MA54862A - Procédé de préparation d'un agoniste double gip/glp1 - Google Patents

Procédé de préparation d'un agoniste double gip/glp1

Info

Publication number
MA54862A
MA54862A MA054862A MA54862A MA54862A MA 54862 A MA54862 A MA 54862A MA 054862 A MA054862 A MA 054862A MA 54862 A MA54862 A MA 54862A MA 54862 A MA54862 A MA 54862A
Authority
MA
Morocco
Prior art keywords
gip
preparing
dual agonist
glp1 dual
glp1
Prior art date
Application number
MA054862A
Other languages
English (en)
Inventor
Stephanie Ruth Coffin
Michael Oliver Frederick
Ankur Jalan
Neil John Kallman
Michael Eugene Kopach
Kevin Dale Seibert
Sergey Vladimirovich Tsukanov
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA54862A publication Critical patent/MA54862A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C07C7/05—Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds
    • C07C7/06—Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds by azeotropic distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/645—Secretins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA054862A 2019-01-29 2020-01-28 Procédé de préparation d'un agoniste double gip/glp1 MA54862A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962797963P 2019-01-29 2019-01-29
US201962815053P 2019-03-07 2019-03-07
US201962818342P 2019-03-14 2019-03-14

Publications (1)

Publication Number Publication Date
MA54862A true MA54862A (fr) 2022-05-04

Family

ID=69724140

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054862A MA54862A (fr) 2019-01-29 2020-01-28 Procédé de préparation d'un agoniste double gip/glp1

Country Status (19)

Country Link
US (6) US12624079B2 (fr)
EP (3) EP4685157A3 (fr)
JP (4) JP7315683B2 (fr)
KR (2) KR20250138827A (fr)
CN (7) CN119119238A (fr)
AU (6) AU2020216922A1 (fr)
BR (1) BR112021012368A2 (fr)
CA (2) CA3128023A1 (fr)
CL (3) CL2021001905A1 (fr)
CO (1) CO2021009662A2 (fr)
EC (1) ECSP21056124A (fr)
IL (2) IL317378A (fr)
MA (1) MA54862A (fr)
MX (1) MX2021008965A (fr)
PE (1) PE20211992A1 (fr)
PH (1) PH12021551786A1 (fr)
SG (1) SG11202107123TA (fr)
TW (1) TWI799680B (fr)
WO (1) WO2020159949A1 (fr)

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TW202140058A (zh) 2020-01-30 2021-11-01 美商美國禮來大藥廠 提派肽（ｔｉｒｚｅｐａｔｉｄｅ）之治療用途
WO2022117056A1 (fr) * 2020-12-02 2022-06-09 南京明德新药研发有限公司 Composés polypeptidiques modifiés par lactame
WO2022159395A1 (fr) * 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions et procédés pour le traitement de troubles métaboliques et hépatiques
US12215133B2 (en) 2021-03-25 2025-02-04 Brightgene Bio-Medical Technology Co., Ltd. GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use
HRP20251468T1 (hr) * 2021-03-25 2026-01-02 Brightgene Bio-Medical Technology Co., Ltd. Agonist dvostrukog receptora gip i glp-1, farmaceutski pripravak i upotreba
IL308392A (en) 2021-05-13 2024-01-01 Carmot Therapeutics Inc G protein-coupled receptor modulators
CN117015551B (zh) * 2021-05-28 2024-05-28 广东众生睿创生物科技有限公司 多肽的制备及其应用
IL311411A (en) 2021-09-15 2024-05-01 Viking Therapeutics Inc Preparations and methods for the treatment of metabolic and liver disorders
US20250019410A1 (en) 2021-11-22 2025-01-16 Sun Pharmaceutical Industries Ltd. Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof
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IL320036A (en) 2022-10-05 2025-06-01 Lilly Co Eli Peptides for incretin synthesis
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AU2023385357A1 (en) 2022-11-21 2025-06-05 Eli Lilly And Company Process for preparing a gip/glp1 dual agonist
WO2024134676A1 (fr) * 2022-12-19 2024-06-27 Dr. Reddy’S Laboratories Limited Procédé de préparation de tirzépatide
WO2024133236A2 (fr) * 2022-12-19 2024-06-27 Forschungsverbund Berlin E.V. Conjugués peptidiques pour le marquage de gipr endogène et de glp-1r
US20260116944A1 (en) * 2022-12-23 2026-04-30 Hanmi Pharm. Co., Ltd. Novel triple glp-1/gip/glucagon receptor agonist and a pharmaceutical composition for preventing or treating obesity comprising the same
WO2024145638A2 (fr) * 2022-12-29 2024-07-04 Eli Lilly And Company Procédés et intermédiaires pour la préparation de tirzépatide
IL323039A (en) 2023-03-06 2025-10-01 Ascendis Pharma As Drug compounds containing albumin-binding moieties
CN116731154A (zh) * 2023-08-14 2023-09-12 苏州金顶生物有限公司 一种全液相法制备替西帕肽的方法
WO2025087344A1 (fr) * 2023-10-25 2025-05-01 Beta Pharma, Inc. Agonistes peptidiques doubles glp1-r/gipr et leur utilisation
CN117736273B (zh) * 2023-12-08 2024-05-07 广东省卓肽医药有限公司 一种替尔泊肽的纯化方法
KR20250109624A (ko) 2024-01-10 2025-07-17 (주)인벤티지랩 터제파타이드 또는 이의 약학적으로 허용 가능한 염을 포함하는 마이크로 입자 및 이의 제조 방법
WO2025163674A1 (fr) * 2024-01-30 2025-08-07 Msn Laboratories Private Limited, R&D Center Procédé de préparation du tirzépatide
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WO2026013138A1 (fr) 2024-07-10 2026-01-15 Ascendis Pharma A/S Composés à liaison à l'albumine améliorée
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Also Published As

Publication number Publication date
CL2025002021A1 (es) 2025-08-29
AU2024205812A1 (en) 2024-09-05
AU2023203001B2 (en) 2024-03-28
JP7856703B2 (ja) 2026-05-11
CO2021009662A2 (es) 2021-08-09
EP4685157A3 (fr) 2026-04-22
PH12021551786A1 (en) 2022-05-30
CN113330024A (zh) 2021-08-31
JP7681050B2 (ja) 2025-05-21
JP7856704B2 (ja) 2026-05-11
NZ778390A (en) 2025-02-28
KR102860373B1 (ko) 2025-09-16
SG11202107123TA (en) 2021-08-30
CN120574308A (zh) 2025-09-02
AU2024201004B2 (en) 2026-02-12
CN119119238A (zh) 2024-12-13
CN113330024B (zh) 2025-06-13
TW202043260A (zh) 2020-12-01
EP4685156A3 (fr) 2026-04-22
AU2023203001A1 (en) 2023-06-08
US20250270276A1 (en) 2025-08-28
WO2020159949A1 (fr) 2020-08-06
CN120574309A (zh) 2025-09-02
IL284446A (en) 2021-08-31
BR112021012368A2 (pt) 2021-09-14
KR20210110349A (ko) 2021-09-07
JP2024170401A (ja) 2024-12-10
IL317378A (en) 2025-02-01
CL2021001905A1 (es) 2022-03-11
KR20250138827A (ko) 2025-09-22
IL284446B1 (en) 2025-06-01
US12624079B2 (en) 2026-05-12
AU2025259828A1 (en) 2025-11-20
US20250382345A1 (en) 2025-12-18
US20220135639A1 (en) 2022-05-05
MX2021008965A (es) 2021-08-24
CN119119237A (zh) 2024-12-13
AU2024201004A1 (en) 2024-03-07
JP2024170402A (ja) 2024-12-10
IL284446B2 (en) 2025-10-01
EP4685156A2 (fr) 2026-01-28
US20240391975A1 (en) 2024-11-28
CA3224820A1 (fr) 2020-08-06
CL2023003709A1 (es) 2024-06-07
CA3128023A1 (fr) 2020-08-06
US20250270277A1 (en) 2025-08-28
JP7315683B2 (ja) 2023-07-26
JP2023078130A (ja) 2023-06-06
TWI799680B (zh) 2023-04-21
JP2022517834A (ja) 2022-03-10
US20240368240A1 (en) 2024-11-07
US20250289862A1 (en) 2025-09-18
AU2024205812B2 (en) 2025-12-18
EP3917950A1 (fr) 2021-12-08
ECSP21056124A (es) 2021-08-31
PE20211992A1 (es) 2021-10-18
EP4685157A2 (fr) 2026-01-28
CN120574307A (zh) 2025-09-02
AU2020216922A1 (en) 2021-07-15
AU2025271228A1 (en) 2025-12-18
CN119119239A (zh) 2024-12-13

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