CL2025002021A1 - Proceso para preparar un agonista dual de gip/glp1 - Google Patents

Proceso para preparar un agonista dual de gip/glp1

Info

Publication number
CL2025002021A1
CL2025002021A1 CL2025002021A CL2025002021A CL2025002021A1 CL 2025002021 A1 CL2025002021 A1 CL 2025002021A1 CL 2025002021 A CL2025002021 A CL 2025002021A CL 2025002021 A CL2025002021 A CL 2025002021A CL 2025002021 A1 CL2025002021 A1 CL 2025002021A1
Authority
CL
Chile
Prior art keywords
preparing
glp1 agonist
gip
dual
dual gip
Prior art date
Application number
CL2025002021A
Other languages
English (en)
Inventor
Ruth Coffin Stephanie
Oliver Frederick Michael
JALAN Ankur
John Kallman Neil
Eugene Kopach Michael
Dale Seibert Kevin
Vladimirovich Tsukanov Sergey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CL2025002021A1 publication Critical patent/CL2025002021A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C07C7/05—Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds
    • C07C7/06—Purification; Separation; Use of additives by distillation with the aid of auxiliary compounds by azeotropic distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/645—Secretins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención proporciona los productos intermedios y los procesos novedosos útiles en la fabricación de la tirzepatida o una sal farmacéuticamente aceptable de esta.
CL2025002021A 2019-01-29 2025-07-08 Proceso para preparar un agonista dual de gip/glp1 CL2025002021A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962797963P 2019-01-29 2019-01-29
US201962815053P 2019-03-07 2019-03-07
US201962818342P 2019-03-14 2019-03-14

Publications (1)

Publication Number Publication Date
CL2025002021A1 true CL2025002021A1 (es) 2025-08-29

Family

ID=69724140

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2021001905A CL2021001905A1 (es) 2019-01-29 2021-07-19 Proceso para preparar un agonista dual de gip/glp1
CL2023003709A CL2023003709A1 (es) 2019-01-29 2023-12-11 Proceso para preparar un agonista dual de gip/glp1
CL2025002021A CL2025002021A1 (es) 2019-01-29 2025-07-08 Proceso para preparar un agonista dual de gip/glp1

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2021001905A CL2021001905A1 (es) 2019-01-29 2021-07-19 Proceso para preparar un agonista dual de gip/glp1
CL2023003709A CL2023003709A1 (es) 2019-01-29 2023-12-11 Proceso para preparar un agonista dual de gip/glp1

Country Status (19)

Country Link
US (6) US12624079B2 (es)
EP (3) EP4685157A3 (es)
JP (4) JP7315683B2 (es)
KR (2) KR20250138827A (es)
CN (7) CN119119238A (es)
AU (6) AU2020216922A1 (es)
BR (1) BR112021012368A2 (es)
CA (2) CA3128023A1 (es)
CL (3) CL2021001905A1 (es)
CO (1) CO2021009662A2 (es)
EC (1) ECSP21056124A (es)
IL (2) IL317378A (es)
MA (1) MA54862A (es)
MX (1) MX2021008965A (es)
PE (1) PE20211992A1 (es)
PH (1) PH12021551786A1 (es)
SG (1) SG11202107123TA (es)
TW (1) TWI799680B (es)
WO (1) WO2020159949A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110642935A (zh) * 2019-09-25 2020-01-03 成都奥达生物科技有限公司 一种替瑞帕肽类似物
TW202140058A (zh) 2020-01-30 2021-11-01 美商美國禮來大藥廠 提派肽（ｔｉｒｚｅｐａｔｉｄｅ）之治療用途
WO2022117056A1 (zh) * 2020-12-02 2022-06-09 南京明德新药研发有限公司 含内酰胺修饰的多肽类化合物
WO2022159395A1 (en) * 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
US12215133B2 (en) 2021-03-25 2025-02-04 Brightgene Bio-Medical Technology Co., Ltd. GIP and GLP-1 dual receptor agonist, pharmaceutical composition, and use
HRP20251468T1 (hr) * 2021-03-25 2026-01-02 Brightgene Bio-Medical Technology Co., Ltd. Agonist dvostrukog receptora gip i glp-1, farmaceutski pripravak i upotreba
IL308392A (en) 2021-05-13 2024-01-01 Carmot Therapeutics Inc G protein-coupled receptor modulators
CN117015551B (zh) * 2021-05-28 2024-05-28 广东众生睿创生物科技有限公司 多肽的制备及其应用
IL311411A (en) 2021-09-15 2024-05-01 Viking Therapeutics Inc Preparations and methods for the treatment of metabolic and liver disorders
US20250019410A1 (en) 2021-11-22 2025-01-16 Sun Pharmaceutical Industries Ltd. Process for the preparation of tirzepatide or pharmaceutically acceptable salt thereof
TW202404996A (zh) 2022-04-04 2024-02-01 美商美國禮來大藥廠 製備glp-1/升糖素雙重促效劑之方法
CA3246912A1 (en) * 2022-04-07 2025-07-09 Guangdong Raynovent Biotech Co., Ltd. Pharmaceutical use of polypeptide in the preparation of medicates to treat and/or prevent diabetes, obesity and related diseases
CN116023444B (zh) * 2022-08-12 2023-08-01 重庆宸安生物制药有限公司 一种gip和glp-1双受体激动剂多肽化合物及其应用
IL320036A (en) 2022-10-05 2025-06-01 Lilly Co Eli Peptides for incretin synthesis
CN117756913B (zh) * 2022-11-07 2025-05-09 内蒙古博睿精创科技有限公司 一种新型长效多肽化合物、组合物及其应用
AU2023385357A1 (en) 2022-11-21 2025-06-05 Eli Lilly And Company Process for preparing a gip/glp1 dual agonist
WO2024134676A1 (en) * 2022-12-19 2024-06-27 Dr. Reddy’S Laboratories Limited Process for the preparation of tirzepatide
WO2024133236A2 (en) * 2022-12-19 2024-06-27 Forschungsverbund Berlin E.V. Peptide conjugates for labelling endogenous gipr and glp-1r
US20260116944A1 (en) * 2022-12-23 2026-04-30 Hanmi Pharm. Co., Ltd. Novel triple glp-1/gip/glucagon receptor agonist and a pharmaceutical composition for preventing or treating obesity comprising the same
WO2024145638A2 (en) * 2022-12-29 2024-07-04 Eli Lilly And Company Processes and intermediates for preparing tirzepatide
IL323039A (en) 2023-03-06 2025-10-01 Ascendis Pharma As Drug compounds containing albumin-binding moieties
CN116731154A (zh) * 2023-08-14 2023-09-12 苏州金顶生物有限公司 一种全液相法制备替西帕肽的方法
WO2025087344A1 (en) * 2023-10-25 2025-05-01 Beta Pharma, Inc. Glp1-r/gipr dual peptide agonists and use thereof
CN117736273B (zh) * 2023-12-08 2024-05-07 广东省卓肽医药有限公司 一种替尔泊肽的纯化方法
KR20250109624A (ko) 2024-01-10 2025-07-17 (주)인벤티지랩 터제파타이드 또는 이의 약학적으로 허용 가능한 염을 포함하는 마이크로 입자 및 이의 제조 방법
WO2025163674A1 (en) * 2024-01-30 2025-08-07 Msn Laboratories Private Limited, R&D Center Process for the preparation of tirzepatide
WO2025193816A1 (en) * 2024-03-14 2025-09-18 Viking Therapeutics, Inc. Pharmaceutical compositions and methods for the treatment of metabolic and liver disorders
WO2026013136A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding compounds
WO2026013135A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding reagents
WO2026013138A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Compounds with improved albumin-binding
CN121064064A (zh) * 2025-11-05 2025-12-05 武汉远大弘元股份有限公司 一种芴甲氧羰基-l-赖氨酸盐酸盐晶型及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1076066A1 (en) * 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
WO2004074315A2 (en) * 2003-02-19 2004-09-02 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Analogues of glp-1
BRPI0606992A2 (pt) 2005-02-11 2009-07-28 Amylin Pharmaceuticals Inc análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
DK2035451T3 (da) 2006-06-23 2010-06-07 Hoffmann La Roche Insulinoptrop peptidsyntese
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
JP5591243B2 (ja) 2008-09-12 2014-09-17 ノボ・ノルデイスク・エー／エス ペプチド又はタンパク質のアシル化の方法
EP2424888A2 (en) 2009-05-01 2012-03-07 F. Hoffmann-La Roche AG Insulinotropic peptide synthesis using solid and solution phase combination techniques
WO2011006644A2 (en) 2009-07-15 2011-01-20 Lonza Ltd Process for the production of exenatide and of an exenatide analogue
WO2011095989A2 (en) 2010-02-04 2011-08-11 Matrix Laboratories Ltd An improved process for the preparation of enfuvirtide
US20110313131A1 (en) 2010-06-21 2011-12-22 Christelle Carl Reversed phase hplc purification of a glp-1 analogue
DK2694095T3 (en) 2011-04-05 2018-05-28 Longevity Biotech Inc COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME
CN103145828B (zh) * 2012-12-12 2014-08-13 宁波盛泰生物医药科技有限公司 一种利拉鲁肽的全固相合成方法
AU2014333979B2 (en) * 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
GR20140100479A (el) 2014-09-23 2016-05-05 Novetide, Ltd., Συνθεση λιραγλουτιδης
CN104356224A (zh) 2014-10-24 2015-02-18 杭州阿德莱诺泰制药技术有限公司 一种制备萨摩鲁泰的方法
RU2716985C2 (ru) * 2014-10-29 2020-03-17 Зилэнд Фарма А/С Соединения-агонисты gip и способы
US10344069B2 (en) * 2014-10-31 2019-07-09 Auro Peptides Ltd. Process for the preparation of liraglutide
JO3575B1 (ar) 2015-01-09 2020-07-05 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
CN106928086B (zh) * 2015-12-31 2019-05-31 深圳翰宇药业股份有限公司 一种长链化合物的制备方法
CN108676086B (zh) * 2018-07-24 2020-06-30 江苏诺泰澳赛诺生物制药股份有限公司 一种利拉鲁肽的合成方法
CN108676087B (zh) 2018-07-24 2020-06-30 江苏诺泰澳赛诺生物制药股份有限公司 一种索玛鲁肽的合成方法
EP4017866A1 (en) 2019-08-19 2022-06-29 Eli Lilly and Company Methods of making incretin analogs

Also Published As

Publication number Publication date
AU2024205812A1 (en) 2024-09-05
AU2023203001B2 (en) 2024-03-28
JP7856703B2 (ja) 2026-05-11
CO2021009662A2 (es) 2021-08-09
EP4685157A3 (en) 2026-04-22
PH12021551786A1 (en) 2022-05-30
CN113330024A (zh) 2021-08-31
JP7681050B2 (ja) 2025-05-21
JP7856704B2 (ja) 2026-05-11
NZ778390A (en) 2025-02-28
KR102860373B1 (ko) 2025-09-16
SG11202107123TA (en) 2021-08-30
CN120574308A (zh) 2025-09-02
AU2024201004B2 (en) 2026-02-12
CN119119238A (zh) 2024-12-13
CN113330024B (zh) 2025-06-13
TW202043260A (zh) 2020-12-01
EP4685156A3 (en) 2026-04-22
AU2023203001A1 (en) 2023-06-08
US20250270276A1 (en) 2025-08-28
WO2020159949A1 (en) 2020-08-06
CN120574309A (zh) 2025-09-02
IL284446A (en) 2021-08-31
BR112021012368A2 (pt) 2021-09-14
KR20210110349A (ko) 2021-09-07
JP2024170401A (ja) 2024-12-10
IL317378A (en) 2025-02-01
CL2021001905A1 (es) 2022-03-11
KR20250138827A (ko) 2025-09-22
IL284446B1 (en) 2025-06-01
US12624079B2 (en) 2026-05-12
AU2025259828A1 (en) 2025-11-20
US20250382345A1 (en) 2025-12-18
US20220135639A1 (en) 2022-05-05
MX2021008965A (es) 2021-08-24
CN119119237A (zh) 2024-12-13
AU2024201004A1 (en) 2024-03-07
JP2024170402A (ja) 2024-12-10
IL284446B2 (en) 2025-10-01
MA54862A (fr) 2022-05-04
EP4685156A2 (en) 2026-01-28
US20240391975A1 (en) 2024-11-28
CA3224820A1 (en) 2020-08-06
CL2023003709A1 (es) 2024-06-07
CA3128023A1 (en) 2020-08-06
US20250270277A1 (en) 2025-08-28
JP7315683B2 (ja) 2023-07-26
JP2023078130A (ja) 2023-06-06
TWI799680B (zh) 2023-04-21
JP2022517834A (ja) 2022-03-10
US20240368240A1 (en) 2024-11-07
US20250289862A1 (en) 2025-09-18
AU2024205812B2 (en) 2025-12-18
EP3917950A1 (en) 2021-12-08
ECSP21056124A (es) 2021-08-31
PE20211992A1 (es) 2021-10-18
EP4685157A2 (en) 2026-01-28
CN120574307A (zh) 2025-09-02
AU2020216922A1 (en) 2021-07-15
AU2025271228A1 (en) 2025-12-18
CN119119239A (zh) 2024-12-13

Similar Documents

Publication Publication Date Title
CL2023003709A1 (es) Proceso para preparar un agonista dual de gip/glp1
MX2022003401A (es) Compuesto de piridona fusionada y metodo de preparacion del mismo y uso del mismo.
IL279827A (en) Gip/glp1 co-agonist compounds
SG11202100112YA (en) Methods of using a gip/glp1 co-agonist for therapy
HUE063059T2 (hu) GIP/GLP1 agonista készítmények
CO2019011809A2 (es) Compuestos de imidazo-piperidina fusionada como inhibidores de jak
BR112022002604A2 (pt) Processo de produção de moduladores de cftr
CR20190124A (es) Inhibidores de ssao de aminopirimidina
IL280159A (en) Method of using a gip/glp1 co-agonist for diabetes
IL281243A (en) Methods of treating immunotherapy-related toxicity using a gm-csf antagonist
MX2020012518A (es) Proteinas de fusion que comprenden progranulina.
MX2019010642A (es) Inhibidores de cinasa activada por mitogeno 2 (mk2), sintesis de los mismos, e intermediarios de los mismos.
ECSP23019419A (es) Proceso e intermedios para preparar un inhibidor de jak1
CO2019008110A2 (es) Activador de nrf2
IL290056A (en) Process for producing a tablet comprising glp-1 peptides
CL2022001417A1 (es) Proceso para los productos de sintegas.
PY1991831A (es) Sales cristalinas de un inhibidor de calicreína plasmática
IT201700073326A1 (it) Procedimento di preparazione di un materiale micro- e mesoporoso adsorbente per gas e materiale micro- e mesoporoso adsorbente così ottenuto.
JOP20210077A1 (ar) طريقة لتصنيع المجوهرات المقلدة
ECSP22046595A (es) Procesos e intermediario para la preparaci?n de oxetan-2-ilmetanamina
IT201900023937A1 (it) Procedimento per la preparazione di Lasmiditan e di un intermedio di sintesi
CO2022009062A2 (es) Composición para la preparación de alulosa y procedimiento para la preparación de alulosa mediante el uso de la misma
IL276557A (en) A process for making metformin
AR117894A1 (es) Proceso para preparar un agonista dual de gip / glp1
IL283678A (en) Process for preparing bicyclic enolether