MA54695A - Inhibiteurs de dihydroorotate déshydrogénase - Google Patents

Inhibiteurs de dihydroorotate déshydrogénase

Info

Publication number
MA54695A
MA54695A MA054695A MA54695A MA54695A MA 54695 A MA54695 A MA 54695A MA 054695 A MA054695 A MA 054695A MA 54695 A MA54695 A MA 54695A MA 54695 A MA54695 A MA 54695A
Authority
MA
Morocco
Prior art keywords
dehydrogenase inhibitors
dihydroorotate dehydrogenase
dihydroorotate
inhibitors
dehydrogenase
Prior art date
Application number
MA054695A
Other languages
English (en)
Inventor
Justin Cisar
Edgar Jacoby
Colleen Elizabeth Keohane
Scott Kuduk
Yvan Rene Ferdinand Simonnet
Chao-Yuan Wang
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MA54695A publication Critical patent/MA54695A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA054695A 2019-01-11 2020-01-10 Inhibiteurs de dihydroorotate déshydrogénase MA54695A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962791057P 2019-01-11 2019-01-11
US201962859851P 2019-06-11 2019-06-11

Publications (1)

Publication Number Publication Date
MA54695A true MA54695A (fr) 2021-11-17

Family

ID=69326572

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054695A MA54695A (fr) 2019-01-11 2020-01-10 Inhibiteurs de dihydroorotate déshydrogénase

Country Status (16)

Country Link
US (1) US20220089568A1 (fr)
EP (1) EP3908579B1 (fr)
JP (1) JP2022517086A (fr)
KR (1) KR20210114968A (fr)
CN (1) CN113574054A (fr)
AU (1) AU2020205842A1 (fr)
BR (1) BR112021013134A2 (fr)
CA (1) CA3126330A1 (fr)
ES (1) ES2971680T3 (fr)
IL (1) IL284537A (fr)
MA (1) MA54695A (fr)
MX (1) MX2021008400A (fr)
PH (1) PH12021551626A1 (fr)
SG (1) SG11202107276WA (fr)
TW (1) TW202043208A (fr)
WO (1) WO2020144638A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202104207A (zh) 2019-04-17 2021-02-01 美商健生生物科技公司 二氫乳清酸脫氫酶抑制劑
KR20220097438A (ko) * 2019-11-01 2022-07-07 얀센 바이오테크 인코포레이티드 암, 자가면역, 및 염증성 질환의 치료를 위한 다이하이드로오로테이트 데하이드로게나제(dhodh) 억제제로서의 플루오르화 퀴놀린 및 퀴녹살린 유도체
JP2023535346A (ja) * 2020-07-14 2023-08-17 ナンジン ゼンシャイン ファーマシューティカルズ カンパニー リミテッド Dhodh阻害剤としての化合物
CN116249702B (zh) * 2020-09-28 2025-04-25 微境生物医药科技(上海)有限公司 用作dhodh抑制剂的1,2,4-三唑酮衍生物
WO2022070069A1 (fr) * 2020-09-30 2022-04-07 Janssen Biotech, Inc. Inhibiteurs de la dihydroorotate déshydrogénase
WO2022074534A1 (fr) 2020-10-05 2022-04-14 Janssen Biotech, Inc. Combinaisons d'inhibiteurs de dihydroorotate déshydrogénase et d'agents hypométhylants
WO2022200615A1 (fr) 2021-03-26 2022-09-29 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Combinaison d'inhibiteur de la biosynthèse de la pyrimidine destinée à être utilisée dans le traitement d'infections virales
WO2023280181A1 (fr) * 2021-07-05 2023-01-12 微境生物医药科技(上海)有限公司 Dérivé de 1,2,4-triazolone utile en tant qu'inhibiteur de dhodh, son procédé de préparation et son utilisation
EP4758126A1 (fr) * 2023-08-08 2026-06-17 The General Hospital Corporation Synthèses et utilisation de bloqueurs de canaux potassiques en imagerie tep et en thérapeutique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10968216B2 (en) * 2016-10-27 2021-04-06 Bayer Aktiengesellschaft 4,5-annulated 1,2,4-triazolones
JOP20190094A1 (ar) * 2016-10-27 2019-04-25 Broad Inst Inc مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
EP3858361B1 (fr) * 2018-09-28 2025-10-08 FUJIFILM Corporation Agent antitumoral contenant de la cytarabine, activateur d'effet antitumoral utilisé en combinaison avec la cytarabine, kit antitumoral, et agent antitumoral utilisé en combinaison avec le cytarabine

Also Published As

Publication number Publication date
WO2020144638A1 (fr) 2020-07-16
EP3908579A1 (fr) 2021-11-17
BR112021013134A2 (pt) 2021-09-28
MX2021008400A (es) 2021-08-16
SG11202107276WA (en) 2021-07-29
TW202043208A (zh) 2020-12-01
CA3126330A1 (fr) 2020-07-16
JP2022517086A (ja) 2022-03-04
PH12021551626A1 (en) 2022-05-02
CN113574054A (zh) 2021-10-29
ES2971680T3 (es) 2024-06-06
US20220089568A1 (en) 2022-03-24
EP3908579B1 (fr) 2023-12-27
KR20210114968A (ko) 2021-09-24
IL284537A (en) 2021-08-31
AU2020205842A1 (en) 2021-07-22

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