MD749F1 - Process for synthesis of cyanocobalamine by the propionic acid bacteries - Google Patents
Process for synthesis of cyanocobalamine by the propionic acid bacteriesInfo
- Publication number
- MD749F1 MD749F1 MD960166A MD960166A MD749F1 MD 749 F1 MD749 F1 MD 749F1 MD 960166 A MD960166 A MD 960166A MD 960166 A MD960166 A MD 960166A MD 749 F1 MD749 F1 MD 749F1
- Authority
- MD
- Moldova
- Prior art keywords
- cyanocobalamine
- synthesis
- bacteries
- propionic acid
- cobalt
- Prior art date
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 title abstract 3
- 235000000639 cyanocobalamin Nutrition 0.000 title abstract 3
- 239000011666 cyanocobalamin Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 241000894006 Bacteria Species 0.000 title abstract 2
- 235000019260 propionic acid Nutrition 0.000 title abstract 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 title abstract 2
- LJUQGASMPRMWIW-UHFFFAOYSA-N 5,6-dimethylbenzimidazole Chemical compound C1=C(C)C(C)=CC2=C1NC=N2 LJUQGASMPRMWIW-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- SEWYNVSKFUSOGA-UHFFFAOYSA-N [N+](=O)([O-])[O-].[Co+3].NN(CCN(Cl)N)Cl.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] Chemical compound [N+](=O)([O-])[O-].[Co+3].NN(CCN(Cl)N)Cl.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] SEWYNVSKFUSOGA-UHFFFAOYSA-N 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 229910017052 cobalt Inorganic materials 0.000 abstract 1
- 239000010941 cobalt Substances 0.000 abstract 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000009973 maize Nutrition 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- VEFZKRNSJXVCGH-UHFFFAOYSA-L nickel(2+) pyridine-2-carboxylate tetrahydrate Chemical compound N1=C(C=CC=C1)C(=O)[O-].[Ni+2].O.O.O.O.N1=C(C=CC=C1)C(=O)[O-] VEFZKRNSJXVCGH-UHFFFAOYSA-L 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
- JDLYKQWJXAQNNS-UHFFFAOYSA-L zinc;dibenzoate Chemical compound [Zn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 JDLYKQWJXAQNNS-UHFFFAOYSA-L 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Process for synthesis of cyanocobalamine by the propionic acid bacteries in accordance with the invention forsees the microorganisms cultivation in two phases at the facultative aerobic conditions in the nutritive medium consisting of (g/l): maize extract - 60,0; glucose - 35,0; ammonium sulfate - 3,5; 5,6-dimethylbenzimidazole - 0,02; Porphyridi- um cruentum extract - 0,6; zinc benzoate - 0,0075 and tetrahydrate nickel(II) picolinate - 0,0075, in which on the third day of cultivation the coordination compound of diaminodichlorethylendiamine cobalt(III) nitrate as cobalt sourse in the quantity of 0,009 is added. The technical result of the invention consists in the stability increasing of the cyanocobalamine synthesis process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD96-0166A MD749G2 (en) | 1996-07-11 | 1996-07-11 | Process for cyanocobalamine synthesis by propionic acid bacteria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD96-0166A MD749G2 (en) | 1996-07-11 | 1996-07-11 | Process for cyanocobalamine synthesis by propionic acid bacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD749F1 true MD749F1 (en) | 1997-06-30 |
| MD749G2 MD749G2 (en) | 1998-02-28 |
Family
ID=19738874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD96-0166A MD749G2 (en) | 1996-07-11 | 1996-07-11 | Process for cyanocobalamine synthesis by propionic acid bacteria |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD749G2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2313C2 (en) * | 2001-05-25 | 2004-05-31 | Институт Микробиологии И Биотехнологии Академии Наук Молдовы | Process for vitamin B12 obtaining |
| MD4278C1 (en) * | 2013-04-30 | 2014-10-31 | Институт Химии Академии Наук Молдовы | Compound bis{bis(dimethylglyoximato)chloro}-µ-3-formylpiridineisonicotinoylhydrazone-di-cobalt(III) and process for cultivation of microalga Porphyridium cruentum with its use |
-
1996
- 1996-07-11 MD MD96-0166A patent/MD749G2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MD749G2 (en) | 1998-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Granted patent for invention | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20160711 |