MD2861F1 -   (µ-Imidazol-N, N?) - bis {4-bromo-2- [2- (oxyethylimino) -methyl] -phenolate (2 -) - copper}, which exhibits antifungal activity - Google Patents

  (µ-Imidazol-N, N?) - bis {4-bromo-2- [2- (oxyethylimino) -methyl] -phenolate (2 -) - copper}, which exhibits antifungal activity Download PDF

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Publication number
MD2861F1
MD2861F1 MDA20040233A MD20040233A MD2861F1 MD 2861 F1 MD2861 F1 MD 2861F1 MD A20040233 A MDA20040233 A MD A20040233A MD 20040233 A MD20040233 A MD 20040233A MD 2861 F1 MD2861 F1 MD 2861F1
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MD
Moldova
Prior art keywords
copper
oxyethylimino
bromo
bis
methyl
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MDA20040233A
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Romanian (ro)
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MD2861G2 (en
Inventor
Victor Tapcov
Iurie Ciumacov
Valeriu Crudu
Nina Samusi
Aurelian Gulea
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Universitatea De Stat Din Moldova
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Priority to MDA20040233A priority Critical patent/MD2861G2/en
Publication of MD2861F1 publication Critical patent/MD2861F1/en
Publication of MD2861G2 publication Critical patent/MD2861G2/en

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Abstract

Inventia se refera la chimia compusilor coordinativi ai metalelor de tranzitie, complecsilor binucleari ai cuprului din clasa salicilideniminoalcoolatilor cu ligand punte de imidazol si anume la (m-imidazol-N,N?)-bis{4-bromo-2-[2-(oxietilimino)-metil]-fenolato(2-)-cupru}, care poate gasi aplicare in medicina sau in medicina veterinara. Esenta inventiei consta in sinteza (m-imidazol-N,N?)-bis{4-bromo-2-[2-(oxietilimino)-metil]-fenolato(2-)-cupru} cu formula : care manifesta activitate antimicotica. Rezultatul inventiei consta in obtinerea unui compus coordinativ nou, care manifesta activitate antimicotica fata de fungii miceliari si levurici, ce depaseste de 1,2...1,5 ori activitatea analogului.The invention relates to the chemistry of the transition metal coordinating compounds, the binuclear copper complexes of the salicylideniminoalcohol class of imidazole bridging ligands, namely (m-imidazole-N, N?) - bis {4-bromo-2- [2- ( oxyethylimino) -methyl] -phenolate (2 -) - copper}, which can be applied in medicine or veterinary medicine. The essence of the invention consists in the synthesis (m-imidazole-N, N?) - bis {4-bromo-2- [2- (oxyethylimino) -methyl] -phenolato (2 -) - copper} of the formula: which exhibits antimycotic activity. The result of the invention consists in obtaining a new coordinating compound, which manifests antifungal activity against mycelial and yeast fungi, which exceeds 1.2 ... 1.5 times the activity of the analog.

MDA20040233A 2004-09-20 2004-09-20 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity MD2861G2 (en)

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MDA20040233A MD2861G2 (en) 2004-09-20 2004-09-20 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity

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MDA20040233A MD2861G2 (en) 2004-09-20 2004-09-20 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity

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MD2861F1 true MD2861F1 (en) 2005-09-30
MD2861G2 MD2861G2 (en) 2006-04-30

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MDA20040233A MD2861G2 (en) 2004-09-20 2004-09-20 (µ-Imidazole-N,N')-bis{4-bromo-2-[2-(oxyethylimino)-methyl]-phenolato(2-)-copper}, manifesting antimycotic activity

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Cited By (12)

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US8575382B2 (en) 2009-07-13 2013-11-05 “Ivy Pharm” LLC Low molecular weight pharmacological activity modulators
MD4254C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Hexafluorotitanate-bis[(dimethylglyoximato)-di-(thiocarbamide)cobalt(III)] dihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4253C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Sulphato-bis(nicotinoylhydrazone)-2,6-diacetylpyridin-cobalt(II )monomethanol trihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4255C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Tetraisothiocyanatocobaltate of bis(nicotinoylhydrazone)-2,6-diformil-4-methylphenol(methanol)(aqua)cobalt(II) and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4258C1 (en) * 2012-05-31 2014-06-30 Государственный Университет Молд0 The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans
MD4303C1 (en) * 2013-07-05 2015-04-30 Институт Химии Академии Наук Молдовы Bis(dimethylglyoximato)chloro(isonicotinoylhydrazone-2-hydroxy-1-naphthaldehyde)cobalt(III) and process for cultivation of Porphyridium cruentum microalga with the use thereof
MD4326C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4327C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4356C1 (en) * 2014-07-09 2016-02-29 Институт Химии Академии Наук Молдовы Bis[N'-(2-hydroxy-kO-benzylidene)pyridine-4-carbohydrazidate(-1)-k2N',O]iron(III) nitrate - water (2/3) and process for cultivation of microalga Porphyridium cruentum with its use
MD4365C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[1-phenyl-3-methyl-6-(pyridinium-4-yl)-4,5-diaza-hexa-1,3,5-triene-1,6-diolato-O1,N4,O6]iron(III) nitrate and process for cultivation of microalga Porphyridium cruentum with its use
MD4367C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[N'-(2-hydroxy-kO-3-carboxybenzilidene)pyridine-3-carbohydrazidate(-1)-k2N',O]iron(III) perchlorate - water (4/5) and process for cultivation of microalga Porphyridium cruentum with its use
MD4366C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[1-phenyl-3-methyl-6-(pyridinium-4-il)-4,5-diaza-hexa-1,3,5-triene-1-hydroxy-6-olato-O1,N4,O6]iron(II)sulphate tetrahydrate and process for cultivation of microalga Porphyridium cruentum with its use

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* Cited by examiner, † Cited by third party
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MD3484G2 (en) * 2007-02-12 2008-08-31 Государственный Университет Молд0 Di-{µ-[N-(2-hydroxyethyl)-(5-chlorosalicylideneiminato)(-1))]-(O,N,O,Cl)}-bis-(nitrato-imidazolecopper) manifesting antimycotic activity
MD4194C1 (en) * 2012-01-23 2013-08-31 Государственный Университет Молд0 Trinuclear coordinative compound tris{µ-[3,5-dibromo-2-hydroxybenzylidene-4′-(pyridin-2-yl)-thiosemicarbazido(2-)]copper}hydrate, exhibiting antifungal activity against Candida albicans

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD2454G2 (en) * 2003-02-04 2004-11-30 Государственный Университет Молд0 Nitrate of catene-µ-{2-hydroxymethyl-2-[(2-hydroxy-5-nitrobenzylidene)amino]-propan-1,3-diolo}aquacopper(II)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8575382B2 (en) 2009-07-13 2013-11-05 “Ivy Pharm” LLC Low molecular weight pharmacological activity modulators
MD4258C1 (en) * 2012-05-31 2014-06-30 Государственный Университет Молд0 The use of biologically active coordinative compounds of copper(II) with 4-(methoxyphenyl)thiosemicarbazones of 2-benzoylpyridine as inhibitors of Candida albicans
MD4254C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Hexafluorotitanate-bis[(dimethylglyoximato)-di-(thiocarbamide)cobalt(III)] dihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4253C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Sulphato-bis(nicotinoylhydrazone)-2,6-diacetylpyridin-cobalt(II )monomethanol trihydrate and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4255C1 (en) * 2012-11-05 2014-05-31 Институт Микробиологии И Биотехнологии Академии Наук Молдовы Tetraisothiocyanatocobaltate of bis(nicotinoylhydrazone)-2,6-diformil-4-methylphenol(methanol)(aqua)cobalt(II) and process for cultivation of microalga Porphyridium cruentum with the use thereof
MD4303C1 (en) * 2013-07-05 2015-04-30 Институт Химии Академии Наук Молдовы Bis(dimethylglyoximato)chloro(isonicotinoylhydrazone-2-hydroxy-1-naphthaldehyde)cobalt(III) and process for cultivation of Porphyridium cruentum microalga with the use thereof
MD4326C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoylamino)carbazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4327C1 (en) * 2013-10-22 2015-09-30 Институт Химии Академии Наук Молдовы N-(D8,13-Bicyclohomofarnesenoyl)-3-amino-1,2,4-triazole compound and process for cultivation of Nostoc linckia cyanobacterium with its use
MD4356C1 (en) * 2014-07-09 2016-02-29 Институт Химии Академии Наук Молдовы Bis[N'-(2-hydroxy-kO-benzylidene)pyridine-4-carbohydrazidate(-1)-k2N',O]iron(III) nitrate - water (2/3) and process for cultivation of microalga Porphyridium cruentum with its use
MD4365C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[1-phenyl-3-methyl-6-(pyridinium-4-yl)-4,5-diaza-hexa-1,3,5-triene-1,6-diolato-O1,N4,O6]iron(III) nitrate and process for cultivation of microalga Porphyridium cruentum with its use
MD4367C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[N'-(2-hydroxy-kO-3-carboxybenzilidene)pyridine-3-carbohydrazidate(-1)-k2N',O]iron(III) perchlorate - water (4/5) and process for cultivation of microalga Porphyridium cruentum with its use
MD4366C1 (en) * 2014-07-09 2016-03-31 Институт Химии Академии Наук Молдовы Bis[1-phenyl-3-methyl-6-(pyridinium-4-il)-4,5-diaza-hexa-1,3,5-triene-1-hydroxy-6-olato-O1,N4,O6]iron(II)sulphate tetrahydrate and process for cultivation of microalga Porphyridium cruentum with its use

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