh) * | 2021-05-28 | 2024-05-28 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
| EP4345105A4 (fr) * | 2021-06-01 | 2025-04-23 | Nanjing Zhihe Medicine Technology Co., Ltd | Dérivé polypeptidique ayant un effet d'activation à double cible de glp-1r et de gipr, procédé de préparation associé et son utilisation |
| IL309067A (en) | 2021-06-09 | 2024-02-01 | Scripps Research Inst | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
| CN115594752A (zh) * | 2021-07-07 | 2023-01-13 | 成都奥达生物科技有限公司（Cn） | 一种长效双激动剂化合物 |
| MX2024002845A (es) | 2021-09-06 | 2024-04-30 | Sanofi Sa | Nuevos peptidos como agonistas potentes y selectivos del receptor de gip. |
| IL311411A (en) | 2021-09-15 | 2024-05-01 | Viking Therapeutics Inc | Preparations and methods for the treatment of metabolic and liver disorders |
| EP4434536A4 (fr) * | 2021-11-19 | 2026-01-07 | Jiangsu Deyuan Pharmaceutical Co Ltd | Peptide agrafé et son utilisation |
| MX2024006492A (es) * | 2021-12-01 | 2024-06-19 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Composicion farmaceutica de doble agonista de los receptores glp-1 y gip y uso de la misma. |
| TW202330584A (zh) | 2022-01-20 | 2023-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 前藥及其用途 |
| CA3246912A1 (fr) * | 2022-04-07 | 2025-07-09 | Guangdong Raynovent Biotech Co., Ltd. | Utilisation pharmaceutique de polypeptide dans la préparation de médicaments pour traiter et/ou prévenir le diabète, l’obésité et des maladies connexes |
| WO2024010379A1 (fr) * | 2022-07-05 | 2024-01-11 | 주식회사 지투지바이오 | Formulation de microsphères à libération prolongée comprenant du sémaglutide ou son sel pharmaceutiquement acceptable et procédé de préparation associé |
| IL318349A (en) * | 2022-07-13 | 2025-03-01 | Hangzhou Zhongmeihuadong Pharmaceutical Co Ltd | Glp-1/gip dual agonist, preparation method and use thereof |
| CA3266547A1 (fr) | 2022-08-29 | 2024-03-07 | Eli Lilly And Company | Compositions pour administration orale |
| WO2024059674A1 (fr) * | 2022-09-15 | 2024-03-21 | Eli Lilly And Company | Composés agonistes doubles de gip et de glp-1 |
| AU2023385357A1 (en) * | 2022-11-21 | 2025-06-05 | Eli Lilly And Company | Process for preparing a gip/glp1 dual agonist |
| IL322205A (en) * | 2023-01-31 | 2025-09-01 | Lilly Co Eli | GIP/GLP1/GCG trireceptor agonists and their uses |
| WO2024165571A2 (fr) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibiteurs d'expression et/ou de fonction |
| WO2024252366A1 (fr) | 2023-06-09 | 2024-12-12 | Sun Pharmaceutical Industries Limited | Agonistes du récepteur double glp-1/gip, double glp-1/gcg et triple glp-1/gip/gcg |
| EP4741420A1 (fr) * | 2023-06-30 | 2026-05-13 | Huonslab Co., Ltd. | Composition pharmaceutique pour prévenir ou traiter l'obésité comprenant un analogue de glp en tant que principe actif |
| WO2025087353A1 (fr) * | 2023-10-26 | 2025-05-01 | 齐鲁制药有限公司 | Polypeptide présentant une activité multi-agoniste et son utilisation |
| WO2025108381A1 (fr) * | 2023-11-22 | 2025-05-30 | 杭州中美华东制药有限公司 | Utilisation d'un agoniste double cible de glp-1r/gipr dans la préparation d'un médicament animal |
| WO2025114501A1 (fr) | 2023-11-30 | 2025-06-05 | Novo Nordisk A/S | Tri-agonistes des récepteurs glp-1, gip et amyline |
| CN117624333A (zh) * | 2023-12-05 | 2024-03-01 | 江苏师范大学 | 一类GLP-1受体、glucagon受体和GIP受体三激动多肽化合物及其应用 |
| WO2025125576A2 (fr) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibiteurs d'expression et/ou de fonction |
| WO2025133348A1 (fr) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibiteurs d'expression et/ou de fonction |
| EP4686757A1 (fr) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibiteurs d expression et/ou de fonction |
| TW202542174A (zh) * | 2023-12-29 | 2025-11-01 | 大陸商杭州中美華東製藥有限公司 | Glp-1/gip雙激動劑的固相合成方法 |
| WO2025147633A2 (fr) * | 2024-01-05 | 2025-07-10 | Indiana University Research And Technology Corporation | Co-agonistes gip/glp-1 et leurs promédicaments associés |
| WO2025149039A1 (fr) * | 2024-01-12 | 2025-07-17 | 杭州中美华东制药有限公司 | Composition pharmaceutique d'agoniste double de glp-1/gip à action prolongée |
| WO2025149041A1 (fr) * | 2024-01-12 | 2025-07-17 | 杭州中美华东制药有限公司 | Composition pharmaceutique d'administration nasale de double agoniste de glp-1/gip à action prolongée |
| WO2025161155A1 (fr) * | 2024-02-04 | 2025-08-07 | 内蒙古博睿精创科技有限公司 | Composé polypeptidique glp-1 à action prolongée, composition et utilisation associées |
| WO2025196502A1 (fr) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Inhibiteurs de choline kinase utilisés en tant que traitement thérapeutique contre l'obésité |
| WO2025264785A1 (fr) * | 2024-06-21 | 2025-12-26 | Neurocrine Biosciences, Inc. | Peptides chimiquement modifiés et leur utilisation |
| WO2025264809A1 (fr) * | 2024-06-21 | 2025-12-26 | Neurocrine Biosciences, Inc. | Peptides chimiquement modifiés et leur utilisation |
| WO2025264776A1 (fr) * | 2024-06-21 | 2025-12-26 | Neurocrine Biosciences, Inc. | Peptides chimiquement modifiés et leur utilisation |
| JP2026031900A (ja) * | 2024-07-24 | 2026-02-25 | イーライ リリー アンド カンパニー | Ｆｃ－アシル化ポリペプチドコンジュゲート |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2694095T3 (en) * | 2011-04-05 | 2018-05-28 | Longevity Biotech Inc | COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME |
| NZ702333A (en) * | 2012-05-03 | 2017-06-30 | Zealand Pharma As | Gip-glp-1 dual agonist compounds and methods |
| CN104583233B (zh) * | 2012-06-21 | 2018-10-23 | 印第安纳大学研究及科技有限公司 | 表现出gip受体活性的胰高血糖素的类似物 |
| AR092873A1 (es) * | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| US20160058881A1 (en) | 2013-03-15 | 2016-03-03 | Indiana University Research And Technology Corporation | Prodrugs with prolonged action |
| KR20210086717A (ko) | 2013-05-02 | 2021-07-08 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
| AU2014345569B2 (en) * | 2013-11-06 | 2020-08-13 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
| US10232020B2 (en) * | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
| JO3575B1 (ar) * | 2015-01-09 | 2020-07-05 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| WO2016198604A1 (fr) * | 2015-06-12 | 2016-12-15 | Sanofi | Dérivés d'exendine-4 non-acylée comme agonistes doubles du récepteur glp-1/glucagon |
| US20170112897A1 (en) | 2015-10-23 | 2017-04-27 | Cedars-Sinai Medical Center | Methods for treating brain insulin resistance |
| TWI622596B (zh) * | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| WO2017112897A1 (fr) * | 2015-12-22 | 2017-06-29 | Engineered Controls International, Llc | Soupape de remplissage à bruit réduit |
| TWI810937B (zh) | 2017-12-21 | 2023-08-01 | 美商美國禮來大藥廠 | 腸促胰島素(incretin)類似物及其用途 |
| TWI735917B (zh) * | 2018-07-23 | 2021-08-11 | 美商美國禮來大藥廠 | Gip/glp1共促效劑化合物 |
-
2019
- 2019-07-22 TW TW108125887A patent/TWI735917B/zh active
- 2019-07-22 CA CA3107345A patent/CA3107345C/fr active Active
- 2019-07-22 PT PT197532187T patent/PT3827015T/pt unknown
- 2019-07-22 CR CR20210040A patent/CR20210040A/es unknown
- 2019-07-22 PE PE2021000081A patent/PE20211637A1/es unknown
- 2019-07-22 LT LTEPPCT/US2019/042822T patent/LT3827015T/lt unknown
- 2019-07-22 DK DK19753218.7T patent/DK3827015T3/da active
- 2019-07-22 BR BR112020026671-0A patent/BR112020026671A2/pt unknown
- 2019-07-22 CN CN201980049095.7A patent/CN112469731B/zh active Active
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