MA71622A - Domaines de liaison à l'antigène cd98hc et leurs utilisations - Google Patents
Domaines de liaison à l'antigène cd98hc et leurs utilisationsInfo
- Publication number
- MA71622A MA71622A MA71622A MA71622A MA71622A MA 71622 A MA71622 A MA 71622A MA 71622 A MA71622 A MA 71622A MA 71622 A MA71622 A MA 71622A MA 71622 A MA71622 A MA 71622A
- Authority
- MA
- Morocco
- Prior art keywords
- cd98hc
- antigen
- binding domains
- domains
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263369885P | 2022-07-29 | 2022-07-29 | |
| US202363489675P | 2023-03-10 | 2023-03-10 | |
| US202363495514P | 2023-04-11 | 2023-04-11 | |
| EP23758167.3A EP4561614A1 (fr) | 2022-07-29 | 2023-07-28 | Domaines de liaison à l'antigène cd98hc et leurs utilisations |
| PCT/US2023/071238 WO2024026471A1 (fr) | 2022-07-29 | 2023-07-28 | Domaines de liaison à l'antigène cd98hc et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA71622A true MA71622A (fr) | 2025-05-30 |
Family
ID=87760570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA71622A MA71622A (fr) | 2022-07-29 | 2023-07-28 | Domaines de liaison à l'antigène cd98hc et leurs utilisations |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250270341A1 (fr) |
| EP (1) | EP4561614A1 (fr) |
| JP (1) | JP2025528751A (fr) |
| CN (1) | CN119584983A (fr) |
| AU (1) | AU2023316021A1 (fr) |
| CA (1) | CA3261511A1 (fr) |
| MA (1) | MA71622A (fr) |
| MX (1) | MX2025000569A (fr) |
| WO (1) | WO2024026471A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025166045A1 (fr) | 2024-01-31 | 2025-08-07 | Alector Llc | ENZYMES DE β-GLUCOCÉRÉBROSIDASE, PROTÉINES DE FUSION ET COMPLEXES LES COMPRENANT, ET LEURS PROCÉDÉS D'UTILISATION |
| WO2025166040A1 (fr) | 2024-01-31 | 2025-08-07 | Alector Llc | Protéines de liaison multi-spécifiques qui se lient à gpnmb et à une cible de barrière hémato-encéphalique et procédés pour les utiliser |
| WO2025166042A1 (fr) * | 2024-01-31 | 2025-08-07 | Alector Llc | Domaines de liaison à l'antigène cd98hc et leurs utilisations |
| WO2025247301A1 (fr) * | 2024-05-30 | 2025-12-04 | Sironax Switzerland Gmbh | Nouveaux anticorps spécifiques d'une chaîne lourde cd98 et leurs procédés d'utilisation |
| CN120842376A (zh) * | 2025-07-28 | 2025-10-28 | 郑州伊美诺生物技术有限公司 | 广谱特异性抗体及其应用 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| DE3668186D1 (de) | 1985-04-01 | 1990-02-15 | Celltech Ltd | Transformierte myeloma-zell-linie und dieselbe verwendendes verfahren zur expression eines gens, das ein eukaryontisches polypeptid kodiert. |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| ES2052027T5 (es) | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2113940T3 (es) | 1990-12-03 | 1998-05-16 | Genentech Inc | Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas. |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| ATE255131T1 (de) | 1991-06-14 | 2003-12-15 | Genentech Inc | Humanisierter heregulin antikörper |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| JP4157160B2 (ja) | 1991-12-13 | 2008-09-24 | ゾーマ テクノロジー リミテッド | 改変抗体可変領域の調製のための方法 |
| US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
| WO1993016185A2 (fr) | 1992-02-06 | 1993-08-19 | Creative Biomolecules, Inc. | Proteine de liaison biosynthetique pour marqueur de cancer |
| US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| DK0979281T3 (da) | 1997-05-02 | 2005-11-21 | Genentech Inc | Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
| ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| IL155977A0 (en) | 2000-11-30 | 2003-12-23 | Medarex Inc | Transgenic transchromosomal rodents for making human antibodies |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| CA2561686C (fr) | 2004-03-31 | 2014-12-02 | Genentech, Inc. | Anticorps anti-tgf-beta humanises |
| CA2577082A1 (fr) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Molecules heteromultimeriques |
| CA2651567A1 (fr) | 2006-05-09 | 2007-11-22 | Genentech, Inc. | Polypeptides de liaison a squelettes optimises |
| CN100592373C (zh) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | 液晶显示面板驱动装置及其驱动方法 |
| EP3663318A1 (fr) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Procédé de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique |
| EP2569337A1 (fr) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Protéines hétérodimériques et leurs procédés de production et de purification |
| SG189174A1 (en) | 2010-10-11 | 2013-05-31 | Biogen Idec Internat Neuroscience Gmbh | Human anti-tau antibodies |
| PL2635607T3 (pl) | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC |
| WO2014067011A1 (fr) | 2012-11-02 | 2014-05-08 | Zymeworks Inc. | Structures cristallines de domaines fc hétérodimères |
| HK1215950A1 (zh) | 2012-09-25 | 2016-09-30 | 艾科诺斯科技股份有限公司 | 异源二聚免疫球蛋白的纯化 |
| EP3878964A1 (fr) | 2012-11-27 | 2021-09-15 | Ajou University Industry-Academic Cooperation Foundation | Paire de variants du domaine ch3 induisant la formation d'hétérodimère de région constante de chaîne lourde d'anticorps à haute efficacité, procédé de préparation associé et utilisation associée |
| US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
| EA038367B1 (ru) | 2013-05-20 | 2021-08-16 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ РЕЦЕПТОРА ТРАНСФЕРРИНА (TfR) И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ |
| TWI599358B (zh) | 2014-09-16 | 2017-09-21 | 美國禮來大藥廠 | 組合療法 |
| JP6904902B2 (ja) | 2014-12-05 | 2021-07-21 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | ドメイン交換抗体 |
| CA2966365A1 (fr) * | 2014-12-10 | 2016-06-16 | Genentech, Inc. | Anticorps diriges contre les recepteurs de la barriere hematoencephalique et procedes d'utilisation associes |
| WO2018027025A1 (fr) | 2016-08-03 | 2018-02-08 | Oncomed Pharmaceuticals, Inc. | Agent liant cd40 et utilisations associées |
| MA46836A (fr) | 2016-11-15 | 2019-09-25 | H Lundbeck As | Agents, utilisations et procédés pour le traitement d'une synucléinopathie |
| US12258414B2 (en) | 2018-06-22 | 2025-03-25 | Ossianix, Inc. | Anti-CD98hc VNARs for crossing the blood brain barrier and type IV VNAR libraries |
| CN115698074A (zh) * | 2020-04-08 | 2023-02-03 | 阿里亚达治疗公司 | 抗-cd98抗体和其用途 |
-
2023
- 2023-07-28 JP JP2025504645A patent/JP2025528751A/ja active Pending
- 2023-07-28 WO PCT/US2023/071238 patent/WO2024026471A1/fr not_active Ceased
- 2023-07-28 CA CA3261511A patent/CA3261511A1/fr active Pending
- 2023-07-28 CN CN202380054112.2A patent/CN119584983A/zh active Pending
- 2023-07-28 AU AU2023316021A patent/AU2023316021A1/en active Pending
- 2023-07-28 EP EP23758167.3A patent/EP4561614A1/fr active Pending
- 2023-07-28 MA MA71622A patent/MA71622A/fr unknown
-
2025
- 2025-01-14 MX MX2025000569A patent/MX2025000569A/es unknown
- 2025-01-28 US US19/039,230 patent/US20250270341A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3261511A1 (fr) | 2024-02-01 |
| WO2024026471A9 (fr) | 2024-11-07 |
| WO2024026471A1 (fr) | 2024-02-01 |
| CN119584983A (zh) | 2025-03-07 |
| US20250270341A1 (en) | 2025-08-28 |
| AU2023316021A1 (en) | 2025-03-06 |
| MX2025000569A (es) | 2025-02-10 |
| EP4561614A1 (fr) | 2025-06-04 |
| JP2025528751A (ja) | 2025-09-02 |
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