MA55301A - Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation - Google Patents

Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation

Info

Publication number
MA55301A
MA55301A MA055301A MA55301A MA55301A MA 55301 A MA55301 A MA 55301A MA 055301 A MA055301 A MA 055301A MA 55301 A MA55301 A MA 55301A MA 55301 A MA55301 A MA 55301A
Authority
MA
Morocco
Prior art keywords
methods
protein tyrosine
tyrosine phosphatase
phosphatase inhibitors
inhibitors
Prior art date
Application number
MA055301A
Other languages
English (en)
Inventor
Jason Abbott
Christina Baumgartner
Andrew Bogdan
Christos Economou
Elliot P Farney
Stacy Fosu
Jennifer M Frost
Geoff T Halvorsen
Philip R Kym
Mark A Matulenko
Matthew O'connor
Reza Shiroodi
Eric Voight
Zhaoming Xiong
Qingwei I Zhang
Original Assignee
Abbvie Inc
Calico Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Calico Life Sciences Llc filed Critical Abbvie Inc
Publication of MA55301A publication Critical patent/MA55301A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Oncology (AREA)
MA055301A 2019-03-14 2020-03-13 Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation MA55301A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962818447P 2019-03-14 2019-03-14

Publications (1)

Publication Number Publication Date
MA55301A true MA55301A (fr) 2022-01-19

Family

ID=70190226

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055301A MA55301A (fr) 2019-03-14 2020-03-13 Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation

Country Status (24)

Country Link
US (1) US10851073B2 (fr)
EP (1) EP3938038A1 (fr)
JP (3) JP7204005B2 (fr)
KR (3) KR102983496B1 (fr)
CN (2) CN116332873A (fr)
AR (1) AR118374A1 (fr)
AU (2) AU2020234712B2 (fr)
BR (1) BR112021017430A2 (fr)
CA (1) CA3131894A1 (fr)
CL (2) CL2021002382A1 (fr)
CO (1) CO2021013524A2 (fr)
CR (1) CR20210516A (fr)
DO (1) DOP2021000188A (fr)
EC (1) ECSP21075909A (fr)
IL (2) IL286373B2 (fr)
MA (1) MA55301A (fr)
MX (2) MX2024010859A (fr)
MY (1) MY209419A (fr)
PE (2) PE20252767A1 (fr)
PH (1) PH12021552194A1 (fr)
SG (1) SG11202109067PA (fr)
TW (2) TWI849082B (fr)
UY (1) UY38613A (fr)
WO (1) WO2020186199A1 (fr)

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EP4211122A1 (fr) * 2020-09-11 2023-07-19 Calico Life Sciences LLC Inhibiteurs de protéine tyrosine phosphatase et leurs méthodes d'utilisation
IL305072A (en) * 2021-02-12 2023-10-01 Recovery Therapeutics Inc Compounds, compositions, and methods for modulating fgf activity
EP4305030A4 (fr) * 2021-03-11 2025-05-21 Kumquat Biosciences Inc. Hétérocycles et leurs utilisations
EP4351558A4 (fr) * 2021-06-10 2025-05-07 Ness Therapeutics, Inc. Composés ayant un 1,1-dioxyde de 5-(2-fluoro-6-hydroxyphényl)-1,2,5-thiadiazolidin-3-one utiles comme inhibiteurs d'enzymes protéine kinase phosphatase
CN118556055A (zh) * 2021-11-11 2024-08-27 卡里科生命科学有限责任公司 蛋白酪氨酸磷酸酶抑制剂及其使用方法
MX2024005658A (es) * 2021-11-11 2024-08-06 Calico Life Sciences Llc Inhibidores de proteina tirosina fosfatasa y metodos de uso de estos.
CN119137117A (zh) * 2022-02-02 2024-12-13 耐瑞欧医疗公司 蛋白酪氨酸磷酸酶抑制剂及其用途
IL314650A (en) * 2022-02-02 2024-09-01 Nerio Therapeutics Inc Protein tyrosine phosphatase inhibitors and uses thereof
EP4472957A4 (fr) * 2022-02-02 2026-04-15 Nerio Therapeutics Inc Inhibiteurs de protéine tyrosine phosphatase et leurs utilisations
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WO2023200964A1 (fr) * 2022-04-14 2023-10-19 Nerio Therapeutics, Inc. Inhibiteurs de protéine tyrosine phosphatase et leurs utilisations
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JP2025530135A (ja) * 2022-09-13 2025-09-11 カムクワット バイオサイエンシーズ インコーポレイテッド ベンゾ縮合n-複素環及びその使用
WO2024067802A1 (fr) * 2022-09-30 2024-04-04 深圳众格生物科技有限公司 Inhibiteur de protéine tyrosine phosphatase, son procédé de préparation et son utilisation pharmaceutique
WO2024141015A1 (fr) * 2022-12-30 2024-07-04 Insilico Medicine Ip Limited Inhibiteurs de protéine tyrosine phosphatase et leurs utilisations
WO2024243441A1 (fr) * 2023-05-24 2024-11-28 Kumquat Biosciences Inc. Composés hétérocycliques et leurs utilisations
JP2026525318A (ja) * 2023-07-11 2026-07-29 シェンチェン チョンコー バイオロジカル テクノロジー カンパニー リミテッド タンパク質チロシンホスファターゼ阻害剤、それを含む組成物、及びその医学的使用
TW202519514A (zh) 2023-07-14 2025-05-16 天主教魯汶大學 新穎化合物(一)
CN121487923A (zh) * 2023-07-28 2026-02-06 杭州中美华东制药有限公司 具有ptpn2抑制作用的化合物及其用途
WO2025030008A1 (fr) * 2023-08-02 2025-02-06 Nerio Therapeutics, Inc. Combinaisons d'inhibiteurs de protéine tyrosine phosphatase
WO2025055985A1 (fr) * 2023-09-15 2025-03-20 深圳众格生物科技有限公司 Inhibiteur de protéine tyrosine phosphatase, composition et utilisation médicale
CN120004876B (zh) * 2023-11-16 2026-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
CN117343052B (zh) * 2023-12-04 2024-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
WO2025136841A1 (fr) * 2023-12-19 2025-06-26 Merck Sharp & Dohme Llc Dérivés d'isoquinoléine substitués et leurs procédés d'utilisation
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WO2019036815A1 (fr) 2017-08-24 2019-02-28 The Royal Institution For The Advancement Of Learning/Mcgill University Amélioration de lymphocytes t cd8+ pour une thérapie cellulaire adoptive par inhibition de ptpn1 (ptp1b) et ptpn2 (tc-ptp))
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KR102983496B1 (ko) * 2019-03-14 2026-06-29 칼리코 라이프 사이언시스 엘엘씨 단백질 티로신 포스파타제 억제제 및 이의 사용 방법

Also Published As

Publication number Publication date
KR20230074822A (ko) 2023-05-31
JP7204005B2 (ja) 2023-01-13
AU2020234712A1 (en) 2021-09-09
CL2024001723A1 (es) 2024-11-22
AU2020234712B2 (en) 2025-12-04
CL2021002382A1 (es) 2022-06-03
KR102533599B1 (ko) 2023-05-17
DOP2021000188A (es) 2022-03-15
WO2020186199A1 (fr) 2020-09-17
CN114025844B (zh) 2022-07-26
US10851073B2 (en) 2020-12-01
TWI849082B (zh) 2024-07-21
CN116332873A (zh) 2023-06-27
MX2024010859A (es) 2024-09-11
IL286373B2 (en) 2026-03-01
IL324019A (en) 2025-12-01
CA3131894A1 (fr) 2020-09-17
MY209419A (en) 2025-07-08
TW202100515A (zh) 2021-01-01
KR20260110254A (ko) 2026-07-14
PH12021552194A1 (en) 2022-08-22
AR118374A1 (es) 2021-09-29
BR112021017430A2 (pt) 2022-01-18
EP3938038A1 (fr) 2022-01-19
JP2025061064A (ja) 2025-04-10
JP2023052094A (ja) 2023-04-11
AU2026201609A1 (en) 2026-03-26
PE20212154A1 (es) 2021-11-09
TW202519515A (zh) 2025-05-16
CN114025844A (zh) 2022-02-08
IL286373B1 (en) 2025-11-01
US20200299246A1 (en) 2020-09-24
MX2021010544A (es) 2021-10-01
SG11202109067PA (en) 2021-09-29
JP2022522526A (ja) 2022-04-19
CO2021013524A2 (es) 2022-02-28
KR102983496B1 (ko) 2026-06-29
JP7617890B2 (ja) 2025-01-20
UY38613A (es) 2020-09-30
CR20210516A (es) 2022-07-19
IL286373A (en) 2021-10-31
PE20252767A1 (es) 2025-12-22
ECSP21075909A (es) 2021-11-30
KR20210151821A (ko) 2021-12-14

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