MA54695A - Inhibiteurs de dihydroorotate déshydrogénase - Google Patents
Inhibiteurs de dihydroorotate déshydrogénaseInfo
- Publication number
- MA54695A MA54695A MA054695A MA54695A MA54695A MA 54695 A MA54695 A MA 54695A MA 054695 A MA054695 A MA 054695A MA 54695 A MA54695 A MA 54695A MA 54695 A MA54695 A MA 54695A
- Authority
- MA
- Morocco
- Prior art keywords
- dehydrogenase inhibitors
- dihydroorotate dehydrogenase
- dihydroorotate
- inhibitors
- dehydrogenase
- Prior art date
Links
- 239000003363 dihydroorotate dehydrogenase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962791057P | 2019-01-11 | 2019-01-11 | |
| US201962859851P | 2019-06-11 | 2019-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA54695A true MA54695A (fr) | 2021-11-17 |
Family
ID=69326572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA054695A MA54695A (fr) | 2019-01-11 | 2020-01-10 | Inhibiteurs de dihydroorotate déshydrogénase |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20220089568A1 (fr) |
| EP (1) | EP3908579B1 (fr) |
| JP (1) | JP2022517086A (fr) |
| KR (1) | KR20210114968A (fr) |
| CN (1) | CN113574054A (fr) |
| AU (1) | AU2020205842A1 (fr) |
| BR (1) | BR112021013134A2 (fr) |
| CA (1) | CA3126330A1 (fr) |
| ES (1) | ES2971680T3 (fr) |
| IL (1) | IL284537A (fr) |
| MA (1) | MA54695A (fr) |
| MX (1) | MX2021008400A (fr) |
| PH (1) | PH12021551626A1 (fr) |
| SG (1) | SG11202107276WA (fr) |
| TW (1) | TW202043208A (fr) |
| WO (1) | WO2020144638A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202104207A (zh) | 2019-04-17 | 2021-02-01 | 美商健生生物科技公司 | 二氫乳清酸脫氫酶抑制劑 |
| KR20220097438A (ko) * | 2019-11-01 | 2022-07-07 | 얀센 바이오테크 인코포레이티드 | 암, 자가면역, 및 염증성 질환의 치료를 위한 다이하이드로오로테이트 데하이드로게나제(dhodh) 억제제로서의 플루오르화 퀴놀린 및 퀴녹살린 유도체 |
| JP2023535346A (ja) * | 2020-07-14 | 2023-08-17 | ナンジン ゼンシャイン ファーマシューティカルズ カンパニー リミテッド | Dhodh阻害剤としての化合物 |
| CN116249702B (zh) * | 2020-09-28 | 2025-04-25 | 微境生物医药科技(上海)有限公司 | 用作dhodh抑制剂的1,2,4-三唑酮衍生物 |
| WO2022070069A1 (fr) * | 2020-09-30 | 2022-04-07 | Janssen Biotech, Inc. | Inhibiteurs de la dihydroorotate déshydrogénase |
| WO2022074534A1 (fr) | 2020-10-05 | 2022-04-14 | Janssen Biotech, Inc. | Combinaisons d'inhibiteurs de dihydroorotate déshydrogénase et d'agents hypométhylants |
| WO2022200615A1 (fr) | 2021-03-26 | 2022-09-29 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Combinaison d'inhibiteur de la biosynthèse de la pyrimidine destinée à être utilisée dans le traitement d'infections virales |
| WO2023280181A1 (fr) * | 2021-07-05 | 2023-01-12 | 微境生物医药科技(上海)有限公司 | Dérivé de 1,2,4-triazolone utile en tant qu'inhibiteur de dhodh, son procédé de préparation et son utilisation |
| EP4758126A1 (fr) * | 2023-08-08 | 2026-06-17 | The General Hospital Corporation | Synthèses et utilisation de bloqueurs de canaux potassiques en imagerie tep et en thérapeutique |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10968216B2 (en) * | 2016-10-27 | 2021-04-06 | Bayer Aktiengesellschaft | 4,5-annulated 1,2,4-triazolones |
| JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| EP3858361B1 (fr) * | 2018-09-28 | 2025-10-08 | FUJIFILM Corporation | Agent antitumoral contenant de la cytarabine, activateur d'effet antitumoral utilisé en combinaison avec la cytarabine, kit antitumoral, et agent antitumoral utilisé en combinaison avec le cytarabine |
-
2020
- 2020-01-09 TW TW109100712A patent/TW202043208A/zh unknown
- 2020-01-10 SG SG11202107276WA patent/SG11202107276WA/en unknown
- 2020-01-10 PH PH1/2021/551626A patent/PH12021551626A1/en unknown
- 2020-01-10 MX MX2021008400A patent/MX2021008400A/es unknown
- 2020-01-10 ES ES20702357T patent/ES2971680T3/es active Active
- 2020-01-10 US US17/421,741 patent/US20220089568A1/en not_active Abandoned
- 2020-01-10 WO PCT/IB2020/050180 patent/WO2020144638A1/fr not_active Ceased
- 2020-01-10 KR KR1020217025217A patent/KR20210114968A/ko not_active Withdrawn
- 2020-01-10 CA CA3126330A patent/CA3126330A1/fr active Pending
- 2020-01-10 EP EP20702357.3A patent/EP3908579B1/fr active Active
- 2020-01-10 JP JP2021540230A patent/JP2022517086A/ja active Pending
- 2020-01-10 BR BR112021013134-5A patent/BR112021013134A2/pt not_active Application Discontinuation
- 2020-01-10 CN CN202080020407.4A patent/CN113574054A/zh active Pending
- 2020-01-10 MA MA054695A patent/MA54695A/fr unknown
- 2020-01-10 AU AU2020205842A patent/AU2020205842A1/en not_active Abandoned
-
2021
- 2021-07-01 IL IL284537A patent/IL284537A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020144638A1 (fr) | 2020-07-16 |
| EP3908579A1 (fr) | 2021-11-17 |
| BR112021013134A2 (pt) | 2021-09-28 |
| MX2021008400A (es) | 2021-08-16 |
| SG11202107276WA (en) | 2021-07-29 |
| TW202043208A (zh) | 2020-12-01 |
| CA3126330A1 (fr) | 2020-07-16 |
| JP2022517086A (ja) | 2022-03-04 |
| PH12021551626A1 (en) | 2022-05-02 |
| CN113574054A (zh) | 2021-10-29 |
| ES2971680T3 (es) | 2024-06-06 |
| US20220089568A1 (en) | 2022-03-24 |
| EP3908579B1 (fr) | 2023-12-27 |
| KR20210114968A (ko) | 2021-09-24 |
| IL284537A (en) | 2021-08-31 |
| AU2020205842A1 (en) | 2021-07-22 |
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