MC1528A1 - Imidazobenzodiazepines - Google Patents

Imidazobenzodiazepines

Info

Publication number: MC1528A1
Authority: MC; Monaco
Prior art keywords: benzodiazepine; oxo; carboxylate; imidazo; millimoles
Prior art date: 1982-07-21

Application number

MC@@@@1648A

Other languages

English (en)

French (fr)

Inventor

Walter Hunkeler

Emilio Kyburz

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-07-21

Filing date

1983-06-19

Publication date

1984-04-13

1983-06-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1984-04-13 Publication of MC1528A1 publication Critical patent/MC1528A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pyrrole Compounds (AREA)

MC@@@@1648A 1982-07-21 1983-06-19 Imidazobenzodiazepines MC1528A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH446082		1982-07-21

Publications (1)

Publication Number	Publication Date
MC1528A1 true MC1528A1 (fr)	1984-04-13

Family

ID=4276529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MC@@@@1648A MC1528A1 (fr)	1982-07-21	1983-06-19	Imidazobenzodiazepines

Country Status (25)

Country	Link
US (1)	US4489003A (cs)
EP (1)	EP0100906B1 (cs)
JP (1)	JPS5933286A (cs)
KR (1)	KR840005836A (cs)
AT (1)	ATE27160T1 (cs)
AU (1)	AU560286B2 (cs)
BR (1)	BR8303898A (cs)
CA (1)	CA1202969A (cs)
CS (1)	CS246063B2 (cs)
CU (1)	CU21554A3 (cs)
DE (1)	DE3371516D1 (cs)
DK (1)	DK335083A (cs)
ES (4)	ES8500945A1 (cs)
FI (1)	FI832654A7 (cs)
GR (1)	GR79322B (cs)
HU (1)	HU189719B (cs)
IE (1)	IE56121B1 (cs)
IL (1)	IL69242A (cs)
MC (1)	MC1528A1 (cs)
NO (1)	NO832633L (cs)
NZ (1)	NZ204912A (cs)
PH (1)	PH18980A (cs)
PT (1)	PT77063B (cs)
ZA (1)	ZA835147B (cs)
ZW (1)	ZW14383A1 (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0150040B1 (de) *	1984-01-19	1994-08-31	F. Hoffmann-La Roche Ag	Imidazodiazepin-Derivate
CA1259612A (en) *	1985-02-28	1989-09-19	Emilio Kyburz	Imidazodiazepine derivatives
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
GB8720414D0 (en) *	1987-08-28	1987-10-07	Roussel Lab Ltd	Chemical compounds
CA2015336A1 (en) *	1989-05-19	1990-11-19	F. Hoffmann-La Roche Ag	Imidazodiazepines for the treatment of neurological symptoms
IE910939A1 (en) *	1990-04-13	1991-10-23	Neurosearch As	Use of benzodiazepine compounds
GB9911152D0 (en) *	1999-05-14	1999-07-14	Glaxo Group Ltd	Short-acting benzodiazepines
US7160880B1 (en)	1999-05-14	2007-01-09	Cenes Limited	Short-acting benzodiazepines
EP1888594A2 (en) *	2005-05-16	2008-02-20	Wisys Technology Foundation, Inc.	Gabaergic agents to treat memory deficits
KR20150081370A (ko)	2006-07-10	2015-07-13	파이온 유케이 리미티드	속효형 벤조디아제핀 염 및 이의 중합체 형태
US20100234359A1 (en) *	2007-08-20	2010-09-16	Evotec Neurosciences Gmbh	Treatment of sleep disorders
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
EP2450039A1 (en)	2010-11-08	2012-05-09	PAION UK Ltd.	Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es)	2013-03-04	2015-09-09	Ono Pharmaceutical Co	Reacción de oxidación excelente en el índice de conversión
EP4069369A4 (en) *	2019-12-06	2024-02-14	Schrödinger, Inc.	CYCLIC COMPOUNDS AND METHODS OF USE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1143728A (en) *	1979-10-04	1983-03-29	Max Gerecke	Imidazodiazepine derivatives
CA1173441A (en) *	1981-02-27	1984-08-28	Hoffmann-La Roche Limited	Imidazodiazepines
CA1185602A (en) *	1981-02-27	1985-04-16	Emilio Kyburz	Imidazodiazepines
CA1184175A (en) *	1981-02-27	1985-03-19	Walter Hunkeler	Imidazodiazepines
US4352817A (en) *	1981-02-27	1982-10-05	Hoffmann-La Roche Inc.	Imidazo-diazepines and their use

1983
- 1983-06-19 MC MC@@@@1648A patent/MC1528A1/fr unknown
- 1983-06-24 CA CA000431129A patent/CA1202969A/en not_active Expired
- 1983-06-24 ZW ZW143/83A patent/ZW14383A1/xx unknown
- 1983-07-14 EP EP83106920A patent/EP0100906B1/de not_active Expired
- 1983-07-14 AT AT83106920T patent/ATE27160T1/de not_active IP Right Cessation
- 1983-07-14 US US06/513,571 patent/US4489003A/en not_active Expired - Fee Related
- 1983-07-14 DE DE8383106920T patent/DE3371516D1/de not_active Expired
- 1983-07-14 ZA ZA835147A patent/ZA835147B/xx unknown
- 1983-07-15 IL IL69242A patent/IL69242A/xx unknown
- 1983-07-15 AU AU16888/83A patent/AU560286B2/en not_active Ceased
- 1983-07-15 NZ NZ204912A patent/NZ204912A/en unknown
- 1983-07-18 HU HU832533A patent/HU189719B/hu unknown
- 1983-07-19 KR KR1019830003325A patent/KR840005836A/ko not_active Withdrawn
- 1983-07-19 CS CS835419A patent/CS246063B2/cs unknown
- 1983-07-19 NO NO832633A patent/NO832633L/no unknown
- 1983-07-19 GR GR71965A patent/GR79322B/el unknown
- 1983-07-20 PT PT77063A patent/PT77063B/pt unknown
- 1983-07-20 DK DK335083A patent/DK335083A/da not_active Application Discontinuation
- 1983-07-20 ES ES524280A patent/ES8500945A1/es not_active Expired
- 1983-07-20 JP JP58131150A patent/JPS5933286A/ja active Pending
- 1983-07-20 BR BR8303898A patent/BR8303898A/pt unknown
- 1983-07-20 PH PH29251A patent/PH18980A/en unknown
- 1983-07-20 IE IE1696/83A patent/IE56121B1/xx unknown
- 1983-07-21 CU CU8335935A patent/CU21554A3/es unknown
- 1983-07-21 FI FI832654A patent/FI832654A7/fi not_active Application Discontinuation
1984
- 1984-03-16 ES ES530672A patent/ES8505180A1/es not_active Expired
- 1984-03-16 ES ES530671A patent/ES8505179A1/es not_active Expired
- 1984-03-16 ES ES530673A patent/ES530673A0/es active Granted

Also Published As

Publication number	Publication date
EP0100906B1 (de)	1987-05-13
ES530671A0 (es)	1985-05-16
IE831696L (en)	1984-01-21
ES524280A0 (es)	1984-11-16
CS246063B2 (en)	1986-10-16
GR79322B (cs)	1984-10-22
IE56121B1 (en)	1991-04-24
ES530672A0 (es)	1985-05-16
AU1688883A (en)	1984-01-26
PT77063A (en)	1983-08-01
IL69242A (en)	1986-09-30
ES8504805A1 (es)	1985-05-01
US4489003A (en)	1984-12-18
ATE27160T1 (de)	1987-05-15
ES8505179A1 (es)	1985-05-16
KR840005836A (ko)	1984-11-19
DK335083D0 (da)	1983-07-20
PT77063B (en)	1986-07-15
ES8500945A1 (es)	1984-11-16
ES530673A0 (es)	1985-05-01
CU21554A3 (en)	1987-06-09
NZ204912A (en)	1986-10-08
EP0100906A2 (de)	1984-02-22
FI832654A7 (fi)	1984-01-22
CA1202969A (en)	1986-04-08
ES8505180A1 (es)	1985-05-16
IL69242A0 (en)	1983-11-30
DK335083A (da)	1984-01-22
AU560286B2 (en)	1987-04-02
EP0100906A3 (en)	1984-08-22
DE3371516D1 (de)	1987-06-19
NO832633L (no)	1984-01-23
CS541983A2 (en)	1985-12-16
BR8303898A (pt)	1984-04-10
JPS5933286A (ja)	1984-02-23
FI832654A0 (fi)	1983-07-21
ZW14383A1 (en)	1985-01-23
ZA835147B (en)	1984-03-28
PH18980A (en)	1985-11-29
HU189719B (en)	1986-07-28

Similar Documents

Publication	Publication Date	Title
MC1442A1 (fr)	1982-12-06	Imidazodiazepines
EP1680421B1 (fr)	2008-02-13	Composes tricycliques comme inhibiteurs de transport de glycine
MC1355A1 (fr)	1981-08-10	Derives d'imidazodiazepine
EP0340064B1 (fr)	1993-03-17	Benzodiazépines, leur procédé et intermédiaires de préparation et leurs applications en thérapeutique
EP0708778B1 (fr)	1997-02-05	Derives d'imidazo [1,2-a]pyrazine-4-one/utiles comme antagonistes des recepteurs ampa et nmda
EP0934319B1 (fr)	2002-06-05	DERIVES DE 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
EP0253711B1 (fr)	1990-05-23	Nouveaux dérivés du 1H,3H-Pyrrolo [1,2-c] thiazole, leur préparation et les Compositions pharmaceutiques qui les contiennent
FR2665441A1 (fr)	1992-02-07	Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
EP0708774A1 (fr)	1996-05-01	DERIVES D'IMIDAZO [1,2-a]PYRAZIN-4-ONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT
EP0100906B1 (de)	1987-05-13	Tri- und tetracyclische Imidazo(1,5-a)(1,4)Benzodiazepin-1-carbonsäurederivate
EP0662971B1 (fr)	1998-05-13	DERIVES DE 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT
BE898383A (fr)	1984-06-06	Pyrazoloquinoleines substituees particulieres, procede pour leur preparation, preparations pharmaceutiques contenant ces composes et leur application therapeutique.
EP0682025A1 (fr)	1995-11-15	Dérivés de 5,6-dihydro-4H-imidazo 2',1':2,3 imidazo- 4,5,1-ij quinoléine et de 4,5-dihydroimidazo 1,2-a pyrrolo- 1,2,3-cd benzimidazole, leur préparation et leur application et thérapeutique
EP0607076A1 (fr)	1994-07-20	Dérivés de 9h-imidazo 1,2-a benzimidazole-3-acétamide à activité GABA
BE1004596A4 (fr)	1992-12-22	Derives de methylpiperazinoazepine, leur preparation et leur utilisation.
MC1918A1 (fr)	1989-04-06	Derives de l'imidazodiazepine
EP0772615A1 (fr)	1997-05-14	DERIVES D'ACIDE IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-2-CARBOXYLIQUE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT
EP0499527B1 (fr)	1997-05-02	Composés dérivés des beta-carbolines ligands du récepteur des benzodiazépines ayant un effet agoniste inverse et antagoniste vis-à-vis des benzodiazépines et médicaments les contenant
EP0335758A2 (fr)	1989-10-04	Dérivés de la 1-arylsulfonyl 2-pyrrolidinone, leur procédé de préparation, leur application comme médicaments et les compositions les renfermant
EP0233800A1 (fr)	1987-08-26	Dérivés d'imidazo[1,2-a]quinoléines, leur préparation et leur application en thérapeutique
BE839365R (fr)	1976-09-09	Derives de diazepine
FR2722501A1 (fr)	1996-01-19	Derives de 9h-imidazo(1,2-a)benzimidazole-3-acetamide, leur preparation et leur application en therapeutique
MC1730A1 (fr)	1986-12-15	Derives de l'imidazodiazepine
MC2052A1 (fr)	1990-07-17	Derives de l'imidazodiazepine
FR2699921A1 (fr)	1994-07-01	Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.

Legal Events

Date	Code	Title	Description
1986-06-05	YP	Annual fee paid