MD4748B1 - Terapii imunooncolitice - Google Patents
Terapii imunooncolitice Download PDFInfo
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- MD4748B1 MD4748B1 MDA20180086A MD20180086A MD4748B1 MD 4748 B1 MD4748 B1 MD 4748B1 MD A20180086 A MDA20180086 A MD A20180086A MD 20180086 A MD20180086 A MD 20180086A MD 4748 B1 MD4748 B1 MD 4748B1
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24171—Demonstrated in vivo effect
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract
Invenţia se referă la virusuri oncolitice de vaccin variolic, modificate pentru a stimula imunitatea antitumorală şi/sau a diminua imunitatea gazdei şi/sau răspunsul anticorpilor gazdei împotriva virusului. Invenţia se bazează, cel puţin parţial, pe descoperirea că virusul oncolitic de vaccin variolic (i) purtând o deleţie genomică a genei, care reduce imunitatea celulelor T (proteina de legare a interleukinei-18); (ii) tratat cu enzima sialidază, care se crede că reduce activarea TLR2 şi, astfel, răspunsul anticorpilor; (iii) care poartă gena care amplifică inducerea limfocitelor T citotoxice (de exemplu TRIF) şi/sau (iv) care reduce numărul de celule supresoare de origine mieloidă în tumoare prin reducerea cantităţii de prostaglandină E2, reduce creşterea tumorii. Astfel, prezenta invenţie se referă la virusuri imunooncolitice de vaccin variolic şi la metode de utilizare a acestora în tratamentul tumorilor maligne.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361868978P | 2013-08-22 | 2013-08-22 | |
| PCT/US2014/052308 WO2015027163A1 (en) | 2013-08-22 | 2014-08-22 | Immuno-oncolytic therapies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20180086A2 MD20180086A2 (ro) | 2019-03-31 |
| MD4748B1 true MD4748B1 (ro) | 2021-02-28 |
| MD4748C1 MD4748C1 (ro) | 2021-09-30 |
Family
ID=52484194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD20160027A MD4624C1 (ro) | 2013-08-22 | 2014-08-22 | Virusuri oncolitice de vaccin variolic şi terapii imunooncolitice |
| MDA20180086A MD4748C1 (ro) | 2013-08-22 | 2014-08-22 | Terapii imunooncolitice |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD20160027A MD4624C1 (ro) | 2013-08-22 | 2014-08-22 | Virusuri oncolitice de vaccin variolic şi terapii imunooncolitice |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US11478518B2 (ro) |
| EP (3) | EP4324918A3 (ro) |
| JP (3) | JP6912199B2 (ro) |
| KR (1) | KR102389240B1 (ro) |
| CN (1) | CN105658795B (ro) |
| AU (1) | AU2014308648B2 (ro) |
| CA (3) | CA3213683A1 (ro) |
| CY (1) | CY1126587T1 (ro) |
| DK (2) | DK3778897T3 (ro) |
| EA (1) | EA037582B1 (ro) |
| ES (2) | ES2847305T3 (ro) |
| FI (1) | FI3778897T3 (ro) |
| HR (1) | HRP20240078T1 (ro) |
| HU (1) | HUE066593T2 (ro) |
| IL (1) | IL243996A0 (ro) |
| LT (1) | LT3778897T (ro) |
| MD (2) | MD4624C1 (ro) |
| MX (1) | MX2016002257A (ro) |
| NZ (1) | NZ716825A (ro) |
| PE (1) | PE20160673A1 (ro) |
| PH (1) | PH12016500329A1 (ro) |
| PL (1) | PL3778897T3 (ro) |
| PT (1) | PT3778897T (ro) |
| RS (1) | RS65104B1 (ro) |
| SG (1) | SG11201600960PA (ro) |
| SI (1) | SI3778897T1 (ro) |
| SM (1) | SMT202400047T1 (ro) |
| WO (1) | WO2015027163A1 (ro) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RS65104B1 (sr) * | 2013-08-22 | 2024-02-29 | Univ Pittsburgh Commonwealth Sys Higher Education | Onkolitičke imunoterapije |
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| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| WO2017014296A1 (ja) * | 2015-07-22 | 2017-01-26 | 国立大学法人鳥取大学 | ワクシニアウイルスの増殖・伝搬を増強する宿主制御因子 |
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| CA3070146A1 (en) * | 2016-07-19 | 2018-01-25 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Oncolytic viruses targeting stat3 |
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| GB201616365D0 (en) * | 2016-09-27 | 2016-11-09 | Helsingin Yliopisto | Non-genetic modification of enveloped viruses |
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| ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
| WO2011119925A2 (en) * | 2010-03-25 | 2011-09-29 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthetic herpes simplex viruses for treatment of cancers |
| ES2733211T3 (es) * | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| US20150250837A1 (en) * | 2012-09-20 | 2015-09-10 | Morningside Technology Ventures Ltd. | Oncolytic virus encoding pd-1 binding agents and uses of the same |
| RS65104B1 (sr) | 2013-08-22 | 2024-02-29 | Univ Pittsburgh Commonwealth Sys Higher Education | Onkolitičke imunoterapije |
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