MD20140023A2 - Derivaţi de pirolpirimidină şi purină - Google Patents

Derivaţi de pirolpirimidină şi purină Download PDF

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Publication number
MD20140023A2
MD20140023A2 MD20140023A MD20140023A MD20140023A2 MD 20140023 A2 MD20140023 A2 MD 20140023A2 MD 20140023 A MD20140023 A MD 20140023A MD 20140023 A MD20140023 A MD 20140023A MD 20140023 A2 MD20140023 A2 MD 20140023A2
Authority
MD
Moldova
Prior art keywords
compounds
pyrrolopyrimidine
purine derivatives
mammals
treatment
Prior art date
Application number
MD20140023A
Other languages
English (en)
Russian (ru)
Inventor
Хэнмяо ШЭН
ДЖР. Теодор Отто ДЖОНСОН
Джон Чарльз Кат
Кевин Кунь-Чинь ЛЮ
Элизабет Энн ЛУННЕЙ
Асако Нагата
Саджив Кришна НАИР
Саймон Пол Планкен
Скотт Чаннинг Саттон
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47116127&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20140023(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20140023A2 publication Critical patent/MD20140023A2/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Prezenta invenţie se referă la compuşi cu formula (I)sau la săruri farmaceutic acceptabile ale acestora, în care Q, T, V, W, X, Y, Z, inelul A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 şi m sunt definite în descriere. Derivaţii noi de pirolpirimidină şi purină, conform invenţiei, sunt utili în tratamentul creşterii celulare anormale, cum ar fi cancerul, la mamifere. Variantele adiţionale de realizare se referă la compoziţii farmaceutice cu conţinut de aceşti compuşi, şi la metode de utilizare a compuşilor şi compoziţiilor în tratamentul creşterii celulare anormale la mamifere.
MD20140023A 2011-09-22 2012-09-10 Derivaţi de pirolpirimidină şi purină MD20140023A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161538103P 2011-09-22 2011-09-22
US201261639639P 2012-04-27 2012-04-27
PCT/IB2012/054702 WO2013042006A1 (en) 2011-09-22 2012-09-10 Pyrrolopyrimidine and purine derivatives

Publications (1)

Publication Number Publication Date
MD20140023A2 true MD20140023A2 (ro) 2014-06-30

Family

ID=47116127

Family Applications (1)

Application Number Title Priority Date Filing Date
MD20140023A MD20140023A2 (ro) 2011-09-22 2012-09-10 Derivaţi de pirolpirimidină şi purină

Country Status (29)

Country Link
US (2) US9040547B2 (ro)
EP (1) EP2758402B9 (ro)
JP (1) JP5914667B2 (ro)
KR (1) KR20140059246A (ro)
CN (1) CN103814030A (ro)
AP (1) AP2014007475A0 (ro)
AR (1) AR088760A1 (ro)
AU (1) AU2012311184A1 (ro)
BR (1) BR112014006840A2 (ro)
CA (1) CA2847540C (ro)
CL (2) CL2014002726A1 (ro)
CO (1) CO6910196A2 (ro)
CR (1) CR20140132A (ro)
DO (1) DOP2014000055A (ro)
EA (1) EA201490673A1 (ro)
ES (1) ES2575710T3 (ro)
IL (1) IL231592A0 (ro)
MA (1) MA35451B1 (ro)
MD (1) MD20140023A2 (ro)
MX (1) MX2014003501A (ro)
NI (1) NI201400023A (ro)
PE (1) PE20141228A1 (ro)
PH (1) PH12014500638A1 (ro)
SG (1) SG2014014450A (ro)
TN (1) TN2014000115A1 (ro)
TW (1) TWI492946B (ro)
UA (1) UA110259C2 (ro)
UY (1) UY34342A (ro)
WO (1) WO2013042006A1 (ro)

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