MA55301A - Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation - Google Patents

Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation

Info

Publication number
MA55301A
MA55301A MA055301A MA55301A MA55301A MA 55301 A MA55301 A MA 55301A MA 055301 A MA055301 A MA 055301A MA 55301 A MA55301 A MA 55301A MA 55301 A MA55301 A MA 55301A
Authority
MA
Morocco
Prior art keywords
methods
protein tyrosine
tyrosine phosphatase
phosphatase inhibitors
inhibitors
Prior art date
Application number
MA055301A
Other languages
English (en)
Inventor
Jason Abbott
Christina Baumgartner
Andrew Bogdan
Christos Economou
Elliot P Farney
Stacy Fosu
Jennifer M Frost
Geoff T Halvorsen
Philip R Kym
Mark A Matulenko
Matthew O'connor
Reza Shiroodi
Eric Voight
Zhaoming Xiong
Qingwei I Zhang
Original Assignee
Abbvie Inc
Calico Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Calico Life Sciences Llc filed Critical Abbvie Inc
Publication of MA55301A publication Critical patent/MA55301A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/101,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
MA055301A 2019-03-14 2020-03-13 Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation MA55301A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962818447P 2019-03-14 2019-03-14

Publications (1)

Publication Number Publication Date
MA55301A true MA55301A (fr) 2022-01-19

Family

ID=70190226

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055301A MA55301A (fr) 2019-03-14 2020-03-13 Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation

Country Status (24)

Country Link
US (1) US10851073B2 (fr)
EP (1) EP3938038A1 (fr)
JP (3) JP7204005B2 (fr)
KR (2) KR102533599B1 (fr)
CN (2) CN114025844B (fr)
AR (1) AR118374A1 (fr)
AU (2) AU2020234712B2 (fr)
BR (1) BR112021017430A2 (fr)
CA (1) CA3131894A1 (fr)
CL (2) CL2021002382A1 (fr)
CO (1) CO2021013524A2 (fr)
CR (1) CR20210516A (fr)
DO (1) DOP2021000188A (fr)
EC (1) ECSP21075909A (fr)
IL (2) IL286373B2 (fr)
MA (1) MA55301A (fr)
MX (2) MX2021010544A (fr)
MY (1) MY209419A (fr)
PE (2) PE20252767A1 (fr)
PH (1) PH12021552194A1 (fr)
SG (1) SG11202109067PA (fr)
TW (2) TWI849082B (fr)
UY (1) UY38613A (fr)
WO (1) WO2020186199A1 (fr)

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* Cited by examiner, † Cited by third party
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IL286373B2 (en) * 2019-03-14 2026-03-01 Calico Life Sciences Llc Protein tyrosine phosphate inhibitor compounds and uses thereof
EP4073242A4 (fr) 2019-12-12 2024-01-03 Kumquat Biosciences Inc. Compositions et procédés pour potentialiser l'activité immunitaire
CA3162069A1 (fr) * 2019-12-18 2021-06-24 Elliot P. Farney Inhibiteurs de proteine tyrosine phosphatase et leurs methodes d'utilisation
MX2023002953A (es) * 2020-09-11 2023-06-01 Calico Life Sciences Llc Inhibidores de proteína tirosina fosfatasa y métodos para su uso.
IL305072A (en) * 2021-02-12 2023-10-01 Recovery Therapeutics Inc Compounds, compositions, and methods for modulating fgf activity
WO2022192598A1 (fr) * 2021-03-11 2022-09-15 Kumquat Biosciences Inc. Hétérocycles et leurs utilisations
EP4351558A4 (fr) * 2021-06-10 2025-05-07 Ness Therapeutics, Inc. Composés ayant un 1,1-dioxyde de 5-(2-fluoro-6-hydroxyphényl)-1,2,5-thiadiazolidin-3-one utiles comme inhibiteurs d'enzymes protéine kinase phosphatase
MX2024005656A (es) * 2021-11-11 2024-08-06 Calico Life Sciences Llc Inhibidores de proteina tirosina fosfatasa y metodos de uso de estos.
WO2023086498A1 (fr) * 2021-11-11 2023-05-19 Calico Life Sciences Llc Inhibiteurs de protéine tyrosine phosphatase et leurs procédés d'utilisation
WO2023150535A1 (fr) * 2022-02-02 2023-08-10 Nerio Therapeutics, Inc. Inhibiteurs de protéine tyrosine phosphatase et leurs utilisations
WO2023150150A1 (fr) * 2022-02-02 2023-08-10 Nerio Therapeutics, Inc. Inhibiteurs de protéine tyrosine phosphatase et leurs utilisations
PE20250780A1 (es) * 2022-02-02 2025-03-14 Nerio Therapeutics Inc Inhibidores de proteina tirosina fosfatasa y usos de estos
US20250206757A1 (en) * 2022-03-21 2025-06-26 Gasherbrum Bio, Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
JP2025513882A (ja) * 2022-04-14 2025-04-30 ネリオ セラピューティクス,インク. タンパク質チロシンホスファターゼ阻害剤およびその使用
EP4522594A4 (fr) * 2022-05-13 2026-04-22 Mondego Bio Lda A Limited Liability Company By Quotas Soc Por Quotas Inhibiteurs de ptpn2
CN119790052A (zh) * 2022-09-13 2025-04-08 金橘生物科技公司 苯并稠合的n-杂环及其用途
WO2024067802A1 (fr) * 2022-09-30 2024-04-04 深圳众格生物科技有限公司 Inhibiteur de protéine tyrosine phosphatase, son procédé de préparation et son utilisation pharmaceutique
WO2024141015A1 (fr) * 2022-12-30 2024-07-04 Insilico Medicine Ip Limited Inhibiteurs de protéine tyrosine phosphatase et leurs utilisations
PE20252789A1 (es) 2023-05-24 2025-12-22 Kumquat Biosciences Inc Compuestos heterociclicos y usos de estos
AU2024288616A1 (en) * 2023-07-11 2026-02-12 Shenzhen Zhongge Biological Technology Co., Ltd. Protein tyrosine phosphatase inhibitor, composition comprising same, and medical use thereof
KR20260040037A (ko) 2023-07-14 2026-03-23 카톨리에케 유니버시테이트 루벤 암 및 대사 질병의 치료를 위한 신규 화합물
WO2025026158A1 (fr) * 2023-07-28 2025-02-06 杭州中美华东制药有限公司 Composés ayant des effets inhibiteurs de ptpn2 et leur utilisation
WO2025030008A1 (fr) * 2023-08-02 2025-02-06 Nerio Therapeutics, Inc. Combinaisons d'inhibiteurs de protéine tyrosine phosphatase
CN121889379A (zh) * 2023-09-15 2026-04-17 深圳众格生物科技有限公司 蛋白酪氨酸磷酸酶抑制剂及其组合物、医药用途
CN120004876B (zh) * 2023-11-16 2026-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
CN117343052B (zh) * 2023-12-04 2024-02-06 英矽智能科技(上海)有限公司 蛋白酪氨酸磷酸酶抑制剂及其应用
WO2025136841A1 (fr) * 2023-12-19 2025-06-26 Merck Sharp & Dohme Llc Dérivés d'isoquinoléine substitués et leurs procédés d'utilisation
WO2025242216A1 (fr) * 2024-05-24 2025-11-27 杭州百新生物医药科技有限公司 Composés indolines et leur utilisation
WO2026077417A1 (fr) * 2024-10-11 2026-04-16 杭州百新生物医药科技有限公司 Intermédiaire pour la préparation d'un inhibiteur de ptpn1/n2, son procédé de préparation et son utilisation

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UA94724C2 (en) * 2005-12-08 2011-06-10 Новартис Аг Thiadiazolidinone derivatives as antidiabetic agents
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AR066820A1 (es) 2007-06-04 2009-09-16 Novartis Ag Compuestos de tiadiazolidin-3 ona
WO2010008852A2 (fr) 2008-06-23 2010-01-21 Taiga Biotechnologies, Inc. Procédés de traitement et procédés de diagnostic d’un trouble immunoprolifératif
US9217012B2 (en) 2009-04-08 2015-12-22 Indiana University Research And Technology Corporation Inhibitors of protein tyrosine phosphatases
WO2011057331A1 (fr) 2009-11-11 2011-05-19 Monash University Procédé de traitement de l'obésité
EP2531616A4 (fr) 2010-02-03 2013-07-10 Univ Monash Dosage de diagnostic et de pronostic pour le cancer du sein
KR101668574B1 (ko) * 2012-11-02 2016-10-24 화이자 인코포레이티드 브루톤 티로신 키나제 억제제
WO2015127548A1 (fr) 2014-02-28 2015-09-03 The Royal Institution For The Advancement Of Learning / Mcgill University Inhibiteurs de tc-ptp en tant qu'activateurs d'apc pour l'immunothérapie
EP3154555A4 (fr) 2014-06-10 2018-02-28 Monash University Procédé de production de leucocytes par utilisation de l'inhibition du ptpn2 pour transfert adoptif de cellules
CN106922146B (zh) * 2014-10-02 2020-05-26 豪夫迈·罗氏有限公司 用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
WO2017078499A2 (fr) 2015-11-06 2017-05-11 경북대학교 산학협력단 Composition pour la prévention ou le traitement d'une maladie neuroinflammatoire, contenant un inhibiteur de la protéine tyrosine phosphatase
US20180325925A1 (en) 2015-11-06 2018-11-15 Kyungpook National University Industry-Academic Cooperation Foundation Composition for prevention or treatment of neuroinflammatory disease, containing protein tyrosine phosphatase inhibitor
WO2018148378A1 (fr) 2017-02-08 2018-08-16 Dana-Farber Cancer Institute, Inc. Modulation de biomarqueurs pour accroître l'immunité antitumorale et améliorer l'efficacité d'une immunothérapie anticancéreuse
WO2018227248A1 (fr) 2017-06-13 2018-12-20 Monash University Méthodes et compositions pour le traitement de l'obésité
WO2019036815A1 (fr) 2017-08-24 2019-02-28 The Royal Institution For The Advancement Of Learning/Mcgill University Amélioration de lymphocytes t cd8+ pour une thérapie cellulaire adoptive par inhibition de ptpn1 (ptp1b) et ptpn2 (tc-ptp))
BR112020026086A2 (pt) * 2018-06-21 2021-03-23 Calico Life Sciences Llc inibidores da proteína tirosina fosfatase e métodos de uso destes
IL286373B2 (en) 2019-03-14 2026-03-01 Calico Life Sciences Llc Protein tyrosine phosphate inhibitor compounds and uses thereof

Also Published As

Publication number Publication date
CL2021002382A1 (es) 2022-06-03
TW202100515A (zh) 2021-01-01
IL286373B1 (en) 2025-11-01
KR20230074822A (ko) 2023-05-31
IL324019A (en) 2025-12-01
BR112021017430A2 (pt) 2022-01-18
AR118374A1 (es) 2021-09-29
AU2020234712B2 (en) 2025-12-04
CN116332873A (zh) 2023-06-27
TW202519515A (zh) 2025-05-16
PE20252767A1 (es) 2025-12-22
EP3938038A1 (fr) 2022-01-19
UY38613A (es) 2020-09-30
CN114025844A (zh) 2022-02-08
JP7204005B2 (ja) 2023-01-13
US20200299246A1 (en) 2020-09-24
ECSP21075909A (es) 2021-11-30
CO2021013524A2 (es) 2022-02-28
CL2024001723A1 (es) 2024-11-22
KR102533599B1 (ko) 2023-05-17
JP2023052094A (ja) 2023-04-11
MX2021010544A (es) 2021-10-01
PH12021552194A1 (en) 2022-08-22
AU2026201609A1 (en) 2026-03-26
TWI849082B (zh) 2024-07-21
AU2020234712A1 (en) 2021-09-09
MY209419A (en) 2025-07-08
IL286373B2 (en) 2026-03-01
SG11202109067PA (en) 2021-09-29
JP7617890B2 (ja) 2025-01-20
CR20210516A (es) 2022-07-19
JP2025061064A (ja) 2025-04-10
DOP2021000188A (es) 2022-03-15
JP2022522526A (ja) 2022-04-19
CN114025844B (zh) 2022-07-26
IL286373A (en) 2021-10-31
WO2020186199A1 (fr) 2020-09-17
US10851073B2 (en) 2020-12-01
PE20212154A1 (es) 2021-11-09
MX2024010859A (es) 2024-09-11
CA3131894A1 (fr) 2020-09-17
KR20210151821A (ko) 2021-12-14

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