MA53485A - Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide - Google Patents

Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide

Info

Publication number
MA53485A
MA53485A MA053485A MA53485A MA53485A MA 53485 A MA53485 A MA 53485A MA 053485 A MA053485 A MA 053485A MA 53485 A MA53485 A MA 53485A MA 53485 A MA53485 A MA 53485A
Authority
MA
Morocco
Prior art keywords
ynoyl
pyrazin
imidazo
pyrrolidin
benzamide
Prior art date
Application number
MA053485A
Other languages
English (en)
Inventor
Paul Allen Bethel
Lai Chun Chan
Katie Grace Cooper
Robert John Cox
Jerry Evarts
Rustam Ferdinand Garrey
Michael David Golden
Shaun Alan Hughes
Lucinda Victoria Jackson
Qiu Junying
Michael Joseph Lawler
Remy E J N Litjens
Kirsty Jane Millard
Andrew John Phillips
David Allen Short
Alexander James Telford
Eijk Peter Johannes Servaas Savio Van
Mathilda Maria Henrica Verstappen
Frank L M Vos
Angang Wang
Eric Jurriën Zijp
Original Assignee
Acerta Pharma Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acerta Pharma Bv filed Critical Acerta Pharma Bv
Publication of MA53485A publication Critical patent/MA53485A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MA053485A 2018-08-29 2019-08-28 Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide MA53485A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862724228P 2018-08-29 2018-08-29

Publications (1)

Publication Number Publication Date
MA53485A true MA53485A (fr) 2021-12-08

Family

ID=67928802

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053485A MA53485A (fr) 2018-08-29 2019-08-28 Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide

Country Status (16)

Country Link
US (2) US12024520B2 (fr)
EP (1) EP3844149A1 (fr)
JP (3) JP7439095B2 (fr)
KR (2) KR102842131B1 (fr)
CN (2) CN120904205A (fr)
AU (4) AU2019332882B2 (fr)
BR (1) BR112021003480A2 (fr)
CA (1) CA3109734A1 (fr)
CO (1) CO2021003676A2 (fr)
EA (1) EA202190557A1 (fr)
IL (3) IL281025B2 (fr)
MA (1) MA53485A (fr)
MX (2) MX2021002246A (fr)
MY (1) MY206899A (fr)
WO (1) WO2020043787A1 (fr)
ZA (2) ZA202306381B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53485A (fr) * 2018-08-29 2021-12-08 Acerta Pharma Bv Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide
EP3947386A1 (fr) * 2019-03-27 2022-02-09 Assia Chemical Industries Ltd Formes à l'état solide d'acalabrutinib
CA3186141A1 (fr) 2020-06-19 2021-12-23 Acerta Pharma B.V. Formes posologiques de maleate d'acalabrutinib

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004282219C1 (en) 2003-10-15 2009-12-17 Osi Pharmaceuticals, Inc. Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors
CA2874756C (fr) 2007-03-28 2018-05-29 Pharmacyclics, Inc. Inhibiteurs de la tyrosine kinase de bruton
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
EP2424368B1 (fr) 2009-04-29 2014-12-31 Locus Pharmaceuticals, Inc. Composés de pyrrolotriazine
US8658794B2 (en) 2010-02-08 2014-02-25 Merck Sharp & Dohme B.V. 8-methyl-1-phenyl-imidazol[1,5-a]pyrazine compounds as Lck inhibitors and uses thereof
CA2841886C (fr) * 2011-07-19 2016-08-16 Merck Sharp & Dohme B.V. 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides en tant qu'inhibiteurs de btk
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
WO2014113942A1 (fr) 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Inhibiteurs de btk
AU2014219855B2 (en) 2013-02-19 2017-09-28 Ono Pharmaceutical Co., Ltd. Trk-inhibiting compound
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
WO2016128912A1 (fr) 2015-02-12 2016-08-18 Acerta Pharma B.V. Combinaisons thérapeutiques d'un inhibiteur de btk, d'un inhibiteur de pi3k, d'un inhibiteur de jak-2, d'un inhibiteur de pd-1, et/ou d'un inhibiteur de pd-l1
KR20240115937A (ko) 2015-07-02 2024-07-26 아세르타 파마. 비.브이. (S)-4-(8-아미노-3-(1-(부트-2-이노일)피롤리딘-2-일)이미다조[1,5-a]피라진-1-일)-N-(피리딘-2-일)벤즈아마이드의고체 형태 및 제제
JP6890602B2 (ja) 2015-11-06 2021-06-18 アセルタ ファーマ ビー．ブイ． ブルトン型チロシンキナーゼのイミダゾピラジン阻害剤
CN107056786B (zh) 2016-10-14 2019-05-07 苏州明锐医药科技有限公司 阿卡替尼的制备方法
MY203083A (en) 2016-12-21 2024-06-07 Acerta Pharma Bv Imidazopyrazine inhibitors of bruton's tyrosine kinase
WO2018115965A1 (fr) * 2016-12-23 2018-06-28 Acerta Pharma Bv Formes solides de composés d'imidazopyrazine
CN106588937B (zh) 2017-01-16 2018-09-21 东莞市真兴贝特医药技术有限公司 咪唑并吡嗪类化合物及其制备方法和应用
WO2018148961A1 (fr) 2017-02-20 2018-08-23 杭州领业医药科技有限公司 Forme cristalline du sel acp-196, procédé de préparation, composition pharmaceutique et utilisation associés
US10800787B2 (en) 2017-04-20 2020-10-13 Apotex Inc. Process for the preparation of acalabrutinib
CN107522701B (zh) 2017-09-01 2019-11-08 苏州富士莱医药股份有限公司 一种治疗慢性淋巴细胞白血病的BTK抑制剂Acalabrutinib的合成方法
US11161851B2 (en) 2017-11-06 2021-11-02 Suzhou Pengxu Pharmatech Co. Ltd. Processes to produce acalabrutinib
CN108250186B (zh) * 2018-02-07 2020-01-14 杭州科巢生物科技有限公司 Acalabrutinib及其中间体的合成方法
WO2019239374A1 (fr) 2018-06-13 2019-12-19 Acerta Pharma B.V. Inhibiteurs imidazopyrazines de kinase de lymphocytes t inductible par l'interleukine-2
MA53485A (fr) * 2018-08-29 2021-12-08 Acerta Pharma Bv Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide
US12065430B2 (en) 2018-10-26 2024-08-20 Taiho Pharmaceutical Co., Ltd. Indazole compound or salt thereof

Also Published As

Publication number Publication date
AU2022200828B2 (en) 2023-05-25
MX2021002246A (es) 2021-05-27
CA3109734A1 (fr) 2020-03-05
AU2022200828A1 (en) 2022-03-03
IL312413A (en) 2024-06-01
CN120904205A (zh) 2025-11-07
JP2026021364A (ja) 2026-02-10
IL281025A (en) 2021-04-29
WO2020043787A1 (fr) 2020-03-05
JP2024037935A (ja) 2024-03-19
US20240317766A1 (en) 2024-09-26
IL312413B1 (en) 2025-09-01
ZA202306381B (en) 2024-11-27
IL312413B2 (en) 2026-01-01
CO2021003676A2 (es) 2021-04-08
US12024520B2 (en) 2024-07-02
AU2023204660A1 (en) 2023-08-03
US12448387B2 (en) 2025-10-21
JP7439095B2 (ja) 2024-02-27
JP7829541B2 (ja) 2026-03-13
JP2021535220A (ja) 2021-12-16
CN112638878A (zh) 2021-04-09
ZA202409391B (en) 2025-04-30
IL281025B1 (en) 2024-08-01
CN112638878B (zh) 2025-07-22
AU2023204660B2 (en) 2024-01-25
AU2024202290A1 (en) 2024-05-02
MX2023011692A (es) 2023-10-19
EA202190557A1 (ru) 2021-07-13
KR20250119664A (ko) 2025-08-07
AU2019332882A1 (en) 2021-04-22
MY206899A (en) 2025-01-13
AU2019332882B2 (en) 2022-01-27
BR112021003480A2 (pt) 2021-05-18
IL322382A (en) 2025-09-01
US20220127270A1 (en) 2022-04-28
KR102842131B1 (ko) 2025-08-04
IL281025B2 (en) 2024-12-01
EP3844149A1 (fr) 2021-07-07
KR20210053304A (ko) 2021-05-11

Similar Documents

Publication Publication Date Title
HUE060797T2 (hu) Eljárás N-(5-(3-(7-(3-fluorfenil)-3H-imidazo[4,5-c]piridin-2-il)-1H-indazol-5-il)- piridin-3-il)-3-metilbutánamid elõállítására
LT3804715T (lt) Farmacinis derinys, kompozicija ir junginio preparatas, apimantys gliukokinazės aktyvatorių ir dpp-iv inhibitorių, bei jų gamybos ir panaudojimo būdas
DK4053128T3 (da) 5-(2-(2,5-difluorphenyl)pyrrolidin-1-yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidinderivater og relaterede forbindelser som trk-kinasehæmmere til cancerbehandling
EA201990048A1 (ru) [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИДИНИЛ-ЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ СОЕДИНЕНИЯ
NO20083002L (no) Fremgangsmate for anvendelse av CD40-bindende forbindelser
EA201691428A1 (ru) Бициклические гетероциклические производные в качестве ингибиторов irak4
WO2015095337A3 (fr) Dérivés pyrazolo [1,5-a]pyrimidine carboxamide pour le traitement de troubles cognitifs
EP3481827A4 (fr) Dérivés d'imidazo[1,2-a]pyridine, leurs procédés de préparation et leur utilisation
IL204437A (en) History of aryl cyclic profile and their use
WO2016130920A3 (fr) Inhibiteurs de lrrk2 et leurs méthodes de production et d'utilisation
ZA201000212B (en) Fused heteroaryl pyridyl and phenyl benzenesulfonamides as ccr2 modulators for the treatment of inflammation
MY167575A (en) Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
DK3357922T3 (da) 2-((5-(1-(3-(methylsulfonyl)propyl)piperidin-4-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8h)-on-derivater og relaterede forbindelser som cdk4-inhibitorer til behandling af tumorer
IL282006B1 (en) Treatment of bone tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
WO2017191130A3 (fr) Inhibiteurs d'arginase et leurs applications thérapeutiques
MA53485A (fr) Procédés de préparation de 4-(8-amino-3-[(2s)-1-(but-2-ynoyl)-pyrrolidin-2-yl] imidazo[1,5-a]-pyrazin-1-yl)n-(pyridin-2-yl)-benzamide
EP3969457A4 (fr) Procédés de préparation d'indoles macrocycliques
EA201000618A1 (ru) 5-цианотиенопиридины для лечения опухолей
EA201991021A1 (ru) Соединения конденсированных бициклических пиридинов и их применение в качестве модуляторов ampa-рецептора
CY1122768T1 (el) (r)-3-((3s,4s)-3-φθορο-4-(4-υδροξυφαινυλ)πιπεριδιν-1-υλ)-1-(4-μεθυλβενζυλ)πυρρολιδιν-2-ονη και προφαρμακα αυτης για τη θεραπεια ψυχιατρικων διαταραχων
NO20072473L (no) Fremgangsmate for fremstilling av kinolinforbindelser og oppnadde produkter
SI3774795T1 (sl) 4-(1H-imidazol-5-il)-1H-pirolo (2,3-B) piridini za uporabo pri zdravljenju levkemij, limfomov in trdnih tumorjev
WO2015124934A8 (fr) Pyrrolidines, térahydrofuranes et cyclopentanes substitués utiles en tant qu'antagonistes des récepteurs des orexines
UY28687A1 (es) Ligandos del receptor de acetilcolina nicotinica
EP3927689A4 (fr) Procédés de préparation de (3r,4r)-1-benzyl-n,4-diméthylpipéridin-3-amine ou d'un sel de celui-ci et procédés de préparation de tofacitinib l'utilisant