MA54538A - Inhibiteurs d'apol1 et leurs procédés d'utilisation - Google Patents

Inhibiteurs d'apol1 et leurs procédés d'utilisation

Info

Publication number
MA54538A
MA54538A MA054538A MA54538A MA54538A MA 54538 A MA54538 A MA 54538A MA 054538 A MA054538 A MA 054538A MA 54538 A MA54538 A MA 54538A MA 54538 A MA54538 A MA 54538A
Authority
MA
Morocco
Prior art keywords
apol1
inhibitors
methods
apol1 inhibitors
Prior art date
Application number
MA054538A
Other languages
English (en)
Inventor
Michael Brodney
Jingrong Cao
Jon H Come
Leslie A Dakin
Francois Denis
Warren A Dorsch
Anne Fortier
Kevin Gagnon
Martine Hamel
Kan-Nian Hu
Elaine B Krueger
Brian Ledford
Ales Medek
Suganthini S Nanthakumar
Olivier Nicolas
Peter Rose
Camil Sayegh
Timothy J Senter
Yi Shi
Muna Shrestha
Tiansheng Wang
Faith Witkos
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MA54538A publication Critical patent/MA54538A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA054538A 2018-12-17 2019-12-17 Inhibiteurs d'apol1 et leurs procédés d'utilisation MA54538A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862780667P 2018-12-17 2018-12-17

Publications (1)

Publication Number Publication Date
MA54538A true MA54538A (fr) 2021-10-27

Family

ID=69182627

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054538A MA54538A (fr) 2018-12-17 2019-12-17 Inhibiteurs d'apol1 et leurs procédés d'utilisation

Country Status (27)

Country Link
US (3) US11618746B2 (fr)
EP (1) EP3897833B1 (fr)
JP (1) JP7573528B2 (fr)
KR (2) KR20260020195A (fr)
CN (1) CN113453760B (fr)
AR (1) AR116913A1 (fr)
AU (1) AU2019405477B2 (fr)
CA (1) CA3121910A1 (fr)
CL (1) CL2021001561A1 (fr)
CO (1) CO2021009053A2 (fr)
CR (1) CR20210383A (fr)
DK (1) DK3897833T3 (fr)
DO (1) DOP2021000116A (fr)
EC (1) ECSP21052184A (fr)
FI (1) FI3897833T3 (fr)
IL (2) IL319575A (fr)
JO (3) JOP20210131A1 (fr)
LT (1) LT3897833T (fr)
MA (1) MA54538A (fr)
MX (1) MX2021007152A (fr)
PE (1) PE20212302A1 (fr)
SA (1) SA521422270B1 (fr)
SG (1) SG11202105769XA (fr)
TW (1) TWI848031B (fr)
UA (1) UA128375C2 (fr)
UY (1) UY38514A (fr)
WO (1) WO2020131807A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
WO2021154997A1 (fr) * 2020-01-29 2021-08-05 Vertex Pharmaceuticals Incorporated Inhibiteurs d'apol1 et leurs méthodes d'utilisation
US20210246121A1 (en) * 2020-02-04 2021-08-12 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and methods of using same
IL296035A (en) * 2020-03-06 2022-10-01 Vertex Pharma Methods of treating apol-1 dependent focal segmental glomerulosclerosis
CN115867543A (zh) * 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CA3185604A1 (fr) * 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibiteurs d'apol1 et leur utilisation
CN115867532A (zh) * 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1的抑制剂及其用途
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
CN116997546A (zh) * 2021-02-19 2023-11-03 梅兹治疗公司 Apol1抑制剂及使用方法
US20230119114A1 (en) * 2021-08-26 2023-04-20 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitors and methods of using same
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
EP4440697A1 (fr) * 2021-11-30 2024-10-09 Vertex Pharmaceuticals Incorporated Inhibiteurs spirocycliques d'apol1 et procédés d'utilisationde ceux-ci
MX2024008868A (es) * 2022-01-18 2024-09-23 Maze Therapeutics Inc Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso.
CA3251050A1 (fr) * 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Dérivés de 2-méthyl-4',5'-dihydrospiro[pipéridine-4,7'-thiéno[2,3-c]pyran] utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation
WO2023194895A1 (fr) 2022-04-06 2023-10-12 Glaxosmithkline Intellectual Property Development Limited Dérivés pyrroliques utilisés en tant qu'inhibiteurs de l'apolipoprotéine l-1
US20260055083A1 (en) * 2022-08-19 2026-02-26 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use
EP4735449A1 (fr) * 2023-06-29 2026-05-06 OmniAB, Inc. Composés tétracycliques contenant un indole fusionné pour le traitement d'une maladie rénale chronique médiée par apol1
GB202401326D0 (en) * 2024-02-01 2024-03-20 Podium Bio Ltd Novel compounds
KR20250122547A (ko) 2024-02-05 2025-08-14 서주사이언티픽 주식회사 AIoT 기반 방사성 동위원소 관리 시스템
WO2026012338A1 (fr) * 2024-07-09 2026-01-15 上海旭成医药科技有限公司 Inhibiteur d'apol

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4039676A (en) 1975-06-23 1977-08-02 Ciba-Geigy Corporation 2-piperidinoalkyl-1,4-benzodioxans
US6518423B1 (en) 1996-08-09 2003-02-11 Eisai Co., Ltd. Benzopiperidine derivatives
EP0924209B1 (fr) 1997-12-19 2003-05-02 Eli Lilly And Company Imidazolines hypoglycémiques
GB9905010D0 (en) 1999-03-04 1999-04-28 Merck Sharp & Dohme Therapeutic agents
AU7514700A (en) 1999-09-07 2001-04-10 Syngenta Participations Ag Cyanopiperidines
FR2801585B1 (fr) 1999-11-25 2002-02-15 Fournier Ind & Sante Nouveaux antagonistes des recepteurs de l'ii-8
GB0003397D0 (en) 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
AU2002211828A1 (en) 2000-10-02 2002-04-15 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
FR2824827B1 (fr) 2001-05-17 2004-02-13 Fournier Lab Sa Nouveaux derives de 5-phenyl-1h-indole antagoniste des recepteurs de l'interleukine-8
FR2824826B1 (fr) 2001-05-17 2003-11-07 Fournier Lab Sa Nouveaux derives de 5-cyano-1h-indole antagonistes des recepteurs de l'interleukine-8
ES2234451T1 (es) 2001-11-14 2005-07-01 Teva Pharmaceutical Industries Ltd. Formas cristalinas y amorfas de losartan potasio y procedimiento para su preparacion.
WO2003104180A1 (fr) * 2002-06-05 2003-12-18 Natco Pharma Limited Procede de preparation d'acide 4-(4-fluorobenzoyl) butyrique
WO2004058717A1 (fr) 2002-12-20 2004-07-15 X-Ceptor Therapeutics, Inc. Derives d'isoquinolinone et leur utilisation comme agents therapeutiques
JP2007504221A (ja) 2003-09-03 2007-03-01 ガラパゴス・エヌブイ 新規な４−ピペリジンカルボキシアミドおよび５ｈｔ２ａ受容体関連障害に対する薬剤の製造のためのその使用
BRPI0507657A (pt) 2004-03-03 2007-07-10 Lilly Co Eli composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, método para tratar um distúrbio, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo
AR048523A1 (es) 2004-04-07 2006-05-03 Kalypsys Inc Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos
WO2007061763A2 (fr) 2005-11-22 2007-05-31 Merck & Co., Inc. Antagonistes des recepteurs de l’indole orexine
US8222288B2 (en) 2006-08-30 2012-07-17 The Regents Of The University Of Michigan Small molecule inhibitors of MDM2 and the uses thereof
JP5406722B2 (ja) 2006-10-16 2014-02-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ブラジキニン１受容体モジュレータとしての置換されたスルホンアミド誘導体
BRPI0721138A2 (pt) 2006-12-22 2014-04-01 Hoffmann La Roche Derivados de espiro-piperidina
PT2118074E (pt) * 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
EP2020414A1 (fr) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. Derivés spiro[piperidine-4,4'-thieno[3,2-c]pyran] et composés similaires en tant que inhibiteurs du recepteur sigma pour le traitement de pyschose
DK2178870T3 (en) 2007-08-17 2018-10-22 Lg Chemical Ltd INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE
CN105254557A (zh) 2009-05-29 2016-01-20 拉夸里亚创药株式会社 作为钙或钠通道阻滞剂的芳基取代羧酰胺衍生物
UA107943C2 (xx) 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
AU2010319400B2 (en) 2009-11-16 2013-12-19 Eli Lilly And Company Spiropiperidine compounds as ORL-1 receptor antagonists
WO2012025155A1 (fr) 2010-08-26 2012-03-01 Novartis Ag Composés à base d'hydroxamate en tant qu'inhibiteurs des désacétylases
BR102012024778A2 (pt) 2012-09-28 2014-08-19 Cristalia Prod Quimicos Farm Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
US10130632B2 (en) 2012-11-27 2018-11-20 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
EP3049405A4 (fr) 2013-09-26 2017-03-08 Pharmakea Inc. Composés inhibiteurs de l'autotaxine
EP3461812B1 (fr) 2014-03-27 2021-10-13 Academisch Medisch Centrum Iminosucres n-(5-(biphén-4-ylméthyloxy)pentyl)-substitués comme inhibiteurs de la glucosylcéramide synthase
EP3186225A4 (fr) 2014-08-27 2018-02-28 The Governing Council of the University of Toronto Modulateurs du récepteur cannabinoïde de type 1
US10654838B2 (en) 2014-10-08 2020-05-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Aminopyridine compounds useful as inhibitors of protein prenylation
JP2017535545A (ja) 2014-11-21 2017-11-30 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有するスピロ−イソキノリン−１，４’−ピペリジン化合物
HUE053705T2 (hu) 2015-08-27 2021-07-28 Pfizer Biciklusos kondenzált heteroaril- vagy aril- vegyületek IRAK4 modulátorokként
WO2017137334A1 (fr) 2016-02-08 2017-08-17 F. Hoffmann-La Roche Ag Spiroindolinones utilisés en tant qu'inhibiteurs de ddr1
EP3787669A4 (fr) 2018-04-30 2022-03-30 The Trustees of Indiana University Composés destinés à moduler les niveaux de ddah et d'adma, ainsi que leurs méthodes d'utilisation pour traiter une maladie
IL278785B2 (en) 2018-05-22 2025-03-01 Ionis Pharmaceuticals Inc Modulators of apol1 expression
US11618746B2 (en) 2018-12-17 2023-04-04 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
US20220144838A1 (en) 2019-03-13 2022-05-12 Nanjing Immunophage Biotech Co., Ltd. Compounds as Inhibitors of Macrophage Migration Inhibitory Factor
TW202136219A (zh) 2019-12-19 2021-10-01 美商卡司馬療法公司 Trpml調節劑
WO2021154997A1 (fr) 2020-01-29 2021-08-05 Vertex Pharmaceuticals Incorporated Inhibiteurs d'apol1 et leurs méthodes d'utilisation
US20210246121A1 (en) * 2020-02-04 2021-08-12 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitor and methods of using same
IL296035A (en) 2020-03-06 2022-10-01 Vertex Pharma Methods of treating apol-1 dependent focal segmental glomerulosclerosis
IL296423A (en) 2020-04-22 2022-11-01 Anima Biotech Inc Collagen 1 translation inhibitors and methods of use thereof
WO2021220178A1 (fr) 2020-04-29 2021-11-04 Cominnex Zrt. Antagonistes d'iap et leurs applications thérapeutiques
JP2023524563A (ja) 2020-05-07 2023-06-12 ラムバム メド－テック リミテッド Ａｐｏｌ１－関連疾患の治療に使用するための組成物
CN115867543A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1抑制剂的固体形式及其使用方法
CA3185604A1 (fr) 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Inhibiteurs d'apol1 et leur utilisation
CN115867532A (zh) 2020-06-12 2023-03-28 弗特克斯药品有限公司 Apol1的抑制剂及其用途
CN116547287B (zh) 2020-08-26 2025-09-26 弗特克斯药品有限公司 Apol1的抑制剂及其使用方法
US20230119114A1 (en) 2021-08-26 2023-04-20 Vertex Pharmaceuticals Incorporated Solid forms of apol1 inhibitors and methods of using same
EP4440697A1 (fr) 2021-11-30 2024-10-09 Vertex Pharmaceuticals Incorporated Inhibiteurs spirocycliques d'apol1 et procédés d'utilisationde ceux-ci
US12612379B2 (en) 2021-11-30 2026-04-28 Vertex Pharmaceuticals Incorporated Inhibitors of APOL1 and methods of using same
EP4476228A1 (fr) 2022-02-08 2024-12-18 Vertex Pharmaceuticals Incorporated Dérivés de 4',5'-dihydrospiro[pipéridine-4,7'-thiéno[2,3-c]pyran] utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation
AU2023219516A1 (en) 2022-02-08 2024-08-22 Vertex Pharmaceuticals Incorporated 2-methyl-4-phenylpiperidin-4-ol derivatives as inhibitors of apol1 and methods of using same
CN119212986A (zh) 2022-02-08 2024-12-27 弗特克斯药品有限公司 作为apol1的抑制剂的螺哌啶衍生物及其使用方法
CA3251050A1 (fr) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Dérivés de 2-méthyl-4',5'-dihydrospiro[pipéridine-4,7'-thiéno[2,3-c]pyran] utilisés en tant qu'inhibiteurs de apol1 et leurs procédés d'utilisation

Also Published As

Publication number Publication date
UY38514A (es) 2020-07-31
KR102912203B1 (ko) 2026-01-16
AU2019405477A1 (en) 2021-06-24
IL283592A (en) 2021-07-29
KR20210116483A (ko) 2021-09-27
KR20260020195A (ko) 2026-02-10
JOP20210129A1 (ar) 2023-01-30
BR112021011564A2 (pt) 2021-08-31
JP2022515369A (ja) 2022-02-18
CN113453760A (zh) 2021-09-28
AR116913A1 (es) 2021-06-23
TW202039471A (zh) 2020-11-01
LT3897833T (lt) 2026-04-27
US20250042878A1 (en) 2025-02-06
CR20210383A (es) 2021-09-22
JP7573528B2 (ja) 2024-10-25
MX2021007152A (es) 2021-11-03
TWI848031B (zh) 2024-07-11
EP3897833B1 (fr) 2026-02-04
PE20212302A1 (es) 2021-12-10
DK3897833T3 (da) 2026-03-30
US11618746B2 (en) 2023-04-04
US20200377479A1 (en) 2020-12-03
IL283592B2 (en) 2025-08-01
JOP20210131A1 (ar) 2023-01-30
US20230271945A1 (en) 2023-08-31
AU2019405477B2 (en) 2025-04-03
FI3897833T3 (fi) 2026-04-07
CL2021001561A1 (es) 2021-11-26
UA128375C2 (uk) 2024-06-26
EP3897833A1 (fr) 2021-10-27
WO2020131807A1 (fr) 2020-06-25
CA3121910A1 (fr) 2020-06-25
DOP2021000116A (es) 2021-09-30
IL283592B1 (en) 2025-04-01
SG11202105769XA (en) 2021-07-29
SA521422270B1 (ar) 2024-02-18
US12060346B2 (en) 2024-08-13
IL319575A (en) 2025-05-01
ECSP21052184A (es) 2021-08-31
JOP20210130A1 (ar) 2023-01-30
CN113453760B (zh) 2024-05-24
CO2021009053A2 (es) 2021-08-09

Similar Documents

Publication Publication Date Title
MA54538A (fr) Inhibiteurs d'apol1 et leurs procédés d'utilisation
EP3911648A4 (fr) Inhibiteurs de pcsk9 et leurs procédés d'utilisation
EP3968999A4 (fr) Inhibiteurs de fgfr et leurs procédés d'utilisation
EP3911640A4 (fr) Inhibiteurs de pcsk9 et leurs procédés d'utilisation
MA55136A (fr) Inhibiteurs de kras g12c et leurs procédés d'utilisation
EP3946329A4 (fr) Agonistes bêta-adrénergique et leurs procédés d'utilisation
EP3962481A4 (fr) Inhibiteurs de kcnt1 et procédés d'utilisation
EP3962479A4 (fr) Inhibiteurs de kcnt1 et procédés d'utilisation
EP3510040A4 (fr) Inhibiteurs d'éctonucléotidase et leurs procédés d'utilisation
EP3790596A4 (fr) Compositions d'oligonucléotides et leurs procédés d'utilisation
EP3846808A4 (fr) Inhibiteurs de papd5 et leurs procédés d'utilisation
EP3775203A4 (fr) Compositions d'oligonucléotides et leurs procédés d'utilisation
MA51837A (fr) Inhibiteurs de l'arginase et leurs procédés d'utilisation
MA71645A (fr) Pyridazinones et leurs procédés d'utilisation
EP3810615A4 (fr) Inhibiteurs d'arginase et procédés d'utilisation
EP3893917A4 (fr) Compositions d'il-15 et leurs procédés d'utilisation
MA50912A (fr) Inhibiteurs d'acss2 et leurs procédés d'utilisation
EP3765006A4 (fr) Inhibiteurs d'arginase et procédés d'utilisation
MA52797A (fr) Inhibiteurs de masp -2 et procédés d'utilisation
MA55381A (fr) Pyridazinones et leurs procédés d'utilisation
EP4034605A4 (fr) Compositions de polissage et leurs procédés d'utilisation
EP3987030A4 (fr) Inhibiteurs de ppm1a et leurs procédés d'utilisation
EP3806834A4 (fr) Clamps dynamiques et leurs procédés d'utilisation
EP3947351A4 (fr) Inhibiteurs de parg à petites molécules et leurs procédés d'utilisation
EP3717504A4 (fr) Inhibiteurs de yeats et leurs procédés d'utilisation