MA54063B1 - Nouveau sel d'un inhibiteur de bcl-2, forme cristalline apparentée, son procédé de préparation et compositions pharmaceutiques le contenant - Google Patents
Nouveau sel d'un inhibiteur de bcl-2, forme cristalline apparentée, son procédé de préparation et compositions pharmaceutiques le contenantInfo
- Publication number
- MA54063B1 MA54063B1 MA54063A MA54063A MA54063B1 MA 54063 B1 MA54063 B1 MA 54063B1 MA 54063 A MA54063 A MA 54063A MA 54063 A MA54063 A MA 54063A MA 54063 B1 MA54063 B1 MA 54063B1
- Authority
- MA
- Morocco
- Prior art keywords
- pharmaceutical compositions
- same
- bcl
- inhibitor
- compositions containing
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000012664 BCL-2-inhibitor Substances 0.000 title 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 title 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne un nouveau sel et des formes cristallines associées du composé (a), le sel étant le sel de sulfate d'hydrogène, caractérisé par son diagramme de diffraction de rayons x sur poudre, son procédé de préparation et des compositions pharmaceutiques le contenant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306430 | 2018-10-31 | ||
| PCT/EP2019/079621 WO2020089281A1 (fr) | 2018-10-31 | 2019-10-30 | Nouveau sel d'un inhibiteur de bcl-2, forme cristalline associée, son procédé de préparation et compositions pharmaceutiques le contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA54063A MA54063A (fr) | 2021-09-08 |
| MA54063B1 true MA54063B1 (fr) | 2023-06-28 |
Family
ID=64270773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA54063A MA54063B1 (fr) | 2018-10-31 | 2019-10-30 | Nouveau sel d'un inhibiteur de bcl-2, forme cristalline apparentée, son procédé de préparation et compositions pharmaceutiques le contenant |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US20210355108A1 (fr) |
| EP (1) | EP3873894B1 (fr) |
| JP (2) | JP2022506137A (fr) |
| KR (1) | KR20210092750A (fr) |
| CN (1) | CN112969693A (fr) |
| AR (1) | AR116921A1 (fr) |
| AU (1) | AU2019370926B2 (fr) |
| BR (1) | BR112021007194A2 (fr) |
| CA (1) | CA3117559C (fr) |
| CL (1) | CL2021000947A1 (fr) |
| CO (1) | CO2021005077A2 (fr) |
| CR (1) | CR20210211A (fr) |
| CY (1) | CY1126057T1 (fr) |
| DK (1) | DK3873894T3 (fr) |
| DO (1) | DOP2021000074A (fr) |
| EA (1) | EA202191143A1 (fr) |
| ES (1) | ES2943511T3 (fr) |
| FI (1) | FI3873894T3 (fr) |
| GE (2) | GEP20237494B (fr) |
| HR (1) | HRP20230563T1 (fr) |
| HU (1) | HUE062000T2 (fr) |
| IL (1) | IL282565A (fr) |
| JO (1) | JOP20210072A1 (fr) |
| LT (1) | LT3873894T (fr) |
| MA (1) | MA54063B1 (fr) |
| MX (1) | MX2021004934A (fr) |
| MY (1) | MY202547A (fr) |
| NI (1) | NI202100025A (fr) |
| PE (1) | PE20211503A1 (fr) |
| PH (1) | PH12021550790A1 (fr) |
| PL (1) | PL3873894T3 (fr) |
| PT (1) | PT3873894T (fr) |
| RS (1) | RS64236B1 (fr) |
| SG (1) | SG11202103594XA (fr) |
| SI (1) | SI3873894T1 (fr) |
| TW (1) | TWI791916B (fr) |
| WO (1) | WO2020089281A1 (fr) |
| ZA (1) | ZA202102783B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3155067A1 (fr) | 2019-09-27 | 2021-04-01 | Shanghai Flyco Electrical Appliance Co., Ltd. | Rasoir electrique, appareil electromenager portatif, systeme de rasoir electrique et procede de commande |
| CA3190276A1 (fr) | 2020-07-31 | 2022-02-03 | Les Laboratoires Servier | Combinaison d'un inhibiteur de bcl-2 et d'un agent hypomethylant pour le traitement de cancers, utilisations et compositions pharmaceutiques associees |
| WO2022090443A1 (fr) | 2020-10-30 | 2022-05-05 | Les Laboratoires Servier | Administration et posologie pour une combinaison d'un inhibiteur de bcl-2 et d'un inhibiteur de mcl-1 |
| EP4313964A1 (fr) | 2021-03-24 | 2024-02-07 | Les Laboratoires Servier | Nouveau procédé de synthèse de dérivés de 5-{5-chloro-2-[(3s)-3-[(morpholin-4-yl)méthyl]-3,4-dihydroisoquinoléine-2(1h )-carbonyl]phényl}-1,2-diméthyl-1h-pyrrole-3-acide carboxylique et son application pour la production de composés pharmaceutiques |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004057195A1 (de) * | 2004-11-26 | 2006-06-01 | Wilex Ag | Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon |
| US7432398B2 (en) * | 2005-01-06 | 2008-10-07 | Cj Corporation | Inorganic acid salts of sibutramine |
| TWI405756B (zh) * | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| CN101962387B (zh) * | 2010-09-13 | 2013-01-30 | 成都雅途生物技术有限公司 | 一种新结晶形态的氯吡格雷硫酸氢盐及其制备方法 |
| CN103664753B (zh) * | 2012-09-04 | 2017-04-26 | 上海迪赛诺化学制药有限公司 | 制备阿扎那韦硫酸氢盐a型结晶的方法 |
| FR3008975A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US10351559B2 (en) * | 2015-04-15 | 2019-07-16 | Beigene, Ltd. | Maleate salts of a B-RAF kinase inhibitor, crystalline forms, methods of preparation, and uses therefore |
-
2019
- 2019-10-30 CA CA3117559A patent/CA3117559C/fr active Active
- 2019-10-30 MY MYPI2021002028A patent/MY202547A/en unknown
- 2019-10-30 LT LTEPPCT/EP2019/079621T patent/LT3873894T/lt unknown
- 2019-10-30 BR BR112021007194-6A patent/BR112021007194A2/pt unknown
- 2019-10-30 FI FIEP19800947.4T patent/FI3873894T3/fi active
- 2019-10-30 CR CR20210211A patent/CR20210211A/es unknown
- 2019-10-30 GE GEAP201915620A patent/GEP20237494B/en unknown
- 2019-10-30 PT PT198009474T patent/PT3873894T/pt unknown
- 2019-10-30 EP EP19800947.4A patent/EP3873894B1/fr active Active
- 2019-10-30 PL PL19800947.4T patent/PL3873894T3/pl unknown
- 2019-10-30 PE PE2021000597A patent/PE20211503A1/es unknown
- 2019-10-30 GE GEAP202215620A patent/GEAP202215620A/en unknown
- 2019-10-30 MX MX2021004934A patent/MX2021004934A/es unknown
- 2019-10-30 DK DK19800947.4T patent/DK3873894T3/da active
- 2019-10-30 US US17/286,936 patent/US20210355108A1/en not_active Abandoned
- 2019-10-30 EA EA202191143A patent/EA202191143A1/ru unknown
- 2019-10-30 WO PCT/EP2019/079621 patent/WO2020089281A1/fr not_active Ceased
- 2019-10-30 AU AU2019370926A patent/AU2019370926B2/en active Active
- 2019-10-30 CN CN201980071289.7A patent/CN112969693A/zh active Pending
- 2019-10-30 MA MA54063A patent/MA54063B1/fr unknown
- 2019-10-30 TW TW108139360A patent/TWI791916B/zh not_active IP Right Cessation
- 2019-10-30 KR KR1020217015833A patent/KR20210092750A/ko not_active Withdrawn
- 2019-10-30 HU HUE19800947A patent/HUE062000T2/hu unknown
- 2019-10-30 SG SG11202103594XA patent/SG11202103594XA/en unknown
- 2019-10-30 AR ARP190103143A patent/AR116921A1/es not_active Application Discontinuation
- 2019-10-30 HR HRP20230563TT patent/HRP20230563T1/hr unknown
- 2019-10-30 ES ES19800947T patent/ES2943511T3/es active Active
- 2019-10-30 SI SI201930557T patent/SI3873894T1/sl unknown
- 2019-10-30 RS RS20230347A patent/RS64236B1/sr unknown
- 2019-10-30 JP JP2021523309A patent/JP2022506137A/ja active Pending
-
2021
- 2021-04-09 NI NI202100025A patent/NI202100025A/es unknown
- 2021-04-09 PH PH12021550790A patent/PH12021550790A1/en unknown
- 2021-04-12 JO JOP/2021/0072A patent/JOP20210072A1/ar unknown
- 2021-04-16 CL CL2021000947A patent/CL2021000947A1/es unknown
- 2021-04-21 DO DO2021000074A patent/DOP2021000074A/es unknown
- 2021-04-21 CO CONC2021/0005077A patent/CO2021005077A2/es unknown
- 2021-04-22 IL IL282565A patent/IL282565A/en unknown
- 2021-04-26 ZA ZA2021/02783A patent/ZA202102783B/en unknown
-
2023
- 2023-05-18 CY CY20231100236T patent/CY1126057T1/el unknown
-
2024
- 2024-08-27 US US18/816,347 patent/US20240417390A1/en active Pending
- 2024-11-26 JP JP2024205589A patent/JP2025028968A/ja not_active Withdrawn
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