MD749G2 - Process for cyanocobalamine synthesis by propionic acid bacteria - Google Patents
Process for cyanocobalamine synthesis by propionic acid bacteriaInfo
- Publication number
- MD749G2 MD749G2 MD96-0166A MD960166A MD749G2 MD 749 G2 MD749 G2 MD 749G2 MD 960166 A MD960166 A MD 960166A MD 749 G2 MD749 G2 MD 749G2
- Authority
- MD
- Moldova
- Prior art keywords
- cyanocobalamine
- synthesis
- propionic acid
- acid bacteria
- cobalt
- Prior art date
Links
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 title abstract 3
- 235000000639 cyanocobalamin Nutrition 0.000 title abstract 3
- 239000011666 cyanocobalamin Substances 0.000 title abstract 3
- 238000003786 synthesis reaction Methods 0.000 title abstract 3
- 241000894006 Bacteria Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 235000019260 propionic acid Nutrition 0.000 title abstract 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 title abstract 2
- LJUQGASMPRMWIW-UHFFFAOYSA-N 5,6-dimethylbenzimidazole Chemical compound C1=C(C)C(C)=CC2=C1NC=N2 LJUQGASMPRMWIW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002028 Biomass Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241001494715 Porphyridium purpureum Species 0.000 abstract 1
- 240000008042 Zea mays Species 0.000 abstract 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 abstract 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 abstract 1
- SEWYNVSKFUSOGA-UHFFFAOYSA-N [N+](=O)([O-])[O-].[Co+3].NN(CCN(Cl)N)Cl.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] Chemical compound [N+](=O)([O-])[O-].[Co+3].NN(CCN(Cl)N)Cl.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-] SEWYNVSKFUSOGA-UHFFFAOYSA-N 0.000 abstract 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 229910017052 cobalt Inorganic materials 0.000 abstract 1
- 239000010941 cobalt Substances 0.000 abstract 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000009973 maize Nutrition 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- VEFZKRNSJXVCGH-UHFFFAOYSA-L nickel(2+) pyridine-2-carboxylate tetrahydrate Chemical compound N1=C(C=CC=C1)C(=O)[O-].[Ni+2].O.O.O.O.N1=C(C=CC=C1)C(=O)[O-] VEFZKRNSJXVCGH-UHFFFAOYSA-L 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- JDLYKQWJXAQNNS-UHFFFAOYSA-L zinc;dibenzoate Chemical compound [Zn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 JDLYKQWJXAQNNS-UHFFFAOYSA-L 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Process for cyanocobalamine synthesis by propionic acid bacteria, according to the invention, forsees the microorganisms cultivation in two phases in facultative aerobic conditions in nutritive medium containing (in g/l): maize extract - 60,0; glucose - 35,0; ammonium sulfate - 3,5; 5,6-dimethylbenzimidazole - 0,02; Porphyridium cruentum biomass extract - 0,6; zinc benzoate - 0,0075; and tetrahydrate nickel(II) picolinate - 0,0075, in which on the third day of cultivation i tis supplrmentary added the coordinative compound of diaminodichlorethylendiamine cobalt(III) nitrate as cobalt sourse in the quantity of 0,009.The technical result of the invention consists in increasing and stabilizing the cyanocobalamine synthesis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD96-0166A MD749G2 (en) | 1996-07-11 | 1996-07-11 | Process for cyanocobalamine synthesis by propionic acid bacteria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD96-0166A MD749G2 (en) | 1996-07-11 | 1996-07-11 | Process for cyanocobalamine synthesis by propionic acid bacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD749F1 MD749F1 (en) | 1997-06-30 |
| MD749G2 true MD749G2 (en) | 1998-02-28 |
Family
ID=19738874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD96-0166A MD749G2 (en) | 1996-07-11 | 1996-07-11 | Process for cyanocobalamine synthesis by propionic acid bacteria |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD749G2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2313C2 (en) * | 2001-05-25 | 2004-05-31 | Институт Микробиологии И Биотехнологии Академии Наук Молдовы | Process for vitamin B12 obtaining |
| MD4278C1 (en) * | 2013-04-30 | 2014-10-31 | Институт Химии Академии Наук Молдовы | Compound bis{bis(dimethylglyoximato)chloro}-µ-3-formylpiridineisonicotinoylhydrazone-di-cobalt(III) and process for cultivation of microalga Porphyridium cruentum with its use |
-
1996
- 1996-07-11 MD MD96-0166A patent/MD749G2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Биологическая химия. Т. 32, 1989 г. В. Я. Быховский, Н.И. Зайцева, "Микробиологический синтез тетрапирольных соединений", с. 139-140. * |
| Обзорная информация. 1984 г., М.,"Микробиологический синтез витамина В12", с. 42. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD2313C2 (en) * | 2001-05-25 | 2004-05-31 | Институт Микробиологии И Биотехнологии Академии Наук Молдовы | Process for vitamin B12 obtaining |
| MD4278C1 (en) * | 2013-04-30 | 2014-10-31 | Институт Химии Академии Наук Молдовы | Compound bis{bis(dimethylglyoximato)chloro}-µ-3-formylpiridineisonicotinoylhydrazone-di-cobalt(III) and process for cultivation of microalga Porphyridium cruentum with its use |
Also Published As
| Publication number | Publication date |
|---|---|
| MD749F1 (en) | 1997-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Granted patent for invention | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20160711 |