MA53852A - Anticorps ciblant le cd137 et leurs méthodes d'utilisation - Google Patents

Anticorps ciblant le cd137 et leurs méthodes d'utilisation

Info

Publication number: MA53852A
Authority: MA; Morocco
Prior art keywords: methods; targetting; antibodies; antibodies targetting
Prior art date: 2018-10-09

Application number

MA053852A

Other languages

English (en)

Inventor

Matthias Brock

Tea Gunde

Christian Hess

Alexandre Simonin

Stefan Warmuth

Original Assignee

Numab Therapeutics AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-10-09

Filing date

2019-10-09

Publication date

2021-08-18

2018-10-09 Priority claimed from EP18199334.6A external-priority patent/EP3636320A1/fr

2019-10-09 Application filed by Numab Therapeutics AG filed Critical Numab Therapeutics AG

2021-08-18 Publication of MA53852A publication Critical patent/MA53852A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

MA053852A 2018-10-09 2019-10-09 Anticorps ciblant le cd137 et leurs méthodes d'utilisation MA53852A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP18199334.6A EP3636320A1 (fr)	2018-10-09	2018-10-09	Anticorps dirigés contre cd137 et leurs procédés d'utilisation
EP19166283		2019-03-29

Publications (1)

Publication Number	Publication Date
MA53852A true MA53852A (fr)	2021-08-18

Family

ID=68208314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA053852A MA53852A (fr)	2018-10-09	2019-10-09	Anticorps ciblant le cd137 et leurs méthodes d'utilisation

Country Status (11)

Country	Link
US (1)	US12209133B2 (fr)
EP (1)	EP3863717A1 (fr)
JP (2)	JP7672333B2 (fr)
CN (1)	CN112805068B (fr)
AU (1)	AU2019358442B2 (fr)
CA (1)	CA3112058A1 (fr)
IL (1)	IL281767B2 (fr)
MA (1)	MA53852A (fr)
SG (1)	SG11202103503WA (fr)
TW (1)	TWI839395B (fr)
WO (1)	WO2020074584A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP7682102B2 (ja) *	2019-05-10	2025-05-23	リビジェンバイオファーマホールディングスリミテッド	ヒト化抗ｃｄ１３７抗体およびその使用
EP4644417A4 (fr) *	2022-12-30	2026-02-11	Abclon Inc	Afficorps se liant de manière spécifique à cd137 et son utilisation

Family Cites Families (29)

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US4458066A (en)	1980-02-29	1984-07-03	University Patents, Inc.	Process for preparing polynucleotides
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
US4881175A (en)	1986-09-02	1989-11-14	Genex Corporation	Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US5260203A (en)	1986-09-02	1993-11-09	Enzon, Inc.	Single polypeptide chain binding molecules
US5013653A (en)	1987-03-20	1991-05-07	Creative Biomolecules, Inc.	Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
ATE243754T1 (de)	1987-05-21	2003-07-15	Micromet Ag	Multifunktionelle proteine mit vorbestimmter zielsetzung
US5258498A (en)	1987-05-21	1993-11-02	Creative Biomolecules, Inc.	Polypeptide linkers for production of biosynthetic proteins
US5091513A (en)	1987-05-21	1992-02-25	Creative Biomolecules, Inc.	Biosynthetic antibody binding sites
US5132405A (en)	1987-05-21	1992-07-21	Creative Biomolecules, Inc.	Biosynthetic antibody binding sites
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
DE3920358A1 (de)	1989-06-22	1991-01-17	Behringwerke Ag	Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
GB9114948D0 (en)	1991-07-11	1991-08-28	Pfizer Ltd	Process for preparing sertraline intermediates
EP0571613B1 (fr)	1991-12-13	2003-09-17	Xoma Corporation	Materiels et methodes pour preparer des domaines variables d'anticorps modifies et leurs utilisations therapeutiques
US5641870A (en)	1995-04-20	1997-06-24	Genentech, Inc.	Low pH hydrophobic interaction chromatography for antibody purification
EP1958962A3 (fr)	1997-06-12	2013-05-01	Novartis International Pharmaceutical Ltd.	Polypeptides anticorps artificiels
DE19819846B4 (de)	1998-05-05	2016-11-24	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Multivalente Antikörper-Konstrukte
CN1440812A (zh) *	2002-02-27	2003-09-10	上海中信国健药业有限公司	一种使用cd137结合激动剂增强免疫应答的方法
JP2006500921A (ja)	2002-07-30	2006-01-12	ブリストル−マイヤーズ　スクイブ　カンパニー	ヒト４−１ｂｂに対するヒト化抗体
KR20140133958A (ko) *	2005-10-21	2014-11-20	엘에프비 유에스에이, 인크.	항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법
ES2627223T3 (es)	2007-06-26	2017-07-27	F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H	Presentación de agentes de unión
US20110311550A1 (en) *	2008-10-24	2011-12-22	The Scripps Research Institute	Agents for hcv treatment
MX337040B (es)	2010-09-09	2016-02-09	Pfizer	Moleculas de union a 4-1bb.
EP3224275B1 (fr) *	2014-11-14	2020-03-04	F.Hoffmann-La Roche Ag	Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
IL293435B1 (en)	2015-06-15	2026-04-01	Numab Therapeutics AG	Heterodimeric multispecific antibody format
KR20180096789A (ko) *	2016-01-11	2018-08-29	인히브릭스, 인크.	다가 및 다중특이적 41bb-결합 융합 단백질
ES2981272T3 (es) *	2016-09-23	2024-10-08	Merus Nv	Moléculas de unión que modulan una actividad biológica expresada por una célula
AU2017380981B2 (en) *	2016-12-19	2025-01-30	F. Hoffmann-La Roche Ag	Combination therapy with targeted 4-1BB (CD137) agonists
AU2018224094B2 (en) *	2017-02-24	2025-04-17	Macrogenics, Inc.	Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof
US12202911B2 (en) *	2017-10-10	2025-01-21	Numab Therapeutics AG	Multispecific antibody comprising CD137 binding domain and PDL1 binding domain

2019
- 2019-10-07 TW TW108136280A patent/TWI839395B/zh active
- 2019-10-09 SG SG11202103503WA patent/SG11202103503WA/en unknown
- 2019-10-09 CN CN201980065887.3A patent/CN112805068B/zh active Active
- 2019-10-09 AU AU2019358442A patent/AU2019358442B2/en active Active
- 2019-10-09 JP JP2021518965A patent/JP7672333B2/ja active Active
- 2019-10-09 MA MA053852A patent/MA53852A/fr unknown
- 2019-10-09 EP EP19786325.1A patent/EP3863717A1/fr active Pending
- 2019-10-09 WO PCT/EP2019/077368 patent/WO2020074584A1/fr not_active Ceased
- 2019-10-09 IL IL281767A patent/IL281767B2/en unknown
- 2019-10-09 US US17/283,128 patent/US12209133B2/en active Active
- 2019-10-09 CA CA3112058A patent/CA3112058A1/fr active Pending
2024
- 2024-10-18 JP JP2024184072A patent/JP2025020172A/ja active Pending

Also Published As

Publication number	Publication date
IL281767B1 (en)	2025-03-01
IL281767A (en)	2021-05-31
JP2022512628A (ja)	2022-02-07
TW202035457A (zh)	2020-10-01
CN112805068A (zh)	2021-05-14
EP3863717A1 (fr)	2021-08-18
AU2019358442A1 (en)	2021-03-25
CN112805068B (zh)	2024-07-05
WO2020074584A1 (fr)	2020-04-16
KR20210076907A (ko)	2021-06-24
TWI839395B (zh)	2024-04-21
SG11202103503WA (en)	2021-05-28
AU2019358442B2 (en)	2025-08-14
CA3112058A1 (fr)	2020-04-16
US12209133B2 (en)	2025-01-28
US20210395379A1 (en)	2021-12-23
JP2025020172A (ja)	2025-02-12
JP7672333B2 (ja)	2025-05-07
IL281767B2 (en)	2025-07-01

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